Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury

Toxicology

Volumn 263, Issue 1, 2009, Pages 41-46

  Anderson, Dana R ^a   Taylor, Stephanie L ^b   Fetterer, David P ^a   Holmes, Wesley W ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

Lung injury; Pulmonary function; Sulfur mustard; Treatment

Indexed keywords

APROTININ; ILOMASTAT; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; MUSTARD GAS; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; HISTOPATHOLOGY; LUNG INJURY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PEAK EXPIRATORY FLOW; PEAK INSPIRATORY FLOW; PRIORITY JOURNAL; TIDAL VOLUME;

ANIMALS; ANTIOXIDANTS; APROTININ; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICAL WARFARE AGENTS; CHROMANS; CYTOKINES; DRUG THERAPY, COMBINATION; INDOLES; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INTUBATION, INTRATRACHEAL; LUNG; LUNG DISEASES; MALE; MUSTARD GAS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY FUNCTION TESTS; SERINE PROTEINASE INHIBITORS;

ANIMALIA; RATTUS;

EID: 67849109680     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.08.025     Document Type: Article

References (36)

1. Anderson D.R., Yourick J.J., Arroyo C.M., Young G.D., and Harris L.W. Use of EPR spin-trapping techniques to detect radicals from rat lung lavage fluid following sulfur mustard exposure. Proceedings of the 1993 Medical Defense Bioscienc Review, USAMRICD. Aberdeen Proving Ground, MD, May 1 (1993) 113-121 AD No. A275667
2. Anderson D.R., Yourick J.J., Moeller R.B., Petrali J.P., Young G.D., and Byers S.L. Pathological changes in rat lungs following acute sulfur mustard inhalation. Inhal. Toxicol. 8 (1996) 285-297
3. Anderson D.R., Byers S.L., Clark C.R., and Schlehr J.A. Biochemical alterations in rat lung lavage fluid following acute sulfur mustard inhalation. Inhal. Toxicol. 9 (1997) 43-51
4. Anderson D.R., Byers S.L., and Vesely K.R. Treatment of sulfur mustard (HD)-induced lung injury. J. Appl. Toxicol. 20 (2000) S129-S132
5. Anderson D.R., and Holmes W.W. Evaluation of trolox, a water soluble vitamin E analog, as a treatment for sulfur mustard (SM) inhalation injury. FASEB J. (San Diego, CA) March-April (2005) 91.4
6. Anderson D.R., Schroth J.M., and Holmes W.W. Evaluation of ilomastat, a matrix metalloprotease inhibitor, as a treatment for sulfur mustard (SM) inhalation injury. FASEB J. (San Francisco, CA) April (2006) 429
7. Asimakopoulos G., Thompson R., Nourshargh S., Lidington E.A., Mason J.C., Ratnatunga C.P., Haskard D.O., Taylor K.M., and Landis R.C. An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation. J. Thorac. Cardiovasc. Surg. 120 (2000) 361-369
8. In: Baum G.L. (Ed). Textbook of Pulmonary Disease. second ed. (1974), Little, Brown, Boston, MA
9. Bhattacharya R., Tulsawani R.K., and Vijayaraghavan R. Effect of trolox and quercetin on HD-induced cytotoxicity in human peripheral blood lymphocytes. Indian J. Pharmacol. 38 (2006) 38-42
10. Calvet J.H., Jarreau P.H., Levame M., D'Ortho M.P., Lorino H., Harf A., and Macquin-Mavier I. Acute and chronic respiratory effects of sulfur mustard intoxication in guinea pig. J. Appl. Physiol. 76 (1994) 681-688
11. Casillas P.R., Kam J.C., and Powers C.-M. Serine and cysteine proteases in sulfur mustard-exposed hairless mouse skin: Enzymatic activity and inhibition profiles. J. Toxicol. Cutan. Ocul. Toxicol. 19 (2000) 137-151
12. Cowan F.M., Anderson D.R., Broomfield C.A., Byers S.L., and Smith W.J. Biochemical alterations in rat lung lavage fluid following acute sulfur mustard inhalation: II. Increase in proteolytic activity. Inhal. Toxicol. 9 (1997) 53-61
13. Cowan F.M., Broomfield C.A., and Smith W.J. Effect of sulfur exposure on protease activity in human peripheral blood lymphocytes. Cell Biol. Toxicol. 7 3 (1991) 239-248
14. Cowan F.M., Broomfield C.A., and Smith W.J. Suppression of sulfur mustard-increased IL-8 in human keratinocyte cell cultures by serine protease inhibitors: implications for toxicity and medical countermeasures. Cell Biol. Toxicol. 18 3 (2002) 175-180
15. Emad A., and Rezaian G.R. The diversity of the effects of sulfur mustard gas inhalation on respiratory system 10 years after a single, heavy exposure: analysis of 197 cases. Chest 112 (1997) 734-738
