A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41381-41390

  Rosental, Noa ^a   Gameiro, Armanda ^b   Grewer, Christof ^b   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

^b BINGHAMTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE RESIDUE; BINDING POCKETS; CATION BINDING; CATION INTERACTIONS; COMPUTATIONAL STUDIES; COUNTERTRANSPORT; ELECTROPHYSIOLOGICAL APPROACH; EXTRACELLULAR; GLUTAMATE TRANSPORTERS; GLUTAMIC ACID; ION SELECTIVITY; MOLECULAR DETERMINANTS; PHYSIOLOGICAL CONDITION; SYNAPTIC CLEFT; TRANSPORT CYCLE; TYROSINE RESIDUES;

AMINO ACIDS; ELECTROPHYSIOLOGY; POSITIVE IONS;

BINDING SITES;

ASPARTIC ACID; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; POTASSIUM ION; PROTEIN EAAC1; SODIUM ION; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMISTRY; BRAIN; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; BINDING SITES; BRAIN; EXCITATORY AMINO ACID TRANSPORTER 3; HELA CELLS; HUMANS; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; RABBITS; RATS; STRUCTURAL HOMOLOGY, PROTEIN; XENOPUS LAEVIS;

EID: 82355184476     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.291021     Document Type: Article

References (60)

1. Kanner, B. I., and Sharon, I. (1978) Biochemistry 17, 3949-3953
2. Brew, H., and Attwell, D. (1987) Nature 327, 707-709
3. Wadiche, J. I., Arriza, J. L., Amara, S. G., and Kavanaugh, M. P. (1995) Neuron 14, 1019-1027
4. Kanner, B. I., and Bendahan, A. (1982) Biochemistry 21, 6327-6330
5. Pines, G., and Kanner, B. I. (1990) Biochemistry 29, 11209-11214
6. Kavanaugh, M. P., Bendahan, A., Zerangue, N., Zhang, Y., and Kanner, B. I. (1997) J. Biol. Chem. 272, 1703-1708
7. Nelson, P. J., Dean, G. E., Aronson, P. S., and Rudnick, G. (1983) Biochemistry 22, 5459-5463
8. Zerangue, N., and Kavanaugh, M. P. (1996) Nature 383, 634-637
9. Levy, L. M., Warr, O., and Attwell, D. (1998) J. Neurosci. 18, 9620-9628
10. Zhang, Y., Bendahan, A., Zarbiv, R., Kavanaugh, M. P., and Kanner, B. I. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 751-755
11. Wadiche, J. I., Amara, S. G., and Kavanaugh,M.P. (1995) Neuron 15, 721-728
12. Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P., and Amara, S. G. (1995) Nature 375, 599-603
13. Arriza, J. L., Eliasof, S., Kavanaugh, M. P., and Amara, S. G. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 4155-4160
14. Otis, T. S., and Kavanaugh, M. P. (2000) J. Neurosci. 20, 2749-2757
15. Grewer, C., Watzke, N., Wiessner, M., and Rauen, T. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 9706-9711
16. Yernool, D., Boudker, O., Jin, Y., and Gouaux, E. (2004) Nature 431, 811-818
17. Koch, H. P., and Larsson, H. P. (2005) J. Neurosci. 25, 1730-1736
18. Grewer, C., Balani, P., Weidenfeller, C., Bartusel, T., Tao, Z., and Rauen, T. (2005) Biochemistry 44, 11913-11923
19. Leary, G. P., Stone, E. F., Holley, D. C., and Kavanaugh, M. P. (2007) J. Neurosci. 27, 2938-2942
20. Koch, H. P., Brown, R. L., and Larsson, H. P. (2007) J. Neurosci. 27, 2943-2947
21. Grunewald, M., Bendahan, A., and Kanner, B. I. (1998) Neuron 21, 623-632
22. Grunewald, M., and Kanner, B. I. (2000) J. Biol. Chem. 275, 9684-9689
23. Slotboom, D. J., Sobczak, I., Konings, W. N., and Lolkema, J. S. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 14282-14287
24. Boudker, O., Ryan, R. M., Yernool, D., Shimamoto, K., and Gouaux, E. (2007) Nature 445, 387-393
