The signaling interface of the yeast multidrug transporter Pdr5 adopts a Cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues

Biochemistry

Volumn 49, Issue 21, 2010, Pages 4440-4449

  Ananthaswamy, Neeti ^a   Rutledge, Robert ^b   Sauna, Zuben E ^c   Ambudkar, Suresh V ^b   Dine, Elliot ^a   Nelson, Emily ^a   Xia, Di ^b   Golin, John ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ATP HYDROLYSIS; ATP-BINDING SITE; DRUG RESISTANCE; DRUG TRANSPORT; EFFLUX TRANSPORTER; GENETIC SCREENS; LOOP RESIDUES; MULTIDRUG TRANSPORTERS; POLYTOPIC PROTEINS; SIGNAL INTERFACE; SINGLE MUTATION; TRANS CONFIGURATION; WILD TYPES;

BINDING ENERGY; RESTORATION; SIGNAL TRANSDUCTION; YEAST;

HYDROLYSIS;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; CLOTRIMAZOLE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG TRANSPORTER PROTEIN PDR5; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG TRANSPORT; GENETIC SCREENING; MULTIDRUG RESISTANCE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WILD TYPE; YEAST;

ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BIOLOGICAL TRANSPORT; EUKARYOTA; HYDROLYSIS; MOLECULAR CONFORMATION; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 77952810407     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100394j     Document Type: Article

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