Small-molecule inhibitors of APE1 DNA repair function: An overview

Current Molecular Pharmacology

Volumn 5, Issue 1, 2012, Pages 14-35

  Al Safi, Rasha I ^a   Odde, Srinivas ^a   Shabaik, Yumna ^a   Neamati, Nouri ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apurinic apyrimidinic endonuclease 1; Base excision repair; Cancer; DNA damage; High throughput; Inhibitor; Structure activity relationship

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; AP ENDONUCLEASE 1; AP ENDONUCLEASE 1 INHIBITOR; AP ENDONUCLEASE 2; CEFAPIRIN; CEFTRIAXONE; CIBACRON BLUE F3GA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; EXODEOXYRIBONUCLEASE III; LYASE INHIBITOR; MESYLIC ACID METHYL ESTER; MITOXANTRONE; MYRICETIN; STAVUDINE; TEMOZOLOMIDE; THIOLACTOMYCIN; UNCLASSIFIED DRUG; ZIDOVUDINE;

CANCER CELL; CATALYSIS; CELL GROWTH; CELL KILLING; CELL LYSATE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA BINDING; DNA DAMAGE; DNA LIBRARY; DNA REPAIR; DRUG BINDING SITE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; EXCISION REPAIR; GLIOMA CELL; HUMAN; MOLECULARLY TARGETED THERAPY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; REVIEW; STREPTOCOCCUS MUTANS; TOOTH FILLING;

CATALYTIC DOMAIN; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENZYME INHIBITORS; HUMANS; NEOPLASMS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855832174     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467211205010014     Document Type: Review

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