25. Zhang, Y., and Kanner, B. I. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1710-1715
26. Borre, L., and Kanner, B. I. (2001) J. Biol. Chem. 276, 40396-40401
27. Bendahan, A., Armon, A., Madani, N., Kavanaugh, M. P., and Kanner, B. I. (2000) J. Biol. Chem. 275, 37436-37442
28. Teichman, S., and Kanner, B. I. (2007) J. Gen. Physiol. 129, 527-539
29. Reyes, N., Ginter, C., and Boudker, O. (2009) Nature 462, 880-885
30. Crisman, T. J., Qu, S., Kanner, B. I., and Forrest, L. R. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 20752-20757
31. Groeneveld, M., and Slotboom, D. J. (2007) J. Mol. Biol. 372, 565-570
32. Groeneveld, M., and Slotboom, D. J. (2010) Biochemistry 49, 3511-3513
33. Teichman, S., Qu, S., and Kanner, B. I. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 14297-14302
34. Tao, Z., Rosental, N., Kanner, B. I., Gameiro, A., Mwaura, J., and Grewer, C. (2010) J. Biol. Chem. 285, 17725-17733
35. Larsson, H. P., Wang, X., Lev, B., Baconguis, I., Caplan, D. A., Vyleta, N. P., Koch, H. P., Diez-Sampedro, A., and Noskov, S. Y. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 13912-13917
36. Rosental, N., Bendahan, A., and Kanner, B. I. (2006) J. Biol. Chem. 281, 27905-27915
37. Kanai, Y., and Hediger, M. A. (1992) Nature 360, 467-471
38. Borre, L., and Kanner, B. I. (2004) J. Biol. Chem. 279, 2513-2519
39. Pines, G., Zhang, Y., and Kanner, B. I. (1995) J. Biol. Chem. 270, 17093-17097
40. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-382
41. Keynan, S., Suh, Y. J., Kanner, B. I., and Rudnick, G. (1992) Biochemistry 31, 1974-1979
42. Fuerst, T. R., Niles, E. G., Studier, F. W., and Moss, B. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8122-8126
43. Pines, G., Danbolt, N. C., Bjørås, M., Zhang, Y., Bendahan, A., Eide, L., Koepsell, H., Storm-Mathisen, J., Seeberg, E., and Kanner, B. I. (1992) Nature 360, 464-467
44. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
45. Holmseth, S., Dehnes, Y., Bjørnsen, L. P., Boulland, J. L., Furness, D. N., Bergles, D., and Danbolt, N. C. (2005) Neuroscience 136, 649-660
46. Rauen, T., Rothstein, J. D., and Wässle, H. (1996) Cell Tissue Res. 286, 325-336
47. Chen, C., and Okayama, H. (1987) Mol. Cell Biol. 7, 2745-2752
48. Wadiche, J. I., and Kavanaugh, M. P. (1998) J. Neurosci. 18, 7650-7661
49. Rosental, N., and Kanner, B. I. (2010) J. Biol. Chem. 285, 21241-21248
50. Watzke, N., Bamberg, E., and Grewer, C. (2001) J. Gen. Physiol. 117, 547-562
51. Zhang, Z., Tao, Z., Gameiro, A., Barcelona, S., Braams, S., Rauen, T., and Grewer, C. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 18025-18030
52. Menaker, D., Bendahan, A., and Kanner, B. I. (2006) J. Neurochem. 99, 20-28
53. Grewer, C., Watzke, N., Rauen, T., and Bicho, A. (2003) J. Biol. Chem. 278, 2585-2592
54. Seal, R. P., Shigeri, Y., Eliasof, S., Leighton, B. H., and Amara, S. G. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 15324-15329
55. Ryan, R. M., and Vandenberg, R. J. (2002) J. Biol. Chem. 277, 13494-13500
56. Borre, L., Kavanaugh, M. P., and Kanner, B. I. (2002) J. Biol. Chem. 277, 13501-13507
57. Tao, Z., and Grewer, C. (2007) J. Gen. Physiol. 129, 331-344
58. Tao, Z., Gameiro, A., and Grewer, C. (2008) Biochemistry 47, 12923-12930
59. Huang, S., Ryan, R. M., and Vandenberg, R. J. (2009) J. Biol. Chem. 284, 4510-4515
60. Ryan, R. M., Kortt, N. C., Sirivanta, T., and Vandenberg, R. J. (2010) J. Neurochem. 114, 565-575