Proteomic profiling of the influence of iron availability on cryptococcus gattii

Journal of Proteome Research

Volumn 11, Issue 1, 2012, Pages 189-205

  Crestani, Juliana ^a   Carvalho, Paulo Costa ^b,c   Han, Xuemei ^d   Seixas, Adriana ^a   Broetto, Leonardo ^a   Fischer, Juliana De Saldanha Da Gama ^b,c   Staats, Charley Christian ^a   Schrank, Augusto ^a   Yates, John R ^d   Vainstein, Marilene Henning ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c INSTITUTO CARLOS CHAGAS   (Brazil)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

2D GE; 2D LC MS MS; Cryptococcus gattii R265; iron; MudPIT; proteomics

Indexed keywords

CYCLIC AMP; IRON;

ARTICLE; CANADA; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CRYPTOCOCCUS GATTII; ENZYME ACTIVITY; FUNGUS ISOLATION; GENE EXPRESSION PROFILING; IRON AVAILABILITY; IRON DEPLETION; IRON REPLETION; MITOCHONDRIAL RESPIRATION; MULTIDIMENSIONAL PROTEIN IDENTIFICATION TECHNOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; PROTEOMIC PROFILING; PROTEOMICS; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

BIOSYNTHETIC PATHWAYS; CRYPTOCOCCUS GATTII; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FUNGAL PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION, FUNGAL; IRON; MOLECULAR SEQUENCE ANNOTATION; PROTEOME; PROTEOMICS;

CRYPTOCOCCUS GATTII;

EID: 84855560464     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr2005296     Document Type: Article

References (101)

1. Morgan, J.; McCarthy, K. M.; Gould, S.; Fan, K.; Arthington-Skaggs, B.; Iqbal, N.; Stamey, K.; Hajjeh, R. A.; Brandt, M. E. Cryptococcus gattii infection: characteristics and epidemiology of cases identified in a South African province with high HIV seroprevalence, 2002-2004 Clin. Infect. Dis. 2006, 43, 1077-80 (Pubitemid 44631112)
2. Litvintseva, A. P.; Thakur, R.; Reller, L. B.; Mitchell, T. G. Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa J. Infect. Dis. 2005, 192, 888-92 (Pubitemid 41193087)
3. Sorrell, T. C. Cryptococcus neoformans variety gattii Med. Mycol. 2001, 39 (2) 155-68 (Pubitemid 32377312)
4. Chayakulkeeree, M.; Perfect, J. R. Cryptococcosis Infect. Dis. Clin. North Am. 2006, 20 (3) 507-44; v-vi (Pubitemid 44375117)
5. Idnurm, A.; Bahn, Y. S.; Nielsen, K.; Lin, X.; Fraser, J. A.; Heitman, J. Deciphering the model pathogenic fungus Cryptococcus neoformans Nat. Rev. Microbiol. 2005, 3 (10) 753-64 (Pubitemid 41518736)
