Hypothesis: Is infantile autism a hypoglutamatergic disorder? Relevance of glutamate-serotonin interactions for pharmacotherapy

Journal of Neural Transmission

Volumn 105, Issue 4-5, 1998, Pages 525-535

  Carlsson, M L ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Box 431 ^*  (Sweden)

Author keywords

Autism; Glutamate; Ketamine; PCP; Perception; Serotonin

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SEROTONIN; SEROTONIN 2A RECEPTOR;

ARTICLE; BRAIN CORTEX; DEPERSONALIZATION; HABITUATION; HUMAN; IMAGING; INFANTILE AUTISM; MOOD; NEUROANATOMY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; VISION;

AUTISTIC DISORDER; BRAIN; CHILD; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; MODELS, NEUROLOGICAL; NEURONS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS;

EID: 0031880046     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050076     Document Type: Article

References (72)

1. Anderson GM, Hoshino Y (1997) Neurochemical studies of autism. In: Cohen DJ, Volkmar FR (eds) Handbook of autism and pervasive developmental disorders, 2nd ed. John Wiley, New York, pp 325-343
2. Baker RW, Bermanzohn PC, Wirshing DA, Chengappa KNR (1997) Obsessions, compulsions, clozapine, and risperidone. CNS Spectrums 2: 26-36
3. Baron-Cohen S, Swettenham J (1997) Theory of mind in autism: its relationship to executive function and central coherence. In: Cohen DJ, Volkmar FR (eds) Handbook of autism and pervasive developmental disorders. 2nd ed. John Wiley, New York, pp 880-893
4. Barry RJ, James AL (1988) Coding of stimulus parameters in autistic, retarded, and normal children: evidence for a two-factor theory of autism. Int J Psychophysiol 6: 139-149
5. Bauman ML (1991) Microscopic neuroanatomic abnormalities in autism. Pediatrics 87: 791-796
6. Bauman MT, Kemper TL (1985) Histoanatomic observations of the brain in early infantile autism. Neurology 35: 866-874
7. Campbell M, Anderson LT, Meier M, Cohen IL, Small AM, Samit C, Sachar EJ (1978) A comparison of haloperidol and behaviour therapy and their interaction in autistic children. J Am Acad Child Psychiat 17: 640-655
8. Carlsson M, Carlsson A (1989) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 75: 221-226
9. Carlsson M, Carlsson A (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease. Trends Neurosci 13: 272-276
10. Carlsson ML (1993) Hypothesis - Are the disparate pharmacological profiles of competitive and un-competitive NMDA antagonists due to different baseline activities of distinct glutamatergic pathways? J Neural Transm [GenSect] 94: 1-10
11. Carlsson ML (1995) The selective 5-HT2a-receptor antagonist MDL 100,907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse-implications for psychosis. J Neural Transm [Gen Sect] 100: 225-237
12. Carlsson ML, Martin P, Carlsson A (1995) Low doses of the 5-HT2a antagonist MDL100,907 counteract NMDA receptor antagonist-induced, but not d-amphetamine-induced, hyperactivity in mice. Society for Neuroscience, 25th Annual Meeting, San Diego, 21: 745
13. Carroll ME (1990) PCP and hallucinogens. Adv Alcohol Subst Abuse 9: 167-190
14. Chugani HT, Da Silva E, Chugani DC (1996) Infantile spasms. III. Prognostic implications of bitemporal hypometabolism on positron emission tomography. Ann Neurol 39: 643-649
15. Cook EH Jr, Leventhal BL (1996) The serotonin system in autism. Curr Opin Pediatr 8: 348-354
16. Cook EH Jr, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, Haas R, Courchesne E, Leventhal BL (1997) Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2: 247-250
17. Cotman CW, Monaghan DT (1987) Chemistry and anatomy of excitatory amino acid systems. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 197-210
18. Courchesne E (1991) Neuroanatomic imaging in autism. Pediatrics 87: 781-790
