LC/MS/MS quantitation assay for pharmacokinetics of naringenin and double peaks phenomenon in rats plasma

International Journal of Pharmaceutics

Volumn 307, Issue 2, 2006, Pages 292-299

  Ma, Yan ^a   Li, Peibo ^b   Chen, Dawei ^a   Fang, Tiezheng ^b   Li, Haitian ^b   Su, Weiwei ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Double peaks; Enterohepatic circulation; LC MS MS; Naringenin; Pharmacokinetics

Indexed keywords

ACETIC ACID ETHYL ESTER; HESPERIDIN; NARINGENIN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; ELECTROSPRAY; ENTEROHEPATIC CIRCULATION; FEMALE; GLUCURONIDATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRECURSOR; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; STANDARD;

ANIMALS; AREA UNDER CURVE; BILE; BILE DUCTS; CHROMATOGRAPHY, LIQUID; ENTEROHEPATIC CIRCULATION; FEMALE; FLAVANONES; GLUCURONIDES; LIGATION; MALE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 29244469477     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.10.018     Document Type: Article

References (22)

1. W. Bors, W. Heller, C. Michel, and M. Saran Flavonoids as antioxidants: determination of radical-scavenging efficiencies Meth. Enzymol. 186 1990 343 355
2. S.J. Chen, Y.M. Yang, Y.M. Liu, B. Zhang, X.B. Pang, and F.D. Zeng The pharmacokinetics of dauricine in rats Chin. Pharmacol. Bull. 17 2001 225 229
3. V. Crespy, C. Morand, C. Besson, C. Demigne, and C. Remesy Quercetin, but not its glycosides, is absorbed from the rat stomach J. Agric. Food Chem. 50 2002 618 621
4. E. Farmakalidis, and P.A. Murphy Semi-preparative high-performance liquid chromatographic isolation of soybean isoflavones J. Chromatogr. A. 295 1984 510 514
5. E. Farmakalidis, and P.A. Murphy Isolation of 6′-O-acetylgenistin and 6′-O-acetyldaidzin from toasted defatted soyflakes J. Agric. Food Chem. 33 1985 385 389
6. U. Fukr, K. Klittich, and A.H. Staib Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man J. Clin. Pharmacol. 35 1993 431 436
7. F.P. Guengerich, and D.H. Kim In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids Carcinogenesis 11 1990 275 279
8. B.H. Havsteen Biochemistry and medical significance of the flavonoids Pharmacol. Ther. 96 2002 67 202
9. S.L. Hsiu, T.Y. Huang, Y.C. Hou, D.H. Chin, and P.-D.L. Chao Comparision of metabolic pharmacokinetics of naringin and naringenin in rabbits Life Sci. 70 2002 1481 1489
10. K. Ishii, T. Furuta, and Y. Kasuya Determination of naringin and naringenin in human plasma by high-performance liquid chromatography J. Chromatogr. B 683 1996 225 229
11. K. Ishii, T. Furuta, and Y. Kasuya Determination of naringin and naringenin in human urine by high-performance liquid chromatography utilizing solid-phase extraction J. Chromatogr. B 704 1997 299 305
12. G. Kroyer The antioxidant activity of Citrus fruit peels Zeitschrift fur Eranhrungswissenschaft 25 1986 63 69
13. W.-M. Keung, and B.L. Vallee Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase Proc. Natl. Acad. Sci. U.S.A. 90 1993 1247 1251
14. A.O.-L. Karen, I.D. Andrea, W.N. Paul, S.S. Williiam, and M.O.-B. Nora Flavonoid glucunides are substrates for human liver β-glucuronidase FEBS Lett. 503 2001 106 130
15. H. Nishino, M. Nagao, H. Fujili, and T. Sugimura Role of flavonoids in suppressing the enhancement of phospholipid metabolism by tumor promoters Cancer Lett. 21 1983 1 8
16. N.S. Parmar The gastric anti-ulcer activity of naringenin, a specific histidine decarboxylase inhibitor Int. Tissue React. 5 1983 415 420
17. T.D. Perri, and A. Auteri Action of S 5682 on the complement system in vitro and in vivo study Int. Angiol. 7 1988 11 15
18. A. Peter, W. Andrea, and W. Siegfried Bioavailability and metabolism of the flavonol qucertin in the pig Free Rad. Bio. Med. 28 2000 1056 1067
19. V.R. Scanchez de Rojas, B. Somoza, T. Ortega, and A.M. Villar Isolation of vasodilatory active flavonoids from the traditional remedy Satureja obovata Planta Med. 62 1996 272 274
20. F.V. So, N. Guthrie, A.F. Chambers, M. Moussa, and K.K. Carroll Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices Nutri. Cancer 26 1996 167 181
21. J.P. Spencer, G. Chowrimootoo, R. Choudhury, E.S. Debnam, and S.K. Srai The small intestine can both absorb and glucuronidate luminal flavonoids FEBS Lett. 458 1999 224 230
22. B.Y. Tang, and N.R. Adams Effect of equol on oestrogen receptors and on synthesis of DNA and protein in the immature rat uterus. J. Endocrinol. 85 1980 291 297