Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury

Neurosurgical Focus

Volumn 25, Issue 5, 2008, Pages

  Tufan, Kadir ^a   Oztanir, Namik ^a   Ofluoglu, Ebru ^a   Ozogul, Candan ^a   Uzum, Nuket ^a   Dursun, Ayse ^a   Pasaoglu, Hatice ^a   Pasaoglu, Aydin ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Electron microscopy; Experimental spinal cord injury; Lamotrigine; Lipid peroxidation; Rat; Spinal cord ultrastructure

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; GLUTAMIC ACID; GLUTATHIONE PEROXIDASE; LAMOTRIGINE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRIAZINE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; DISEASE MODEL; DRUG EFFECT; FEMALE; LAMINECTOMY; LIPID PEROXIDATION; METABOLISM; METHODOLOGY; PATHOLOGY; RANDOMIZATION; RAT; SPINAL CORD; SPINAL CORD INJURY; SYNAPTOSOME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DISEASE MODELS, ANIMAL; FEMALE; GLUTAMIC ACID; GLUTATHIONE PEROXIDASE; LAMINECTOMY; LIPID PEROXIDATION; MALONDIALDEHYDE; MICROSCOPY, ELECTRON, TRANSMISSION; PRESYNAPTIC TERMINALS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SPINAL CORD; SPINAL CORD INJURIES; SUPEROXIDE DISMUTASE; TRIAZINES;

EID: 63849233635     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/FOC.2008.25.11.E6     Document Type: Article

References (24)

1. Agrawal SK, Fehlings MG: Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 17:1055-1063, 1997
2. Agrawal SK, Theriault E, Fehlings MG: Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury. J Neurotrauma 15:929-941, 1998
3. Bacher A, Zornow MH: Lamotrigine inhibits extracellular glutamate accumulation during transient global cerebral ischemia in rabbits. Anesthesiology 86:459-463, 1997
4. Faden AI, Lemke M, Simon RP, Noble LJ: N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies. J Neurotrauma 5:33-45, 1988
5. Fairbanks FB, Klee GG: Biochemical aspects of haematology in Burtis CA, Ashwood ER (eds): Tietz Textbook Of Clinical Chemistry, ed 2. Philadelphia, WB Saunders Company: 1994, pp 1974-2072
6. Hollmann M, Hartley M, Heinemann S: Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252:851-853, 1991
7. Hurley SC: Lamotrigine update and its use in mood disorders. Ann Pharmacother 36:860-873, 2002
8. Kaptanoglu E, Palaoglu S, Surucu HS, Hayran M, Beskanonakli E: Ultrastructural scoring of graded acute spinal cord injury in the rat. J Neurosurg 97 (1 Suppl):49-56, 2002
9. Kaptanoglu E, Solaroglu I, Okutan O, Surucu HS, Akbiyik F, Beskonakli E: Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: effect on lipid peroxidation and early ultrastructural findings. Neurosurg Rev 27:113- 120, 2004
10. Lees G, Leach MJ: Studies on the mechanism of action of the novel anticonvulsant lamotrigine using primary neurological cultures from rat cortex. Brain Res 612:190-199, 1993
11. Li S, Tator CH: Effects of MK801 on evoked potentials, spinal cord blood flow and cord edema in acute spinal cord injury in rats. Spinal Cord 37:820-832, 1999
12. Liu D, Thangnipon W, McAdoo DJ: Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res 547:344-348, 1991
13. Low SJ, Roland CL: Review of NMDA antagonist-induced neurotoxicity and implications for clinical development. Int J Clin Pharmacol Ther 42:1-14, 2004
14. Mills CD, Johnson KM, Hulsebosch CE: Role of Group II and Group III metabotropic glutamate receptors in spinal cord injury. Exp Neurol 173:153-167, 2002
15. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358, 1979
16. Paglia DE, Valentine WN: Studies on quantitative and qualitativ characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-168, 1967
17. Panter SS, Yum SW, Faden AI: Alteration in extracellular amino acids after traumatic spinal cord injury. Ann Neurol 27:96-99, 1990
18. Rataud J, Debarnot F, Mary V, Pratt J, Stutzmann JM: Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents. Neurosci Lett 172:19-23, 1994
19. Rivlin AS, Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:38-43, 1978
20. Smith SE, Meldrum BS: Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke 26:117-121, 1995
21. Stefani A, Spadoni F, Bernardi G: Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies. Exp Neurol 147:115-122, 1997
22. Wrathall JR, Choiniere D, Teng YD: Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J Neurosci 14:6598-6607, 1994
23. Yoshioka T, Kawada K, Shimada T, Mori M: Lipid peroxidation in maternal and cord blood and protective mechanism against activated oxygen toxicity in the blood. Am J Obstet Gynecol 135:372-376, 1979
24. Zileli M, Ovul I, Dalbasti T: Effects of methyl prednisolone, dimethyl sulphoxide and naloxone in experimental spinal cord injuries in rats. Neurol Res 10:232-235, 1988