A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5p

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Guo, Xiaoxian ^a   Li, Jingkai ^a   Wang, Tanjun ^a   Liu, Zhenhua ^a   Chen, Xin ^a   Li, Yudong ^c   Gu, Zhenglong ^b   Mao, Xuming ^a   Guan, Wenjun ^a   Li, Yongquan ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Department of Obstetrics Gynecology   (United States)

^c ZHEJIANG GONGSHANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALANINE; AMINO ACID; CYCLOHEXIMIDE; DNA FRAGMENT; FLUCONAZOLE; METHIONINE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN PDR5P; UNCLASSIFIED DRUG; ABC TRANSPORTER; ANTIFUNGAL AGENT; PDR5 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME SUBSTRATE; FUNGAL GENE; GENE EXPRESSION; GENE MUTATION; INTRACELLULAR LOOP 4; NONHUMAN; PDR5P GENE; SENSITIVITY ANALYSIS; YEAST; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MULTIDRUG RESISTANCE; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; TRANSGENIC ORGANISM;

ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CYCLOHEXIMIDE; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, MULTIPLE; FLUCONAZOLE; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORGANISMS, GENETICALLY MODIFIED; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE PROTEINS; YEASTS;

EID: 84855441982     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029520     Document Type: Article

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