A multivalent approach to the discovery of long-acting β 2- adrenoceptor agonists for the treatment of asthma and COPD

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1213-1218

  Jacobsen, John R ^a   Choi, Seok Ki ^a   Combs, Jesse ^a   Fournier, Eric J L ^a   Klein, Uwe ^a   Pfeiffer, Juergen W ^a   Thomas, G Roger ^a   Yu, Cecile ^a   Moran, Edmund J ^a  

^a THERAVANCE INC   (United States)

Author keywords

2 Adrenoceptor agonist; Bronchodilator; Inhaled; LABA; Milveterol; Multivalent approach

Indexed keywords

4 PHENETHYLAMINE; AMINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; MILVETEROL; NITROGEN; SALBUTAMOL; SALMETEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; NONHUMAN; SUBSTITUTION REACTION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; CELL LINE; DRUG DISCOVERY; GUINEA PIGS; HUMANS; MOLECULAR STRUCTURE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; STEREOISOMERISM;

CAVIA;

EID: 84855663296     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.072     Document Type: Article

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