Thymic microenvironmental alterations in experimentally induced diabetes

Immunobiology

Volumn 215, Issue 12, 2010, Pages 971-979

  Nagib, Patrícia R A ^a   Gameiro, Jacy ^a   Guilherme Stivanin Silva, Luiz ^a   Sueli Parreira de Arruda, Maria ^b   Maria Serra Villa Verde, Déa ^c   Savino, Wilson ^c   Verinaud, Liana ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Chemokines; Diabetes; Extracellular matrix; Thymic microenvironment; Thymus

Indexed keywords

CHEMOKINE; CHEMOKINE CCL25; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR4; FIBRONECTIN; FIBRONECTIN RECEPTOR; LAMININ; LAMININ RECEPTOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS ATROPHY;

ALLOXAN; ANIMALS; ATROPHY; BODY WEIGHT; CELL MOVEMENT; CELL SURVIVAL; CHEMOKINE CXCL12; CHEMOKINES, CC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FIBRONECTINS; FLOW CYTOMETRY; INTEGRIN ALPHA5BETA1; LAMININ; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; ORGAN SIZE; RECEPTORS, CCR; RECEPTORS, LAMININ; T-LYMPHOCYTES; THYMUS GLAND;

EID: 77956461180     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2010.02.001     Document Type: Article

References (36)

