Primary biliary cirrhosis associated with systemic sclerosis: Diagnostic and clinical challenges

International Journal of Rheumatology

Volumn 2011, Issue , 2011, Pages

  Rigamonti, Cristina ^a   Bogdanos, Dimitrios P ^b   Mytilinaiou, Maria G ^b   Smyk, Daniel S ^b   Rigopoulou, Eirini I ^c   Burroughs, Andrew K ^d  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF THESSALY   (Greece)

^d ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN ANTIBODY; MITOCHONDRION ANTIBODY; PLACEBO; URSODEOXYCHOLIC ACID;

ANTIBODY DETECTION; CLINICAL FEATURE; COMORBIDITY; DISEASE ASSOCIATION; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDEMIOLOGICAL DATA; GENETIC ASSOCIATION; HUMAN; IMMUNOPATHOGENESIS; PATIENT IDENTIFICATION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SCREENING TEST; SYSTEMIC SCLEROSIS; TREATMENT OUTCOME;

EID: 84855608174     PISSN: 16879260     EISSN: 16879279     Source Type: Journal    
DOI: 10.1155/2011/976427     Document Type: Review

References (155)

1. Kaplan M. M., Gershwin M. E., Primary biliary cirrhosis The New England Journal of Medicine 2005 353 12 1261 1273 (Pubitemid 41345948)
2. Hohenester S., Oude-Elferink R. P. J., Beuers U., Primary biliary cirrhosis Seminars in Immunopathology 2009 31 3 283 307
3. Neuberger J., Primary biliary cirrhosis The Lancet 1997 350 9081 875 879 (Pubitemid 27404357)
4. Rautiainen H., Salomaa V., Niemel S., Karvonen A. L., Nurmi H., Isoniemi H., Frkkil M., Prevalence and incidence of primary biliary cirrhosis are increasing in Finland Scandinavian Journal of Gastroenterology 2007 42 11 1347 1353 (Pubitemid 47537072)
5. James O. E. W., Bhopal R., Howel D., Gray J., Burt A. D., Metcalf J. V., Primary biliary cirrhosis once rare, now common in the United Kingdom? Hepatology 1999 30 2 390 394 (Pubitemid 29357502)
6. Kim W. R., Lindor K. D., Locke G. R., Therneau T. M., Homburger H. A., Batts K. P., Yawn B. P., Petz J. L., Melton J., Dickson E. R., Epidemiology and natural history of primary biliary cirrhosis in a U.S. community Gastroenterology 2000 119 6 1631 1636 (Pubitemid 32198688)
7. Sood S., Gow P. J., Christie J. M., Angus P. W., Epidemiology of primary biliary cirrhosis in Victoria, Australia: high prevalence in migrant populations Gastroenterology 2004 127 2 470 475 (Pubitemid 39091895)
8. Bogdanos D. P., Baum H., Vergani D., Antimitochondrial and other autoantibodies Clinics in Liver Disease 2003 7 4 759 777 (Pubitemid 37229503)
9. Bernal W., Meda F., Ma Y., Bogdanos D. P., Vergani D., Disease-specific autoantibodies in patients with acute liver failure: the King's College London experience Hepatology 2008 47 3 1096 1097 (Pubitemid 351449704)
10. Bogdanos D. P., Komorowski L., Disease-specific autoantibodies in primary biliary cirrhosis Clinica Chimica Acta 2011 412 7-8 502 512
11. Dhnrich C., Pares A., Caballeria L., Rosemann A., Schlumberger W., Probst C., Mytilinaiou M., Bogdanos D., Vergani D., Stcker W., Komorowski L., New ELISA for detecting primary biliary cirrhosis-specific antimitochondrial antibodies Clinical Chemistry 2009 55 5 978 985
12. Liu H., Norman G. L., Shums Z., Worman H. J., Krawitt E. L., Bizzaro N., Vergani D., Bogdanos D. P., Dalekos G. N., Milkiewicz P., Czaja A. J., Heathcote E. J., Hirschfield G. M., Tan E. M., Miyachi K., Bignotto M., Battezzati P. M., Lleo A., Leung P. S., Podda M., Gershwin M. E., Invernizzi P., PBC Screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis Journal of Autoimmunity 2010 35 4 436 442
13. Ma Y., Thomas M. G., Okamoto M., Bogdanos D. P., Nagl S., Kerkar N., Lopes A. R., Muratori L., Lenzi M., Bianchi F. B., Mieli-Vergani G., Vergani D., Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule Journal of Immunology 2002 169 1 277 285 (Pubitemid 34686146)
14. Rigopoulou E. I., Davies E. T., Bogdanos D. P., Liaskos C., Mytilinaiou M., Koukoulis G. K., Dalekos G. N., Vergani D., Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis Liver International 2007 27 9 1226 1231 (Pubitemid 47543151)
15. Vergani D., Bogdanos D. P., Positive markers in AMA-negative PBC American Journal of Gastroenterology 2003 98 2 241 243 (Pubitemid 36232366)
16. Wen L., Ma Y., Bogdanos D. P., Susan Wong F., Demaine A., Mieli-Vergani G., Vergani D., Pédiatrie autoimmune liver diseases: the molecular basis of humoral and cellular immunity Current Molecular Medicine 2001 1 3 379 389 (Pubitemid 33772964)
17. Metcalf J. V., Mitchison H. C., Palmer J. M., Jones D. E., Bassendine M. F., James O. F. W., Natural history of early primary biliary cirrhosis The Lancet 1996 348 9039 1399 1402 (Pubitemid 26395233)
18. European Association for the Study of the Liver, EASL Clinical Practice Guidelines: management of cholestatic liver diseases Journal of Hepatology 2009 51 2 237 267
19. Oertelt S., Rieger R., Selmi C., Invernizzi P., Ansari A. A., Coppel R. L., Podda M., Leung P. S. C., Gershwin M. E., A sensitive bead assay for antimitochondrial antibodies: chipping away at AMA-negative primary biliary cirrhosis Hepatology 2007 45 3 659 665 (Pubitemid 46450617)
