Modeling neurological disorders by human induced pluripotent stem cells

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Kunkanjanawan, Tanut ^a   Noisa, Parinya ^a   Parnpai, Rangsun ^a  

^a SURANAREE UNIVERSITY OF TECHNOLOGY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN; I KAPPA B KINASE; OCTAMER TRANSCRIPTION FACTOR 4; STAGE SPECIFIC EMBRYO ANTIGEN 3; STAGE SPECIFIC EMBRYO ANTIGEN 4; TRANSCRIPTION FACTOR NANOG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN DEVELOPMENT; CELL LINEAGE; DEGENERATIVE DISEASE; DOWN SYNDROME; DYSAUTONOMIA; EMBRYONIC STEM CELL; FRAGILE X SYNDROME; FRIEDREICH ATAXIA; GENE EXPRESSION; HAPPY PUPPET SYNDROME; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL DIFFERENTIATION; NEUROLOGIC DISEASE; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRADER WILLI SYNDROME; PROTEIN EXPRESSION; RETT SYNDROME; REVIEW; SPINAL MUSCULAR ATROPHY; BIOLOGICAL MODEL; BRAIN; CELL DIFFERENTIATION; CYTOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT;

BRAIN; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, NEUROLOGICAL; NERVOUS SYSTEM DISEASES;

EID: 84855546273     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/350131     Document Type: Review

References (102)

1. Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., LaFerla F. M., Triple-transgenic model of Alzheimer's Disease with plaques and tangles: intracellular A and synaptic dysfunction Neuron 2003 39 3 409 421 (Pubitemid 36937044)
2. Olson L. E., Roper R. J., Baxter L. L., Carlson E. J., Epstein C. J., Reeves R. H., Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes Developmental Dynamics 2004 230 3 581 589 (Pubitemid 38802484)
3. Kwon M. S., Seo Y. J., Lee J. K., Lee H. K., Jung J. S., Jang J. E., Park S. H., Suh H. W., The repeated immobilization stress increases IL-1 immunoreactivities in only neuron, but not astrocyte or microglia in hippocampal CA1 region, striatum and paraventricular nucleus Neuroscience Letters 2008 430 3 258 263
4. Thomson J. A., Embryonic stem cell lines derived from human blastocysts Science 1998 282 5391 1145 1147 (Pubitemid 28516247)
5. Schuldiner M., Yanuka O., Itskovitz-Eldor J., Melton D. A., Benvenisty N., Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America 2000 97 21 11307 11312
6. Menendez P., Wang L., Bhatia M., Genetic manipulation of human embryonic stem cells: a system to study early human development and potential therapeutic applications Current Gene Therapy 2005 5 4 375 385 (Pubitemid 41052429)
7. Ben-Nun I. F., Benvenisty N., Human embryonic stem cells as a cellular model for human disorders Molecular and Cellular Endocrinology 2006 252 1-2 154 159
8. Campbell K. H. S., Fisher P., Chen W. C., Choi I., Kelly R. D. W., Lee J. H., Xhu J., Somatic cell nuclear transfer: past, present and future perspectives Theriogenology 2007 68 1 S214 S231
9. Ben-Yosef D., Malcov M., Eiges R., PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders Molecular and Cellular Endocrinology 2008 282 1-2 153 158
10. Lee G. S., Kim H. S., Hyun S. H., Kim D. Y., Lee S. H., Nam D. H., Jeong Y. W., Kim S., Kang S. K., Lee B. C., Hwang W. S., Improved developmental competence of cloned porcine embryos with different energy supplements and chemical activation Molecular Reproduction and Development 2003 66 1 17 23 (Pubitemid 36927782)
11. Einsiedel E., Premji S., Geransar R., Orton N. C., Thavaratnam T., Bennett L. K., Diversity in public views toward stem cell sources and policies Stem Cell Reviews and Reports 2009 5 2 102 107
