Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4- oxadiazoles as benzodiazepine receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 12, 2005, Pages 3126-3129

  Zarghi, Afshin ^a   Faizi, Mehrdad ^a   Shafaghi, Bijan ^a   Ahadian, Avideh ^a   Khojastehpoor, Hamid R ^a   Zanganeh, Vahideh ^a   Tabatabai, Sayyed A ^a   Shafiee, Abbas ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,3,4 Oxadiazole; Benzodiazepine receptor agonists; MES; PTZ

Indexed keywords

AMINO ACID; ANTICONVULSIVE AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DIAZEPAM; ESTAZOLAM; FLUMAZENIL; OXADIAZOLE DERIVATIVE; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; ELECTRIC SHOCK; ENERGY; MOUSE; NONHUMAN; PHARMACOPHORE; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ANIMALS; ANTICONVULSANTS; BENZODIAZEPINES; CONVULSANTS; DIAZEPAM; DRUG DESIGN; ELECTROSHOCK; FLUMAZENIL; GABA MODULATORS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; PENTYLENETETRAZOLE; RECEPTORS, GABA-A; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944369750     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.04.018     Document Type: Article

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