6. Casadevall, A.; Perfect, J. R. Cryptococcus neoformans; ASM Press: Washington, D.C., 1998.
7. Kidd, S. E.; Hagen, F.; Tscharke, R. L.; Huynh, M.; Bartlett, K. H.; Fyfe, M.; Macdougall, L.; Boekhout, T.; Kwon-Chung, K. J.; Meyer, W. A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada) Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (49) 17258-63 (Pubitemid 39627807)
8. Lester, S. J.; Malik, R.; Bartlett, K. H.; Duncan, C. G. Cryptococcosis: update and emergence of Cryptococcus gattii Vet. Clin. Pathol. 2011, 40 (1) 4-17
9. Galanis, E.; Macdougall, L. Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007 Emerg Infect. Dis. 2010, 16 (2) 251-7
10. Nicol, A. M.; Hurrell, C.; McDowall, W.; Bartlett, K.; Elmieh, N. Communicating the risks of a new, emerging pathogen: the case of Cryptococcus gattii Risk Anal. 2008, 28 (2) 373-86 (Pubitemid 351550594)
11. Duncan, C.; Stephen, C.; Campbell, J. Clinical characteristics and predictors of mortality for Cryptococcus gattii infection in dogs and cats of southwestern British Columbia Can. Vet. J. 2006, 47 (10) 993-8 (Pubitemid 44768557)
12. Kronstad, J. W.; Attarian, R.; Cadieux, B.; Choi, J.; D'Souza, C. A.; Griffiths, E. J.; Geddes, J. M.; Hu, G.; Jung, W. H.; Kretschmer, M.; Saikia, S.; Wang, J. Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box Nat. Rev. Microbiol. 2011, 9, 193-203
13. D'Souza, C. A.; Kronstad, J. W.; Taylor, G.; Warren, R.; Yuen, M.; Hu, G.; Jung, W. H.; Sham, A.; Kidd, S. E.; Tangen, K.; Lee, N.; Zeilmaker, T.; Sawkins, J.; McVicker, G.; Shah, S.; Gnerre, S.; Griggs, A.; Zeng, Q.; Bartlett, K.; Li, W.; Wang, X.; Heitman, J.; Stajich, J. E.; Fraser, J. A.; Meyer, W.; Carter, D.; Schein, J.; Krzywinski, M.; Kwon-Chung, K. J.; Varma, A.; Wang, J.; Brunham, R.; Fyfe, M.; Ouellette, B. F.; Siddiqui, A.; Marra, M.; Jones, S.; Holt, R.; Birren, B. W.; Galagan, J. E.; Cuomo, C. A. Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts mBio 2011, 2 (1) e00342-10
14. Ngamskulrungroj, P.; Price, J.; Sorrell, T.; Perfect, J. R.; Meyer, W. Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver Island outbreak strains PLoS One 2011, 6 (1) e16076
15. Ngamskulrungroj, P.; Gilgado, F.; Faganello, J.; Litvintseva, A. P.; Leal, A. L.; Tsui, K. M.; Mitchell, T. G.; Vainstein, M. H.; Meyer, W. Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties PLoS One 2009, 4 (6) e5862
16. Frealle, E.; Noel, C.; Viscogliosi, E.; Camus, D.; Dei-Cas, E.; Delhaes, L. Manganese superoxide dismutase in pathogenic fungi: an issue with pathophysiological and phylogenetic involvements FEMS Immunol. Med. Microbiol. 2005, 45, 411-22 (Pubitemid 41247777)
17. Hicks, J. K.; Heitman, J. Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade Eukaryot Cell 2007, 6 (3) 413-20 (Pubitemid 46492329)
18. Latouche, G. N.; Sorrell, T. C.; Meyer, W. Isolation and characterisation of the phospholipase B gene of Cryptococcus neoformans var. gattii FEMS Yeast Res. 2002, 2 (4) 551-61 (Pubitemid 35373960)
19. Narasipura, S. D.; Chaturvedi, V.; Chaturvedi, S. Characterization of Cryptococcus neoformans variety gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence Mol. Microbiol. 2005, 55 (6) 1782-800 (Pubitemid 40445213)