20. Courvalin J. C., Worman H. J., Nuclear envelope protein autoantibodies in primary biliary cirrhosis Seminars in Liver Disease 1997 17 1 79 90 (Pubitemid 27157374)
21. Invernizzi P., Selmi C., Ranftler C., Podda M., Wesierska-Gadek J., Antinuclear antibodies in primary biliary cirrhosis Seminars in Liver Disease 2005 25 3 298 310 (Pubitemid 41254577)
22. Bogdanos D. P., Baum H., Vergani D., Burroughs A. K., The role of E. coli infection in the pathogenesis of primary biliary cirrhosis Disease Markers 2010 29 6 301 311
23. Bogdanos D. P., Vergani D., Origin of cross-reactive autoimmunity in primary biliary cirrhosis Liver International 2006 26 6 633 635 (Pubitemid 43983878)
24. Bogdanos D. P., Vergani D., Bacteria and primary biliary cirrhosis Clinical Reviews in Allergy and Immunology 2009 36 1 30 39
25. Gershwin M. E., Mackay I. R., Primary biliary cirrhosis: paradigm or paradox for autoimmunity Gastroenterology 1991 100 3 822 833
26. Gershwin M. E., Mackay I. R., The causes of primary biliary cirrhosis: convenient and inconvenient truths Hepatology 2008 47 2 737 745 (Pubitemid 351280742)
27. Jones D. E. J., Enesis of primary biliary cirrhosis Gut 2007 56 11 1615 1624 (Pubitemid 350033203)
28. Mackay I. R., Whittingham S., Fida S., Myers M., Ikuno N., Gershwin M. E., Rowley M. J., The peculiar autoimmunity of primary biliary cirrhosis Immunological Reviews 2000 174 226 237 (Pubitemid 30201391)
29. Shimoda S., Nakamura M., Ishibashi H., Hayashida K., Niho Y., HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases Journal of Experimental Medicine 1995 181 5 1835 1845
30. Shimoda S., Nakamura M., Shigematsu H., Tanimoto H., Gushima T., Gershwin M. E., Ishibashi H., Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T- cell epitope of primary biliary cirrhosis Hepatology 2000 31 6 1212 1216 (Pubitemid 30351280)
31. Shimoda S., Van De Water J., Ansari A., Nakamura M., Ishibashi H., Coppel R. L., Lake J., Keeffe E. B., Roche T. E., Gershwin M. E., Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis Journal of Clinical Investigation 1998 102 10 1831 1840 (Pubitemid 28533830)
32. Smyk D., Autoimmunity and environment: am I at risk? Clinical Reviews in Allergy and Immunology. In press
33. Smyk D., Mytilinaiou M. G., Rigopoulou E. I., Bogdanos D. P., PBC triggers in water reservoirs, coal mining areas and waste disposal sites: from Newcastle to New York Disease Markers 2010 29 6 337 344
34. Bogdanos D. P., Baum H., Gunsar F., Arioli D., Polymeros D., Ma Y., Burroughs A. K., Vergani D., Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity Scandinavian Journal of Gastroenterology 2004 39 10 981 987 (Pubitemid 39388463)
35. Bogdanos D. P., Pares A., Baum H., Caballeria L., Rigopoulou E. I., Ma Y., Burroughs A. K., Rodes J., Vergani D., Disease-specific cross-reactivity between mimicking peptides of heat shock protein of mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis Journal of Autoimmunity 2004 22 4 353 362 (Pubitemid 38543228)
36. Muratori L., Bogdanos D. P., Muratori P., Lenzi M., Granito A., Ma Y., Mieli-Vergani G., Bianchi F. B., Vergani D., Susceptibility to thyroid disorders in hepatitis C Clinical Gastroenterology and Hepatology 2005 3 6 595 603 (Pubitemid 40824753)
37. Polymeros D., Bogdanos D. P., Day R., Arioli D., Vergani D., Forbes A., Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease? Gastroenterology 2006 131 1 85 96 (Pubitemid 44015754)
38. Vergani D., Bogdanos D. P., Baum H., Unusual suspects in primary biliary cirrhosis Hepatology 2004 39 1 38 41 (Pubitemid 38461464)
39. Gershwin M. E., Selmi C., Worman H. J., Gold E. B., Watnik M., Utts J., Lindor K. D., Kaplan M. M., Vierling J. M., Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients Hepatology 2005 42 5 1194 1202 (Pubitemid 43112687)
40. Hudson M., Rojas-Villarraga A., Coral-Alvarado P., Lpez-Guzmn S., Mantilla R. D., Chalem P., Baron M., Anaya J. M., Polyautoimmunity and familial autoimmunity in systemic sclerosis Journal of Autoimmunity 2008 31 2 156 159
41. Poupon R., Primary biliary cirrhosis: a 2010 update Journal of Hepatology 2010 52 5 745 758
42. Abraham S., Begum S., Isenberg D., Hepatic manifestations of autoimmune rheumatic diseases Annals of the Rheumatic Diseases 2004 63 2 123 129 (Pubitemid 38124506)
43. Bartholomew L. G., Cain J. C., Winkelmann R. K., Baggenstoss A. H., Chronic disease of the liver associated with systemic scleroderma The American Journal of Digestive Diseases 1964 9 1 43 55
44. Murray-Lyon I. M., Thompson R. P., Ansell I. D., Williams R., Scleroderma and primary biliary cirrhosis British Medical Journal 1970 1 717 258 259
45. D'Angelo W. A., Fries J. F., Masi A. T., Shulman L. E., Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls The American Journal of Medicine 1969 46 3 428 440
46. Tuffanelli D. L., Winkelmann R. K., Systemic scleroderma, a clinical study of 727 cases Archives of Dermatology 1961 84 359 371
