Sulfur mustard primes human neutrophils for increased degranulation and stimulates cytokine release via TRPM2/p38 MAPK signaling

Toxicology and Applied Pharmacology

Volumn 258, Issue 1, 2012, Pages 82-88

  Ham, Hwa Yong ^a   Hong, Chang Won ^b   Lee, Si Nae ^a   Kwon, Min Soo ^c   Kim, Yeon Ja ^a   Song, Dong Keun ^a  

^a Hallym University   (South Korea)

^b Armed Forces Medical Research Institute   (South Korea)

^c CHA University   (South Korea)

Author keywords

Cytokine release; Neutrophil; P38 MAPK; Priming; Sulfur mustard; TRPM2

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM ION; CLOTRIMAZOLE; CLUSTERIN; ECONAZOLE; ENZYME INHIBITOR; FLUFENAMIC ACID; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; MUSTARD GAS; PD 98057; SHORT HAIRPIN RNA; SP 600215; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE RELEASE; DEGRANULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUTROPHIL; PROTEIN PHOSPHORYLATION;

CALCIUM; CELL DEGRANULATION; CHEMICAL WARFARE AGENTS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MAP KINASE SIGNALING SYSTEM; MUSTARD GAS; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TRANSCRIPTION FACTOR RELA; TRPM CATION CHANNELS;

EID: 84855454213     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.10.010     Document Type: Article

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