20. Ren, P.; Springer, D. J.; Behr, M. J.; Samsonoff, W. A.; Chaturvedi, S.; Chaturvedi, V. Transcription factor STE12alpha has distinct roles in morphogenesis, virulence, and ecological fitness of the primary pathogenic yeast Cryptococcus gattii Eukaryot. Cell 2006, 5 (7) 1065-80 (Pubitemid 44100705)
21. Wright, L. C.; Payne, J.; Santangelo, R. T.; Simpanya, M. F.; Chen, S. C.; Widmer, F.; Sorrell, T. C. Cryptococcal phospholipases: a novel lysophospholipase discovered in the pathogenic fungus Cryptococcus gattii Biochem. J. 2004, 384, 377-84 (Pubitemid 39656250)
22. Ngamskulrungroj, P.; Himmelreich, U.; Breger, J. A.; Wilson, C.; Chayakulkeeree, M.; Krockenberger, M. B.; Malik, R.; Daniel, H. M.; Toffaletti, D.; Djordjevic, J. T.; Mylonakis, E.; Meyer, W.; Perfect, J. R. The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii Infect. Immun. 2009, 77 (10) 4584-96
23. Ma, H.; Hagen, F.; Stekel, D. J.; Johnston, S. A.; Sionov, E.; Falk, R.; Polacheck, I.; Boekhout, T.; May, R. C. The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation Proc. Natl. Acad. Sci. U.S.A. 2009, 106 (31) 12980-5
24. Dimmer, K. S.; Rapaport, D. Proteomic view of mitochondrial function Genome Biol. 2008, 9, 209
25. Levi, S.; Rovida, E. The role of iron in mitochondrial function Biochim. Biophys. Acta 2009, 1790 (7) 629-36
26. Jung, W. H.; Saikia, S.; Hu, G.; Wang, J.; Fung, C. K.; D'Souza, C.; White, R.; Kronstad, J. W. HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans PLoS Pathog. 2010, 6 (11) e1001209
27. Jung, W. H.; Kronstad, J. W. The iron-responsive, GATA-type transcription factor cir1 influences mating in Cryptococcus neoformans Mol. Cells 2010, 31 (1) 73-7
28. Jung, W. H.; Kronstad, J. W. Iron and fungal pathogenesis: a case study with Cryptococcus neoformans Cell Microbiol. 2008, 10 (2) 277-84
29. Jung, W. H.; Sham, A.; Lian, T.; Singh, A.; Kosman, D. J.; Kronstad, J. W. Iron source preference and regulation of iron uptake in Cryptococcus neoformans PLoS Pathog. 2008, 4 (2) e45
30. Jung, W. H.; Sham, A.; White, R.; Kronstad, J. W. Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans PLoS Biol. 2006, 4 (12) e410
31. Lian, T.; Simmer, M. I.; D'Souza, C. A.; Steen, B. R.; Zuyderduyn, S. D.; Jones, S. J.; Marra, M. A.; Kronstad, J. W. Iron-regulated transcription and capsule formation in the fungal pathogen Cryptococcus neoformans Mol. Microbiol. 2005, 55 (5) 1452-72 (Pubitemid 40342072)
32. Jacobson, E. S.; Goodner, A. P.; Nyhus, K. J. Ferrous iron uptake in Cryptococcus neoformans Infect. Immun. 1998, 66 (9) 4169-75 (Pubitemid 28402688)
33. Barluzzi, R.; Saleppico, S.; Nocentini, A.; Boelaert, J. R.; Neglia, R.; Bistoni, F.; Blasi, E. Iron overload exacerbates experimental meningoencephalitis by Cryptococcus neoformans J. Neuroimmunol. 2002, 132 (1-2) 140-6 (Pubitemid 35333336)
34. Silva, M.; Schrank, A.; Bailão, E. F.; Bailão, A. M.; Borges, C. L.; Staats, C. C.; Parente, J. A.; Pereira, M.; Salem-Izacc, S. M.; Mendes-Giannini, M. J. S.; Zancopé-Oliveira, R. M.; Rosa e Silva, L. K.; Nosanchuk, J. D.; Vainstein, M. H.; Soares, C. M. The homeostasis of iron, copper and zinc in Paracoccidioides brasiliensis, Cryptococcus neoformans var. grubii and Cryptococcus gattii: A comparative analysis Front. Microbiol. 2011, 2, 1-15