47. Reynolds T. B., Denison E. K., Frankl H. D., Lieberman F. L., Peters R. L., Primary biliary cirrhosis with scleroderma, Raynaud's phenomenon and telangiectasia. New syndrome The American Journal of Medicine 1971 50 3 302 312
48. O'Brien S. T., Eddy W. M., Krawitt E. L., Primary biliary cirrhosis associated with scleroderma Gastroenterology 1972 62 1 118 121
49. Rigamonti C., Shand L. M., Feudjo M., Bunn C. C., Black C. M., Denton C. P., Burroughs A. K., Clinical features and prognosis of primary biliary cirrhosis associated with systemic sclerosis Gut 2006 55 3 388 394 (Pubitemid 43268280)
50. Assassi S., Fritzler M. J., Arnett F. C., Norman G. L., Shah K. R., Gourh P., Manek N., Perry M., Ganesh D., Rahbar M. H., Mayes M. D., Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients Journal of Rheumatology 2009 36 10 2250 2256
51. Watt F. E., James O. F. W., Jones D. E. J., Patterns of autoimmunity in primary biliary cirrhosis patients and their families: a population-based cohort study Quarterly Journal of Medicine 2004 97 7 397 406 (Pubitemid 38967413)
52. Akimoto S., Ishikawa O., Muro Y., Takagi H., Tamura T., Miyachi Y., Clinical and immunological characterization of patients with systemic sclerosis overlapping primary biliary cirrhosis: a comparison with patients with systemic sclerosis alone Journal of Dermatology 1999 26 1 18 22 (Pubitemid 29088828)
53. Akimoto S., Ishikawa O., Takagi H., Miyachi Y., Immunological features of patients with primary biliary cirrhosis (PBC) overlapping systemic sclerosis: a comparison with patients with PBC alone Journal of Gastroenterology and Hepatology 1998 13 9 897 901 (Pubitemid 28448960)
54. Brzeziska-Kolarz B., Undas A., Dyczek A., Musia J., Reynolds syndrome: the combination of scleroderma and primary biliary cirrhosis. Case report Polskie Archiwum Medycyny Wewnetrznej 2001 105 3 231 234 (Pubitemid 33706837)
55. Clarke A. K., Galbraith R. M., Hamilton E. B. D., Williams R., Rheumatic disorders in primary biliary cirrhosis Annals of the Rheumatic Diseases 1978 37 1 42 47 (Pubitemid 8371822)
56. Geffroy Y., Colin R., Hemet J., Primary biliary cirrhosis and scleroderma Medecine et Chirurgie Digestives 1973 2 5 281 286
57. Goring H. D., [Coincidence of scleroderma and primary biliary cirrhosis. Results of a systematic study of a dermatologic patient sample] Der Hautarzt 1998 49 361 366
58. Maekawa S., Yano E., Shintani S., A case of rheumatoid arthritis associated with progressive systemic sclerosis and primary biliary cirrhosis in the presence of various autoantibodies Ryumachi 1992 32 5 515 521
59. Marasini B., Gagetta M., Rossi V., Ferrari P., Rheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients Annals of the Rheumatic Diseases 2001 60 11 1046 1049 (Pubitemid 32989177)
60. Powell F. C., Schroeter A. L., Dickson E. R., Primary biliary cirrhosis and the CREST syndrome: a report of 22 cases Quarterly Journal of Medicine 1987 62 237 75 82 (Pubitemid 17015918)
61. Sherlock S., Scheuer P. J., The presentation and diagnosis of 100 patients with primary biliary cirrhosis The New England Journal of Medicine 1973 289 13 674 678
62. Stadie V., Wohlrab J., Marsch W. C., The Reynolds' syndromea rare combination of two autoimmune diseases Medizinische Klinik 2002 97 1 40 43 (Pubitemid 34072395)
63. Ueno Y., Shibata M., Onozuka Y., Association of extrahepatic autoimmune diseases in primary biliary cirrhosisclinical statistics and analyses of Japanese and non-Japanese cases Nippon Rinsho 1998 56 10 2687 2698
64. Culp K. S., Fleming C. R., Duffy J., Autoimmune associations in primary biliary cirrhosis Mayo Clinic Proceedings 1982 57 6 365 370 (Pubitemid 12012061)
65. Modena V., Marengo C., Amoroso A., Primary biliary cirrhosis and rheumatic diseases: a clinical, immunological and immunogenetical study Clinical and Experimental Rheumatology 1986 4 2 129 134 (Pubitemid 16056599)
66. Corpechot C., Chrétien Y., Chazouillres O., Poupon R., Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis Journal of Hepatology 2010 53 1 162 169
67. Parikh-Patel A., Gold E. B., Worman H., Krivy K. E., Gershwin M. E., Risk factors for primary biliary cirrhosis in a cohort of patients from the United States Hepatology 2001 33 1 16 21 (Pubitemid 32016882)
68. Feghali-Bostwick C., Medsger T. A., Wright T. M., Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies Arthritis and Rheumatism 2003 48 7 1956 1963 (Pubitemid 36828691)
69. Selmi C., Mayo M. J., Bach N., Ishibashi H., Invernizzi P., Gish R. G., Gordon S. C., Wright H. I., Zweiban B., Podda M., Gershwin M. E., Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment Gastroenterology 2004 127 2 485 492 (Pubitemid 39091897)
70. Mayo M. J., Jenkins R. N., Combes B., Lipsky P. E., Association of clonally expanded T cells with the syndrome of primary biliary cirrhosis and limited scleroderma Hepatology 1999 29 6 1635 1642 (Pubitemid 29247032)
