The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-κB and inflammatory response in lung epithelial cells

Journal of Applied Toxicology

Volumn 25, Issue 4, 2005, Pages 328-337

  Österlund, Camilla ^a,b   Lilliehöök, Bo ^a   Ekstrand Hammarström, Barbro ^a   Sandström, Thomas ^b   Bucht, Anders ^a,b,c  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^c FOI NBC Defence ^*  (Sweden)

Author keywords

A549; BEAS 2B; ICAM 1; MAPK, ERK1 2; Melphalan; NF B; p38; Respiratory epithelial cells; TNF

Indexed keywords

ALKYLATING AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MELPHALAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BRONCHUS MUCOSA; CELL ADHESION; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY CELL; LUNG ALVEOLUS EPITHELIUM; MONOCYTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CELL ADHESION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; FLAVONOIDS; FLOW CYTOMETRY; INTERCELLULAR ADHESION MOLECULE-1; LUNG; MELPHALAN; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; OXAZINES; PNEUMONIA; PROTEIN KINASE C; PULMONARY ALVEOLI; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1; XANTHENES;

EID: 22844448196     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.1070     Document Type: Article

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