Human AP endonuclease possesses a significant activity as major 3′-5′ exonuclease in human leukemia cells

Biochemical and Biophysical Research Communications

Volumn 310, Issue 2, 2003, Pages 522-528

  Yoshida, Akira ^a   Ueda, Takanori ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

3 5 exonuclease; AP endonuclease; Human leukemia cells

Indexed keywords

3',5' EXONUCLEASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; EXONUCLEASE; PHOSPHATASE; PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOPLASM; CYTOSOLIC FRACTION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

EID: 0141458937     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.09.033     Document Type: Article

References (27)

1. Demple B., Herman T., Chen D.S. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc. Natl. Acad. Sci. USA. 88:1991;11450-11454.
2. Robson C.N., Hickson I.D. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res. 19:1991;5519-5523.
3. Xanthoudakis S., Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J. 11:1992;653-665.
4. Seki S., Akiyama K., Watanabe S., Hatsushika M., Ikeda S., Tsutsui K. cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J. Biol. Chem. 266:1991;20797-20802.
5. Barzilay G., Hickson I.D. Structure and function of apurinic/ apyrimidinic endonucleases. Bioessays. 17:1995;713-719.
6. ′ -phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation Biochem. Pharmacol. 57:1999;531-538.
7. Jayaraman L., Murthy K.G., Zhu C., Curran T., Xanthoudakis S., Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev. 11:1997;558-570.
8. Xanthoudakis S., Miao G., Wang F., Pan Y.C., Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11:1992;3323-3335.
9. Walker L.J., Robson C.N., Black E., Gillespie D., Hickson I.D. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol. Cell. Biol. 13:1993;5370-5376.
10. Zhivotovsky B., Wade D., Nicotera P., Orrenius S. Role of nucleases in apoptosis. Int. Arch. Allergy Immunol. 105:1994;333-338.
11. Zhivotovsky B., Wade D., Gahm A., Orrenius S., Nicotera P. Formation of 50. kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation FEBS Lett. 351:1994;150-154.
12. McConkey D.J., Orrenius S., Okret S., Jondal M. Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes. FASEB J. 7:1993;580-585.
13. Yoshida A., Takauji R., Inuzuka M., Ueda T., Nakamura T. Role of serine and ICE-like proteases in induction of apoptosis by etoposide in human leukemia HL-60 cells. Leukemia. 10:1996;821-824.
14. Pourquier P., Ueng L.M., Kohlhagen G., Mazumder A., Gupta M., Kohn K.W., Pommier Y. Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I. J. Biol. Chem. 272:1997;7792-7796.
15. Cleaver J.E., Boyer H.W. Solubility and dialysis limits of DNA oligonucleotides. Biochim. Biophys. Acta. 262:1972;116-124.
16. Seki S., Ikeda S., Watanabe S., Hatsushika M., Tsutsui K., Akiyama K., Zhang B. A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization. Biochim. Biophys. Acta. 1079:1991;57-64.
17. ′ termini of DNA J. Biol. Chem. 275:2000;31009-31015.
18. ′ mispaired DNA Nature. 415:2002;655-659.
19. Kakolyris S., Kaklamanis L., Engels K., Turley H., Hickson I.D., Gatter K.C., Harris A.L. Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence. Cancer Res. 57:1997;1794-1797.
20. Duguid J.R., Eble J.N., Wilson T.M., Kelley M.R. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res. 55:1995;6097-6102.
21. Fan Z., Beresford P.J., Zhang D., Xu Z., Novina C.D., Yoshida A., Pommier Y., Lieberman J. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat. Immunol. 4:2003;145-153.
22. Fan Z., Beresford P.J., Zhang D., Lieberman J. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22:2002;2810-2820.
23. Beresford P.J., Zhang D., Oh D.Y., Fan Z., Greer E.L., Russo M.L., Jaju M., Lieberman J. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J. Biol. Chem. 276:2001;43285-43293.
24. Hoss M., Robins P., Naven T.J., Pappin D.J., Sgouros J., Lindahl T. A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. EMBO J. 18:1999;3868-3875.
25. ′ exonucleases J. Biol. Chem. 274:1999;19655-19660.
26. ′ -directed exonuclease from human placenta J. Biol. Chem. 256:1981;8074-8079.
27. Chen G.L., Grossman L. DNase VII of human placenta. Mechanism studies. J. Biol. Chem. 260:1985;5073-5080.