71. Steen V. D., Autoantibodies in systemic sclerosis Seminars in Arthritis and Rheumatism 2005 35 1 35 42 (Pubitemid 41111469)
72. Bernstein R. M., Callender M. E., Neuberger J. M., Anticentromere antibody in primary biliary cirrhosis Annals of the Rheumatic Diseases 1982 41 6 612 614 (Pubitemid 13208403)
73. Chan H. L., Lee Y. S., Hong H. S., Kuo T. T., Anticentromere antibodies (ACA): clinical distribution and disease specificity Clinical and Experimental Dermatology 1994 19 4 298 302 (Pubitemid 24231229)
74. Hansen B. U., Eriksson S., Lindgren S., High prevalence of autoimmune liver disease in patients with multiple nuclear dot, anti-centromere, and mitotic spindle antibodies Scandinavian Journal of Gastroenterology 1991 26 7 707 713
75. Powell F. C., Winkelmann R. K., Venencie-Lemarchand F., The anticentromere antibody: disease specificity and clinical significance Mayo Clinic Proceedings 1984 59 10 700 706 (Pubitemid 14014356)
76. Chou M. J., Lai M. Y., Lee S. L., Tsay G. J., Reactivity of anti-mitochondrial antibodies in primary biliary cirrhosis and systemic sclerosis Journal of the Formosan Medical Association 1992 91 11 1075 1080
77. Gupta R. C., Seibold J. R., Krishnan M. R., Steigerwald J. C., Precipitating autoantibodies to mitochondrial proteins in progressive systemic sclerosis Clinical and Experimental Immunology 1984 58 1 68 76 (Pubitemid 14029126)
78. Mytilinaiou M. G., Bogdanos D. P., Primary biliary cirrhosis-specific autoantibodies in patients with systemic sclerosis Digestive and Liver Disease 2009 41 12 916
79. Norman G. L., Bialek A., Encabo S., Butkiewicz B., Wiechowska-Kozlowska A., Brzosko M., Shums Z., Milkiewicz P., Is prevalence of PBC underestimated in patients with systemic sclerosis? Digestive and Liver Disease 2009 41 10 762 764
80. Sakauchi F., Mori M., Zeniya M., Toda G., Antimitochondrial antibody negative primary biliary cirrhosis in Japan: utilization of clinical data when patients applied to receive public financial aid Journal of Epidemiology 2005 16 1 30 34 (Pubitemid 43055685)
81. Whyte J., Hough D., Maddison P. J., McHugh N. J., The association of primary biliary cirrhosis and systemic sclerosis is not accounted for by cross reactivity between mitochondrial and centromere antigens Journal of Autoimmunity 1994 7 3 413 424 (Pubitemid 24190622)
82. Kallenberg C. G. M., Pastoor G. W., Wouda A. A., The T. H., Antinuclear antibodies in patients with Raynaud's phenomenon: clinical significance of anticentromere antibodies Annals of the Rheumatic Diseases 1982 41 4 382 387 (Pubitemid 12038905)
83. McCarty G. A., Rice J. R., Bembe M. L., Barada F. A., Anticentromere antibody. Clinical correlations and association with favorable prognosis in patients with scleroderma variants Arthritis and Rheumatism 1983 26 1 1 7 (Pubitemid 13175193)
84. Miyawaki S., Asanuma H., Nishiyama S., Yoshinaga Y., Clinical and serological heterogeneity in patients with anticentromere antibodies Journal of Rheumatology 2005 32 8 1488 1494 (Pubitemid 41113969)
85. Seibold J. R., Trontell M. C., Anticentromere antibody and primary pulmonary hypertension Journal of Rheumatology 1982 9 4 607 609 (Pubitemid 13205183)
86. Makinen D., Fritzler M., Davis P., Sherlock S., Anticentromere antibodies in primary biliary cirrhosis Arthritis and Rheumatism 1983 26 7 914 917 (Pubitemid 13069738)
87. Shoji I., Takagi T., Kasukawa R., Anti-centromere antibody and CREST syndrome in patients with primary biliary cirrhosis Internal Medicine 1992 31 12 1348 1355
88. Agarwal S. K., Reveille J. D., The genetics of scleroderma (systemic sclerosis) Current Opinion in Rheumatology 2010 22 2 133 138
89. Arnett F. C., Gourh P., Shete S., Ahn C. W., Honey R. E., Agarwal S. K., Tan F. K., McNearney T., Fischbach M., Fritzler M. J., Mayes M. D., Reveille J. D., Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls Annals of the Rheumatic Diseases 2010 69 5 822 827
90. Simen C. P., Fonollosa V., Tolosa C., Palou E., Selva A., Solans R., Armadans L., Moreno E., Marsal S., Vilardell M., Association of HLA class II genes with systemic sclerosis in Spanish patients Journal of Rheumatology 2009 36 12 2733 2736
91. Dieudé P., Guedj M., Wipff J., Ruiz B., Hachulla E., Diot E., Granel B., Sibilia J., Tiev K., Mouthon L., Cracowski J. L., Carpentier P. H., Amoura Z., Fajardy I., Avouac J., Meyer O., Kahan A., Boileau C., Allanore Y., STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis Arthritis and Rheumatism 2009 60 8 2472 2479
92. Gourh P., Agarwal S. K., Divecha D., Assassi S., Paz G., Arora-Singh R. K., Reveille J. D., Shete S., Mayes M. D., Arnett F. C., Tan F. K., Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines Arthritis and Rheumatism 2009 60 12 3794 3806
93. Rueda B., Broen J., Simeon C., Hesselstrand R., Diaz B., Surez H., Ortego-Centeno N., Riemekasten G., Fonollosa V., Vonk M. C., Van den Hoogen F. H. J., Sanchez-Romn J., Aguirre-Zamorano M. A., Garca-Portales R., Pros A., Camps M. T., Gonzalez-Gay M. A., Coenen M. J. H., Airo P., Beretta L., Scorza R., Van Laar J., Gonzalez-Escribano M. F., Nelson J. I., Radstake T. R. D. J., Martin J., The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype Human Molecular Genetics 2009 18 11 2071 2077
