Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7246-7250

  Ahsan, Mohamed Jawed ^a,b   Samy, Jeyabalan Govinda ^a   Khalilullah, Habibullah ^a   Nomani, Md Shivli ^a   Saraswat, Pankaj ^a   Gaur, Ramakant ^a   Singh, Abhimanyu ^a  

^a Alwar Pharmacy College   (India)

^b Department of Computer Science and Engineering   (India)

Author keywords

Antimicrobial agents; Antitubercular agents; Lipinski 'Rule of five'; Molecular properties prediction; Oxadiazoles

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 1,5 DIMETHYL 2 PHENYL 4 [[(5 ARYL 1,3,4 OXADIAZOL 2 YL) METHYL] AMINO] 1,2 DIHYDRO 3H PYRAZOL 3 ONE; ANTIINFECTIVE AGENT; ANTIMYCOBACTERIAL AGENT; CIPROFLOXACIN; FLUCONAZOLE; ISONIAZID; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; COMPUTER PROGRAM; DRUG BIOAVAILABILITY; DRUG LIKENESS SCORE; DRUG SCREENING; DRUG SYNTHESIS; INFRARED RADIATION; LIPOPHILICITY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR PROPERTIES PREDICTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PREDICTION; SCORING SYSTEM; SOLUBILITY;

ADMINISTRATION, ORAL; ANTI-INFECTIVE AGENTS; ANTITUBERCULAR AGENTS; BACTERIA; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; OXADIAZOLES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 81255189376     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.057     Document Type: Article

References (28)

1. Global Alliance for TB Drug Development, http://www.tballiance.org/home/ home.php.
2. WHO report 2010, Global Tuberculosis Control Surveillance, Financing and Planning.
3. A.M. Mohamed, M.G. Magdy, N.N. Magda, and A.H.B. Waleed Arch. Pharm. Pharm. Med. Chem. 337 2004 427
4. B.G. Spratt Science. 264 1994 388
5. S.D. Joshi, H.M. Vagdevi, V.P. Vaidya, and G.S. Gadaginamath Eur. J. Med. Chem. 43 2008 1989
6. M.D. Mullican, M.W. Wilson, D.T. Connor, C.R. Kostlan, D.J. Schrier, and R.D. Dyer J. Med. Chem. 361 1993 1090
7. D.H. Boschelli, D.T. Connor, D.A. Bornemeier, R.D. Dyer, J.A. Kennedy, P.J. Kuipers, G.C. Okonkwo, D.J. Schrier, and C.D. Wright J. Med. Chem. 36 1993 1802
8. K. Raman, K.H. Singh, S.K. Salzman, and S.S. Parmar J. Pharm. Sci. 821 1993 167
9. G. Sahin, E. Palaska, P. Kelicen, R. Demirdamar, G. Altinok, and F. Arzneim Drug Res. 51 2001 478
10. S.L. Gaonkar, K.M.L. Rai, and B. Prabhuswamy Eur. J. Med. Chem. 41 2006 841
11. A.A. El-Emam, O.A. Al-Deeb, M. Al-Omar, and J. Lehmann Bioorg. Med. Chem. 12 2004 5107
12. M.A. Bakht, M.S. Yar, S.G. Abdel-Hamid, S.I. Al-Qasoumi, and A. Samad Eur. J. Med. Chem. 45 2010 5862
13. W. Shi, X. Qian, R. Zhang, and G. Song J. Agric. Food Chem. 49 2001 124
14. A. Andreani, M. Granaiola, A. Leoni, R. Morigi, and M. Ramballdi Eur. J. Med. Chem. 36 2001 743
15. S.G. Kini, A.R. Bhat, B. Bryant, J.S. Williamson, and F.E. Dayan Eur. J. Med. Chem. 44 2009 492
16. M.A. Ali, G.J. Samy, E. Manogaran, V. Sellappan, M.Z. Hassan, M.J. Ahsan, S. Pandian, and M. ShaharYar Bioorg. Med. Chem. Lett. 19 2009 7000
17. M.J. Ahsan, G.J. Samy, K.R. Dutt, U.K. Agrawal, B. Shankar, S. Vyas, R. Kaur, and G. Yadav Bioorg. Med. Chem. Lett. 21 2011 4451
18. Y. Zhao, M.H. Abraham, J. Lee, A. Hersey, N.C. Luscombe, G. Beck, B. Sherborne, and I. Cooper Pharm. Res. 19 2002 1446
19. D.F. Veber, S.R. Johnson, H.Y. Cheng, B.R. Smith, K.W. Ward, and K.D. Kapple J. Med. Chem. 45 2002 2615
20. H.H.F. Refsgaard, B.F. Jensen, P.B. Brockhoff, S.B. Padkjaer, M. Guldbrandt, and M.S. Christensen J. Med. Chem. 48 2005 805
21. A. Ertl, B. Rohde, and P. Selzer J. Med. Chem. 43 2000 3714
22. C.A. Lipinski, L. Lombardo, B.W. Dominy, and P.J. Feeney Adv. Drug Delivery Rev. 46 2001 3
23. L.B. Heifets, M.A. Flory, and P. Lindholm-Levy J. Antimicrob. Agents. Chemother 33 1989 1252
24. A.H. Collins Microbiological Methods 2nd ed. 1976 Butterworth London
25. R. Cruickshank, J.P. Duguid, B.P. Marmion, and R.H.A. Swain 12th ed. Medicinal Microbiology Vol. 2 1975 Churchill Livingstone London 196
26. Khan, Z. K. In-vitro And In-vivo Screening Techniques for Bioactivity Screening and Evaluation, In Proceedings of Internationl Workshop UNIDO-CDRI, 1997, 210.
27. R.S. Varma Antifungal Agents: Past, Present and Future Prospects, National Academy of Chemistry & Biology 1998 Lucknow India
28. L.L. Gundersen, J. Nissen-Meyer, and B. Spilsberg J. Med. Chem. 45 2002 1383