19. Courchesne E, Press GA, Yeung-Courchesne R (1993) Parietal lobe abnormalities detected with MR in patients with infantile autism. Am J Roentgenol 160: 387-393
20. Damasio AR, Maurer RG (1978) A neurological model for childhood autism. Arch Neurol 35: 777-786
21. DeVeaugh-Geiss J (1994) Pharmacological therapy of obsessive-compulsive disorder. Adv Pharmacol 30: 35-52
22. Ehlers S, Gillberg C (1993) The epidemiology of Asperger's syndrome. A total population study. J Child Psychol Psychiat 34: 1327-1350
23. Eveloff HH (1968) The LSD syndrome. A review. California Med 109: 368-373
24. Fisman S, Steele M, Short J, Byrne T, Lavallee C (1996) Case study: Anorexia nervosa and autistic disorder in an adoloescent girl. J Am Acad Child Adolesc Psychiatry 35: 937-940
25. Freedman DX (1968) On the use and abuse of LSD. Arch Gen Psychiatry 18: 330-347
26. Garey RE, Weisberg LA, Heath RG (1977) Phencyclidine: an overview. J Psychedelic Drugs 9: 280-285
27. Gerland G (1996) En riktig människa. Bokförlaget Cura AB, Stockholm
28. Gillberg C (1993) Autism and related behaviours. J Intellect Disabil Res 37: 343-372
29. Gillberg C, Coleman M (1992) The biology of the autistic syndromes, 2nd ed. Clinics in developmental medicine, no 126. Mac Keith Press, London
30. Grandin T (1992) An inside view of autism. In: Schopler E, Mesibov GB (eds) High-functioning individuals with autism. Plenum Press, New York, pp 105-126
31. Grandin T (1996) My experiences with visual thinking sensory problems and communication difficulties. http://www.autism.org/temple/visual.html
32. Hansen G, Jensen SB, Chandresh L, Hilden T (1988) The psychotropic effect of ketamine. J Psychoact Drugs 20: 419-425
33. Harvey RJ, Cooray SE (1995) The effective treatment of severe repetitive behaviour with fluvoxamine in a 20 year old autistic female. Int Clin Psychopharmacol 10: 201-203
34. Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Horowitz A, Kelly D (1996) Doubleblind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry 169: 610-617
35. Hoon Jr AH, Reiss AL (1992) The mesial-temporal lobe and autism: case report and review. Dev Med Child Neurol 34: 252-265
36. Huxley A (1954) The doors of perception
37. Javitt DC, Zukin SR (1991) Recent advances in the phencyclidine model of schizophrenia [see comments]. Am J Psychiatry 148: 1301-1308
38. Kanner L (1943) Autistic disturbances of affective contact. Nervous Child 2: 217-250
39. Katz MM, Waskow IE, Olsson J (1968) Characterizing the psychological state produced by LSD. J Abnorm Psychol 73: 1-14
40. Kim JS, Kornhuber HH, Brand U, Menge HG (1981) Effects of chronic amphetamine treatment on the glutamate concentration in cerebrospinal fluid and brain: implications for a theory of schizophrenia. Neurosci Lett 24: 93-96
41. Kootz JP, Cohen DJ (1981) Modulation of sensory intake in autistic children. J Am Acad Child Psychiat 20: 692-701
42. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB, Charney DS (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 51: 199-214
43. Lovaas OI, Schreibman L (1971) Stimulus overselectivity of autistic children in a two stimulus situation. Behav Res Ther 9: 305-310
44. Lovaas OI, Schreibman L, Koegel R, Rehm R (1971) Selective responding by autistic children to multiple sensory input. J Abnorm Psychol 77: 211-222
45. Lydiard RB (1994) Obsessive-compulsive disorder: a new perspective in diagnosis and treatment. Int Clin Psychopharmacol 9 [Suppl 3]: 33-37
46. Marek GJ, Aghajanian GK (1994) Excitation of interneurons in piriform cortex by 5-hydroxytryptamine (5-HT): blockade by MDL 100,907, a highly selective 5-HT2A antagonist. Eur J Pharmacol 259: 137-141
47. Martin P, Waters N, Schmidt CJ, Carlsson A, Carlsson ML (1998) Rodent data and general hypothesis: antipsychotic action exerted through 5-HT2A receptor antagonism is dependent on increased serotonergic tone. J Neural Transm (this volume)
