Healthy first-degree relatives of patients with type 1 diabetes exhibit significant differences in basal gene expression pattern of immunocompetent cells compared to controls: Expression pattern as predeterminant of autoimmune diabetes

Scandinavian Journal of Immunology

Volumn 75, Issue 2, 2012, Pages 210-219

  Stechova, K ^a   Kolar, M ^b   Blatny, R ^c   Halbhuber, Z ^c   Vcelakova, J ^a   Hubackova, M ^a   Petruzelkova, L ^a   Sumnik, Z ^a   Obermannova, B ^a   Pithova, P ^a   Stavikova, V ^a   Krivjanska, M ^b   Neuwirth, A ^b   Kolouskova, S ^a   Filipp, D ^b  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c Central European Biosystems   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD137 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; INTERLEUKIN 1; AUTOANTIBODY; CCR3 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR3; LEUKOCYTE ANTIGEN; TOLL LIKE RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE DISEASE; CHILD; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DIABETOGENESIS; EOSINOPHIL; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMORAL IMMUNITY; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; RELATIVE; SIGNAL TRANSDUCTION; AUTOIMMUNITY; BIOSYNTHESIS; CASE CONTROL STUDY; FAMILY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; IMMUNOLOGY; INFANT; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; PATHOLOGY; PRESCHOOL CHILD; PRIMARY CELL CULTURE;

ADOLESCENT; ADULT; ANTIGENS, CD; AUTOANTIBODIES; AUTOIMMUNITY; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNITY, HUMORAL; IMMUNITY, INNATE; INFANT; INTERLEUKIN-1; LEUKOCYTES, MONONUCLEAR; MALE; MOLECULAR SEQUENCE ANNOTATION; PRIMARY CELL CULTURE; RECEPTORS, CCR3; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84855748035     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02637.x     Document Type: Article

References (45)

