Conditional peripheral membrane proteins: Facing up to limited specificity

Structure

Volumn 20, Issue 1, 2012, Pages 15-27

  Moravcevic, Katarina ^a   Oxley, Camilla L ^a   Lemmon, Mark A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; INOSITOL PYROPHOSPHATE KINASE; MEMBRANE LIPID; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 5 PHOSPHATE; PHOSPHOLIPID BINDING PROTEIN; PHOSPHOTRANSFERASE; POLYANION; UNCLASSIFIED DRUG;

CELL MEMBRANE; HUMAN; MEMBRANE BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; STEREOSPECIFICITY;

CELL MEMBRANE; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84855807389     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.11.012     Document Type: Review

References (92)

1. B. Antonny Mechanisms of membrane curvature sensing Annu. Rev. Biochem. 80 2011 101 123
2. J. Bravo, D. Karathanassis, C.M. Pacold, M.E. Pacold, C.D. Ellson, K.E. Anderson, P.J. Butler, I. Lavenir, O. Perisic, and P.T. Hawkins The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate Mol. Cell 8 2001 829 839 (Pubitemid 33030216)
3. B. Catimel, C. Schieber, M. Condron, H. Patsiouras, L. Connolly, J. Catimel, E.C. Nice, A.W. Burgess, and A.B. Holmes The PI(3,5)P2 and PI(4,5)P2 interactomes J. Proteome Res. 7 2008 5295 5313
4. B. Catimel, M.X. Yin, C. Schieber, M. Condron, H. Patsiouras, J. Catimel, D.E. Robinson, L.S. Wong, E.C. Nice, A.B. Holmes, and A.W. Burgess PI(3,4,5)P3 Interactome J. Proteome Res. 8 2009 3712 3726
5. D.F. Ceccarelli, I.M. Blasutig, M. Goudreault, Z. Li, J. Ruston, T. Pawson, and F. Sicheri Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9 J. Biol. Chem. 282 2007 13864 13874 (Pubitemid 47100518)
6. M.L. Cheever, T.K. Sato, T. de Beer, T.G. Kutateladze, S.D. Emr, and M. Overduin Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes Nat. Cell Biol. 3 2001 613 618 (Pubitemid 32624416)
7. W. Cho, and R.V. Stahelin Membrane binding and subcellular targeting of C2 domains Biochim. Biophys. Acta 1761 2006 838 849 (Pubitemid 44332329)
8. B.M. Collins, A.J. McCoy, H.M. Kent, P.R. Evans, and D.J. Owen Molecular architecture and functional model of the endocytic AP2 complex Cell 109 2002 523 535 (Pubitemid 34564478)
9. F. Colón-González, and M.G. Kazanietz C1 domains exposed: from diacylglycerol binding to protein-protein interactions Biochim. Biophys. Acta 1761 2006 827 837 (Pubitemid 44404081)
10. F. Dancea, K. Kami, and M. Overduin Lipid interaction networks of peripheral membrane proteins revealed by data-driven micelle docking Biophys. J. 94 2008 515 524
11. P. De Camilli, H. Chen, J. Hyman, E. Panepucci, A. Bateman, and A.T. Brünger The ENTH domain FEBS Lett. 513 2002 11 18 (Pubitemid 34242972)
12. G. Di Paolo, and P. De Camilli Phosphoinositides in cell regulation and membrane dynamics Nature 443 2006 651 657 (Pubitemid 44564702)
13. J.P. DiNitto, and D.G. Lambright Membrane and juxtamembrane targeting by PH and PTB domains Biochim. Biophys. Acta 1761 2006 850 867 (Pubitemid 44332328)
14. H.C. Dippold, M.M. Ng, S.E. Farber-Katz, S.K. Lee, M.L. Kerr, M.C. Peterman, R. Sim, P.A. Wiharto, K.A. Galbraith, and S. Madhavarapu GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding Cell 139 2009 337 351
15. M.J. Dixon, A. Gray, F.M. Boisvert, M. Agacan, N.A. Morrice, R. Gourlay, N.R. Leslie, C.P. Downes, and I.H. Batty A screen for novel phosphoinositide 3-kinase effector proteins Mol. Cell. Proteomics 10 2011 M110.003178
