Induction of contact-dependent CD8 + regulatory T cells through stimulation with staphylococcal and streptococcal superantigens

Immunology

Volumn 135, Issue 2, 2012, Pages 158-167

  Taylor, Amanda L ^a   Cross, Elizabeth L A ^a   Llewelyn, Martin J ^a  

^a BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

Author keywords

CD8; Cytotoxic T cells; Regulatory T cells; T cells

Indexed keywords

APRIL PROTEIN; CD103 ANTIGEN; CUTANEOUS LYMPHOCYTE ASSOCIATED ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; STAPHYLOCOCCUS ENTEROTOXIN A; STREPTOCOCCUS ANTIGEN; SUPERANTIGEN; TOXIC SHOCK SYNDROME TOXIN 1; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL INFECTION; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CONTACT; CELL ISOLATION; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; T LYMPHOCYTE ACTIVATION;

ANTIGENS, BACTERIAL; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; SUPERANTIGENS; T-LYMPHOCYTES, REGULATORY;

EID: 84855846017     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03529.x     Document Type: Article

References (39)

1. Fraser JD, Proft T. The bacterial superantigen and superantigen-like proteins. Immunol Rev 2008; 225:226-43.
2. Petersson K, Pettersson H, Skartved NJ, Walse B, Forsberg G. Staphylococcal enterotoxin H induces Vα-specific expansion of T cells. J Immunol 2003; 170:4148-54.
3. Llewelyn M, Sriskandan S, Terrazzini N, Cohen J, Altmann DM. The TCR Vβ signature of bacterial superantigens spreads with stimulus strength. Int Immunol 2006; 18:1433-41.
4. Schlievert PM, Nemeth KA, Davis CC, Peterson ML, Jones BE. Staphylococcus aureus exotoxins are present in vivo in tampons. Clin Vaccine Immunol 2010; 17:722-7.
5. Sriskandan S, Moyes D, Cohen J. Detection of circulating bacterial superantigen and lymphotoxin-α in patients with streptococcal toxic-shock syndrome. Lancet 1996; 348:1315-6.
6. LeClaire RD, Bavari S. Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality. Antimicrob Agents Chemother 2001; 45:460-3.
7. Basma H, Norrby-Teglund A, Guedez Y, McGeer A, Low DE, El-Ahmedy O, Schwartz B, Kotb M. Risk factors in the pathogenesis of invasive group A streptococcal infections: role of protective humoral immunity. Infect Imm 1999; 67:1871-7.
8. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64.
9. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193:1285-94.
10. + T cells with regulatory properties from human blood. J Exp Med 2001; 193:1303-10.
11. + Tregs in lupus, autoimmunity, and beyond. Autoimmun Rev 2010; 9:560-8.
12. - cells. Proc Natl Acad Sci USA 2005; 102:4103-8.
13. + T cells. J Immunol 2006; 177:2775-83.
14. + T cells. J Immunol 2002; 168:2247-54.
15. + T cells upon antigen recognition in vitro. J Immunol 2007; 179:1039-48.
16. + regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc Natl Acad Sci USA 2007; 104:8029-34.
17. Modlin RL, Mehra V, Wong L et al. Suppressor T lymphocytes from lepromatous leprosy skin lesions. J Immunol 1986; 137:2831-4.
18. + Tregs. J Clin Invest 2005; 115:2904-13.
19. + regulatory T cells by continuous antigen stimulation. Eur J Immunol 2008; 38:640-6.
20. - T cells is followed by a switch to a functional regulatory phenotype. J Immunol 2010; 185:6591-8.
21. Fraser JD. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 1989; 339:221-3.
22. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16:311-23.
23. + regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002; 3:135-42.
24. + regulatory cells that control intestinal inflammation. J Exp Med 2000; 192:295-302.
25. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192:303-10.
26. + regulatory T cells. J Exp Med 2004; 199:303-13.
27. + regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 2007; 204:1335-47.
28. + Treg and control of Leishmania major infection. J Immunol 2005; 174:5444-55.
29. + regulatory T cells in spontaneous tolerance of liver allografts. Int Immunopharmacol 2009; 9:546-8.
30. + T reg cells. J Exp Med 2006; 203:1701-11.
31. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-700.
32. + regulatory T cells. Eur J Immunol 2010; 40:2528-38.
33. Leung DY, Gately M, Trumble A, Ferguson-Darnell B, Schlievert PM, Picker LJ. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 1995; 181:747-53.
34. Reddy M, Davis C, Wong J, Prabhakar U. Cutaneous lymphocyte antigen expression on activated lymphocytes and its association with IL-12R (β1 and β2), IL-2Rα, and CXCR3. Cell Immunol 2005; 236:131-9.
35. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol 2005; 6:353-60.
36. + T cells with a regulatory phenotype and function. Eur J Immunol 2005; 35:2896-908.
37. Gilliet M, Liu YJ. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 2002; 195:695-704.
38. + T cells. J Immunol 2007; 178:3265-71.
39. - regulatory T cells. J Immunol 1998; 161:5193-202.