Novel nonphosphorylated peptides with conserved sequences selectively bind to grb7 sh2 domain with affinity comparable to its phosphorylated ligand

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Zhang, Dan ^a   Shao, Chen ^a   Hu, Siqi ^b   Ma, Sucan ^a   Gao, Youhe ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b INSTITUTE OF PATHOGEN BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 3; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; PROLINE; PROTEIN SH2; SERINE; THREONINE; AMINO ACID; LIGAND; PEPTIDE;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; EX VIVO STUDY; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RESIDUE ANALYSIS; TWO HYBRID SYSTEM; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; SRC HOMOLOGY DOMAIN; TUMOR CELL LINE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; CONSERVED SEQUENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GRB7 ADAPTOR PROTEIN; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 84855713151     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029902     Document Type: Article

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