CD8+CD103+ regulatory T cells in spontaneous tolerance of liver allografts

International Immunopharmacology

Volumn 9, Issue 5, 2009, Pages 546-548

  Lu, Ling ^a,b,c   Yu, Yue ^a,b   Li, Guoqiang ^a,b   Pu, Liyong ^a,b   Zhang, Feng ^a,b   Zheng, Songguo ^c   Wang, Xuehao ^a,b  

^a BEIJING HOSPITAL   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

CD8+CD103+ T cells; Foxp3; Liver transplantation; Rat; Regulatory T cells

Indexed keywords

ALLOANTIGEN; CD103 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; ALPHA E INTEGRINS; ALPHA INTEGRIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, RAT; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL CONTACT; CONTROLLED STUDY; EFFECTOR CELL; GENE EXPRESSION REGULATION; IMMUNOREGULATION; LIVER GRAFT; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RECIPIENT; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; UPREGULATION; ANIMAL; GENETICS; IMMUNOLOGY; LEWIS RAT; LIVER TRANSPLANTATION; METABOLISM; PATHOLOGY;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD8; FORKHEAD TRANSCRIPTION FACTORS; INTEGRIN ALPHA CHAINS; ISOANTIGENS; LIVER TRANSPLANTATION; RATS; RATS, INBRED LEW; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION TOLERANCE;

EID: 63549098516     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.01.021     Document Type: Article

References (16)

1. Asakura H., Takayashiki T., Ku G., and Flye M.W. The persistence of regulatory cells developing after rat spontaneous liver acceptance. Surgery 138 (2005) 329-334
2. Yuan R., El-Asady R., Liu K., Wang D., Drachenberg C.B., and Hadley G.A. Critical role for CD103+CD8+ effectors in promoting tubular injury following allogeneic renal transplantation. J Immunol 175 (2005) 2868-2879
3. Uss E., Yong S.L., Hooibrink B., van Lier R.A., and ten Berge I.J. Rapamycin enhances the number of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro. Transplantation 83 (2007) 1098-1106
4. Kamada N., and Calne R.Y. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 28 (1979) 47-50
5. Pu L.Y., Wang X.H., Zhang F., Li X.C., Yao A.H., Yu Y., et al. Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4+CD25+ regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation. Surgery 142 (2007) 67-73
6. Lu L., Zhang F., Pu L.Y., Yao A.H., Yu Y., Sun B.C., et al. Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation. Front Med China 1 (2007) 373-376
7. Zheng S.G., Wang J.H., Koss M.N., Quismorio Jr. F., Gray J.D., and Horwitz D.A. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol 172 (2004) 1531-1539
8. + T cells. J Immunol 177 (2006) 2775-2783
9. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and nonself. Nat Immunol 6 (2005) 345-352
10. Jiang S., Herrera O., and Lechler R.I. New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance. Curr Opin Immunol 16 (2004) 550-557
11. Jiang X., Morita M., Sugioka A., Harada M., Kojo S., Wakao H., et al. The importance of CD25+ CD4+ regulatory T cells in mouse hepatic allograft tolerance. Liver Transpl 12 (2006) 1112-1118
12. Liu Y., Chen N., Chen G., and You P. The protective effect of CD8+CD28- T suppressor cells on the acute rejection responses in rat liver transplantation. Transplant Proc 39 (2007) 3396-3403
13. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
14. Zheng S.G., Wang J.H., Stohl W., Kim K.S., Gray J.D., and Horwitz D.A. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol 176 (2006) 3321-3329
15. Wang D., Yuan R., Feng Y., El-Asady R., Farber D.L., Gress R.E., et al. Regulation of CD103 expression by CD8+T cells responding to renal allografts. J Immunol 172 (2004) 214-221
16. Battaglia M., Stabilini A., and Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105 (2005) 4743-4748