Evaluation of α,β-unsaturated ketone-based probes for papain-family cysteine proteases

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1071-1078

  Yang, Zhimou ^a   Fonović, Marko ^a,b   Verhelst, Steven H L ^a   Blum, Galia ^a   Bogyo, Matthew ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Active site labeling; Activity based probes; Cysteine protease; Irreversible inhibitor

Indexed keywords

BIOTIN PHENYLALANYLALANYL KETONE; CYSTEINE; CYSTEINE PROTEINASE; FLUORESCENT DYE; FUNCTIONAL GROUP; KETONE DERIVATIVE; MOLECULAR SCAFFOLD; PAPAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL LABELING; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVE SITE; EVALUATION; HUMAN; HUMAN CELL; MOLECULAR PROBE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN FAMILY;

ANIMALS; CATALYTIC DOMAIN; CATHEPSIN B; CATHEPSINS; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; FLUORESCENT DYES; HUMANS; INDICATORS AND REAGENTS; KETONES; MICE; MOLECULAR PROBES; PAPAIN; SUBSTRATE SPECIFICITY;

EID: 58949099705     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.089     Document Type: Article

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