Nuclear envelope protein autoantibodies in primary biliary cirrhosis

Seminars in Liver Disease

Volumn 17, Issue 1, 1997, Pages 79-90

  Courvalin, Jean Claude ^a   Worman, Howard J ^b  

^a INSTITUT JACQUES MONOD   (France)

^b Columbia University ^*  (United States)

Author keywords

antinuclear antibodies; autoimmunity; liver diseases; nuclear membrane; nuclear pore complex; nuclear proteins

Indexed keywords

ANTINUCLEAR ANTIBODY; ENVELOPE PROTEIN;

ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CELL NUCLEUS MEMBRANE; EPITHELIUM CELL; HUMAN; INTERMEDIATE FILAMENT; LIVER DISEASE; PATHOPHYSIOLOGY; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0030903041     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007185     Document Type: Article

References (88)

1. Rubin E, Schaffner F, Popper H. Primary biliary cirrhosis: chronic nonsuppurative cholangitis Am J Pathol 46:387-407, 1965.
2. Popper H, Schaffner F: Nonsuppurative destructive cholangitis and chronic hepatitis In: Popper H, Schaffner F (eds): Progress in liver diseases. Vol. 3 New York, Grune & Stratton, 1970, pp 336-54.
3. Gershwin ME, Mackay IR: Primary biliary cirrhosis: paradigm or paradox for autoimmunity. Gastroenterology 100:822-33, 1991.
4. Nakanuma Y, Tsuneyama K, Gershwin ME, et al: Pathology and immunopathology of primary biliary cirrhosis with emphasis on bile duct lesions: recent progress. Semin Liver Dis 15:313-28, 1995.
5. Cha S, Leung PS, Gershwin ME, et al: Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis. Proc Natl Acad Sci USA 90:2527-31, 1993.
6. Van de Water J, Turchany J, Leung PS, et al: Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest 91:2653-64, 1993.
7. Cha S, Leung PS, Coppel RL, et al: Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis. Hepatology 20:574-83, 1994.
8. Szostecki C, Krippner H, Penner E, et al: Autoimmune sera recognize a 100 kD nuclear protein antigen (sp-100) Clin Exp Immunol 68:108-16, 1987.
9. Szostecki C, Guldner HH, Netter HJ, et al: Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. J Immunol 145:4338-47, 1990.
10. Worman HJ, Courvalin J-C: Autoantibodies against nuclear envelope proteins in liver disease. Hepatology 14:1269-79, 1991.
11. Chaudhary N, Courvalin J-C: Stepwise reassembly of the nuclear envelope at the end of mitosis. J Cell Biol 122:295-306, 1993.
12. Aebi U, Cohn J, Buhle L, et al: The nuclear lamina is a meshwork of intermediate-type filaments. Nature 323:560-4, 1986.
13. Fisher DZ, Chaudhary N, Blobel G: cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci USA 83:6450-4, 1986.
14. McKeon FD, Kirschner MW, Caput D. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins Nature 319:463-8, 1986.
15. Lin F, Worman HJ: Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J Biol Chem 268:16321-6, 1993.
16. Wydner KL, McNeil JA, Lin F, et al: Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1 and LBR by fluorescence in situ hybridization. Genomics 32:474-8, 1996.
17. Lin F, Worman HJ: Structural organization of the human gene (LMNB1) encoding nuclear lamin B1. Genomics 27:230-6, 1995.
18. Biamonti G, Giacca M, Perini G, et al: The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. Mol Cell Biol 12:3499-506, 1992.
19. Guilly M-N, Bensussan A, Bourge JF, et al: A human lymphoblastic cell line lacks lamins A and C. EMBO J 6:3795-9, 1987.
20. Guilly M-N, Kolb J-P, Gosti F, et al: Lamins A and C are not expressed at early stages of human lymphocyte differentiation. Exp Cell Res 189:145-8, 1990.
21. Lebel S, Lampron C, Royal A, et al: Lamins A and C appear during retinoic acid-induced differentiation of mouse embryonal carcinoma cells. J Cell Biol 105.1099-1104, 1987.
22. Stewart C, Burke B: Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Cell 51:383-92, 1987.
23. Worman HJ, Lazaridis I, Georgatos SD: Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins, and variations in lamin B phosphorylation. J Biol Chem 263:12135-41, 1988.
24. Cance WG, Chaudhary N, Worman HJ, et al Expression of the nuclear lamins in normal and neoplastic human tissues. J Exp Clin Cancer Res 11:233-46, 1992.
25. Georgatos SD, Stournaras C, Blobel G: Heterotypic and homotypic association between the nuclear lamins. Site-specificity and control by phosphorylation. Proc Natl Acad Sci USA 85:4325-9, 1988.