12. French A. J., Wood S. H., Trounson A. O., Human therapeutic cloning (NTSC) Stem Cell Reviews 2006 2 4 265 276
13. Reiss M. J., Ethical dimensions of therapeutic human cloning Journal of Biotechnology 2002 98 1 61 70 (Pubitemid 34786234)
14. Takahashi K., Yamanaka S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 2006 126 4 663 676 (Pubitemid 44233629)
15. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 2007 131 5 861 872 (Pubitemid 350138099)
16. Takahashi K., Okita K., Nakagawa M., Yamanaka S., Induction of pluripotent stem cells from fibroblast cultures Nature Protocols 2007 2 12 3081 3089
17. Griffiths I., Klugmann M., Anderson T., Yool D., Thomson C., Schwab M. H., Schneider A., Zimmermann F., McCulloch M., Nadon N., Nave K. A., Axonal swellings and degeneration in mice lacking the major proteolipid of myelin Science 1998 280 5369 1610 1613 (Pubitemid 28278256)
18. Hoffman L. M., Carpenter M. K., Characterization and culture of human embryonic stem cells Nature Biotechnology 2005 23 6 699 708 (Pubitemid 41716360)
19. Henderson J. K., Draper J. S., Baillie H. S., Fishel S., Thomson J. A., Moore H., Andrews P. W., Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens Stem Cells 2002 20 4 329 337 (Pubitemid 34765092)
20. Hay D. C., Sutherland L., Clark J., Burdon T., Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells Stem Cells 2004 22 2 225 235 (Pubitemid 38282637)
21. Darr H., Mayshar Y., Benvenisty N., Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features Development 2006 133 6 1193 1201
22. Fong H., Hohenstein K. A., Donovan P. J., Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells Stem Cells 2008 26 8 1931 1938
23. Kopper O., Giladi O., Golan-Lev T., Benvenisty N., Characterization of gastrulation-stage progenitor cells and their inhibitory crosstalk in human embryoid bodies Stem Cells 2010 28 1 75 83
24. Tzukerman M., Rosenberg T., Ravel Y., Reiter I., Coleman R., Skorecki K., An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America 2003 100 23 13507 13512 (Pubitemid 37444772)
25. Lensch M. W., Schlaeger T. M., Zon L. I., Daley G. Q., Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera Cell Stem Cell 2007 1 3 253 258 (Pubitemid 47355327)
26. Kim J. B., Zaehres H., Wu G., Gentile L., Ko K., Sebastiano V., Arazo-Bravo M. J., Ruau D., Han D. W., Zenke M., Schler H. R., Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors Nature 2008 454 7204 646 650
27. Gupta D. M., Panetta N. J., Sun N., Rapid and efficient feeder-free generation of human adipose stromal cell-derived induced pluripotent stem cells (hASC-iPSCs) Journal of the American College of Surgeons 2009 209 3, supplement 1 S87 S87
28. Giorgetti A., Montserrat N., Aasen T., Gonzalez F., Rodrguez-Piz I., Vassena R., Raya A., Boué S., Barrero M. J., Corbella B. A., Torrabadella M., Veiga A., Belmonte J. C. I., Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2 Cell Stem Cell 2009 5 4 353 357
29. Brown M. E., Rondon E., Rajesh D., Mack A., Lewis R., Feng X., Zitur L. J., Learish R. D., Nuwaysir E. F., Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes PLoS One 2010 5 6
30. Seki T., Yuasa S., Oda M., Egashira T., Yae K., Kusumoto D., Nakata H., Tohyama S., Hashimoto H., Kodaira M., Okada Y., Seimiya H., Fusaki N., Hasegawa M., Fukuda K., Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells Cell Stem Cell 2010 7 1 11 14
31. Marchetto M. C. N., Carromeu C., Acab A., Yu D., Yeo G. W., Mu Y., Chen G., Gage F. H., Muotri A. R., A model for neural development and treatment of rett syndrome using human induced pluripotent stem cells Cell 2010 143 4 527 539