16. S.K. Dove, F.T. Cooke, M.R. Douglas, L.G. Sayers, P.J. Parker, and R.H. Michell Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis Nature 390 1997 187 192 (Pubitemid 27507990)
17. S.K. Dove, K. Dong, T. Kobayashi, F.K. Williams, and R.H. Michell Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function Biochem. J. 419 2009 1 13
18. S. Dowler, R.A. Currie, D.G. Campbell, M. Deak, G. Kular, C.P. Downes, and D.R. Alessi Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities Biochem. J. 351 2000 19 31
19. J.J. Dumas, E. Merithew, E. Sudharshan, D. Rajamani, S. Hayes, D. Lawe, S. Corvera, and D.G. Lambright Multivalent endosome targeting by homodimeric EEA1 Mol. Cell 8 2001 947 958 (Pubitemid 34031798)
20. W. Fan, A. Nassiri, and Q. Zhong Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L) Proc. Natl. Acad. Sci. USA 108 2011 7769 7774
21. K.M. Ferguson, M.A. Lemmon, J. Schlessinger, and P.B. Sigler Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain Cell 83 1995 1037 1046 (Pubitemid 26006545)
22. K.M. Ferguson, J.M. Kavran, V.G. Sankaran, E. Fournier, S.J. Isakoff, E.Y. Skolnik, and M.A. Lemmon Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Mol. Cell 6 2000 373 384
23. M.G. Ford, B.M. Pearse, M.K. Higgins, Y. Vallis, D.J. Owen, A. Gibson, C.R. Hopkins, P.R. Evans, and H.T. McMahon Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes Science 291 2001 1051 1055 (Pubitemid 32157415)
24. M.G. Ford, I.G. Mills, B.J. Peter, Y. Vallis, G.J. Praefcke, P.R. Evans, and H.T. McMahon Curvature of clathrin-coated pits driven by epsin Nature 419 2002 361 366
25. M.C. Frame, H. Patel, B. Serrels, D. Lietha, and M.J. Eck The FERM domain: organizing the structure and function of FAK Nat. Rev. Mol. Cell Biol. 11 2010 802 814
26. A. Frost, V.M. Unger, and P. De Camilli The BAR domain superfamily: membrane-molding macromolecules Cell 137 2009 191 196
27. R. Gallardo, Y. Ivarsson, J. Schymkowitz, F. Rousseau, and P. Zimmermann Structural diversity of PDZ-lipid interactions ChemBioChem 11 2010 456 467
28. O. Gallego, M.J. Betts, J. Gvozdenovic-Jeremic, K. Maeda, C. Matetzki, C. Aguilar-Gurrieri, P. Beltran-Alvarez, S. Bonn, C. Fernández-Tornero, and L.J. Jensen A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae Mol. Syst. Biol. 6 2010 430
29. A. Godi, A. Di Campli, A. Konstantakopoulos, G. Di Tullio, D.R. Alessi, G.S. Kular, T. Daniele, P. Marra, J.M. Lucocq, and M.A. De Matteis FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P Nat. Cell Biol. 6 2004 393 404 (Pubitemid 38607499)
30. N.A. Gokhale, A. Zaremba, and S.B. Shears Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain Biochem. J. 434 2011 415 426
31. O. Gozani, P. Karuman, D.R. Jones, D. Ivanov, J. Cha, A.A. Lugovskoy, C.L. Baird, H. Zhu, S.J. Field, and S.L. Lessnick The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor Cell 114 2003 99 111 (Pubitemid 36859844)
32. M. Guerrero-Valero, C. Ferrer-Orta, J. Querol-Audí, C. Marin-Vicente, I. Fita, J.C. Gómez-Fernández, N. Verdaguer, and S. Corbalán-García Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2 Proc. Natl. Acad. Sci. USA 106 2009 6603 6607
33. B.K. Han, and S.D. Emr Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1 Genes Dev. 25 2011 984 995
