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1
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37049025380
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The molecular basis of macrophage fusion
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This article reviews current knowledge of cell-to-cell fusion mediators in the development of MGCs. The function of MGCs during granulomatous diseases is currently unknown, and there is a lack of knowledge regarding the mechanistic basis of macrophage fusion
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Helming L, Gordon S. The molecular basis of macrophage fusion. Immunobiology 2007; 219:785-793. This article reviews current knowledge of cell-to-cell fusion mediators in the development of MGCs. The function of MGCs during granulomatous diseases is currently unknown, and there is a lack of knowledge regarding the mechanistic basis of macrophage fusion.
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(2007)
Immunobiology
, vol.219
, pp. 785-793
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Helming, L.1
Gordon, S.2
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2
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40849094515
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Foreign body reaction to biomaterials
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This review presents current knowledge of FBGC formation and function in the context of implanted medical devices, prostheses, and biomaterials. The importance of chemical properties of the monocyte/macrophage adhesion substrate in the fusion of macrophages to form FBGCs is identified
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Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol 2008; 20:86-100. This review presents current knowledge of FBGC formation and function in the context of implanted medical devices, prostheses, and biomaterials. The importance of chemical properties of the monocyte/macrophage adhesion substrate in the fusion of macrophages to form FBGCs is identified.
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(2008)
Semin Immunol
, vol.20
, pp. 86-100
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Anderson, J.M.1
Rodriguez, A.2
Chang, D.T.3
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3
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33846254553
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Lay G, Poquet Y, Salek-Peyron P, et al. Langhans giant cells from M tuberculosis-induced human granulomas cannot mediate mycobacterial uptake. J Pathol 2007; 211:76-85. This study presents a new in-vitro human model of tuberculous granulomas and the role of mycobacterium virulence in modulating the phagocytosis capability of MGCs. M. tuberculosis (high virulence) induces the differentiation of granuloma macrophages into very large MGCs that are unable to mediate bacterial uptake (phagocytosis).
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Lay G, Poquet Y, Salek-Peyron P, et al. Langhans giant cells from M tuberculosis-induced human granulomas cannot mediate mycobacterial uptake. J Pathol 2007; 211:76-85. This study presents a new in-vitro human model of tuberculous granulomas and the role of mycobacterium virulence in modulating the phagocytosis capability of MGCs. M. tuberculosis (high virulence) induces the differentiation of granuloma macrophages into very large MGCs that are unable to mediate bacterial uptake (phagocytosis).
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4
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33847339885
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Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway
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This study, utilizing the in-vitro human model of mycobacterial granulomas, delineates the role of mycobacterial envelope glycolipids in inducing MGC formation
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Puissegur MP, Lay G, Gilleron M, et al. Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway. J Immunol 2007; 1:3161-3169. This study, utilizing the in-vitro human model of mycobacterial granulomas, delineates the role of mycobacterial envelope glycolipids in inducing MGC formation.
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(2007)
J Immunol
, vol.1
, pp. 3161-3169
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Puissegur, M.P.1
Lay, G.2
Gilleron, M.3
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5
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33845381060
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Giant cell tumor of bone: Morphological, biological, and histogenetical aspects
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Werner M. Giant cell tumor of bone: morphological, biological, and histogenetical aspects. Int Orthop 2006; 30:484-489.
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(2006)
Int Orthop
, vol.30
, pp. 484-489
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Werner, M.1
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6
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24344475607
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Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact
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Nishimura M, Yuasa K, Mori K, et al. Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact. J Orthop Res 2005; 23:979-987.
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(2005)
J Orthop Res
, vol.23
, pp. 979-987
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Nishimura, M.1
Yuasa, K.2
Mori, K.3
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8
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33144481680
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Osteoclasts; culprits in inflammatory osteolysis
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Teitelbaum SL. Osteoclasts; culprits in inflammatory osteolysis. Arthritis Res Ther 2006; 8:201-208.