1. Alba-Loureiro T.C., Munhoz C.D., Martins J.O., Cerchiaro G.A., Scavone C., Curi R., Sannomiya P. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz. J. Med. Biol. Res. 2007, 40:1037-1044.
2. Andrade C.F., Gameiro J., Nagib P.R., Carvalho B.O., Talaisys R.L., Costa F.T., Verinaud L. Thymic alterations in Plasmodium berghei-infected mice. Cell Immunol. 2008, 253:1-4.
3. Barreto E.O., Riederer I., Arantes A.C., Carvalho V.F., Farias-Filho F.A., Cordeiro R.S.B., Martins M.A., Savino W., Silva P.M.R. Thymus involution in alloxan diabetes: analysis of mast cells. Mem. Inst. Oswaldo Cruz 2005, 100:127-130.
4. Benfield T., Jensen J.S., Nordestgaard B.G. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 2007, 50:549-554.
5. Bernotiene E., Palmer G., Gabay C. The role of leptin in innate and adaptive immune responses. Arthritis Res. Ther. 2006, 8:217-226.
6. Carvalho V.F., Barreto E.O., Diaz B.L., Serra M.F., Azevedo V., Cordeiro R.S.M., Martins A., Silva P.M. Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism dependent on glucocorticoids. Eur. J. Pharmacol. 2003, 472:221-227.
7. Chen X., Makala L.H., Jin Y., Hopkins D., Muir A., Garge N., Podolsky R.H., She J.X. Type 1 diabetes patients have significantly lower frequency of plasmacytoid dendritic cells in the peripheral blood. Clin. Immunol. 2008, 129:413-418.
8. Ciofani M., Zúñiga-Pflücker J.C. The thymus as an inductive site for T lymphopoiesis. Annu. Rev. Cell Dev. Biol. 2007, 23:463-493.
9. Collins T.J. ImageJ for microscopy. Biotechniques 2007, 43:25-30.
10. Cotta-de-Almeida V., Bonomo A., Mendes-da-Cruz D.A., Riederer I., Meis J., Lima-Quaresma K.R.F., Vieira-de-Abreu A., Villa-Verde D.M.S., Savino W. Trypanosoma cruzi infection modulates intrathymic contents of extracellular matrix ligands and receptors and alters thymocyte migration. Eur. J. Immunol. 2003, 33:2439-2448.
11. Delamaire M., Maugendre D., Moreno M., Le Goff M.C., Allannic H., Genetet B. Impaired leucocyte functions in diabetic patients. Diabetic Med. 1997, 14:29-34.
12. Dunn J.S., Duffy E., Gilmour M.K.K.J., McLetchie N.G.B. Further observations on the effects of alloxan on the pancreatic islets. J. Physiol. 1944, 103:233-243.
13. Elmas C., Erdogan D., Take G., Ozogul C., Nacar A., Koksal M. Ultrastructure of the thymus in diabetes mellitus and starvation. Adv. Ther. 2008, 25:67-76.
14. Gaulton G.N., Schwartz J.L., Eardley D.D. Assessment of the diabetogenic drugs alloxan and streptozotocin as models for the study defects in diabetic mice. Diabetologia 1985, 28:769-775.
15. Geutskens S.B., Mendes-da-Cruz D.A., Dardenne M., Savino W. Fibronectin receptor defects in NOD mouse leucocytes: possible consequences for type 1 diabetes. Scand. J. Immunol. 2004, 60:30-38.
16. Gruver A.L., Sempowski G.D. Cytokines, leptin, and stress-induced thymic atrophy. J. Leukoc. Biol. 2008, 84:915-923.
17. Hirsch T., Spielmann M., Zuhaili B., Koehler T., Fossum M., Steinau H.-U., Yao F., Steinstraesser L., Onderdonk A.B., Eriksson E. Enhanced susceptibility to infections in a diabetic wound healing model. BMC Surg. 2008, 8:5-12.
18. Howard J.K., Lord G.M., Matarese G., Vendetti S., Ghatei M.A., Ritter M.A., Lechler R.I., Bloom S.R. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 1999, 104:1051-1059.
19. Kiess W., Anil M., Blum W.F., Englaro P., Juul A., Attanasio A., Dötsch J., Rascher W. Serum leptin levels in children and adolescents with insulin-dependent diabetes mellitus in relation to metabolic control and body mass index. Eur. J. Endocrinol. 1998, 138:501-509.
20. Mendes-da-Cruz D.A., Smaniotto S., Keller A.C., Dardenne M., Savino W. Multivectorial abnormal cell migration in the NOD mouse thymus. J. Immunol. 2008, 180:4639-4647.
21. Mendes-da-Cruz D.A., Silva J.S., Cotta-de-Almeida V., Savino W. Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4. Eur. J. Immunol. 2006, 36:1486-1493.
22. Mito N., Yoshino H., Hosoda T., Sato K. Analysis of the effect of leptin on immune function in vivo using diet-induced obese mice. J. Endocrinol. 2004, 180:167-173.
23. Muller L.M., Gorter K.J., Hak E., Goudzwaard W.L., Schellevis F.G., Hoepelman A.I., Rutten G.E. Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus. Clin. Infect. Dis. 2005, 4:281-288.
24. Ocampo J.S.P., Brito J.M., Corrĉa-de-Santana E., Borojevic R., Villa-Verde D.M.S., Savino W. Laminin-211 controls thymocyte-thymic epithelial cell interactions. Cell Imunol. 2008, 254:1-9.
25. Overbergh L., Giulietti A., Valckx D., Decallonne R., Bouillon R., Mathieu C. The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J. Biomol. Tech. 2003, 14:33-43.
26. Park J.Y., Chong A.Y., Cochran E.K., Kleiner D.E., Haller M.J., Schatz D.A., Gorden P. Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy. J. Clin. Endocrinol. Metab. 2008, 93:26-31.
27. Petrie H.T., Zúñiga-Pflücker J.C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 2007, 25:649-679.
28. Savino W. The thymus is a common target organ in infectious diseases. PLoS Pathog. 2006, 2(e62):472-483.
29. Savino W., Dardenne M., Velloso L.A., Silva-Barbosa S.D. The thymus is a common target in malnutrition and infection. Br. J. Nutr. 2007, 98:S11-S16.
30. Savino W., Mendes-Da-Cruz D.A., Smaniotto S., Silva-Monteiro E., Villa-Verde D.M. Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix. J. Leukocyte Biol. 2004, 75:951-961.
31. Sivitz W.I., Walsh S., Morgan D., Donohoue P., Haynes W., Leibel R.L. Plasma leptin in diabetic and insulin-treated diabetic and normal rats. Metabolism 1998, 47:584-591.
32. Smaniotto S., Melo-Coelho V., Villa-Verde D.M.S., Pléau J.M., Postel-Vinay M.C., Dardenne M., Savino W. Growth hormone modulates thymocyte development in vivo through a combined action of laminin and CXC chemokine ligand 12. Endocrinology 2005, 146:3005-3017.
33. Tabata T., Okuno Y., Fujii S., Kimura S., Kinoshita Y. Maturational impairment of thymic lymphocytes in streptozotocin-induced diabetes in rats. Cell Immunol. 1984, 89:250-258.
34. Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 2006, 6:127-135.
35. Thomas D.C., Mellanby R.J., Phillips J.M., Cooke A. An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology 2007, 121:565-576.
36. Velloso L.A., Savino W., Mansour E. Leptin action in the thymus. Ann. N. Y. Acad. Sci. 2009, 1156:29-34.