Quantitation assay for absorption and first-pass metabolism of emodin in isolated rat small intestine using liquid chromatography-tandem mass spectrometry

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 9, 2007, Pages 1628-1633

  Teng, Zeng Hui ^a   Zhou, Si Yuan ^a   Yang, Run Tao ^a   Liu, Xin You ^b   Liu, Ren Wang ^a   Yang, Xi ^a   Zhang, Bang Le ^a   Yang, Jing Yue ^c   Cao, Da Yong ^c   Mei, Qi Bing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Absorption; Emodin; First pass metabolism; LC MS MS; Small intestine

Indexed keywords

DRUG METABOLITE; EMODIN; EMODIN GLUCURONIDE; EMODIN SULFATE; GLUCURONOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; ENZYME ACTIVITY; FIRST PASS EFFECT; ISOLATED ORGAN; MALE; NONHUMAN; RAT; SMALL INTESTINE ABSORPTION;

ANIMALS; BIOLOGICAL AVAILABILITY; CATHARTICS; CHROMATOGRAPHY, LIQUID; EMODIN; GLUCURONIDES; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION; SULFATES; TANDEM MASS SPECTROMETRY;

EID: 34548620886     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.1628     Document Type: Article

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