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(2006)
Arthritis Res Ther
, vol.8
, pp. 201-208
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Teitelbaum, S.L.1
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9
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17844399226
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Effect of L-000845704, an αvβ3 integrin antagonist, on markers of bone mineral density in postmenopausal osteoporotic women
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Murphy MG, Cerchio K, Stoch SA, et al. Effect of L-000845704, an αvβ3 integrin antagonist, on markers of bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab 2005; 90:2022-2028.
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(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 2022-2028
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Murphy, M.G.1
Cerchio, K.2
Stoch, S.A.3
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10
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23744459835
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DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells
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Yagi M, Miyamoto T, Sawatani Y, et al. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med 2005; 203:345-351.
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(2005)
J Exp Med
, vol.203
, pp. 345-351
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Yagi, M.1
Miyamoto, T.2
Sawatani, Y.3
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11
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23744473936
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Macrophage fusion: The making of osteoclasts and giant cells
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Vignery A. Macrophage fusion: the making of osteoclasts and giant cells. J Exp Med 2005; 202:337-340.
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(2005)
J Exp Med
, vol.202
, pp. 337-340
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Vignery, A.1
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12
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34547898806
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McNally AK, MacEwan SR, Anderson JM. Alpha subunit partners to beta1 and beta2 integrins during II-4-induced foreign body giant cell formation. J Biomed Mater Res A 2007; 82A:568-574. This study identifies the time-dependent nature of integrin expression during IL-4-induced FBGC formation. Early expression of αMβ2 and αXβ2 with subsequent expression of α5β1, αvβ1, α2β1, and α3β1 is identified in FBGC and at macrophage fusion interfaces. Potential receptor/ligand interactions with multiple proteins adherent to the synthetic surface are implicated
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1 is identified in FBGC and at macrophage fusion interfaces. Potential receptor/ligand interactions with multiple proteins adherent to the synthetic surface are implicated.
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13
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47049125311
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McNally AK, Jones JA, MacEwan SR, et al. Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation. J Biomed Mater Res 2007; 86A:535-543. This study identifies vitronectin as a critical substrate-adherent protein in supporting significant macrophage adhesion, development, and fusion leading to FBGC formation. Although other blood and extracellular matrix proteins facilitate monocyte/macrophage adhesion, vitronectin is the only protein to sustain cellular events leading to FBGC formation.
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McNally AK, Jones JA, MacEwan SR, et al. Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation. J Biomed Mater Res 2007; 86A:535-543. This study identifies vitronectin as a critical substrate-adherent protein in supporting significant macrophage adhesion, development, and fusion leading to FBGC formation. Although other blood and extracellular matrix proteins facilitate monocyte/macrophage adhesion, vitronectin is the only protein to sustain cellular events leading to FBGC formation.
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14
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33846373694
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Helming L, Gordon S. Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur J Immunol 2007; 37:33-42. Utilizing a bifluorescent system to study IL-4-induced fusion of primary murine macrophages in vitro, this study identifies a multistage process involving multiple target molecules for FBGC formation. This study demonstrates that macrophage fusion depends on the source of macrophages, and not all types of macrophages are capable of fusion to form FBGCs.
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Helming L, Gordon S. Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur J Immunol 2007; 37:33-42. Utilizing a bifluorescent system to study IL-4-induced fusion of primary murine macrophages in vitro, this study identifies a multistage process involving multiple target molecules for FBGC formation. This study demonstrates that macrophage fusion depends on the source of macrophages, and not all types of macrophages are capable of fusion to form FBGCs.
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15
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37249085025
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Moreno JL, Mikhailenko I, Tondravi MM, Keegan AD. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. J Leukoc Biol 2007; 82:1542-1553. The presence of the STAT6 pathway is necessary for macrophage differentiation and fusion into MGCs. E-cadherin expression was critical for the formation of MGC by IL-4, and both E-cadherin and DC-STAMP were expressed in a STAT6-dependent manner.
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Moreno JL, Mikhailenko I, Tondravi MM, Keegan AD. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. J Leukoc Biol 2007; 82:1542-1553. The presence of the STAT6 pathway is necessary for macrophage differentiation and fusion into MGCs. E-cadherin expression was critical for the formation of MGC by IL-4, and both E-cadherin and DC-STAMP were expressed in a STAT6-dependent manner.