48. Maurel Remy S, Bervoets K, Millan MJ (1995) Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors. Eur J Pharmacol 280: R9-11
49. McDonald AJ (1996) Glutamate and aspartate immunoreactive neurons of the rat basolateral amygdala: colocalization of excitatory amino acids and projections to the limbic circuit. J Comp Neurol 365: 367-379
50. McDougle CJ (1997) Psychopharmacology. In: Cohen DJ, Volkmar FR (eds) Handbook of autism and pervasive developmental disorders, 2nd ed. John Wiley, New York, pp 707-729
51. McDougle CJ, Brodkin ES, Yeung PP, Naylor ST, Cohen DJ, Price LH (1995) Risperidone in adults with autism or pervasive developmental disorder. J Child Adolesc Psychopharmacol 5: 273-282
52. McDougle CJ, Naylor ST, Cohen DJ, Volkmar FR, Heninger GR, Price LH (1996) A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry 53: 1001-1008
53. Milman DH (1967) An untoward reaction to accidental ingestion of LSD in a 5-year-old girl. JAMA 201: 143-146
54. Minshew NJ (1991) Indices of neural function in autism: clinical and biological implications. Pediatrics 87: 774-780
55. Muir KW, Lees KR (1995) Clinical experience with excitatory amino acid antagonist drugs. Stroke 26: 503-515
56. O'Brien CP (1996) Drug addiction and drug abuse. In: Goodman & Gilman's: The pharmacological basis of therapeutics, 9th ed. McGraw-Hill, New York, p 573
57. Ornitz EM (1969) Disorders of perception common to early infantile autism and schizophrenia. Compr Psychiat 10: 259-274
58. Ornitz EM, Ritvo ER (1968) Perceptual inconstancy in early infantile autism. Arch Gen Psychiatry 18: 76-98
59. Parashos AJ (1977) The psilocybin-induced "state of drunkenness" in normal volunteers and schizophrenics. Behav Neuropsychiatry 8: 83-86
60. Purdon SE, Lit W, Labelle A, Jones BDW (1994) Risperidone in the treatment of pervasive developmental disorder. Can J Psychiatry 39: 400-405
61. Rapin I (1991) Autistic children: diagnosis and clinical features. Pediatrics 87: 751-760
62. Raymond GV, Bauman ML, Kemper TL (1996) Hippocampus in autism: a Golgi analysis. Acta Neuropathol 91: 117-119
63. Sacks O (1993/1994) An anthropologist on mars. The New Yorker Dec 27-Jan 3: 106-125
64. Schäfer S (1996) Stjärnor, linser och äpplen - att leva med autism. Bokförlaget Cura AB, Stockholm
65. Vollenweider FX, Leenders KL, Scharfetter C, Maguire P, Stadelmann O, Angst J (1997a) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology 16: 357-372
66. Vollenweider FX, Leenders KL, Øye I, Hell D, Angst J (1997b) Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)-and (R)-ketamine in healthy volunteers using positron emission tomography (PET). Eur Neuropsychopharmacol 7: 25-38
67. Waterhouse L, Fein D (1997) Perspectives on social impairment. In: Cohen DJ, Volkmar FR (eds) Handbook of autism and pervasive developmental disorders, 2nd ed. John Wiley, New York, pp 901-919
68. Waters N, Lundgren C, Hansson LO, Carlsson ML (1996) Concurrent locomotor stimulation and decrease in dopamine release in rats and mice after treatment with the competitive NMDA recepetor antagonists D-CPPene and CGS 19755. J Neural Transm 103: 117-129
69. Wing L (1981) Asperger's syndrome: a clinical account. Psychol Med 11: 115-129
70. Wing L (1997) Syndromes of autism and atypical development. In: Cohen DJ, Volkmar FR (eds) Handbook of autism and pervasive developmental disorders. 2nd ed. John Wiley, New York, pp 148-170
71. Zilbovicius M, Garreau B, Samson Y, Remy P, Barthélémy C, Syrota A, Lelord G (1995) Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 152: 248-252
72. Zuddas A, Ledda MG, Fratta A, Muglia P, Cianchetti C (1996) Clinical effects of clozapine on autistic disorder. Am J Psychiatry 153: 738