94. Tsuchiya N., Kawasaki A., Hasegawa M., Fujimoto M., Takehara K., Kawaguchi Y., Kawamoto M., Hara M., Sato S., Association of STAT4 polymorphism with systemic sclerosis in a Japanese population Annals of the Rheumatic Diseases 2009 68 8 1375 1376
95. Dieudé P., Guedj M., Wipff J., Avouac J., Fajardy I., Diot E., Granel B., Sibilia J., Cabane J., Mouthon L., Cracowski J. L., Carpentier P. H., Hachulla E., Meyer O., Kahan A., Boileau C., Allanore Y., Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis Arthritis and Rheumatism 2009 60 1 225 233
96. Ito I., Kawaguchi Y., Kawasaki A., Hasegawa M., Ohashi J., Hikami K., Kawamoto M., Fujimoto M., Takehara K., Sato S., Hara M., Tsuchiya N., Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population Arthritis and Rheumatism 2009 60 6 1845 1850
97. Dieudé P., Wipff J., Guedj M., Ruiz B., Melchers I., Hachulla E., Riemekasten G., Diot E., Hunzelmann N., Sibilia J., Tiev K., Mouthon L., Cracowski J. L., Carpentier P. H., Distler J., Amoura Z., Tarner I., Avouac J., Meyer O., Kahan A., Boileau C., Allanore Y., BANK1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4 Arthritis and Rheumatism 2009 60 11 3447 3454
98. Rueda B., Gourh P., Broen J., Agarwal S. K., Simeon C., Ortego-Centeno N., Vonk M. C., Coenen M., Riemekasten G., Hunzelmann N., Hesselstrand R., Tan F. K., Reveille J. D., Assassi S., Garcia-Hernandez F. J., Carreira P., Camps M., Fernandez-Nebro A., Garcia De La Pea P., Nearney T., Hilda D., Gnzalez-Gay M. A., Airo P., Beretta L., Scorza R., Radstake T. R. D. J., Mayes M. D., Arnett F. C., Martin J., BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians Annals of the Rheumatic Diseases 2010 69 4 700 705
99. Gourh P., Arnett F. C., Tan F. K., Assassi S., Divecha D., Paz G., McNearney T., Draeger H., Reveille J. D., Mayes M. D., Agarwal S. K., Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis Annals of the Rheumatic Diseases 2010 69 3 550 555
100. Agarwal S. K., Gourh P., Shete S., Paz G., Divecha D., Reveille J. D., Assassi S., Tan F. K., Mayes M. D., Arnett F. C., Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis Journal of Rheumatology 2009 36 12 2715 2723
101. Gourh P., Agarwal S. K., Martin E., Divecha D., Rueda B., Bunting H., Assassi S., Paz G., Shete S., McNearney T., Draeger H., Reveille J. D., Radstake T. R. D. J., Simeon C. P., Rodriguez L., Vicente E., Gonzalez-Gay M. A., Mayes M. D., Tan F. K., Martin J., Arnett F. C., Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations Journal of Autoimmunity 2010 34 2 155 162
102. Hirschfield G. M., Liu X., Xu C., Lu Y., Xie G., Lu Y., Gu X., Walker E. J., Jing K., Juran B. D., Mason A. L., Myers R. P., Peltekian K. M., Ghent C. N., Coltescu C., Atkinson E. J., Heathcote E. J., Lazaridis K. N., Amos C. I., Siminovitch K. A., Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants The New England Journal of Medicine 2009 360 24 2544 2555
103. Donaldson P. T., Baragiotta A., Heneghan M. A., Floreani A., Venturi C., Underhill J. A., Jones D. E. J., James O. F. W., Bassendine M. F., HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study Hepatology 2006 44 3 667 674 (Pubitemid 44433723)
104. Hirschfield G. M., Liu X., Han Y., Gorlov I. P., Lu Y., Xu C., Lu Y., Chen W., Juran B. D., Coltescu C., Mason A. L., Milkiewicz P., Myers R. P., Odin J. A., Luketic V. A., Speiciene D., Vincent C., Levy C., Gregersen P. K., Zhang J., Heathcote E. J., Lazaridis K. N., Amos C. I., Siminovitch K. A., Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis Nature Genetics 2010 42 8 655 657
105. Liu X., Invernizzi P., Lu Y., Kosoy R., Lu Y., Bianchi I., Podda M., Xu C., Xie G., MacCiardi F., Selmi C., Lupoli S., Shigeta R., Ransom M., Lleo A., Lee A. T., Mason A. L., Myers R. P., Peltekian K. M., Ghent C. N., Bernuzzi F., Zuin M., Rosina F., Borghesio E., Floreani A., Lazzari R., Niro G., Andriulli A., Muratori L., Muratori P., Almasio P. L., Andreone P., Margotti M., Brunetto M., Coco B., Alvaro D., Bragazzi M. C., Marra F., Pisano A., Rigamonti C., Colombo M., Marzioni M., Benedetti A., Fabris L., Strazzabosco M., Portincasa P., Palmieri V. O., Tiribelli C., Croce L., Bruno S., Rossi S., Vinci M., Prisco C., Mattalia A., Toniutto P., Picciotto A., Galli A., Ferrari C., Colombo S., Casella G., Morini L., Caporaso N., Colli A., Spinzi G., Montanari R., Gregersen P. K., Heathcote E. J., Hirschfield G. M., Siminovitch K. A., Amos C. I., Gershwin M. E., Seldin M. F., Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis Nature Genetics 2010 42 8 658 660
106. Mells G. F., Floyd J. A., Morley K. I., Cordell H. J., Franklin C. S., Shin S. Y., Heneghan M. A., Neuberger J. M., Donaldson P. T., Day D. B., Ducker S. J., Muriithi A. W., Wheater E. F., Hammond C. J., Dawwas M. F., UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones D. E., Peltonen L., Alexander G. J., Sandford R. N., Anderson C. A., Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis Nature Genetics 2011 43 4 329 332