32. Kim K., Doi A., Wen B., Ng K., Zhao R., Cahan P., Kim J., Aryee M. J., Ji H., Ehrlich L. I. R., Yabuuchi A., Takeuchi A., Cunniff K. C., Hongguang H., McKinney-Freeman S., Naveiras O., Yoon T. J., Irizarry R. A., Jung N., Seita J., Hanna J., Murakami P., Jaenisch R., Weissleder R., Orkin S. H., Weissman I. L., Feinberg A. P., Daley G. Q., Epigenetic memory in induced pluripotent stem cells Nature 2010 467 7313 285 290
33. Mattis V. B., Svendsen C. N., Induced pluripotent stem cells: a new revolution for clinical neurology? The Lancet Neurology 2011 10 4 383 394
34. Ebert A. D., Yu J., Rose F. F., Mattis V. B., Lorson C. L., Thomson J. A., Svendsen C. N., Induced pluripotent stem cells from a spinal muscular atrophy patient Nature 2009 457 7227 277 280
35. Nguyen H. A., Byers B., Cord B., LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress Cell Stem Cell 2011 8 3 267 280
36. Soldner F., Hockemeyer D., Beard C., Gao Q., Bell G. W., Cook E. G., Hargus G., Blak A., Cooper O., Mitalipova M., Isacson O., Jaenisch R., Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors Cell 2009 136 5 964 977
37. Zhang N., An M. C., Montoro D., Ellerby L. M., Characterization of human Huntington's disease cell model from induced pluripotent stem cells PLoS Currents 2010 2 RRN1193
38. Dimos J. T., Rodolfa K. T., Niakan K. K., Weisenthal L. M., Mitsumoto H., Chung W., Croft G. F., Saphier G., Leibel R., Goland R., Wichterle H., Henderson C. E., Eggan K., Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons Science 2008 321 5893 1218 1221
39. Hagerman R. J., McBogg P., Hagerman P. J., The fragile X syndrome: history, diagnosis, and treatment Journal of Developmental and Behavioral Pediatrics 1983 4 2 122 130 (Pubitemid 13046024)
40. Crawford D. C., Acua J. M., Sherman S. L., FMR1 and the fragile X syndrome: human genome epidemiology review Genetics in Medicine 2001 3 5 359 371
41. Pearson C. E., Edamura K. N., Cleary J. D., Repeat instability: mechanisms of dynamic mutations Nature Reviews Genetics 2005 6 10 729 742 (Pubitemid 41400831)
42. Irwin S. A., Idupulapati M., Gilbert M. E., Harris J. B., Chakravarti A. B., Rogers E. J., Crisostomo R. A., Larsen B. P., Mehta A., Alcantara C. J., Patel B., Swain R. A., Weiler I. J., Oostra B. A., Greenough W. T., Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice The American Journal of Medical Genetics 2002 111 2 140 146 (Pubitemid 34809494)
43. Irwin S. A., Patel B., Idupulapati M., Harris J. B., Crisostomo R. A., Larsen B. P., Kooy F., Willems P. J., Cras P., Kozlowski P. B., Swain R. A., Weiler I. J., Greenough W. T., Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination The American Journal of Medical Genetics 2001 98 2 161 167 (Pubitemid 32051804)
44. Urbach A., Bar-Nur O., Daley G. Q., Benvenisty N., Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells Cell Stem Cell 2010 6 5 407 411
45. Chamberlain S. J., Lalande M., Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11-q13 Neurobiology of Disease 2010 39 1 13 20
46. Buiting K., Prader-Willi syndrome and Angelman syndrome The American Journal of Medical Genetics, Part C 2010 154 3 365 376
47. Runte M., Httenhofer A., Gro S., Kiefmann M., Horsthemke B., Buiting K., The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A Human Molecular Genetics 2001 10 23 2687 2700 (Pubitemid 33133410)
