The discovery of long-acting saligenin β 2 adrenergic receptor agonists incorporating hydantoin or uracil rings

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 14, 2011, Pages 4192-4201

  Procopiou, Panayiotis A ^a   Barrett, Victoria J ^a   Bevan, Nicola J ^a   Butchers, Peter R ^a   Conroy, Richard ^a   Emmons, Amanda ^a   Ford, Alison J ^a   Jeulin, Séverine ^a   Looker, Brian E ^a   Lunniss, Gillian E ^a   Morrison, Valerie S ^a   Mutch, Peter J ^a   Perciaccante, Rossana ^a   Ruston, Mark ^a   Smith, Claire E ^a   Somers, Graham ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

2 Agonist; Asthma; COPD; Hydantoin; Saligenin

Indexed keywords

1 (3 IODOPHENYL) 2,4 [1H 3H]PYRIMINEDIONE; 1 [3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 2,4 IMIDAZOLIDINEDIONE FORMATE SALT; 1 [3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 2,4[1H 3H]PYRIMIDINEDIONE ACETATE SALT; 1 [[3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL]METHYL] 2,4 IMIDAZOLIDINEDIONE ACETATE SALT; 1 [[3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL]METHYL] 2,4,5 IMIDAZOLIDINETRIONE FORMATE SALT; 2 [3 [3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 2,5 DIOXO 1 IMIDAZOLIDINYL]ACETAMIDE ACETATE SALT; 2 AZIDO 1 (2,2 DIMETHYL 4H 1,3 BENZODIOXIN 6 YL)ETHANOL; 2 AZIDO 1 (2,2 DIMETHYL 4H 1,3 BENZODIOXIN 6 YL)ETHANONE; 3 [2 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 2,4 IMIDAZOLIDINEDIONE ACETATE SALT; 3 [3 [4 [(6 BROMOHEXYL)OXY]BUT 1 YNYL]PHENYL]IMIDAZOLIDINE 2,4 DIONE; 3 [3 [4 [[6 [[2 (2,2 DIMETHYL 4H 1,3 BENZODIOXIN 6 YL) 2 HYDROXETHYL]AMINO]HEXYL]OXY]BUT 1 YNYL]PHENYL]IMIDAZOLIDINE 2,4 DIONE; 3 [3 [4 [[6 [[2 (2,2 DIMETHYL 4H 1,3 BENZODIOXIN 6 YL) 2 HYDROXETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL]IMIDAZOLIDINE 2,4 DIONE; 3 [3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 2,4[1H 3H]PYRIMIDINEDIONE ACETATE SALT; 3 [3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 5,5 DIMETHYL 2,4 IMIDAZOLIDINEDIONE ACETATE SALT; 3 [3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL]IMIDAZOLIDINE 2,4 DIONE ACETATE; 3 [4 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL] 2,4 IMIDAZOLIDINEDIONE ACETATE SALT; 3 [[3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL]METHYL] 2,4 IMIDAZOLIDINEDIONE ACETATE SALT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; ETHYL N [[(3 IODOPHENYL)AMINO]CARBONYL]GLYCINATE; FORMOTEROL; HYDANTOIN; ISOPRENALINE; LONG ACTING DRUG; N [[[3 [4 [[6 [[2 HYDROXY 2 [4 HYDROXY 3 (HYDROXYMETHYL)PHENYL]ETHYL]AMINO]HEXYL]OXY]BUTYL]PHENYL]AMINO]CARBONYL]GLYCINE ACETATE SALT; SALIGENIN; SALMETEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE LIVER FUNCTION RELATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; ISOMERISM; LIVER CELL; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; SWINE; TRACHEA;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FEMALE; GUINEA PIGS; HEPATOCYTES; HUMANS; HYDANTOINS; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-2; STEREOISOMERISM; TRACHEA; URACIL;

CANIS FAMILIARIS; CAVIA; RATTUS;

EID: 79959982959     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.064     Document Type: Article

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