Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5060-5062

  Vásquez, David ^a   Rodríguez, Jaime A ^b   Theoduloz, Cristina ^b   Verrax, Julien ^c   Calderon, Pedro Buc ^c   Valderrama, Jaime A ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSIDAD DE TALCA   (Chile)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Pyrimido 45 c isoquinolinequinones; Redox cycling, cancer cells, cytotoxicity; Substitution reaction

Indexed keywords

8 PHENYLAMINOPYRIMIDO[4,5 C]ISOQUINOLINEQUINONE DERIVATIVE; AROMATIC AMINE; ASCORBIC ACID; ISOQUINOLINE DERIVATIVE; LEWIS ACID; PYRIMIDO[4,5 C]ISOQUINOLINE 7,10 QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATALYSIS; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; OXIDATION REDUCTION REACTION; REACTION ANALYSIS; STEREOCHEMISTRY;

ANTINEOPLASTIC AGENTS; ASCORBIC ACID; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; QUINONES;

EID: 68349152488     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.041     Document Type: Article

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