1. Castano L, Eisenbarth GS. Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 1990;8:647-79.
2. Foulis AK, Farquharson MA, Meager A. Immunoreactive a-interferon in insulin-secreting b cells in type 1 diabetes mellitus. Lancet 1987;2:1423-7.
3. Atkinson MA, Kaufman DL, Campbell L et al. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 1992;339:458-9.
4. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PG, Gamble DR. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985;313:353-60.
5. Bingley PJ, Williams AJ, Gale EA. Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials. Diabetes Care 1999;22:1796-801.
6. Achenbach P, Bonifacio E, Ziegler AG. Predicting type 1 diabetes. Curr Diab Rep 2005;5:98-103.
7. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-9.
8. Todd JA. Etiology of type 1 diabetes. Immunity 2010;32:457-67.
9. Tree TI, Peakman M. Autoreactive T cells in human type 1 diabetes. Endocrinol Metab Clin North Am 2004;33:113-33.
10. Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab 2007;92:3705-11.
11. Vrabelova Z, Kolouskova S, Böhmova K et al. Protein microarray analysis as a tool for monitoring cellular autoreactivity in type 1 diabetes patients and their relatives. Pediatr Diabetes 2007;8:252-60.
12. Reynier F, Pachot A, Paye M et al. Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis. Genes Immun 2010;11:269-78.
13. Planas R, Pujol-Borrell R, Vives-Pi M. Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery. Immunol Lett 2010;133:55-61.
14. Petrich de Marquesini LG, Fu J, Connor KJ et al. IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes. Diabetologia 2010;53:1451-60.
15. Borowiec M, Liew CW, Thompson R et al. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A 2009;106:14460-5.
16. Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 2009;361:2143-52.
17. Fiorina P, Vergani A, Dada S et al. Targeting CD22 reprograms B-cells and reverses autoimmune diabetes. Diabetes 2008;57:3013-24.
18. Goldberg E, Krause I. Infection and type 1 diabetes mellitus - a two edged sword? Autoimmun Rev 2009;8:682-6.
19. Dasu MR, Jialal I. Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab 2011;300:E145-54.
20. Devaraj S, Dasu MR, Park SH, Jialal I. Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes. Diabetologia 2009;52:1665-8.
21. Castiblanco J, Varela DC, Castaño-Rodríguez N, Rojas-Villarraga A, Hincapié ME, Anaya JM. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol 2008;8:541-4.
22. Reynolds JM, Angkasekwinai P, Dong C. IL-17 family member cytokines: regulation and function in innate immunity. Cytokine Growth Factor Rev 2010;21:413-23.
23. Moreno-Navarrete JM, Martínez-Barricarte R, Catalán V et al. Complement factor H is expressed in adipose tissue in association with insulin resistance. Diabetes 2010;59:200-9.
24. Crozat K, Vivier E, Dalod M. Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies. Immunol Rev 2009;227:129-49.
25. Smyth DJ, Howson JM, Payne F et al. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. BMC Med Genet 2006;7:20.
26. Sutherland AP, Van BelleT, Wurster AL et al. Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Diabetes 2009;58:1144-55.
27. Monteleone G, Sarra M, Pallone F. Interleukin-21 in T cell-mediated diseases. Discov Med 2009;8:113-7.
28. Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 1998;14:129-51.
29. Hoe E, McKay FC, Schibeci SD et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol 2010;184:2512-7.
30. Qin H, Lee IF, Panagiotopoulos C et al. Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling. Diabetes 2011;60:857-66.
31. Kuczyński S, Winiarska H, Abramczyk M, Szczawińska K, Wierusz-Wysocka B, Dworacka M. IL-15 is elevated in serum patients with type 1 diabetes mellitus. Diabetes Res Clin Pract 2005;69:231-6.
32. Pieper CM, Roza AM, Henderson JD Jr, Zhu YR, Lai CS. Spatial distribution and temporal onset of NF-kB activation and inducible nitric oxide synthase within pancreatic islets in the pre-diabetic stage of genetic, diabetic-prone BB rats: attenuation by drug intervention decreases inflammatory cell infiltration and incidence of diabetes. Inflamm Res 2004;53:22-30.
33. Gene database via Medline
34. Baker C, Chang L, Elsegood KA et al. Activated T cell subsets in human type 1 diabetes: evidence for expansion of the DR+ CD30+ subpopulation in new-onset disease. Clin Exp Immunol 2007;147:472-82.
35. Hunt KA, Zhernakova A, Turner G et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 2008;40:395-402.
36. Lohmann T, Laue S, Nietzschmann U et al. Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Diabetes 2002;51:2474-80.
37. Manousou P, Kolios G, Valatas V et al. Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies. Clin Exp Immunol 2010;162:337-47.
38. Aloush V, George J, Elkayam O et al. Decreased levels of CCR3 in CD4+ lymphocytes of rheumatoid arthritis patients. Clin Exp Rheumatol 2010;28:462-7.
39. Nagib PR, Gameiro J, Stivanin-Silva LG et al. Thymic microenvironmental alterations in experimentally induced diabetes. Immunobiology 2010;215:971-9.
40. Ryden A, Stechova K, Durilova M, Faresjö M. Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes. Diabetes Metab Res Rev 2009;25:335-43.
41. Stechova K, Bohmova K, Vrabelova Z et al. High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes. Diabetes Metab Res Rev 2007;23:462-71.
42. Nguyen K, Miller BC. CD28 costimulation induces delta opioid receptor expression during anti-CD3 activation of T cells. J Immunol 2002;168:4440-5.
43. Wagner DH Jr, Vaitaitis G, Sanderson R, Poulin M, Dobbs C, Haskins K. Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc Natl Acad Sci U S A 2002;99:3782-7.
44. Irie J, Wu Y, Kachapati K, Mittler RS, Ridgway WM. Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes. Diabetes 2007;56:186-96.
45. Kretowski A, Myśliwiec J, Kinalska I. In vitro interleukin-13 production by peripheral blood in patients with newly diagnosed insulin-dependent diabetes mellitus and their first degree relatives. Scand J Immunol 2000;51:321-5.