48. Yang J., Cai J., Zhang Y., Wang X., Li W., Xu J., Li F., Guo X., Deng K., Zhong M., Chen Y., Lai L., Pei D., Esteban M. A., Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome Journal of Biological Chemistry 2010 285 51 40303 40311
49. Tamminga C. A., Diseases of the mind and brain The American Journal of Psychiatry 2002 159 7 1103 (Pubitemid 34743248)
50. Azmitia E. C., Neuronal instability: implications for Rett's syndrome Brain and Development 2001 23 1 S1 S10
51. Blumenfeld A., Slaugenhaupt S. A., Axelrod F. B., Lucente D. E., Maayan C., Liebert C. B., Ozelius L. J., Trofatter J. A., Haines J. L., Breakefield X. O., Gusella J. F., Localization of the gene for familial dysautonomia on chromosome 9 and definition of DNA markers for genetic diagnosis Nature Genetics 1993 4 2 160 164 (Pubitemid 23179100)
52. Slaugenhaupt S. A., Blumenfeld A., Gill S. P., Leyne M., Mull J., Cuajungco M. P., Liebert C. B., Chadwick B., Idelson M., Reznik L., Robbins C. M., Makalowska I., Brownstein M. J., Krappmann D., Scheidereit C., Maayan C., Axelrod F. B., Gusella J. F., Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia The American Journal of Human Genetics 2001 68 3 598 605 (Pubitemid 32202755)
53. Close P., Hawkes N., Cornez I., Creppe C., Lambert C. A., Rogister B., Siebenlist U., Merville M. P., Slaugenhaupt S. A., Bours V., Svejstrup J. Q., Chariot A., Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia Molecular Cell 2006 22 4 521 531 (Pubitemid 44255542)
54. Lee G., Papapetrou E. P., Kim H., Chambers S. M., Tomishima M. J., Fasano C. A., Ganat Y. M., Menon J., Shimizu F., Viale A., Tabar V., Sadelain M., Studer L., Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs Nature 2009 461 7262 402 406
55. Anderson S. L., Qiu J., Rubin B. Y., Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia Biochemical and Biophysical Research Communications 2003 306 1 303 309 (Pubitemid 36629442)
56. Simson G. G. V., Goldberg J. D., Rolnitzky L. M., Mull J., Leyne M., Voustianiouk A., Slaugenhaupt S. A., Axelrod F. B., Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing Pediatric Research 2009 65 3 341 346
57. Drr A., Cossee M., Agid Y., Campuzano V., Mignard C., Penet C., Mandel J. L., Brice A., Koenig M., Clinical and genetic abnormalities in patients with Friedreich's ataxia The New England Journal of Medicine 1996 335 16 1169 1175 (Pubitemid 26339770)
58. Voncken M., Ioannou P., Delatycki M. B., Friedreich ataxiaupdate on pathogenesis and possible therapies Neurogenetics 2004 5 1 1 8 (Pubitemid 38297467)
59. Al-Mahdawi S., Pinto R. M., Ruddle P., Carroll C., Webster Z., Pook M., GAA repeat instability in Friedreich ataxia YAC transgenic mice Genomics 2004 84 2 301 310 (Pubitemid 38834168)
60. Al-Mahdawi S., Pinto R. M., Varshney D., Lawrence L., Lowrie M. B., Hughes S., Webster Z., Blake J., Cooper J. M., King R., Pook M. A., GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology Genomics 2006 88 5 580 590 (Pubitemid 44540244)
61. Ku S., Soragni E., Campau E., Thomas E. A., Altun G., Laurent L. C., Loring J. F., Napierala M., Gottesfeld J. M., Friedreich's ataxia induced pluripotent stem cells model intergenerational GAATTC triplet repeat instability Cell Stem Cell 2010 7 5 631 637
62. Mabb A. M., Judson M. C., Zylka M. J., Philpot B. D., Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes Trends in Neurosciences 2011 34 6 293 303
63. Williams C. A., The behavioral phenotype of the Angelman syndrome The American Journal of Medical Genetics, Part C 2010 154 4 432 437
