Synthesis of some new 1-acylthiosemicarbazides, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones and their anti-inflammatory activities

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 6, 2001, Pages 478-484

  Sahin, G ^a   Palaska, E ^a   Kelicen, P ^a   Demirdamar, R ^a   Altinok, G ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

1,2,4 Triazol 5 thione, antiinflammatory activity, synthesis, ulcerogenic activity; 1,3,4 Oxadiazole, anti inflammatory activity, synthesis, ulcerogenic activity; 1,3,4 Thiadiazole, anti inflammatory activity, synthesis, ulcerogenic activity; Thiosemicarbazide, anti inflammatory activity, synthesis, ulcerogenic activity

Indexed keywords

1 ACYLTHIOSEMICARBAZIDE DERIVATIVE; 1 NAPHTHYLOXYACETYL 4 THIOSEMICARBAZIDE DERIVATIVE; 2 NAPHTHYLOXYMETHYL 5 AMINO 1,3,4 OXADIAZOLE DERIVATIVE; 2 NAPHTHYLOXYMETHYL 5 AMINO 1,3,4 THIADIAZOLE DERIVATVE; 5 NAPHTHYLOXYMETHYL 5 AMINO 1,3,4 THIADIAZOLE DERIVATIVE; ANTIINFLAMMATORY AGENT; CARRAGEENAN; NAPROXEN; PHENYLBUTAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HISTOPATHOLOGY; INFLAMMATION; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; TOXICITY TESTING;

EID: 0034950802     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300066     Document Type: Article

References (15)

1. Synthesis of some s-triazoles with potential analgesic and antiinflammatory activities
2. Protection of carrageenin edema and trypsin hydrolysis of bovine serum albumin by naphtylthiosemicarbazides and their cyclized oxadiazoles
3. Synthesis and biological activity of acetamides, arylureas and 2-alkoxy-phenyl-6-phenyl-1,3,4-oxa(thia)diazole[3,2-a]-s-triazin-5,7-diones derived from 2-amino-5-alkoxyphenyl-1,3,4-oxa(thia)diazole
4. Anti-inflammatory and analgesic activities of 5-{4-[Aryl(arylazo)methyleneamino]phenyl}-1,3,4-oxadiazole-2(3H)-thiones
5. Anti-inflammatory activity of substituted 1,3,4-oxadiazoles
6. Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles and -1,2,4-triazoles as orally-active nonulcerogenic antiinflammatory agents
7. 1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: In vitro inhibition of cyclooxygenase and 5-lipoxygenase activities
8. Substituted thiosemicarbazides and corresponding cyclized 1,3,4-oxadiazoles and their anti-inflammatory activity
9. Antiinflammatory activity of substituted 1,3,4-oxadiazoles
10. Carraegeenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs
11. Studies into the influence of carrageenan-induced inflammation on articular cartilage degradation using implantation into air pouches
12. Effect of sodium aurothiomalate on carrageenan induced inflammation of the air pouch in mice
13. A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: Investigation of the modulatory action of systemic and local dexamethasone
14. The formation of a structure with the features of synovial lining by subcutaneous injection of air. An in vivo tissue culture system
15. Studies into the mode of action of non-steroidal anti-inflammatory drugs using a model of fascimile synovium