Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt Ph through metadynamics simulations

Journal of the American Chemical Society

Volumn 134, Issue 1, 2012, Pages 453-463

  Grazioso, Giovanni ^a   Limongelli, Vittorio ^b,c,d   Branduardi, Davide ^e   Novellino, Ettore ^d   De Micheli, Carlo ^a   Cavalli, Andrea ^e,f   Parrinello, Michele ^b,c  

^a UNIVERSITY OF MILAN   (Italy)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF LUGANO   (Switzerland)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; DYNAMICAL BEHAVIORS; GLUTAMATE TRANSPORTERS; INTERMEDIATE STATE; METADYNAMICS; MOLECULAR MECHANISM; NEURONAL DEATH; NEURONAL NETWORKS; STRUCTURAL STUDIES; SUBSTRATE UPTAKE; SYNAPTIC CLEFT; X RAY DATA;

NEURAL NETWORKS; NEURODEGENERATIVE DISEASES; SIGNAL TRANSDUCTION;

SUBSTRATES;

GLUTAMATE TRANSPORTER; SODIUM ION;

ARTICLE; CONTROLLED STUDY; INTERNALIZATION; INTRACELLULAR TRANSPORT; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SYNAPSE; X RAY;

AMINO ACID TRANSPORT SYSTEM X-AG; APOPROTEINS; ARCHAEAL PROTEINS; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PYROCOCCUS HORIKOSHII; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

EID: 84855716593     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208485w     Document Type: Article

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