Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D

Blood

Volumn 99, Issue 4, 2002, Pages 1434-1441

  Mansfield, Pamela J ^a,b   Hinkovska Galcheva, Vania ^a,b   Carey, Shannon S ^a,b   Shayman, James A ^a,b   Boxer, Laurence A ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CERAMIDE; CYTOCHALASIN B; DIACYLGLYCEROL; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GELATINASE; GRANULOCYTE COLONY STIMULATING FACTOR; LACTOFERRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDIC ACID; PHOSPHOLIPASE D; PROTEIN KINASE C; PROTEIN P47; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SPHINGOMYELIN PHOSPHODIESTERASE; SUPEROXIDE;

ARTICLE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NEUTROPHIL; NORMAL HUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

EID: 0037082447     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.4.1434     Document Type: Article

References (50)

1. Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: Inhibition by ceramide
2. Activation of p38 in stimulated human neutrophils: Phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK
3. The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylala-nine-induced p47phox phosphorylation in human neutrophils
4. Sphingosine blocks human polymorphonuclear leuko-cyte phagocytosis through inhibition of mitogen-activated protein kinase activation
5. A phosphatidic acid-activated protein kinase and conventional protein kinase C isoforms phosphorylate p22(phox), an NADPH oxidase component
6. 2 and lactoferrin release in adherent human neutrophils
7. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes
8. Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release
9. Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase
10. Naphthalenesulphonamides block neutrophil superoxide production by intact cells and in a cell-free system: Is myosin light chain kinase responsible for these effects?
11. 2 production in adherent human neutrophils
12. Kinase pathways in chemoattractant-induced degranulation of neutrophils: The role of p38 mitogen-activated protein kinase activated by Src family kinases
13. CD16 cross-linking induces both secretory and extracellular signal-regulated kinase (ERK)-dependent cytosolic phospholipase A2 (PLA2) activity in human natural killer cells: Involvement of ERK, but not PLA2, in CD16-triggered granule exocytosis
14. Cutting edge: Extracellular signal-regulated kinase activates syk: A new potential feedback regulation of Fcε receptor signaling
15. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases
16. Transforming growth factor-β1 stimulates degranulation and oxidant release by adherent human neutrophils
17. Phospholipase C and phospholipase D are activated independently of each other in chemotactic peptide-stimulated human neutrophils
18. NADPH oxidase: An update
19. NADPH oxidase activation and assembly during phagocytosis
20. Phosphatidic acid-mediated phosphorylation of the NADPH oxidase component p47-phox: Evidence that phosphatidic acid may activate a novel protein kinase
21. Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils
22. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: Role in activation of reduced nicotin-amide adenine dinucleotide oxidase
23. Activation of a plasma membrane-associated neutral sphingo-myelinase and concomitant ceramide accumulation during IgG-dependent phagocytosis in human polymorphonuclear leukocytes
24. Ceramide regulates oxidant release in adherent human neutrophils
25. 2-ceramide) inhibited neutrophil superoxide formation and calcium influx
26. Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated fatty acids
27. Tumor necrosis factor-α-mediated signal transduction in human neutrophils: Involvement of sphingomyelin metabolites in the priming effect of TNF-α on the fMLP-stimulated superoxide production
28. Ceramide inhibits phospholipase D in a cell-free system
29. Cell-permeable ceramides prevent the activation of phospholipase D by ADP-ribosylation factor and RhoA
30. Human neutrophil annexin I promotes granule aggregation and modulates Ca(2+)-dependent membrane fusion
31. Physiological levels of diacylglycerols in phospholipid membranes induce membrane fusion and stabilize inverted phases
32. Isolation and characterization of gelatinase granules from human neutrophils
33. cis-poly-unsaturated fatty acids induce high levels of superoxide production by human neutrophils
34. Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells
35. Subcellular fractionation of human neutrophils on Percoll density gradients
36. Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis
37. Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils: Involvement of phosphatidate phosphohydrolase in signal transduction
38. Control of exocytosis in early neutrophil activation
39. ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils
40. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
41. Regulation of phospholipase D
42. ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils
43. Protein kinase C isotypes and signal-transduction in human neutrophils: Selective substrate specificity of calcium-dependent β-PKC and novel calcium-independent nPKC
44. Activation of human neutrophil NADPH oxidase by phosphatidic acid or diacylglycerol in a cell-free system: Activity of diacylglycerol is dependent on its conversion to phosphatidic acid
45. Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan: Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase
46. Importance of MEK in neutrophil microbicidal responsiveness
47. Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors
48. Rab proteins in regulated exocytosis
49. Rho as a regulator of the cytoskeleton
50. Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein