Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 3, 2012, Pages 263-271

  Matuszak, Nicolas ^a   Hamtiaux, Laurie ^a   Baldeyroux, Brigitte ^b   Muccioli, Giulio G ^a   Poupaert, Jacques H ^a   Lansiaux, Amélie ^b   Lambert, Didier M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIV LILLE   (France)

Author keywords

2 Arachidonoylglycerol; Endocannabinoid; Maleimide; Monoacylglycerol lipase; Topoisomerase

Indexed keywords

1 (2 CHLORO 6 METHYLPHENYL) 1H PYRROLE 2,5 DIONE; 1 (2,4,6 TRICHLOROPHENYL) 1H PYRROLE 2,5 DIONE; 1 (2,6 DICHLOROPHENYL) 1H PYRROLE 2,5 DIONE; 2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; CAY 10488; CAY 10499; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; JZL 184; MALEIMIDE DERIVATIVE; N PHENYLMALEIMIDE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ARACHIDONIC ACIDS; BENZODIOXOLES; CARBAMATES; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; ENDOCANNABINOIDS; ETOPOSIDE; GLYCERIDES; HUMANS; MALEIMIDES; MONOACYLGLYCEROL LIPASES; NEUROBLASTOMA; OXADIAZOLES; PIPERIDINES; TOPOISOMERASE II INHIBITORS; TUMOR CELLS, CULTURED;

EID: 84855760061     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.11.011     Document Type: Article

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