64. Jiang Y. H., Tsai T. F., Bressler J., Beaudet A. L., Imprinting in angelman and Prader-Willi syndromes Current Opinion in Genetics and Development 1998 8 3 334 342 (Pubitemid 28340086)
65. Chamberlain S. J., Chen P. F., Ng K. Y., Bourgois-Rocha F., Lemtiri-Chlieh F., Levine E. S., Lalande M., Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes Proceedings of the National Academy of Sciences of the United States of America 2010 107 41 17668 17673
66. Rougeulle C., Glatt H., Lalande M., The Angelman syndrome candidate gene, UBE3A/E6-AP, is imprinted in brain Nature Genetics 1997 17 1 14 15
67. Rougeulle C., Cardoso C., Fontés M., Colleaux L., Lalande M., An imprinted antisense RNA overlaps UBE3A and a second maternally expressed transcript Nature Genetics 1998 19 1 15 16
68. Hussey S., Yates C. M., Christie J. E., Elton R. A., Gordon A., Alzheimer-type dementia and Down's syndrome: solubility of neurofibrillary tangles is related to duration of dementia Journal of Neurology Neurosurgery and Psychiatry 1987 50 6 823 824
69. Park I. H., Arora N., Huo H., Maherali N., Ahfeldt T., Shimamura A., Lensch M. W., Cowan C., Hochedlinger K., Daley G. Q., Disease-specific induced pluripotent stem cells Cell 2008 134 5 877 886
70. Ebert A. D., Svendsen C. N., Stem cell model of spinal muscular atrophy Archives of Neurology 2010 67 6 665 669
71. Lorson C. L., Rindt H., Shababi M., Spinal muscular atrophy: mechanisms and therapeutic strategies Human Molecular Genetics 2010 19 1 R111 R118
72. Feldktter M., Schwarzer V., Wirth R., Wienker T. F., Wirth B., Quantitative analyses of SMN1 and SMN2 based on real-time lightcycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy The American Journal of Human Genetics 2002 70 2 358 368 (Pubitemid 34112291)
73. Kato S., Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences Acta Neuropathologica 2008 115 1 97 114 (Pubitemid 50003823)
74. Gros-Louis F., Gaspar C., Rouleau G. A., Genetics of familial and sporadic amyotrophic lateral sclerosis Biochimica et Biophysica Acta 2006 1762 11-12 956 972 (Pubitemid 44781174)
75. Rosen D. R., Siddique T., Patterson D., Figlewicz D. A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J. P., Deng H. X., Rahmani Z., Krizus A., McKenna-Yasek D., Cayabyab A., Gaston S. M., Berger R., Tanzi R. E., Halperin J. J., Herzfeldt B., Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 1993 362 6415 59 62 (Pubitemid 23087289)
76. Cattaneo E., Rigamonti D., Goffredo D., Zuccato C., Squitieri F., Sipione S., Loss of normal huntingtin function: new developments in Huntington's disease research Trends in Neurosciences 2001 24 3 182 188 (Pubitemid 32166824)
77. Ross C. A., Margolis R. L., Huntington's disease Clinical Neuroscience Research 2001 1 1-2 142 152 (Pubitemid 33713792)
78. Laowtammathron C., Cheng E. C. H., Cheng P. H., Snyder B. R., Yang S. H., Johnson Z., Lorthongpanich C., Kuo H. C., Parnpai R., Chan A. W. S., Monkey hybrid stem cells develop cellular features of Huntington's disease BMC Cell Biology 2010 11, article 12
79. Shulman J. M., De Jager P. L., Feany M. B., Parkinson's disease: genetics and pathogenesis Annual Review of Pathology 2011 6 1 193 222
80. Lee F. J. S., Liu F., Genetic factors involved in the pathogenesis of Parkinson's disease Brain Research Reviews 2008 58 2 354 364
81. Caviness J. N., Lue L., Adler C. H., Walker D. G., Parkinson's disease dementia and potential therapeutic strategies CNS Neuroscience Therapeutics 2011 17 1 32 44
82. Turkington C., Mitchell D., The Encyclopedia of Alzheimaer's Disease 2010 2nd New York, NY, USA Infobase Publishing