34. J.E. Harlan, P.J. Hajduk, H.S. Yoon, and S.W. Fesik Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate Nature 371 1994 168 170 (Pubitemid 24284017)
35. J. Hasegawa, E. Tokuda, T. Tenno, K. Tsujita, H. Sawai, H. Hiroaki, T. Takenawa, and T. Itoh SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain J. Cell Biol. 193 2011 901 916
36. J. He, J.L. Scott, A. Heroux, S. Roy, M. Lenoir, M. Overduin, R.V. Stahelin, and T.G. Kutateladze Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain J. Biol. Chem. 286 2011 18650 18657
37. W.M. Henne, N.J. Buchkovich, and S.D. Emr The ESCRT pathway Dev. Cell 21 2011 77 91
38. W. Huang, H. Zhang, F. Davrazou, T.G. Kutateladze, X. Shi, O. Gozani, and G.D. Prestwich Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling J. Am. Chem. Soc. 129 2007 6498 6506
39. J.H. Hurley, and P.I. Hanson Membrane budding and scission by the ESCRT machinery: it's all in the neck Nat. Rev. Mol. Cell Biol. 11 2010 556 566
40. J. Hyman, H. Chen, P.P. Di Fiore, P. De Camilli, and A.T. Brunger Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF) J. Cell Biol. 149 2000 537 546 (Pubitemid 30252388)
41. M. Hyvönen, M.J. Macias, M. Nilges, H. Oschkinat, M. Saraste, and M. Wilmanns Structure of the binding site for inositol phosphates in a PH domain EMBO J. 14 1995 4676 4685
42. S.J. Isakoff, T. Cardozo, J. Andreev, Z. Li, K.M. Ferguson, R. Abagyan, M.A. Lemmon, A. Aronheim, and E.Y. Skolnik Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast EMBO J. 17 1998 5374 5387 (Pubitemid 28427051)
43. P.A. Janmey Protein regulation by phosphatidylinositol lipids Chem. Biol. 2 1995 61 65
44. P.A. Janmey, and T.P. Stossel Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate Nature 325 1987 362 364 (Pubitemid 17053178)
45. D. Karathanassis, R.V. Stahelin, J. Bravo, O. Perisic, C.M. Pacold, W. Cho, and R.L. Williams Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction EMBO J. 21 2002 5057 5068
46. J.D. Knight, M.G. Lerner, J.G. Marcano-Velázquez, R.W. Pastor, and J.J. Falke Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics Biophys. J. 99 2010 2879 2887
47. T.G. Kutateladze Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain Biochim. Biophys. Acta 1761 2006 868 877 (Pubitemid 44332324)
48. T.G. Kutateladze Translation of the phosphoinositide code by PI effectors Nat. Chem. Biol. 6 2010 507 513
49. I. Lassing, and U. Lindberg Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin Nature 314 1985 472 474 (Pubitemid 15145594)
50. M.A. Lemmon Membrane recognition by phospholipid-binding domains Nat. Rev. Mol. Cell Biol. 9 2008 99 111 (Pubitemid 351158910)
51. M.A. Lemmon, K.M. Ferguson, R. O'Brien, P.B. Sigler, and J. Schlessinger Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain Proc. Natl. Acad. Sci. USA 92 1995 10472 10476
52. M. Lenoir, U. Coskun, M. Grzybek, X. Cao, S.B. Buschhorn, J. James, K. Simons, and M. Overduin Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains EMBO Rep. 11 2010 279 284
53. I. Letunic, T. Doerks, and P. Bork SMART 6: recent updates and new developments Nucleic Acids Res. 37 Database issue 2009 D229 D232
54. T.P. Levine, and S. Munro Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components Curr. Biol. 12 2002 695 704 (Pubitemid 34455422)