35. Fischer Jde, S.; Liao, L.; Carvalho, P. C.; Barbosa, V. C.; Domont, G. B.; Carvalho Mda, G.; Yates, J. R., 3rd Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol J. Proteomics 2010, 73, 1018-27
36. Zybailov, B.; Mosley, A. L.; Sardiu, M. E.; Coleman, M. K.; Florens, L.; Washburn, M. P. Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae J. Proteome Res. 2006, 5 (9) 2339-47 (Pubitemid 44330827)
37. Carrozza, M. J.; Florens, L.; Swanson, S. K.; Shia, W. J.; Anderson, S.; Yates, J. R., 3rd; Washburn, M. P.; Workman, J. L. Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex Biochim. Biophys. Acta 2005, 1731, 77-87 (Pubitemid 41712766)
38. Graumann, J.; Dunipace, L. A.; Seol, J. H.; McDonald, W. H.; Yates, J. R., 3rd; Wold, B. J.; Deshaies, R. J. Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast Mol Cell Proteomics 2004, 3 (3) 226-37 (Pubitemid 38714278)
39. Wu, C. C.; MacCoss, M. J.; Mardones, G.; Finnigan, C.; Mogelsvang, S.; Yates, J. R., 3rd; Howell, K. E. Organellar proteomics reveals Golgi arginine dimethylation Mol. Biol. Cell 2004, 15 (6) 2907-19 (Pubitemid 38691878)
40. Washburn, M. P.; Ulaszek, R. R.; Yates, J. R., 3rd Reproducibility of quantitative proteomic analyses of complex biological mixtures by multidimensional protein identification technology Anal. Chem. 2003, 75 (19) 5054-61 (Pubitemid 37238557)
41. Koller, A.; Washburn, M. P.; Lange, B. M.; Andon, N. L.; Deciu, C.; Haynes, P. A.; Hays, L.; Schieltz, D.; Ulaszek, R.; Wei, J.; Wolters, D.; Yates, J. R., 3rd Proteomic survey of metabolic pathways in rice Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (18) 11969-74 (Pubitemid 34994508)
42. Florens, L.; Washburn, M. P.; Raine, J. D.; Anthony, R. M.; Grainger, M.; Haynes, J. D.; Moch, J. K.; Muster, N.; Sacci, J. B.; Tabb, D. L.; Witney, A. A.; Wolters, D.; Wu, Y.; Gardner, M. J.; Holder, A. A.; Sinden, R. E.; Yates, J. R., 3rd; Carucci, D. J. A proteomic view of the Plasmodium falciparum life cycle Nature 2002, 419 (6906) 520-6
43. Tangen, K. L.; Jung, W. H.; Sham, A. P.; Lian, T.; Kronstad, J. W. The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans Microbiology 2007, 153 (Pt 1) 29-41 (Pubitemid 46115660)
44. Washburn, M. P.; Wolters, D.; Yates, J. R., 3rd Large-scale analysis of the yeast proteome by multidimensional protein identification technology Nat. Biotechnol. 2001, 19 (3) 242-7 (Pubitemid 32220565)
45. McDonald, W. H.; Tabb, D. L.; Sadygov, R. G.; MacCoss, M. J.; Venable, J.; Graumann, J.; Johnson, J. R.; Cociorva, D.; Yates, J. R., 3rd MS1, MS2, and SQT-three unified, compact, and easily parsed file formats for the storage of shotgun proteomic spectra and identifications Rapid Commun. Mass Spectrom. 2004, 18 (18) 2162-8 (Pubitemid 39222458)
46. Eng, J.; McCormack, A.; Yates, J. R., 3rd An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database J. Am. Soc. Mass Spectrom. 1994, 5 (11) 976-89
47. Tabb, D. L.; McDonald, W. H.; Yates, J. R., 3rd DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics J. Proteome Res. 2002, 1 (1) 21-6
48. Carvalho, P. C.; Yates, J. R., III; Barbosa, V. C. Analyzing shotgun proteomic data with PatternLab for proteomics. In Current Protocols in Bioinformatics; John Wiley & Sons: New York, 2010; Chapter 13, Unit 13.13, pp 1-15.
