Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling

Science Signaling

Volumn 4, Issue 191, 2011, Pages

  Ramel, Damien ^a   Lagarrigue, Frédéric ^a   Pons, Véronique ^a   Mounier, Joëlle ^b   Dupuis Coronas, Sophie ^a   Chicanne, Gaëtan ^a   Sansonetti, Philippe J ^b,c   Gaits Iacovoni, Frédérique ^a   Tronchère, Hélène ^a   Payrastre, Bernard ^a  

^a INSERM   (France)

^b INSTITUT PASTEUR   (France)

^c l'alimentation et l'Environnement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IPGD PROTEIN; LIPID; PHOSPHATIDYLINOSITOL 5 PHOSPHATE; POLYPHOSPHOINOSITIDE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; BACTERIAL PROTEIN; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; IPGD PROTEIN, SHIGELLA FLEXNERI; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; DYSENTERY; ENDOCYTOSIS; ENDOSOME; HELA CELL; HOST CELL; HUMAN; HUMAN TISSUE; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHIGELLA FLEXNERI; SHIGELLOSIS; SIGNAL TRANSDUCTION; BIOSYNTHESIS; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; METABOLISM; MICROBIOLOGY; PROTEIN DEGRADATION; PROTEIN TRANSPORT;

BACTERIA (MICROORGANISMS); SHIGELLA FLEXNERI;

BACTERIAL PROTEINS; CELL SURVIVAL; DYSENTERY, BACILLARY; ENDOCYTOSIS; ENDOSOMES; ENZYME ACTIVATION; HELA CELLS; HUMANS; LYSOSOMES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN TRANSPORT; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SHIGELLA FLEXNERI; SIGNAL TRANSDUCTION;

EID: 80053111626     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001619     Document Type: Article

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53. Acknowledgments: We thank E. Saland for excellent technical assistance and S. Manenti, C. Racaud-Sultan, and C. Lamaze for stimulating discussions. We thank S. Allart and D. Sapede (Cellular Imaging Platform, IFR150) for their help with confocal imaging and M. Tremblay-Franco (Plateforme AXIOM, Genotoul) for her help in statistical analysis. Funding: This work was supported by the Agence Nationale de la Recherche (ANR; Programme Blanc), ANR E-rare, and Association pour la Recherche sur le Cancer (ARC). D.R. and F.L. were supported by grants from the Ministere de la Recherche et de la Technologie and ARC. P.J.S. is a Howard Hughes Medical Institute foreign scholar. Author contributions: D.R. and F.L. conducted biochemical and cell biology experiments with the assistance of H.T.; S.D.-C. and V.P. conducted endosome isolation; J.M. performed S. flexneri infection experiments; G.C. performed HPLC phosphoinositide analysis; P.J.S. directed and interpreted S. flexneri infection experiments; F.G.-I., H.T., and B.P. directed the study, analyzed the data, and wrote the paper. Competing interests: The authors declare that they have no competing interests.