55. A.E. Lewis, L. Sommer, M.Ø. Arntzen, Y. Strahm, N.A. Morrice, N. Divecha, and C.S. D'Santos Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction Mol. Cell. Proteomics 10 2011 M110.003376
56. S.E. Lietzke, S. Bose, T. Cronin, J. Klarlund, A. Chawla, M.P. Czech, and D.G. Lambright Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains Mol. Cell 6 2000 385 394
57. S. McLaughlin, and D. Murray Plasma membrane phosphoinositide organization by protein electrostatics Nature 438 2005 605 611 (Pubitemid 41740564)
58. M. Medkova, and W. Cho Interplay of C1 and C2 domains of protein kinase C-alpha in its membrane binding and activation J. Biol. Chem. 274 1999 19852 19861
59. R.H. Michell, V.L. Heath, M.A. Lemmon, and S.K. Dove Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions Trends Biochem. Sci. 31 2006 52 63 (Pubitemid 43117543)
60. S.K. Milano, Y.M. Kim, F.P. Stefano, J.L. Benovic, and C. Brenner Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding J. Biol. Chem. 281 2006 9812 9823 (Pubitemid 43864700)
61. T.H. Millard, G. Bompard, M.Y. Heung, T.R. Dafforn, D.J. Scott, L.M. Machesky, and K. Fütterer Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53 EMBO J. 24 2005 240 250 (Pubitemid 40216129)
62. S. Misra, and J.H. Hurley Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p Cell 97 1999 657 666 (Pubitemid 29256968)
63. K. Moravcevic, J.M. Mendrola, K.R. Schmitz, Y.H. Wang, D. Slochower, P.A. Janmey, and M.A. Lemmon Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids Cell 143 2010 966 977
64. E. Oancea, and T. Meyer Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals Cell 95 1998 307 318 (Pubitemid 28507320)
65. W.S. Park, W.D. Heo, J.H. Whalen, N.A. O'Rourke, H.M. Bryan, T. Meyer, and M.N. Teruel Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging Mol. Cell 30 2008 381 392 (Pubitemid 351615320)
66. B.J. Peter, H.M. Kent, I.G. Mills, Y. Vallis, P.J. Butler, P.R. Evans, and H.T. McMahon BAR domains as sensors of membrane curvature: the amphiphysin BAR structure Science 303 2004 495 499 (Pubitemid 38120842)
67. L. Premkumar, A.A. Bobkov, M. Patel, L. Jaroszewski, L.A. Bankston, B. Stec, K. Vuori, J.F. Côté, and R.C. Liddington Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs) J. Biol. Chem. 285 2010 13211 13222
68. B. Qualmann, D. Koch, and M.M. Kessels Let's go bananas: revisiting the endocytic BAR code EMBO J. 30 2011 3501 3515
69. L.E. Rameh, K.F. Tolias, B.C. Duckworth, and L.C. Cantley A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature 390 1997 192 196 (Pubitemid 27507991)
70. D. Ramel, F. Lagarrigue, V. Pons, J. Mounier, S. Dupuis-Coronas, G. Chicanne, P.J. Sansonetti, F. Gaits-Iacovoni, H. Tronchre, and B. Payrastre Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling Sci. Signal. 4 2011 ra61
71. R. Sanchez, and M.M. Zhou The PHD finger: a versatile epigenome reader Trends Biochem. Sci. 36 2011 364 372
72. S. Sánchez-Bautista, C. Marín-Vicente, J.C. Gómez-Fernández, and S. Corbalán-García The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway J. Mol. Biol. 362 2006 901 914 (Pubitemid 44389732)
73. S. Santagata, T.J. Boggon, C.L. Baird, C.A. Gomez, J. Zhao, W.S. Shan, D.G. Myszka, and L. Shapiro G-protein signaling through tubby proteins Science 292 2001 2041 2050 (Pubitemid 32691568)
