IκB kinase ε (IKKε) regulates the balance between type I and type II interferon responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 52, 2011, Pages 21170-21175

  Ng, Sze Ling ^a   Friedman, Brad A ^a   Schmid, Sonja ^b   Gertz, Jason ^c   Myers, Richard M ^c   TenOever, Benjamin R ^b   Maniatis, Tom ^a,d  

^a HARVARD UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Gamma activated sequences; IFN stimulated response element; JAK STAT; STAT dimerization

Indexed keywords

GAMMA INTERFERON; I KAPPA B KINASE EPSILON; INTERFERON; INTERFERON STIMULATED GENE FACTOR 3; STAT1 PROTEIN; STAT2 PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; GENETIC TRANSCRIPTION; INFLUENZA A; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CHROMATOGRAPHY, GEL; DIMERIZATION; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; IMMUNOPRECIPITATION; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE I; INTERFERON-GAMMA; INTERFERON-STIMULATED GENE FACTOR 3; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RNA VIRUS INFECTIONS; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 84855495283     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119137109     Document Type: Article

References (42)

1. Thompson AJ, Locarnini SA (2007) Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol 85:435-445. (Pubitemid 47367510)
2. Baumgarth N, Choi YS, Rothaeusler K, Yang Y, Herzenberg LA (2008) B cell lineage contributions to antiviral host responses. Curr Top Microbiol Immunol 319:41-61.
3. Platanias LC (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 5:375-386.
4. Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ (2004) Characterization of the type I interferon locus and identification of novel genes. Genomics 84:331-345. (Pubitemid 38834171)
5. van Pesch V, Lanaya H, Renauld JC, Michiels T (2004) Characterization of the murine alpha interferon gene family. J Virol 78:8219-8228. (Pubitemid 38944305)
6. de Veer MJ, et al. (2001) Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 69:912-920.
7. Der SD, Zhou A, Williams BR, Silverman RH (1998) Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 95:15623-15628.
8. Darnell JE, Jr., Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421. (Pubitemid 24217131)
9. Greenlund AC, Farrar MA, Viviano BL, Schreiber RD (1994) Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J 13:1591-1600.
10. Krishnan K, Singh B, Krolewski JJ (1998) Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor. J Biol Chem 273:19495-19501. (Pubitemid 28367000)
11. Nguyen VP, et al. (2002) Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. J Biol Chem 277:9713-9721.
12. Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J 15:1064-1074.
13. Schindler C, Shuai K, Prezioso VR, Darnell JE, Jr. (1992) Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257:809-813.
14. Shuai K, et al. (1994) Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821-828. (Pubitemid 24085320)
15. Fu XY, Kessler DS, Veals SA, Levy DE, Darnell JE, Jr. (1990) ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci USA 87:8555-8559.
16. Levy DE, Kessler DS, Pine R, Darnell JE, Jr. (1989) Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev 3:1362-1371.
17. Levy DE, Kessler DS, Pine R, Reich N, Darnell JE, Jr. (1988) Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev 2:383-393.
18. Shuai K, Schindler C, Prezioso VR, Darnell JE, Jr. (1992) Activation of transcription by IFN-gamma: Tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258:1808-1812. (Pubitemid 23087351)
19. Decker T, Kovarik P, Meinke A (1997) GAS elements: A few nucleotides with a major impact on cytokine-induced gene expression. J Interferon Cytokine Res 17:121-134. (Pubitemid 27148701)
20. Tenoever BR, et al. (2007) Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science 315:1274-1278.
21. Peters RT, Liao SM, Maniatis T (2000) IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell 5:513-522.
22. Peters RT, Maniatis T (2001) A new family of IKK-related kinases may function as I kappa B kinase kinases. Biochim Biophys Acta 1471:M57-M62.
23. Shimada T, et al. (1999) IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol 11:1357-1362. (Pubitemid 29355675)
24. Fitzgerald KA, et al. (2003) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4:491-496. (Pubitemid 36592443)
25. Hemmi H, et al. (2004) The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med 199: 1641-1650. (Pubitemid 38821997)
26. Perry AK, Chow EK, Goodnough JB, Yeh WC, Cheng G (2004) Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med 199:1651-1658. (Pubitemid 38821998)
27. Sharma S, et al. (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300:1148-1151. (Pubitemid 36583100)
28. Hiscott J (2007) Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev 18:483-490.
29. Maniatis T, et al. (1998) Structure and function of the interferon-beta enhanceosome. Cold Spring Harb Symp Quant Biol 63:609-620.
30. Berchtold S, et al. (2008) Forced IFIT-2 expression represses LPS induced TNF-alpha expression at posttranscriptional levels. BMC Immunol 9:75.
31. Matsumoto M, et al. (1999) Activation of the transcription factor ISGF3 by interferon-gamma. Biol Chem 380:699-703. (Pubitemid 29322361)
32. Zimmermann A, et al. (2005) A cytomegaloviral protein reveals a dual role for STAT2 in IFN-gamma signaling and antiviral responses. J Exp Med 201:1543-1553. (Pubitemid 40721000)
33. Levy DE, Darnell JE, Jr. (2002) Stats: Transcriptional control and biological impact. Nat Rev Mol Cell Biol 3:651-662. (Pubitemid 34987786)
34. Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD (1998) How cells respond to interferons. Annu Rev Biochem 67:227-264. (Pubitemid 28411130)
35. Juang YT, et al. (1998) Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3. Proc Natl Acad Sci USA 95:9837-9842.
36. Chen X, et al. (1998) Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93:827-839. (Pubitemid 28257588)
37. Mao X, et al. (2005) Structural bases of unphosphorylated STAT1 association and receptor binding. Mol Cell 17:761-771. (Pubitemid 40386938)
38. Mertens C, et al. (2006) Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes Dev 20:3372-3381. (Pubitemid 44969156)
39. Stancato LF, David M, Carter-Su C, Larner AC, Pratt WB (1996) Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation. J Biol Chem 271:4134-4137. (Pubitemid 26070511)
40. Schmid S, Mordstein M, Kochs G, García-Sastre A, Tenoever BR (2010) Transcription factor redundancy ensures induction of the antiviral state. J Biol Chem 285:42013-42022.
41. Becker S, Groner B, Müller CW (1998) Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394:145-151. (Pubitemid 28325960)
42. Altschul SF, Erickson BW (1985) Significance of nucleotide sequence alignments: A method for random sequence permutation that preserves dinucleotide and codon usage. Mol Biol Evol 2:526-538. (Pubitemid 16234736)