49. Carvalho, P. C.; Fischer, J. S.; Chen, E. I.; Yates, J. R., 3rd; Barbosa, V. C. PatternLab for proteomics: a tool for differential shotgun proteomics BMC Bioinform. 2008, 9, 316
50. Carvalho, P. C.; Fischer, J. S.; Chen, E. I.; Domont, G. B.; Carvalho, M. G.; Degrave, W. M.; Yates, J. R., 3rd; Barbosa, V. C. GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data Proteome Sci. 2009, 7, 6
51. Benjamini, Y.; Hochberg, Y. Controlling the False Discovery Rate: a practical and powerful approach to multiple testing J. R. Stat. Soc., B 1995, 57, 289-300
52. Gotz, S.; Garcia-Gomez, J. M.; Terol, J.; Williams, T. D.; Nagaraj, S. H.; Nueda, M. J.; Robles, M.; Talon, M.; Dopazo, J.; Conesa, A. High-throughput functional annotation and data mining with the Blast2GO suite Nucleic Acids Res. 2008, 36, 3420-35 (Pubitemid 351859009)
53. Conesa, A.; Gotz, S.; Garcia-Gomez, J. M.; Terol, J.; Talon, M.; Robles, M. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research Bioinformatics 2005, 21, 3674-6 (Pubitemid 41264107)
54. Kanehisa, M.; Goto, S. KEGG: kyoto encyclopedia of genes and genomes Nucleic Acids Res. 2000, 28, 27-30 (Pubitemid 30047706)
55. Niessen, S.; Mcleod, I.; Yates, J. R., III Silver staining, digestion, and extraction of peptides from an acrylamide gel for MS analysis Cold Spring Harb. Protoc. 2006, 10.1101/pdb.prot4661
56. Gatlin, C. L.; Kleemann, G. R.; Hays, L. G.; Link, A. J.; Yates, J. R., 3rd Protein identification at the low femtomole level from silver-stained gels using a new fritless electrospray interface for liquid chromatography-microspray and nanospray mass spectrometry Anal. Biochem. 1998, 263, 93-101 (Pubitemid 28445431)
57. Oliveira, M. C.; Hirata, I. Y.; Chagas, J. R.; Boschcov, P.; Gomes, R. A.; Figueiredo, A. F.; Juliano, L. Intramolecularly quenched fluorogenic peptide substrates for human renin Anal. Biochem. 1992, 203, 39-46
58. Barbosa, M. S.; Bao, S. N.; Andreotti, P. F.; de Faria, F. P.; Felipe, M. S.; dos Santos Feitosa, L.; Mendes-Giannini, M. J.; Soares, C. M. Glyceraldehyde-3-phosphate dehydrogenase of Paracoccidioides brasiliensis is a cell surface protein involved in fungal adhesion to extracellular matrix proteins and interaction with cells Infect. Immun. 2006, 74, 382-9 (Pubitemid 43023094)
59. Ogur, M., St.; John, R.; Nagai, S. Tetrazolium overlay technique for population studies of respiration deficiency in yeast Science 1957, 125 (3254) 928-9
60. Ashburner, M.; Ball, C. A.; Blake, J. A.; Botstein, D.; Butler, H.; Cherry, J. M.; Davis, A. P.; Dolinski, K.; Dwight, S. S.; Eppig, J. T.; Harris, M. A.; Hill, D. P.; Issel-Tarver, L.; Kasarskis, A.; Lewis, S.; Matese, J. C.; Richardson, J. E.; Ringwald, M.; Rubin, G. M.; Sherlock, G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium Nat. Genet. 2000, 25 (1) 25-9 (Pubitemid 30257031)
61. Maeng, S.; Ko, Y. J.; Kim, G. B.; Jung, K. W.; Floyd, A.; Heitman, J.; Bahn, Y. S. Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans Eukaryot. Cell 2010, 9 (3) 360-78
62. Jobbins, S. E.; Hill, C. J.; D'Souza-Basseal, J. M.; Padula, M. P.; Herbert, B. R.; Krockenberger, M. B. Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by Cryptococcus gattii J. Proteome Res. 2010, 9 (8) 3832-41
63. Hwang, N. R.; Yim, S. H.; Kim, Y. M.; Jeong, J.; Song, E. J.; Lee, Y.; Lee, J. H.; Choi, S.; Lee, K. J. Oxidative modifications of glyceraldehyde-3- phosphate dehydrogenase play a key role in its multiple cellular functions Biochem. J. 2009, 423, 253-64
