Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 265-274

  Kumar, Puneet ^a   Kalonia, Harikesh ^a   Kumar, Anil ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

3 nitropropionic acid; GABA; Gabapentin; Huntington; Lamotrigine

Indexed keywords

3 NITROPROPIONIC ACID; 4 AMINOBUTYRIC ACID; CATALASE; GABAPENTIN; LAMOTRIGINE; LIPID; MITOCHONDRIAL COMPLEX ENZYME II; MUSCIMOL; NITRITE; OXIDOREDUCTASE; PICROTOXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BEHAVIOR; BODY WEIGHT; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DOSE COMPARISON; DRUG MECHANISM; ENZYME ACTIVITY; GRIP STRENGTH; HUNTINGTON CHOREA; LIPID PEROXIDATION; LOCOMOTION; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINES; ANIMALS; BODY WEIGHT; BRAIN; CATALASE; CYCLOHEXANECARBOXYLIC ACIDS; GABAERGIC NEURONS; GAMMA-AMINOBUTYRIC ACID; HUNTINGTON DISEASE; LIPID PEROXIDATION; LOCOMOTION; MALE; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRITES; NITRO COMPOUNDS; OXIDATIVE STRESS; PROPIONIC ACIDS; RATS; RATS, WISTAR; ROTAROD PERFORMANCE TEST; SUPEROXIDE DISMUTASE; TRIAZINES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855564048     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.030     Document Type: Article

References (58)