74. K.R. Schmitz, J. Liu, S. Li, T.G. Setty, C.S. Wood, C.G. Burd, and K.M. Ferguson Golgi localization of glycosyltransferases requires a Vps74p oligomer Dev. Cell 14 2008 523 534 (Pubitemid 351479939)
75. S. Schoebel, W. Blankenfeldt, R.S. Goody, and A. Itzen High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA EMBO Rep. 11 2010 598 604
76. L.F. Seet, and W. Hong The Phox (PX) domain proteins and membrane traffic Biochim. Biophys. Acta 1761 2006 878 896 (Pubitemid 44348964)
77. A. Shimada, H. Niwa, K. Tsujita, S. Suetsugu, K. Nitta, K. Hanawa-Suetsugu, R. Akasaka, Y. Nishino, M. Toyama, and L. Chen Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis Cell 129 2007 761 772 (Pubitemid 46813111)
78. R.V. Stahelin, D. Karathanassis, D. Murray, R.L. Williams, and W. Cho Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity J. Biol. Chem. 282 2007 25737 25747 (Pubitemid 47372820)
79. C.J. Stefan, A. Audhya, and S.D. Emr The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate Mol. Biol. Cell 13 2002 542 557 (Pubitemid 34165082)
80. P.C. Stolt, H. Jeon, H.K. Song, J. Herz, M.J. Eck, and S.C. Blacklow Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes Structure 11 2003 569 579 (Pubitemid 36579134)
81. Z. Szentpetery, A. Balla, Y.J. Kim, M.A. Lemmon, and T. Balla Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study BMC Cell Biol. 10 2009 67
82. M. Tabuchi, A. Audhya, A.B. Parsons, C. Boone, and S.D. Emr The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation Mol. Cell. Biol. 26 2006 5861 5875 (Pubitemid 44134340)
83. H. Teo, D.J. Gill, J. Sun, O. Perisic, D.B. Veprintsev, Y. Vallis, S.D. Emr, and R.L. Williams ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes Cell 125 2006 99 111
84. Y. Uchida, J. Hasegawa, D. Chinnapen, T. Inoue, S. Okazaki, R. Kato, S. Wakatsuki, R. Misaki, M. Koike, and Y. Uchiyama Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes Proc. Natl. Acad. Sci. USA 108 2011 15846 15851
85. N. Verdaguer, S. Corbalan-Garcia, W.F. Ochoa, I. Fita, and J.C. Gómez-Fernández Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine EMBO J. 18 1999 6329 6338 (Pubitemid 29533237)
86. C.S. Wood, K.R. Schmitz, N.J. Bessman, T.G. Setty, K.M. Ferguson, and C.G. Burd PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking J. Cell Biol. 187 2009 967 975
87. T. Yeung, G.E. Gilbert, J. Shi, J. Silvius, A. Kapus, and S. Grinstein Membrane phosphatidylserine regulates surface charge and protein localization Science 319 2008 210 213
88. J.W. Yu, J.M. Mendrola, A. Audhya, S. Singh, D. Keleti, D.B. DeWald, D. Murray, S.D. Emr, and M.A. Lemmon Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains Mol. Cell 13 2004 677 688 (Pubitemid 38368125)
89. G. Zhang, M.G. Kazanietz, P.M. Blumberg, and J.H. Hurley Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester Cell 81 1995 917 924
90. C. Zhao, G. Du, K. Skowronek, M.A. Frohman, and D. Bar-Sagi Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos Nat. Cell Biol. 9 2007 706 712
91. J. Zheng, R.H. Chen, S. Corblan-Garcia, S.M. Cahill, D. Bar-Sagi, and D. Cowburn The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains J. Biol. Chem. 272 1997 30340 30344 (Pubitemid 27512241)
92. H. Zhu, M. Bilgin, R. Bangham, D. Hall, A. Casamayor, P. Bertone, N. Lan, R. Jansen, S. Bidlingmaier, and T. Houfek Global analysis of protein activities using proteome chips Science 293 2001 2101 2105 (Pubitemid 32848060)