64. Broetto, L.; Da Silva, W. O.; Bailao, A. M.; De Almeida Soares, C.; Vainstein, M. H.; Schrank, A. Glyceraldehyde-3-phosphate dehydrogenase of the entomopathogenic fungus Metarhizium anisopliae: cell-surface localization and role in host adhesion FEMS Microbiol. Lett. 2010, 312 (2) 101-9
65. Dill, B. D.; Dessus-Babus, S.; Raulston, J. E. Identification of iron-responsive proteins expressed by Chlamydia trachomatis reticulate bodies during intracellular growth Microbiology 2009, 155, 210-9
66. Latifi, A.; Jeanjean, R.; Lemeille, S.; Havaux, M.; Zhang, C. C. Iron starvation leads to oxidative stress in Anabaena sp. strain PCC 7120 J. Bacteriol. 2005, 187 (18) 6596-8 (Pubitemid 41318423)
67. Zaragoza, O.; Fries, B. C.; Casadevall, A. Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO(2) Infect. Immun. 2003, 71 (11) 6155-64 (Pubitemid 37337669)
68. Moyrand, F.; Janbon, G. UGD1, encoding the Cryptococcus neoformans UDP-glucose dehydrogenase, is essential for growth at 37 degrees C and for capsule biosynthesis Eukaryot. Cell 2004, 3 (6) 1601-8 (Pubitemid 40025117)
69. D'Souza, C. A.; Alspaugh, J. A.; Yue, C.; Harashima, T.; Cox, G. M.; Perfect, J. R.; Heitman, J. Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans Mol. Cell. Biol. 2001, 21 (9) 3179-91 (Pubitemid 32298384)
70. Shoshan-Barmatz, V.; De Pinto, V.; Zweckstetter, M.; Raviv, Z.; Keinan, N.; Arbel, N. VDAC, a multi-functional mitochondrial protein regulating cell life and death Mol. Aspects Med. 2010, 31, 227-85
71. Jung, W. H.; Hu, G.; Kuo, W.; Kronstad, J. W. Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans Eukaryot. Cell 2009, 8 (10) 1511-20
72. Nyhus, K. J.; Wilborn, A. T.; Jacobson, E. S. Ferric iron reduction by Cryptococcus neoformans Infect. Immun. 1997, 65 (2) 434-8 (Pubitemid 27053205)
73. Jacobson, E. S.; Hong, J. D. Redox buffering by melanin and Fe(II) in Cryptococcus neoformans J. Bacteriol. 1997, 179 (17) 5340-6 (Pubitemid 27387601)
74. Leung, K.; Dacks, J.; Field, M. Evolution of the Multivesicular Body ESCRT Machinery; Retention across the Eukaryotic lineage Traffic 2008, 9, 1-18
75. Blatch, G.; Lässle, M. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions Bioessays 1999, 21, 932-9 (Pubitemid 29530602)
76. Lim, H.; Eng, J.; Yates, J. R., 3rd; Tollaksen, S. L.; Giometti, C. S.; Holden, J. F.; Adams, M. W.; Reich, C. I.; Olsen, G. J.; Hays, L. G. Identification of 2D-gel proteins: a comparison of MALDI/TOF peptide mass mapping to mu LC-ESI tandem mass spectrometry J. Am. Soc. Mass Spectrom. 2003, 14, 957-70 (Pubitemid 37040757)
77. Ambatipudi, K.; Old, J.; Guilhaus, M.; Raftery, M.; Hinds, L.; Deane, E. Proteomic analysis of the neutrophil proteins of the tammar wallaby (Macropus eugenii) Comp. Biochem. Physiol., Part D: Genomics Proteomics 2006, 1, 283-91 (Pubitemid 44437816)
78. Berkow, R. L.; Dodson, R. W. Tyrosine-specific protein phosphorylation during activation of human neutrophils Blood 1990, 75 (12) 2445-52 (Pubitemid 20202326)
79. Yates, J. R., 3rd Mass spectral analysis in proteomics Annu. Rev. Biophys. Biomol. Struct. 2004, 33, 297-316
80. Sutak, R.; Lesuisse, E.; Tachezy, J.; Richardson, D. R. Crusade for iron: iron uptake in unicellular eukaryotes and its significance for virulence Trends Microbiol. 2008, 16 (6) 261-8
81. Weinberg, E. D. Suppression of bacterial biofilm formation by iron limitation Med. Hypotheses 2004, 63 (5) 863-5 (Pubitemid 39370008)