107. Burroughs A. K., Rosenstein I. J., Epstein O., Bacteriuria and primary biliary cirrhosis Gut 1984 25 2 133 137 (Pubitemid 14131405)
108. Fussey S. P. M., Ali S. T., Guest J. R., James O. F. W., Bassendine M. F., Yeaman S. J., Reactivity of primary biliary cirrhosis sera Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region Proceedings of the National Academy of Sciences of the United States of America 1990 87 10 3987 3991
109. Grossman C., Dovrish Z., Shoenfeld Y., Amital H., Do infections facilitate the emergence of systemic sclerosis? Autoimmunity Reviews 2010
110. Gabrielli A., Avvedimento E. V., Krieg T., Mechanisms of disease: scleroderma The New England Journal of Medicine 2009 360 19 1989 2003
111. Macchia G., Massone A., Burroni D., Covacci A., Censini S., Rappuoli R., The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases Molecular Microbiology 1993 9 3 645 652 (Pubitemid 23248775)
112. Randone S. B., Guiducci S., Cerinic M. M., Systemic sclerosis and infections Autoimmunity Reviews 2008 8 1 36 40
113. Abdulkarim A. S., Petrovic L. M., Kim W. R., Angulo P., Lloyd R. V., Lindor K. D., Primary biliary cirrhosis: an infectious disease caused by Chlamydia pneumoniae? Journal of Hepatology 2004 40 3 380 384 (Pubitemid 38230836)
114. Liu H. Y., Deng A. M., Zhang J., Zhou Y., Yao D. K., Tu X. Q., Fan L. Y., Zhong R. Q., Correlation of Chlamydia pneumoniae infection with primary biliary cirrhosis World Journal of Gastroenterology 2005 11 26 4108 4110 (Pubitemid 41235612)
115. Bogdanos D. P., Pares A., Rodés J., Vergani D., Muratori P., Muratori L., Rodrigo L., Bianchi F. B., Primary biliary cirrhosis specific antinuclear antibodies in patients from Spain American Journal of Gastroenterology 2004 99 4 763 765 (Pubitemid 38607983)
116. Nilsson H. O., Castedal M., Olsson R., Wadstrm T., Detection of Helicobacter in the liver of patients with chronic cholestatic liver diseases Journal of Physiology and Pharmacology 1999 50 5 875 882 (Pubitemid 30090019)
117. Nilsson H. O., Taneera J., Castedal M., Glatz E., Olsson R., Wadstrm T., Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis Journal of Clinical Microbiology 2000 38 3 1072 1076 (Pubitemid 30140562)
118. Nilsson I., Kornilovs'ka I., Lindgren S., Ljungh A., Wadstrm T., Increased prevalence of seropositivity for non-gastric Helicobacter species in patients with autoimmune liver disease Journal of Medical Microbiology 2003 52 11 949 953 (Pubitemid 38648133)
119. Nilsson I., Lindgren S., Eriksson S., Wadstrm T., Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease Gut 2000 46 3 410 414 (Pubitemid 30313396)
120. Leung P. S. C., Park O., Matsumura S., Ansari A. A., Coppel R. L., Gershwin M. E., Is there a relation between chlamydia infection and primary biliary cirrhosis? Clinical and Developmental Immunology 2003 10 2-4 227 233 (Pubitemid 38089415)
121. Taylor-Robinson D., Sharif A. W., Dhanjal N. S., Taylor-Robinson S. D., Chlamydia pneumoniae infection is an unlikely cause of primary biliary cirrhosis Journal of Hepatology 2005 42 5 779 780
122. Mitchison H. C., Bassendine M. F., Hendrick A., Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis? Hepatology 1986 6 6 1279 1284 (Pubitemid 17210555)
123. Prince M. I., Chetwynd A., Craig W. L., Metcalf J. V., James O. F. W., Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort Gut 2004 53 6 865 870 (Pubitemid 38662138)
124. Corpechot C., El Naggar A., Poujol-Robert A., Ziol M., Wendum D., Chazouillres O., De Lédinghen V., Dhumeaux D., Marcellin P., Beaugrand M., Poupon R., Assessment of biliary fibrosis by transient elastography in patients with PBC and PSC Hepatology 2006 43 5 1118 1124 (Pubitemid 43724636)
125. Roulot D., Costes J. L., Buyck J. F., Warzocha U., Gambier N., Czernichow S., Le Clesiau H., Beaugrand M., Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years Gut 2010
126. Nakamura M., Kondo H., Mori T., Komori A., Matsuyama M., Ito M., Takii Y., Koyabu M., Yokoyama T., Migita K., Daikoku M., Abiru S., Yatsuhashi H., Takezaki E., Masaki N., Sugi K., Honda K., Adachi H., Nishi H., Watanabe Y., Nakamura Y., Shimada M., Komatsu T., Saito A., Saoshiro T., Harada H., Sodeyama T., Hayashi S., Masumoto A., Sando T., Yamamoto T., Sakai H., Kobayashi M., Muro T., Koga M., Shums Z., Norman G. L., Ishibashi H., Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis Hepatology 2007 45 1 118 127 (Pubitemid 46144371)
127. Caramaschi P., Biasi D., Manzo T., Carletto A., Poli F., Bambara L. M., Anticentromere antibodyclinical associations. A study of 44 patients Rheumatology International 1995 14 6 253 255
128. Spencer-Green G., Alter D., Welch H. G., Test performance in systemic sclerosis: anti-centromere and anti-Scl-70 antibodies American Journal of Medicine 1997 103 3 242 248 (Pubitemid 27413407)