1. Albin, R.L., Young, A.B., Penney, J.B., 1989. The functional anatomy of basal ganglia disorders. Trends Neurosci. 12, 366-375. (Pubitemid 19238787)
2. Allen, K.L., Waldvogel, H.J., Glass, M., Faull, R.L., 2009. Cannabinoid (CB1), GABAA and GABAB receptor subunit changes in the globus pallidus in Huntington's disease. J. Chem. Neuroanat. 37, 266-281.
3. Araujo, D.M., Hilt, D.C., 1997. Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease. Neuroscience 81, 1099-1110. (Pubitemid 27421773)
4. Baydas, G., Sonkaya, E., Tuzcu, M., Yasar, A., Donder, E., 2005. Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats. Acta Pharmacol. Sin. 26, 417-422. (Pubitemid 40477988)
5. Beal, M.F., Brouillet, E., Jenkins, B.G., Ferrante, R.J., Kowall, N.W., Miller, J.M., Storey, E., Srivastava, R., Rosen, B.R., Hyman, B.T., 1993. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13, 4181-4192. (Pubitemid 23299942)
6. Berman, S.B., Hastings, T.G., 1999. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J. Neurochem. 73, 1127-1137. (Pubitemid 29395471)
7. Boll, M.C., Alcaraz-Zubeldia, M., Montes, S., Rios, C., 2008. Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases. Neurochem. Res. 33, 1717-1723.
8. Bonelli, M.R., Gregor, K.W., Kapfhammer, P.H., 2004. Huntington's disease: present treatments and future therapeutic modalities. Int. Clin. Psychopharmacol. 19, 51-62.
9. Borlongan, C.V., Koutouzis, T.K., Randall, T.S., Freeman, T.B., Cahill, D.W., Sanberg, P.R., 1995. Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult rats. Brain Res. Bull. 36, 549-556.
10. Borlongan, C.V., Koutouzis, T.K., Freeman, T.B., Hauser, R.A., Cahill, D.W., Sanberg, P.R., 1997. Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model. Brain Res. Brain Res. Protoc. 1, 253-257. (Pubitemid 28281321)
11. Brickell, K.L., Nicholson, L.F., Waldvogel, H.J., Faull, R.L., 1999. Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: a detailed time course of the cellular and GABA (A) receptor changes. J. Chem. Neuroanat. 17, 75-97. (Pubitemid 29512395)
12. Browne, S.E., Ferrante, R.J., Beal, M.F., 1999. Oxidative stress in Huntington's disease. Brain Pathol. 9, 147-163. (Pubitemid 29056525)
13. Caraceni, T.A., Girotti, F., Giovannini, P., Pederzoli, M., Parati, E.A., 1980. Effects of DA agonist in Huntington disease hyperkinesia. Ital. J. Neurol. Sci. 1, 155-161.
14. DiFiglia, M., 1990. Excitotoxic injury of the neostriatum: a model for Huntington's disease. Trends Neurosci. 13, 286-289. (Pubitemid 20193460)
15. Frank-Cannon, T.C., Alto, L.T., McAlpine, F.E., Tansey, M.G., 2009. Does neuroinflammation fan the flame in neurodegenerative diseases? Mol. Neurodegener. 4, 47.
16. Gornall, A.G., Bardawill, C.J., David, M.M., 1949. Determination of serum proteins by means of the Biuret reaction. J. Biol. Chem. 177, 751-756.
17. Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannebaum, S.R., 1982. Analysis of nitrate, nitrite, and [15N) nitrate in biological fluids. Ann. Biochem. 126, 131-138. (Pubitemid 13203451)
18. Hendrich, J., Van Minh, A.T., Heblich, F., Nieto-Rostro, M., Watschinger, K., Striessnig, J., Wratten, J., Davies, A., Dolphin, A.C., 2008. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc. Natl. Acad. Sci. U. S. A. 105, 3628-3633. (Pubitemid 351723603)
19. Kalonia, H., Kumar, P., Kumar, A., 2010a. Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor- γ (PPAR-γ) in Huntington's disease. Pharmacol. Biochem. Behav. 96, 115-124.
20. Kalonia, H., Kumar, P., Kumar, A., 2010b. Targeting oxidative stress attenuates malonic acid induced Huntington like behavioral and mitochondrial alterations in rats. Eur. J. Pharmacol. 634, 46-52.
21. Kent, A., 2004. Huntington's disease. Nurs. Stand. 21, 45-51.
22. Kim, Y.J., Ko, H.H., Han, E.S., Lee, C.S., 2007. Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death. Brain Res. Bull. 71, 633-640. (Pubitemid 46209530)
23. Kim, Y.S., Chang, H.K., Lee, J.W., Sung, Y.H., Kim, S.E., Shin, M.S., Yi, J.W., Park, J.H., Kim, H., Kim, C.J., 2009. Protective effect of gabapentin on N-methyl-D-aspartate-induced excitotoxicity in rat hippocampal CA1 neurons. J. Pharmacol. Sci. 109, 144-147.
24. King, T.E., 1967. Preparation of succinate dehydrogenase and reconstitution of succinate oxidase. Methods Enzymol. 10, 322-331.
25. King, T.E., Howard, R.L., 1967. Preparations and properties of soluble NADH dehydrogenases from cardiac muscle. Methods Enzymol. 10, 275-284.
26. Kono, Y., 1978. Generation of superoxide radical during auto-oxidation of hydroxylamine and an assay of superoxide dismutase. Arch. Biochem. Biophys. 186, 189-195. (Pubitemid 8290500)
27. Kumar, A., Goyal, R., 2008. Gabapentin attenuates acute hypoxic stress-induced behavioral alterations and oxidative damage in mice: possible involvement of GABAergic mechanism. Indian J. Exp. Biol. 46, 159-163.
28. Kumar, P., Kumar, A., 2009a. Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 100-108.
29. Kumar, P., Kumar, A., 2009b. Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease. J. Med. Food 12, 591-600.
30. Kumar, P., Padi, S.S., Naidu, P.S., Kumar, A., 2006. Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms. Behav. Pharmacol. 17, 485-492. (Pubitemid 44325810)