82. Pieper, R.; Huang, S. T.; Parmar, P. P.; Clark, D. J.; Alami, H.; Fleischmann, R. D.; Perry, R. D.; Peterson, S. N. Proteomic analysis of iron acquisition, metabolic and regulatory responses of Yersinia pestis to iron starvation BMC Microbiol. 2010, 10, 30
83. Vidakovics, M. L.; Paba, J.; Lamberti, Y.; Ricart, C. A.; de Sousa, M. V.; Rodriguez, M. E. Profiling the Bordetella pertussis proteome during iron starvation J. Proteome Res. 2007, 6 (7) 2518-28 (Pubitemid 47122349)
84. Knight, S. A.; Vilaire, G.; Lesuisse, E.; Dancis, A. Iron acquisition from transferrin by Candida albicans depends on the reductive pathway Infect. Immun. 2005, 73 (9) 5482-92 (Pubitemid 41192982)
85. Cherayil, B. J. The role of iron in the immune response to bacterial infection Immunol. Res. 2011, 50 (1) 1-9
86. Ramanan, N.; Wang, Y. A high-affinity iron permease essential for Candida albicans virulence Science 2000, 288 (5468) 1062-4 (Pubitemid 30324240)
87. Ratledge, C. Iron metabolism and infection Food Nutr. Bull. 2007, 28 (4 Suppl) S515-23
88. Shakoury-Elizeh, M.; Protchenko, O.; Berger, A.; Cox, J.; Gable, K.; Dunn, T. M.; Prinz, W. A.; Bard, M.; Philpott, C. C. Metabolic response to iron deficiency in Saccharomyces cerevisiae J. Biol. Chem. 2010, 285 (19) 14823-33
89. Ozer, A.; Bruick, R. K. Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat. Chem. Biol. 2007, 3, 144-53
90. Philpott, C. C.; Protchenko, O. Response to iron deprivation in Saccharomyces cerevisiae Eukaryot. Cell 2008, 7 (1) 20-7 (Pubitemid 351959590)
91. Puig, S.; Vergara, S. V.; Thiele, D. J. Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency Cell Metab. 2008, 7, 555-64 (Pubitemid 351729206)
92. Masse, E.; Salvail, H.; Desnoyers, G.; Arguin, M. Small RNAs controlling iron metabolism Curr. Opin. Microbiol. 2007, 10, 140-5 (Pubitemid 46590053)
93. Eigenheer, R. A.; Jin Lee, Y.; Blumwald, E.; Phinney, B. S.; Gelli, A. Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans FEMS Yeast Res. 2007, 7 (4) 499-510 (Pubitemid 46788671)
94. Rodrigues, M. L.; dos Reis, F. C.; Puccia, R.; Travassos, L. R.; Alviano, C. S. Cleavage of human fibronectin and other basement membrane-associated proteins by a Cryptococcus neoformans serine proteinase Microb. Pathog. 2003, 34 (2) 65-71 (Pubitemid 36293486)
95. Yoo, Ji, J.; Lee, Y. S.; Song, C. Y.; Kim, B. S. Purification and characterization of a 43-kilodalton extracellular serine proteinase from Cryptococcus neoformans J. Clin. Microbiol. 2004, 42 (2) 722-6 (Pubitemid 38222653)
96. Radtke, A.; O'Riordan, M. Intracellular innate resistance to bacterial pathoens Cell Microbiol. 2006, 8, 1720-9 (Pubitemid 44530665)
97. Ratledge, C.; Dover, L. G. Iron metabolism in pathogenic bacteria Annu. Rev. Microbiol. 2000, 54, 881-941
98. Pukkila-Worley, R.; Gerrald, Q. D.; Kraus, P. R.; Boily, M. J.; Davis, M. J.; Giles, S. S.; Cox, G. M.; Heitman, J.; Alspaugh, J. A. Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade Eukaryot. Cell 2005, 4 (1) 190-201 (Pubitemid 40234436)
99. Alspaugh, J. A.; Pukkila-Worley, R.; Harashima, T.; Cavallo, L. M.; Funnell, D.; Cox, G. M.; Perfect, J. R.; Kronstad, J. W.; Heitman, J. Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans Eukaryot. Cell 2002, 1 (1) 75-84 (Pubitemid 36562350)
100. Kline, K. G.; Wu, C. C. MudPIT analysis: application to human heart tissue Methods Mol. Biol. 2009, 528, 281-93
101. Gygi, S. P.; Corthals, G. L.; Zhang, Y.; Rochon, Y.; Aebersold, R. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (17) 9390-5 (Pubitemid 30650785)