26. Ye Q, Worman HJ: Protein-protein interactions between human nuclear lamins expressed in yeast. Exp Cell Res 219:292-8, 1995.
27. Panté N, Aebi U: The nuclear pore complex. J Cell Biol 122:977-84, 1993.
28. Rout MP, Wente SR: Pores for thought: nuclear pore complex proteins. Trends Cell Biol 4:357-65, 1994.
29. Gerace L, Ottaviano Y, Kondor-Koch C: Identification of a major polypeptide of the nuclear pore complex. J Cell Biol 95:826-37, 1982.
30. Wozniak RW, Bartnik E, Blobel G: Primary structure analysis of an integral membrane glycoprotein of the nuclear pore J Cell Biol 108:2083-92, 1989.
31. Hallberg E, Wozniak RW, Blobel G: An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region. J Cell Biol 122:513-21.
32. Wozniak RW, Blobel G, Rout MP: POM152 is an integral protein of the pore membrane domain of the yeast nuclear envelope. J Cell Biol 125:31-42, 1994.
33. Greber UL, Senior A, Gerace L: A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large luminal domain and a small cytoplasmic tail. EMBO J 9:1495-1502, 1990
34. Söderqvist H, Hallberg E: The large C-termmal region of the integral pore membrane protein, POM121, is facing the nuclear pore complex. Eur J Cell Biol 64:186-91, 1994.
35. Amar-Costesec A, Beaufay H, Wibo M, et al: Analytical study of microsomes and isolated subcellular membranes from rat liver. II. Preparation and composition of the microsomal fraction. J Cell Biol 61:201-12, 1974.
36. Worman HJ, Yuan J, Blobel G, et al: A lamm B receptor in the nuclear envelope. Proc Natl Acad Sci USA 85:8531-4, 1988.
37. Senior A, Gerace L: Integral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina. J Cell Biol 107:2029-36, 1988.
38. Harel A, Zlotkin I, Nainudel-Epszteyn S, et al: Persistence of a major nuclear envelope antigen in an envelope-like structure during mitosis in Drosophila melanogaster embryos. J Cell Sci 94:463-70, 1989.
39. Courvalin J-C, Lassoued K, Worman HJ, et al: Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis. J Exp Med 172:961-7, 1990.
40. Bailer SM, Eppenberger HM, Griffiths G, et al: Characterization of a 54-kD protein of the inner nuclear membrane. evidence for a cell cycle-dependent interaction with the nuclear lamina J Cell Biol 114:389-400, 1991.
41. Foisner R, Gerace L: Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell 73:1 267-79, 1993.
42. Worman HJ, Evans CD, Blobel G The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains. J Cell Biol 111: 1534-42, 1990.
43. Padan R, Nainudel-Epszteyn S, Goitein R, et al: Isolation and characterization of Drosophila nuclear envelope otefin cDNA. J Biol Chem 265:7808-13, 1990.
44. Ye Q, Worman HJ: Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J Biol Chem 269:11306-11, 1994.
45. Harris CA, Andryuk PJ, Cline S, et al: Three distinct human thymopoietins are derived from alternatively spliced mRNAs. Proc Natl Acad Sci USA 91:6283-7, 1994.
46. Martin L, Crimaudo C, Gerace L: cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane. J Biol Chem 270.8822-8, 1995.
47. Furukawa K, Panté N, Aebi U, et al Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. EMBO J 14:1626-36, 1995.
48. Schuler E, Lin F, Worman HJ: Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane J Biol Chem 269:11312-17, 1994.
49. Tan EM: Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44:93-151, 1989.
50. Blobel G, Potter VR: Nuclei from rat liver. isolation method that combines purity with high yield. Science 154:1662-5, 1966.
51. Dwyer N, Blobel G. A modified procedure for the isolation of a pore complex-lamina fraction from rat liver nuclei. J Cell Biol 70:581-91, 1976.
52. Wozniak RW, Blobel G: The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope. J Cell Biol 119:1441-9, 1992.
53. Favreau C, Worman HJ, Wozniak RW, et al: Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein gp210. Biochemistry 53:8035-44, 1996.
54. Ruffati A, Arslan P, Flureani A, et al: Nuclear membrane-staining antinuclear antibody in patients with primary biliary cirrhosis. J Clin Immunol 5.357-61, 1985.
55. Lozano F, Parés A, Borche L, et al: Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis. Hepatology 8:930-8, 1988.
56. Lassoued K, Guilly M-N, André C, et al: Autoantibodies to a 200 kD polypeptide(s) of the nuclear envelope: a new serological marker for primary biliary cirrhosis. Clin Exp Immunol 74:283-8, 1988.