129. Avouac J., Fransen J., Walker U. A., Riccieri V., Smith V., Muller C., Miniati I., Tarner I. H., Bellando Randone S., Cutolo M., Allanore Y., Distler O., Valentini G., Czirjak L., Mller-Ladner U., Furst D. E., Tyndall A., Matucci-Cerinic M., De Keyser F., Sulli A., Pizzorni C., Maurer B., Sierakowsky S., Kowal-Bielecka O., Coelho P., Riemekasten G., Rednic S., Nicoara I., Caporali R., tork J., Inanc M., Carreira P., Novak S., Varju C., Chizzolini C., Ribi C., Kucharz E. J., Kotulska A., Widuchowska M., Richter J., Sipek-Dolnicar A., Rozman B., Gabrielli A., Moroncini G., Farge D., Durant C., Kiener H. P., Rath E., Airo P., Wollheim F. A., Hunzelmann N., Bombardieri S., Della Rossa A., Bazzichi L., Pellerito R., Saracco M., Denton C., Vonk M., Van Den Hoogen F., Damjanov N., Ktter I., Heitmann S., Seidel M., Hasler P., Van Laar J. M., Salvador M. J., Pereira Da Silva J. A., Jacobsen S., Worm M., Kuhn A., Nevskaya T., Nasonov E. L., Scorza R., Nielsen H., Silver R. M., Hachulla E., Launay D., Valesini G., Ionescu R., Opris D., Del Papa N., Maglione W., Comina D., Udrea G., Ciurtin C., Ionitescu R., Mihai C., Sunderktter C., Jun J. -B., Derk C., Alhasani S., Alhajjar L., Ton E., Seibold J., Nash P., Mouthon L., Von Mhlen C. A., Krummel-Lorenz B., Eilbacher P., Westhovens R., De Langhe E., Mayer M., Anic B., Baresic M., Stoeckl F., prus M., Popa S., Buslau M., Granel B., Zenone T., Mathieu A., Vacca A., Amerio P., Tourinho T., Lonzetti L., Lemos Lopes M., De Souza R., Vealex D., Caramaschi P., Balbir-Gurman A., Braun Y., Ullman S., Szmyrka-Kaczmarek M., Morgiel E., Vanthuyne M., Meurer M., Rehberger P., Mller C., Sampaio-Barros P., Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi consensus study from EULAR scleroderma trials and research group Annals of the Rheumatic Diseases 2011 70 3 476 481
130. Marasini B., Pipia C., DeValle G., Crosignani A., Petroni L., Cugno M., Zeni S., Bruno S., Bassani C., Vascular impairment in patients with primary biliary cirrhosis International Journal of Microcirculation, Clinical and Experimental 1995 15 2 75 79
131. Fonollosa V., Simen C. P., Castells L., Garcia F., Castro A., Solans R., Lima J., Vargas V., Guardia J., Vilardell M., Morphologic capillary changes and manifestations of connective tissue diseases in patients with primary biliary cirrhosis Lupus 2001 10 9 628 631 (Pubitemid 32959277)
132. Jurez M., Misischia R., Alarcn G. S., Infections in systemic connective tissue diseases: systemic lupus erythematosus, scleroderma, and polymyositis/dermatomyositis Rheumatic Disease Clinics of North America 2003 29 1 163 184 (Pubitemid 36298109)
133. Abu-Shakra M., Lee P., Mortality in systemic sclerosis: a comparison with the general population Journal of Rheumatology 1995 22 11 2100 2102
134. Bryan C., Howard Y., Brennan P., Black C., Silman A., Survival following the onset of scleroderma: results from a retrospective inception cohort study of the UK population British Journal of Rheumatology 1996 35 11 1122 1126
135. Jackson H., Solaymani-Dodaran M., Card T. R., Aithal G. P., Logan R., West J., Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study Hepatology 2007 46 4 1131 1137 (Pubitemid 350144777)
136. Jacobsen S., Halberg P., Ullman S., Mortality and causes of death of 344 Danish patients with systemic sclerosis (scleroderma) British Journal of Rheumatology 1998 37 7 750 755
137. Mahl T. C., Shockcor W., Boyer J. L., Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years Journal of Hepatology 1994 20 6 707 713 (Pubitemid 24216880)
138. Mitchison H. C., Lucey M. R., Kelly P. J., Neuberger J. M., Williams R., James O. F. W., Symptom development and prognosis in primary biliary cirrhosis: a study in two centers Gastroenterology 1990 99 3 778 784 (Pubitemid 20243371)
139. Myers R. P., Shaheen A. A. M., Fong A., Burak K. W., Wan A., Swain M. G., Hilsden R. J., Sutherland L., Quan H., Epidemiology and natural history of primary biliary cirrhosis in a Canadian Health Region: a population-based study Hepatology 2009 50 6 1884 1892
140. Tyndall A. J., Bannert B., Vonk M., Air P., Cozzi F., Carreira P. E., Bancel D. F., Allanore Y., Mller-Ladner U., Distler O., Iannone F., Pellerito R., Pileckyte M., Miniati I., Ananieva L., Gurman A. B., Damjanov N., Mueller A., Valentini G., Riemekasten G., Tikly M., Hummers L., Henriques M. J. S., Caramaschi P., Scheja A., Rozman B., Ton E., Kumnovics G., Coleiro B., Feierl E., Szucs G., Von Mhlen C. A., Riccieri V., Novak S., Chizzolini C., Kotulska A., Denton C., Coelho P. C., Ktter I., Simsek I., Lefebvre P. G. D. L. P., Hachulla E., Seibold J. R., Rednic S., tork J., Morovic-Vergles J., Walker U. A., Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database Annals of the Rheumatic Diseases 2010 69 10 1809 1815
141. Jones D. E., Al-Rifai A., Frith J., Patanwala I., Newton J. L., The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: results of a 9 year follow-up Journal of Hepatology 2010 53 5 911 917
