The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation

International Immunology

Volumn 24, Issue 1, 2012, Pages 5-15

  Sakai, Hidemasa ^a   Okafuji, Ikuo ^a   Nishikomori, Ryuta ^a   Abe, Junya ^a   Izawa, Kazushi ^a   Kambe, Naotomo ^b   Yasumi, Takahiro ^a   Nakahata, Tatsutoshi ^a   Heike, Toshio ^a  

^a KYOTO UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Concanavalin A; Granuloma; Multinucleated giant cell

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CONCANAVALIN A; GAMMA INTERFERON; MEMBRANE PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELL FUNCTION; COCULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LANGHANS GIANT CELL; LANGHANS GIANT CELL FORMATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; UPREGULATION;

EID: 84855401001     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxr088     Document Type: Article

References (50)

1. Williams, G. T. and Williams, W. J. 1983. Granulomatous inflammation-a review. J. Clin. Pathol. 36:723.
2. Shibuya, K., Hirata, A., Omuta, J. et al. 2005. Granuloma and cryptococcosis. J. Infect. Chemother. 11:115.
3. Stasia, M. J. and Li, X. J. 2008. Genetics and immunopathology of chronic granulomatous disease. Semin. Immunopathol. 30:209.
4. Iannuzzi, M. C., Rybicki, B. A. and Teirstein, A. S. 2007. Sarcoidosis. N. Engl. J. Med. 357:2153.
5. Rose, C. D., Doyle, T. M. and McIlvain-Simpson, G. et al. 2005. Blau syndrome mutation of CARD15/NOD2 in sporadic early onset granulomatous arthritis. J. Rheumatol. 32:373.
6. Arostegui, J. I., Arnal, C., Merino, R. et al. 2007. NOD2 geneassociated pediatric granulomatous arthritis: clinical diversity, novel and recurrent mutations, and evidence of clinical improvement with interleukin-1 blockade in a Spanish cohort. Arthritis Rheum. 56:3805.
7. Okafuji, I., Nishikomori, R., Kanazawa, N. et al. 2009. Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis. Arthritis Rheum. 60:242.
8. Moller, D. R. 1999. Cells and cytokines involved in the pathogenesis of sarcoidosis. Sarcoidosis Vasc. Diffuse Lung Dis. 16:24.
9. Okamoto, H., Mizuno, K. and Horio, T. 2003. Monocyte-derived multinucleated giant cells and sarcoidosis. J Dermatol Sci. 31:119.
10. Hassan, N. F., Kamani, N., Meszaros, M. M. and Douglas, S. D. 1989. Induction of multinucleated giant cell formation from human blood-derived monocytes by phorbol myristate acetate in in vitro culture. J. Immunol. 143:2179.
11. Gerberding, K. and Yoder, M. C. 1993. In vitro comparison of multinucleated giant cell formation from human umbilical cord and adult peripheral blood mononuclear phagocytes. Pediatr. Res. 33:19.
12. Merrill, J. T., Shen, C., Schreibman, D. et al. 1997. Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Arthritis Rheum. 40:1308.
13. Most, J., Neumayer, H. P. and Dierich, M. P. 1990. Cytokineinduced generation of multinucleated giant cells in vitro requires interferon-gamma and expression of LFA-1. Eur. J. Immunol. 20:1661.
14. Most, J., Spotl, L., Mayr, G., Gasser, A., Sarti, A. and Dierich, M. P. 1997. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 89:662.
15. Takashima, T., Ohnishi, K., Tsuyuguchi, I. and Kishimoto, S. 1993. Differential regulation of formation of multinucleated giant cells from concanavalin A-stimulated human blood monocytes by IFNgamma and IL-4. J. Immunol. 150:3002.
16. Weinberg, J. B., Hobbs, M. M. and Misukonis, M. A. 1984. Recombinant human gamma-interferon induces human monocyte polykaryon formation. Proc. Natl Acad. Sci. USA 81:4554.
17. Weinberg, J. B., Hobbs, M. M. and Misukonis, M. A. 1985. Phenotypic characterization of gamma interferon-induced human monocyte polykaryons. Blood 66:1241.
18. Enelow, R. I., Sullivan, G. W., Carper, H. T. and Mandell, G. L. 1992. Induction of multinucleated giant cell formation from in vitro culture of human monocytes with interleukin-3 and interferongamma: comparison with other stimulating factors. Am. J. Respir. Cell Mol. Biol. 6:57.
19. Fais, S., Burgio, V. L., Silvestri, M., Capobianchi, M. R., Pacchiarotti, A. and Pallone, F. 1994. Multinucleated giant cells generation induced by interferon-gamma. Changes in the expression and distribution of the intercellular adhesion molecule- during macrophages fusion and multinucleated giant cell formation. Lab. Invest. 71:737.
