High productivity chromatography refolding process for Hepatitis B Virus X (HBx) protein guided by statistical design of experiment studies

Journal of Chromatography A

Volumn 1223, Issue , 2012, Pages 64-71

  Basu, Anindya ^a   Leong, Susanna Su Jan ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Bioprocess intensification; Chromatography refolding; Design of experiments; Hepatitis B Virus X protein; Immobilised metal affinity chromatography

Indexed keywords

BIOPHARMACEUTICAL INDUSTRY; BIOPROCESS DESIGN; BIOPROCESS INTENSIFICATION; BIOPROCESSES; DIRECT USE; HEPATITIS B VIRUS; HEPATOCELLULAR CARCINOMA; HIGH PRODUCTIVITY; IMMOBILISED METAL AFFINITY CHROMATOGRAPHY; IN-LINE; INCLUSION BODIES; METAL-AFFINITY CHROMATOGRAPHY; MOLECULAR CHARACTERIZATION; NOVEL PROTEINS; QUALITY BY DESIGNS; REFOLDING; REFOLDING PROCESS; SPEED-TO-MARKET; STATISTICAL DESIGN OF EXPERIMENTS; THERAPEUTIC STRATEGY; THERAPEUTIC TARGETS;

AFFINITY CHROMATOGRAPHY; BIOCHEMISTRY; DESIGN; EXPERIMENTS; PRODUCTIVITY; PROTEINS; VIRUSES;

DESIGN OF EXPERIMENTS;

HEPATITIS B VIRUS X PROTEIN;

ANALYTICAL PARAMETERS; ARTICLE; BIOPROCESS; EXPERIMENTAL STUDY; EXPERIMENTATION; HEPATITIS B VIRUS; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN REFOLDING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; QUANTITATIVE TRAIT; STATISTICAL ANALYSIS;

CHROMATOGRAPHY, AFFINITY; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; PROTEIN REFOLDING; TRANS-ACTIVATORS;

HEPATITIS B VIRUS;

EID: 84855835486     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.12.037     Document Type: Article

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