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16
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24344449008
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Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum
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McNally AK, Anderson JM. Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exp Mol Pathol 2005; 79:126-135.
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(2005)
Exp Mol Pathol
, vol.79
, pp. 126-135
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McNally, A.K.1
Anderson, J.M.2
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17
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33750842904
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Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells
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Lemaire I, Falzoni S, Leduc N, et al. Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells. J Immunol 2006; 15:7257-7265.
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(2006)
J Immunol
, vol.15
, pp. 7257-7265
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Lemaire, I.1
Falzoni, S.2
Leduc, N.3
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18
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30444441681
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The intracellular domain of CD44 promotes the fusion of macrophages
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Cui W, Ke JZ, Zhang Q, et al. The intracellular domain of CD44 promotes the fusion of macrophages. Blood 2006; 107:796-805.
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(2006)
Blood
, vol.107
, pp. 796-805
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Cui, W.1
Ke, J.Z.2
Zhang, Q.3
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19
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34548399453
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Herde K, Hartmann S, Brehm R, et al. Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite. Biomaterials 2007; 28:4912-4921. This study identifies connexin 43 as playing a functional role in gap junction communication in the formation of osteoclast-like FBGCs formed in response to implantation of the nanoparticulate hydroxyapatite. These studies have implications for the role of FBGCs in tissue engineering and regenerative medicine.
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Herde K, Hartmann S, Brehm R, et al. Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite. Biomaterials 2007; 28:4912-4921. This study identifies connexin 43 as playing a functional role in gap junction communication in the formation of osteoclast-like FBGCs formed in response to implantation of the nanoparticulate hydroxyapatite. These studies have implications for the role of FBGCs in tissue engineering and regenerative medicine.
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21
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58149135581
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Paracrine and juxtacrine lymphocyte enhancement of adherent macrophage and foreign body giant cell activation
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Epub ahead of print
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Chang DT, Colton E, Anderson JM. Paracrine and juxtacrine lymphocyte enhancement of adherent macrophage and foreign body giant cell activation. J Biomed Mater Res A 2008 [Epub ahead of print].
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(2008)
J Biomed Mater Res A
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Chang, D.T.1
Colton, E.2
Anderson, J.M.3
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22
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36049026219
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Jones JA, Chang DT, Meyerson H, et al. Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells. J Biomed Mater Res A 2007; 83:585-596. This study presents proteomic and quantitative enzyme-linked immunosorbent assay data on the effect of material surface chemistry on human monocyte, macrophage, and FBGC production of cytokines and chemokines. The importance of material surface chemistry in effecting monocyte/macrophage/FBGC adhesion and activation is clearly identified.
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Jones JA, Chang DT, Meyerson H, et al. Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells. J Biomed Mater Res A 2007; 83:585-596. This study presents proteomic and quantitative enzyme-linked immunosorbent assay data on the effect of material surface chemistry on human monocyte, macrophage, and FBGC production of cytokines and chemokines. The importance of material surface chemistry in effecting monocyte/macrophage/FBGC adhesion and activation is clearly identified.
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23
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34748848694
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Anderson JM, Jones JA. Phenotypic dichotomies in the foreign body reaction. Biomaterials 2007; 28:5114-5120. This study identifies the significance of material surface chemistry in modulating adhesion, activation, and apoptosis of adherent macrophages and FBGCs. Poorly adherent surface, that is, low-adherence cell densities, can result in high levels of cytokine/chemokine production. On the basis of cytokine/chemokine profiles, a time-dependent phenotypic switch in the activity of macrophages/FBGCs is suggested.
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Anderson JM, Jones JA. Phenotypic dichotomies in the foreign body reaction. Biomaterials 2007; 28:5114-5120. This study identifies the significance of material surface chemistry in modulating adhesion, activation, and apoptosis of adherent macrophages and FBGCs. Poorly adherent surface, that is, low-adherence cell densities, can result in high levels of cytokine/chemokine production. On the basis of cytokine/chemokine profiles, a time-dependent phenotypic switch in the activity of macrophages/FBGCs is suggested.
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