20. Kao, W. J., McNally, A. K., Hiltner, A. and Anderson, J. M. 1995. Role for interleukin-4 in foreign-body giant cell formation on a poly (etherurethane urea) in vivo. J. Biomed. Mater. Res. 29:1267.
21. McNally, A. K. and Anderson, J. M. 1995. Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. Am. J. Pathol. 147:1487.
22. McNally, A. K., DeFife, K. M. and Anderson, J. M. 1996. Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity. Am. J. Pathol. 149:975.
23. DeFife, K. M., Jenney, C. R., McNally, A. K., Colton, E. and Anderson, J. M. 1997. Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression. J. Immunol. 158:3385.
24. Mizuno, K., Okamoto, H. and Horio, T. 2001. Muramyl dipeptide and mononuclear cell supernatant induce Langhans-type cells from human monocytes. J. Leukoc. Biol. 70:386.
25. Wang, M., Windgassen, D. and Papoutsakis, E. T. 2008. Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-cell activation. BMC Genomics 9:225.
26. Shu, U., Kiniwa, M., Wu, C. Y. et al. 1995. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1125.
27. Chen, E. H., Grote, E., Mohler, W. and Vignery, A. 2007. Cell-cell fusion. FEBS Lett. 581:2181.
28. Helming, L. and Gordon, S. 2007. The molecular basis of macrophage fusion. Immunobiology 212:785.
29. Vignery, A. 2008. Macrophage fusion: molecular mechanisms. Methods Mol. Biol. 475:149.
30. Brodbeck, W. G. and Anderson, J. M. 2009. Giant cell formation and function. Curr. Opin. Hematol. 16:53.
31. Helming, L. and Gordon, S. 2009. Molecular mediators of macrophage fusion. Trends Cell Biol. 19:514.
32. Suttles, J., Milhorn, D. M., Miller, R. W., Poe, J. C., Wahl, L. M. and Stout, R. D. 1999. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action. J. Biol. Chem. 274:5835.
33. Mukundan, L., Bishop, G. A., Head, K. Z., Zhang, L., Wahl, L. M. and Suttles, J. 2005. TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J. Immunol. 174:1081.
34. Lutgens, E., Lievens, D., Beckers, L., Donners, M. and Daemen, M. 2007. CD40 and its ligand in atherosclerosis. Trends Cardiovasc. Med. 17:118.
35. Agostini, C., Meneghin, A. and Semenzato, G. 2002. T-lymphocytes and cytokines in sarcoidosis. Curr. Opin. Pulm. Med. 8:435.
36. Kukita, T., Wada, N., Kukita, A. et al. 2004. RANKL-induced DCSTAMP is essential for osteoclastogenesis. J. Exp. Med. 200:941.
37. Yagi, M., Miyamoto, T., Sawatani, Y. et al. 2005. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202:345.
38. Miyamoto, T. 2006. The dendritic cell-specific transmembrane protein DC-STAMP is essential for osteoclast fusion and osteoclast bone-resorbing activity. Mod. Rheumatol. 16:341.
39. Yagi, M., Miyamoto, T., Toyama, Y. and Suda, T. 2006. Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J. Bone Miner. Metab. 24:355.
40. Yagi, M., Ninomiya, K., Fujita, N. et al. 2007. Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J. Bone Miner. Res. 22:992.
41. Kim, K., Lee, S. H., Ha Kim, J., Choi, Y. and Kim, N. 2008. NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol. Endocrinol. 22:176.
42. Ruland, J. 2008. CARD9 signaling in the innate immune response. Ann. N. Y. Acad. Sci. 1143:35.
43. Kambe, N., Nishikomori, R. and Kanazawa, N. 2005. The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders. J. Dermatol. Sci. 39:71.
44. Takayanagi, H., Ogasawara, K., Hida, S. et al. 2000. T-cellmediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408:600.
45. Flory, C. M., Jones, M. L. and Warren, J. S. 1993. Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1. Lab. Invest. 69:396.
46. Chensue, S. W., Warmington, K. S., Ruth, J. H., Sanghi, P. S., Lincoln, P. and Kunkel, S. L. 1996. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157:4602.
47. Lu, B., Rutledge, B. J., Gu, L. et al. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187:601.
48. Hogaboam, C. M., Bone-Larson, C. L., Lipinski, S. et al. 1999. Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models. J. Immunol. 163:2193.
49. Boumpas, D. T., Furie, R., Manzi, S. et al. 2003. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum. 48:719.
50. Advani, R., Forero-Torres, A., Furman, R. R. et al. 2009. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J. Clin. Oncol. 27:4371.