31. Kumar, P., Padi, S.S., Naidu, P.S., Kumar, A., 2007. Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. Methods Find. Exp. Clin. Pharmacol. 29, 19-25. (Pubitemid 46447219)
32. Kumar, P., Kalonia, H., Kumar, A., 2009. Sesamol attenuate 3-nitropropionic acid-induced Huntington-like behavioral, biochemical, and cellular alterations in rats. J. Asian Nat. Prod. Res. 11, 439-450.
33. Kumar, P., Kalonia, H., Kumar, A., 2010a. Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntington's disease. Behav. Pharmacol. 21, 217-230.
34. Kumar, P., Kalonia, H., Kumar, A., 2010b. Huntington's disease: pathogenesis to animal models. Pharmacol. Rep. 62, 1-14.
35. Kumar, P., Kalonia, H., Kumar, A., 2010c. Novel protective mechanisms of antidepressants against 3-nitropropionic acid induced Huntington's-like symptoms: a comparative study. J. Psychopharmacol. (0: 0269881110364269v1).
36. Lee, W.T., Chang, C., 2004. Magnetic resonance imaging and spectroscopy in assessing 3-nitropropionic acid-induced brain lesions: an animal model of Huntington's disease. Prog. Neurobiol. 72, 87-110. (Pubitemid 38519588)
37. Lee, W.T., Shen, Y.Z., Chang, C., 2000. Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy. Neuroscience 95, 89-95.
38. Liu, Y., Peterson, D.A., Kimura, H., Schubert, D., 1997. Mechanisms of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolinium bromide (MTT) reduction. J. Neurochem. 69, 581-593. (Pubitemid 27327958)
39. Luck, H., 1971. Catalase. In: Bergmeyer, H.U. (Ed.), Methods of Enzymatic Analysis. Academic Press, New York, pp. 885-893.
40. Meffert, M.K., Baltimore, D., 2005. Physiological functions for brain NF-kappaB. Trends Neurosci. 28, 37-43.
41. Pallier, P.N., Drew, C.J., Morton, A.J., 2009. The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task and protocol-dependent: influence of non-motor factors on locomotor function. Brain Res. Bull. 78, 347-355.
42. Perry, T.L., Hansen, S., Kloster, M., 1973. Huntington's chorea: deficiency of gamma-aminobutyric acid in brain. N. Engl. J. Med. 288, 337-342.
43. Pisani, A., Gubellini, P., Bonsi, P., Conquet, F., Picconi, B., Centonze, D., Bernardi, G., Calabresi, P., 2001. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience 106, 579-587. (Pubitemid 32925246)
44. Saulle, E., Gubellini, P., Picconi, B., Centonze, D., Tropepi, D., Pisani, A., Morari, M., Marti, M., Rossi, L., Papa, M., Bernardi, G., Calabresi, P., 2004. Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease. Mol. Cell. Neurosci. 25, 9-20. (Pubitemid 38220860)
45. Schulz, J.B., Henshaw, D.R., MacGarvey, U., Beal, M.F., 1996. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity. Neurochem. Int. 29, 167-171. (Pubitemid 26232004)
46. Shimoyama, M., Shimoyama, N., Hori, Y., 2000. Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 85, 405-414. (Pubitemid 30214167)
47. Sottocasa, G.L., Kuylenstierna, B., Ernster, L., Bergstrand, A., 1967. An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J. Cell Biol. 32, 415-428.
48. Su, B., Wang, X., Zheng, L., Perry, G., Smith, M.A., Zhu, X., 2010. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim. Biophys. Acta 1802, 135-142.
49. Tadros, M.G., Khalifa, A.E., Abdel-Naim, A.B., Arafa, H.M., 2005. Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype. Pharmacol. Biochem. Behav. 82, 574-582. (Pubitemid 41827601)
50. Tansey, M.G., Frank-Cannon, T.C., McCoy, M.K., Lee, J.K., Martinez, T.N., McAlpine, F.E., Ruhn, K.A., Tran, T.A., 2008. Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy? Front. Biosci. 13, 709-717. (Pubitemid 351599776)
51. Teunissen, C.E., Steinbusch, H.W., Angevaren, M., Appels, M., de Bruijn, C., Prickaerts, J., de Vente, J., 2001. Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation. Neuroscience 105, 153-167. (Pubitemid 32722102)
52. Traa, B.S., Mulholland, J.D., Kadam, S.D., Johnston, M.V., Comi, A.M., 2008. Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. Pediatr. Res. 64, 81-85.
53. Tufan, K., Oztanir, N., Ofluoglu, E., Ozogul, C., Uzum, N., Dursun, A., Pasaoglu, H., Pasaoglu, A., 2008. Ultra-structure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury. Neurosurg. Focus. 25, E6-E10.
54. Tunez, I., Feijoo, M., Collado, J.A., Medina, F.J., Pena, J., Munoz, M. del C., Jimena, I., Franco, F., Rueda, I., Muntane, J., Montilla, P., 2007. Effect of testosterone on oxidative stress and cell damage induced by 3-nitropropionic acid in striatum of ovariectomized rats. Life Sci. 80, 1221-1227. (Pubitemid 46329008)
55. Turner, C., Cooper, J.M., Schapira, A.H., 2007. Clinical correlates of mitochondrial function in Huntington's disease muscle. Mov. Disord. 22, 1715-1721. (Pubitemid 47597594)
56. Villarán, R.F., Tomás-Camardiel, M., de Pablos, R.M., Santiago, M., Herrera, A.J., Navarro, A., Machado, A., Cano, J., 2008. Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. Neurotoxicology 29, 244-258.
57. Vonsattel, J.P., Myers, R.H., Stevens, T.J., Ferrante, R.J., Bird, E.D., Richardson Jr., E.P., 1985. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44, 559-577. (Pubitemid 16196286)
58. Wills, E.D., 1966. Mechanism of lipid peroxide formation in animal. Biochem. J. 99, 667-676.