Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 473-478

  Liu, Kai ^a   Lu, Xiang ^a   Zhang, Hong Jia ^a   Sun, Juan ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Anti tumor; EGFR; Oxadiazole

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 2 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL) 5 METHOXYPHENOL; 2 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL) 5 METHYLPHENOL; 2 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL)ANILINE; 2 (BENZYLTHIO) 5 ( 2 CHLOROPYRIDIN 4 YL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 2 ETHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 2 FLUOROPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 2 METHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 2 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 3,5 DIMETHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 4 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 4 FLUOROPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 4 ISOPROPYLPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 ( 4 TERT BUTYLPHENYL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 O TOLYL 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 PHENYL 1,3,4 OXADIAZOLE; 4 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL) N,N DIMETHYLANILINE; 4 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL)ANILINE; 4 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL)PYRIDIN 2 AMINE; 5 ( 5 (BENZYLTHIO) 1,3,4 OXADIAZOL 2 YL)PYRIDIN 2 AMINE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MODELS, MOLECULAR; OXADIAZOLES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855757938     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.015     Document Type: Article

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