83. Gonzalo-Ruiz A., Sanz J. M., Arévalo J., Geula C., Gonzalo P., Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age Journal of Chemical Neuroanatomy 2005 29 1 31 48 (Pubitemid 39602786)
84. Hardy J., Selkoe D. J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science of Aging Knowledge Environment 2002 297 5580 353 356 (Pubitemid 34790756)
85. Kar S., Quirion R., Laurent Descarries K. K., Mircea S., Amyloid [beta] peptides and central cholinergic neurons: functional interrelationship and relevance to Alzheimer's disease pathology Brain Research 2004 New York, NY, USA Elsevier 261 274 (Pubitemid 37442949)
86. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T. D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S., Secreted amyloid -protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease Nature Medicine 1996 2 8 864 870 (Pubitemid 26296755)
87. Yagi T., Ito D., Okada Y., Modeling familial Alzheimer's disease with induced pluripotent stem cells Human Molecular Genetics 2011 20 23 4530 4539
88. Saha K., Jaenisch R., Technical challenges in using human induced pluripotent stem cells to model disease Cell Stem Cell 2009 5 6 584 595
89. Ellis J., Bhatia M., iPSC technology: platform for drug discovery Clinical Pharmacology Therapeutics 2011 89 5 639 641
90. Junying Y., Kejin H., Kim S. O., Shulan T., Stewart R., Slukvin I. I., Thomson J. A., Human induced pluripotent stem cells free of vector and transgene sequences Science 2009 324 5928 797 801
91. Chou B.-K., Mali P., Huang X., Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures Cell Research 2011 21 3 518 529
92. Warren L., Manos P. D., Ahfeldt T., Loh Y. H., Li H., Lau F., Ebina W., Mandal P. K., Smith Z. D., Meissner A., Daley G. Q., Brack A. S., Collins J. J., Cowan C., Schlaeger T. M., Rossi D. J., Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 2010 7 5 618 630
93. Kim D., Kim C. H., Moon J. I., Chung Y. G., Chang M. Y., Han B. S., Ko S., Yang E., Cha K. Y., Lanza R., Kim K. S., Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins Cell Stem Cell 2009 4 6 472 476
94. Zhou H., Wu S., Joo J. Y., Zhu S., Han D. W., Lin T., Trauger S., Bien G., Yao S., Zhu Y., Siuzdak G., Schler H. R., Duan L., Ding S., Generation of induced pluripotent stem cells using recombinant proteins Cell Stem Cell 2009 4 5 381 384
95. Anokye-Danso F., Trivedi C. M., Juhr D., Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency Cell Stem Cell 2011 8 4 376 388
96. Yang C.-S., Li Z., Rana T. M., microRNAs modulate iPS cell generation RNA 2011 17 8 1451 1460
97. Behringer R. R., Human-animal chimeras in biomedical research Cell Stem Cell 2007 1 3 259 262 (Pubitemid 47355328)
98. Shultz L. D., Ishikawa F., Greiner D. L., Humanized mice in translational biomedical research Nature Reviews Immunology 2007 7 2 118 130 (Pubitemid 46174859)
99. Bergmans B. A., Shariati S. A. M., Habets R. L. P., Verstreken P., Schoonjans L., Mller U., Dotti C. G., De Strooper B., Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation Stem Cells 2010 28 3 399 406
100. Colman A., Dreesen O., Induced pluripotent stem cells and the stability of the differentiated state EMBO Reports 2009 10 7 714 721
101. Kim S. Y., Kim M.-J., Jung H., Comparative proteomic analysis of human somatic cells, induced pluripotent stem cells, and embryonic stem cells. Stem Cells and Development. In press
102. Wu S. M., Hochedlinger K., Harnessing the potential of induced pluripotent stem cells for regenerative medicine Nature Cell Biology 2011 13 5 497 505