New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1427-1436

  El Gazzar, A B A ^a   Hafez, H N ^a   Nawwar, G A M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

2 Thioxopyrimido 4,5 b quinoline; Analgesic; Anti inflammatory activities; Anti oxidant; Glycosidopyrimido 4,5 b quinolines; Microwave

Indexed keywords

2 (1',2',3',4' TETRA O ACETYLARABINOSYLHYDRAZON) N3 ACETYL 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (1',2',3',4' TETRA O ACETYLRIBOSYLHYDRAZON) N3 ACETYL 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (1',2',3',4' TETRA O ACETYLXYLOSYLHYDRAZON) N3 ACETYL 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (ARABINOSYLHYDRAZON) 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (GALACTOSYLHYDRAZON) 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (GLUCOSYLHYDRAZON) 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (MANNOSYLHYDRAZON) 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (RIBOSYLHYDRAZON) 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2 (XYLOSYLHYDRAZON) 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (1',2',3',4','5' PENTA O ACETYLGALACTOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO[1,2,4]TRIAZOLO[4',3':1,2] PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (1',2',3',4',5' PENTA O ACETYLGLUCOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO[1,2,4]TRIAZOLO[4',3':1,2] PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (1',2',3',4',5' PENTA O ACETYLMANNOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO[1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (ARABINOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO[1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (GALACTOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO[1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (GLUCOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO [1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 (MANNOSYL) 6 (4 CHLOROPHENYL) 10 (4 CHLOROPHENYLMETHYLENE) 7,8,9,10 TETRAHYDRO [1,2,4]TRIAZOLO[4',3':1,2]PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 5 (4 CHLOROPHENYL) 9 (4 CHLOROPHENYLMETHYLENE) 2 HYDRAZINO 3,6,7,8,9 PENTAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 4(4H) ONE; 9 (4 CHLOROPHENYLMETHYLENE) 5 (4 CHLOROPHENYL) 2 THIOXO 2,3,6,7,8,9 HEXAHYDRO PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 9 (4 METHOXYPHENYMETHYLENE) 5 (4 METHOXYPHENYL) 2 THIOXO 2,3,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 4 ONE; 9 PHENYLMETHYLENE 5 PHENYL 2 THIOXO 2,3,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINO LIN 4 ONE; ACYCLIC NUCLEOSIDE; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASCORBIC ACID; NUCLEOSIDE DERIVATIVE; PYRIMIDINONE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACILLUS SUBTILIS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MICROWAVE OVEN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANALGESICS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BACTERIA; CARRAGEENAN; DRUG DISCOVERY; EDEMA; FEMALE; LIPID PEROXIDATION; MALE; MICE; MICROWAVES; NUCLEOSIDES; QUINOLINES; RATS;

EID: 61449168879     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.030     Document Type: Article

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