16. Guignabert C., Taysee L., Calvet J.-H., Planus E., Delamanche S., Galiacy S., and d'Ortho M.-P. Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs. Am. J. Physiol. Cell. Mol. Physiol. 289 (2005) L67-L74
17. Henderson R.F. Use of bronchoalveolar lavage to detect respiratory tract toxicity of inhaled material. Exp. Toxicol. Pathol. 57 (2005) 155-159
18. Henderson R.F. Bronchoalveolar lavage: a tool for assessing the health status of the lung. In: McClellan R.O., and Henderson R.F. (Eds). Concepts in Inhalation Toxicology (1989), Raven Press, New York 253-282
19. Holmes W.W., Schroth J.M., and Anderson D.R. Evaluation of aprotinin as a treatment for sulfur mustard (SM)-induced lung injury. FASEB J. (San Francisco, CA) 20 April (2006) A672
20. Kumar O., Sugendran K., and Vijayaraghavan R. Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes. Chem. Biol. Interact. 134 (2001) 1-12
21. Lee C.G., Homer R.J., Zhu Z., Lanone S., Wang X., Koteliansky V., Shipley J.M., Gotwals P., Noble P., Chen Q., Senior R.M., and Elias J.A. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J. Exp. Med. 194 6 (Sep 17 2001) 809-821
22. Levy J., Bailey J., and Salmenpera M. Pharmacokinetics of aprotinin in preoperative cardiac surgical patients. Anesthesiology 80 (1994) 1013-1018
23. Lindsay C.D., Hambrook J.L., Smith C.N., and Rice P. Histological assessment of the effects of percutaneous exposure of sulfur mustard in an in vitro human skin system and therapeutic properties of protease inhibitors. Medical Defense Bioscience Review, USAMRICD. Baltimore, MD, May 12-16 (1996) 148 AD No. A321840
24. McClintock S.D., Hoesel L.M., Das S.K., Till G.O., Neff T., Kunkel R.G., Smith M.G., and Ward P.A. Attenuation of half sulfur mustard gas-induced acute lung injury in rats. J. Appl. Toxicol. 26 2 (2006) 126-131
25. Naghii M.R. Sulfur mustard intoxication, oxidative stress, and antioxidants. Mil. Med. 167 7 (2002) 573-575
26. Papirmeister B., Feister A.J., Robinson S.I., and Ford R.D. Medical Defense Against Mustard Gas: Toxic Mechanisms and Pharmacological Implications (1991), CRC Press, Boca Raton, FL
27. Pemberton P.A., Cantwell J.S., Kim K.A., Sundin D.J., Kobayashi D., Fink J.B., Shapiro S.D., and Barr P.J. An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD 2 3 (2005) 303-310
28. In: Putnam J.B., and Royston D. (Eds). Evaluating the Role of Serine Protease Inhibition in the Management of Tumor Micrometastases. Oncol. 17 (10), suppl. 10 (2003) 1-32
29. Sabourin C.L., Danne M.M., Buxton K.L., Casillas R.P., and Schlager J.J. Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin. J. Biochem. Mol. Toxicol. 16 6 (2002) 263-272
30. Schroth J.M., Holmes W.W., and Anderson D.R. Evaluation of Trolox, a water soluble Vitamin E analog, as a treatment for sulfur mustard inhalation injury. Medical Defense Bioscience Review, USAMRICD. Hunt Valley, MD, June (2006) 23-28
31. Schultz G.S., Strelow S., Stern A., Chegini N., Grant M.B., Galardy R.E., Grobelny D., Rowsey J.J., Stonecipher K., Parmley V., and Khaw P.T. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest. Opthalmol. Vis. Sci. 33 12 (1992) 3325-3331
32. Shakarjian M.P., Bhatt P., Gordon M.K., Chang Y.C., Casbohm S.L., Rudge T.L., Kiser R.C., Sabourin C.l., Casillas R.P., Ohman-Strickland P., Riley D.J., and Gerecke D.R. Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure. J. Appl. Toxicol. 26 3 (2006) 239-246
33. Wilde P.E., and Upshall D.G. Cysteine esters protect cultured rodent lung slices from sulphur mustard. Hum. Exp. Toxicol. 13 (1994) 743-748
34. Willems J.L. Clinical management of mustard gas casualties. Ann. Med. Mil. Belg. 3 (1989) S1-S61
35. In: Witschi H., and Nettasheim P. (Eds). Mechanism of Respiratory Toxicology vol.1 (1982), CRC Press, Boca Raton, FL
36. Woessner Jr. J.F., Dannenberg Jr. A.M., Pula P.J., Selzer M.G., Ruppert C.L., Higuchi K., Kajiki A., Nakamura M., Dahms N.M., Kerr J.S., et al. Extracellular collagenase, proteoglycanase and products of their activity, released in organ culture by intact dermal inflammatory lesions produced by sulfur mustard. J. Invest. Dermatol. 95 6 (1990) 717-726