Discovery of novel antitubercular 1,5-dimethyl-2-phenyl-4-([5-(arylamino)- 1,3,4-oxadiazol-2-yl]methylamino)-1,2-dihydro-3H-pyrazol-3-one analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 969-972

  Ahsan, Mohamed Jawed ^a,b   Samy, Jeyabalan Govinda ^a   Jain, Chandra Bhushan ^c   Dutt, Kunduri Rajeswar ^b   Khalilullah, Habibullah ^a   Nomani, Md Shivli ^a  

^a Alwar Pharmacy College   (India)

^b NIMS UNIVERSITY   (India)

^c RAJASTHAN UNIVERSITY OF HEALTH SCIENCES   (India)

Author keywords

Antitubercular agents; Lipinski rule of five; Molecular properties prediction; Oxadiazoles

Indexed keywords

4 [[5 [(2 CHLOROPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(2,4 DIMETHOXYPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(2,4 DIMETHYLPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(2,6 DIMETHYLPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(3 CHLORO 2 METHYLPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(3 CHLORO 4 FLUOROPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 BROMOPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 CHLOROPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 ETHOXYPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 FLUOROPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 HYDROXYPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 METHOXYPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 METHYLPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 NITROPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; 4 [[5 [(4 SULPHAMYLPHENYLAMINO) 1,3,4 OXADIAZOL 2 YL]METHYLAMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYLPYRAZOL 3 ONE; ISONIAZID; PYRAZOLONE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS, MULTIDRUG-RESISTANT; VERO CELLS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84855659970     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.014     Document Type: Article

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