57. Lassoued K, Brenard R, Degos R, et al: Antinuclear antibodies directed to a 200 kD polypeptide of the nuclear envelope in primary biliary cirrhosis. A clinical and immunological study of a series of 150 patients with primary biliary cirrhosis. Gastroenterology 99:181-6, 1990.
58. Courvalin J-C, Lassoued K, Bartnik E, et al: The 210 kilodalton nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. J Clin invest 86:279-85, 1990.
59. Nickowitz RE, Worman HJ. Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein gp210. J Exp Med 178:2237-42, 1993.
60. Nickowitz RE, Wozniak RW, Schaffner F, et al: Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis. Gastroenterology 106: 193-9, 1994.
61. Tartakovsky F, Worman HJ: Detection of gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope. Hepatology 21:495-500, 1995.
62. Wesierska-Gadek J, Hohenauer H, Hitchman E, et al: Autoantibodies from patients with primary biliary cirrhosis preferentially react with the ammo-terminal domain of nuclear pore complex glycoprotein gp210. J Exp Med 182-1159-62, 1995.
63. Bandin O, Courvalin J-C, Poupon R, et al: Specificity and sensitivity of gp210 autoantibodies detected using an ELISA and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis. Hepatology 23:1020-4, 1996.
64. Soullam B, Worman HJ. The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal. J Cell Biol 120:1093-1100, 1993
65. Soullam B, Worman HJ: Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane. J Cell Biol 130:15-27, 1995.
66. Ye Q, Worman HJ: Interaction between an integral protein of the nuclear envelope inner membrane and human chromo-domain proteins homologous to Drosophila HPI. J Biol Chem 1996. 271:14653-6, 1996.
67. cde2-type protein kinase. J Biol Chem 267:19035-8, 1992.
68. Lassoued K, Danon F, Brouet J-C: Human autoantibodies to lamin B receptor are also anti-idiotypic to certain anti-lamin B antibodies. Eur J Immunol 21-1959-62, 1991.
69. Lin F, Noyer CM, Ye Q, et al: Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Hepatology 23:57-61, 1996.
70. McKeon FD, Tuffanelli DL, Fukuyama K, et al: Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma. Proc Natl Acad Sci USA 80:4374-8, 1983.
71. Reeves WH, Chaudhary N, Salerno A, et al: Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 165.750-62, 1987.
72. Chou C-H, Ali SA, Roubey R, et al: Onset and regulation of anti-lamin B autoantibody production is independent of the level of polyclonal activation. Autoimmunity 8:297-305, 1991
73. Guilly M-N, Danon F, Brouet J-C, et al: Autoantibodies to lamin B in a patient with thrombopenia. Eur J Cell Biol 43: 266-72, 1987.
74. Lassoued K, Guilly M-N, Danon F, et al: Antinuclear autoantibodies specific for lamins: characterization and clinical significance. Ann Intern Med 108:829-33, 1988.
75. Wesierska-Gadek J, Penner E, Hitchman E, et al. Antibodies to nuclear lamins in autoimmune liver disease. Clin Immunol Immunopathol 49:107-15, 1988.
76. Courvalin J-C, Chaudhary N, Danon F, et al: Characterization of human autoantibodies specific for lamin A. Biol Cell 69: 93-7, 1990.
77. Wesierska-Gadek J, Penner E, Hitchman E, et al: Antibodies to nuclear lamin C in chronic hepatitis delta virus infection. Hepatology 12:1129-33, 1990.
78. Chou CH, Reeves WH: Recognition of multiple epitopes in the coiled-coil domain of lamin B by human autoantibodies Mol Immunol 29-1055-64, 1992.
79. Konstantinov K, Foisner R, Byrd D, et al: Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 74:89-99, 1995.
80. Earnshaw WC: Nuclear changes in apoptosis. Curr Opin Cell Biol 7:337-43, 1995.
81. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179:1317-30, 1994.
82. Casciola-Rosen LA, Anhalt GJ, Rosen A: DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 182:1625-34, 1995.
83. Tan EM: Autoimmunity and apoptosis. J Exp Med 179:1083-6, 1994.
84. Lazebnik YA, Takahashi A, Moir RD, et al: Studies on the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci USA 92:9042-6, 1995.
85. Oldstone MBA: Molecular mimicry and autoimmune disease. Cell 50:819-20, 1987.
86. Burroughs AK, Butler P, Sternberg MJE, et al: Molecular mimicry in liver disease Nature 358:377-8, 1992.
87. Wilken N, Kossner U, Senecal JL, et al. Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils. J Cell Biol 123:1345-1354, 1993.
88. Byrd DA, Sweet DJ, Panté N, et al: Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol 127:1515-26, 1994.