142. Pollak C., Minar E., Dragosics B., Marosi L., Primary biliary cirrhosis and sclerodermia: long term benign course of a complex autoimmune disease Leber Magen Darm 1985 15 2 85 89 (Pubitemid 15112554)
143. Beswick D. R., Klatskin G., Boyer J. L., Asymptomatic primary biliary cirrhosis. A progress report on long-term follow-up and natural history Gastroenterology 1985 89 2 267 271 (Pubitemid 15028581)
144. Beuers U., Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis Nature Clinical Practice Gastroenterology and Hepatology 2006 3 6 318 328 (Pubitemid 43842248)
145. Combes B., Carithers R. L., Maddrey W. C., Lin D., Mcdonald M. F., Wheeler D. E., Eigenbrodt E. H., Munoz S. J., Rubin R., Garcia-Tsao G., Bonner G. F., West A. B., Boyer J. L., Luketic V. A., Shffman M. L., Mills A. S., Peters M. G., White H. M., Zetterman R. K., Rossi S. S., Hofmann A. F., Markin R. S., A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 1995 22 3 759 766
146. Heathcote E. J., Cauch-Dudek K., Walker V., Bailey R. J., Blendis L. M., Ghent C. N., Michieletti P., Minuk G. Y., Pappas S. C., Scully L. J., Steinbrecher U. P., Sutherland L. R., Williams C. N., Witt-Sullivan H., Worobetz L. J., Milner R. A., Wanless I. R., The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 1994 19 5 1149 1156 (Pubitemid 24134236)
147. Lindor K. D., Dickson E. R., Baldus W. P., Jorgensen R. A., Ludwig J., Murtaugh P. A., Harrison J. M., Wiesner R. H., Anderson M. L., Lange S. M., Lesage G., Rossi S. S., Hofmann A. F., Ursodeoxycholic acid in the treatment of primary biliary cirrhosis Gastroenterology 1994 106 5 1284 1290 (Pubitemid 24129246)
148. Parés A., Caballera L., Rodés J., Bruguera M., Rodrigo L., Garca-Plaza A., Berenguer J., Rodrguez-Martnez D., Mercader J., Velicia R., Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: results of a double-blind controlled multicentric trial. UDCA-Cooperative Group from the Spanish Association for the Study of the Liver Journal of Hepatology 2000 32 4 561 566 (Pubitemid 30180374)
149. Poupon R. E., Balkau B., Eschwege E., Poupon R., A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group The New England Journal of Medicine 1991 324 22 1548 1554
150. Goulis J., Leandro G., Burroughs A. K., Randomised controlled trials of ursodeoxychoric-acid therapy for primary biliary cirrhosis: a meta-analysis The Lancet 1999 354 9184 1053 1060 (Pubitemid 29452816)
151. Corpechot C., Abenavoli L., Rabahi N., Chrétien Y., Andréani T., Johanet C., Chazouillres O., Poupon R., Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis Hepatology 2008 48 3 871 877
152. Parés A., Caballera L., Rodés J., Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid Gastroenterology 2006 130 3 715 720 (Pubitemid 43374522)
153. Avouac J., Kowal-Bielecka O., Landewe R., Chwiesko S., Miniati I., Czirjak L., Clements P., Denton C., Farge D., Fligelstone K., Fldvari I., Furst D. E., Mller-Ladner U., Seibold J., Silver R. M., Takehara K., Garay Toth B., Tyndall A., Valentini G., Van Den Hoogen F., Wigley F., Zulian F., Matucci-Cerinic M., European League Against Rheumatism (EULAR) Scleroderma Trial and Research group (EUSTAR) recommendations for the treatment of systemic sclerosis: methods of elaboration and results of systematic literature research Annals of the Rheumatic Diseases 2009 68 5 629 634
154. Kowal-Bielecka O., Landewé R., Avouac J., Chwiesko S., Miniati I., Czirjak L., Clements P., Denton C., Farge D., Fligelstone K., Fldvari I., Furst D. E., Mller-Ladner U., Seibold J., Silver R. M., Takehara K., Garay Toth B., Tyndall A., Valentini G., Van Den Hoogen F., Wigley F., Zulian F., Matucci-Cerinic M., Wollheim F., Scheja A., Nevskaya T., Ananieva L., Nassonov E., Allanore Y., Kahan A., Hachulla E., Launay D., Herrick A., Van Laar J., Chizzolini C., Ciurtin C., Opris D., Ionescu R., Capraru M., Rednic S., Distler O., Simsek I., Dinc A., Inanc M., Graninger W., Kotter I., Gran J. T., Midvedt O., Kucharz E., Krasowska D., Majdan M., Sierakowski S., Salvador M. J., Pereira Da Silva J. A., Damjanov N., Carreira P., Garcia De La Pena Lefebvre P., Szucs G., Szekanecz Z., Becvar R., Pinto P., Coelho P., Novak S., Walker U., Aringer M., Glaenz T., Neumann C. H., Emmert S., Worm M., Riemekasten G., Krieg T., Hunzelmann N., Steinbrink K., Sunderkotter C., Heitmann S., Foldvari I., Iannone F., Lapadula G., Air P., Giacomelli R., Scorza R., Rizzi M., Indiveri F., Riccieri V., Zulian F., Rozman B., Takehara K., Jun J. B., Derk C., Sandorfi N., Jimenez S., Tikly M., Alhasani S., Shoenfeld Y., Balbir Gurmann A., EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR) Annals of the Rheumatic Diseases 2009 68 5 620 628
155. Rubin L. J., Badesch D. B., Barst R. J., Gali N., Black C. M., Keogh A., Pulido T., Frost A., Roux S., Leconte I., Landzberg M., Simonneau G., Bosentan therapy for pulmonary arterial hypertension The New England Journal of Medicine 2002 346 12 896 903 (Pubitemid 34984638)