메뉴 건너뛰기




Volumn 502, Issue , 2012, Pages 167-214

Cell-targeting fusion constructs containing recombinant gelonin

Author keywords

Antitumor; Fusion toxins; Gelonin; Immunotoxins; Recombinant proteins; Toxin rGel

Indexed keywords

CASPASE 3; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELONIN; I KAPPA B KINASE BETA; IMMUNOTOXIN; INDIUM 111; PROTEIN BCL XL; PROTEIN MCL 1; SURVIVIN; TRASTUZUMAB; VASCULOTROPIN; VASCULOTROPIN 121;

EID: 84855399797     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-416039-2.00008-2     Document Type: Chapter
Times cited : (24)

References (86)
  • 1
    • 79952264098 scopus 로고    scopus 로고
    • New strategies in HER2-overexpressing breast cancer: Many combinations of targeted drugs available
    • V. Abramson, and C.L. Arteaga New strategies in HER2-overexpressing breast cancer: Many combinations of targeted drugs available Clin. Cancer Res. 17 5 2011 952 958
    • (2011) Clin. Cancer Res. , vol.17 , Issue.5 , pp. 952-958
    • Abramson, V.1    Arteaga, C.L.2
  • 4
    • 77955312203 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Targeted drug delivery for cancer
    • S.C. Alley, N.M. Okeley, and P.D. Senter Antibody-drug conjugates: Targeted drug delivery for cancer Curr. Opin. Chem. Biol. 14 4 2010 529 537
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , Issue.4 , pp. 529-537
    • Alley, S.C.1    Okeley, N.M.2    Senter, P.D.3
  • 6
    • 71549169552 scopus 로고    scopus 로고
    • Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: In vitro and in vivo studies
    • Y. Cao, J.D. Marks, J.W. Marks, L.H. Cheung, S. Kim, and M.G. Rosenblum Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: In vitro and in vivo studies Cancer Res. 69 23 2009 8987 8995
    • (2009) Cancer Res. , vol.69 , Issue.23 , pp. 8987-8995
    • Cao, Y.1    Marks, J.D.2    Marks, J.W.3    Cheung, L.H.4    Kim, S.5    Rosenblum, M.G.6
  • 8
    • 34249777558 scopus 로고    scopus 로고
    • Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein
    • DOI 10.1128/JVI.02426-06
    • R. Clemente, and J.C. de la Torre Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein J. Virol. 81 11 2007 5968 5977 (Pubitemid 46847033)
    • (2007) Journal of Virology , vol.81 , Issue.11 , pp. 5968-5977
    • Clemente, R.1    De La Torre, J.C.2
  • 9
    • 0030614825 scopus 로고    scopus 로고
    • Cytotoxic activity of a diphtheria toxin/FGF6 mitotoxin on human tumour cell lines
    • P.M. Coll-Fresno, M. Batoz, S. Tarquin, D. Birnbaum, and F. Coulier Cytotoxic activity of a diptheria toxin/FGF6 mitotoxin on human tumour cell lines Oncogene 14 2 1997 243 247 (Pubitemid 27068310)
    • (1997) Oncogene , vol.14 , Issue.2 , pp. 243-247
    • Coll-Fresno, P.M.1    Batoz, M.2    Tarquin, S.3    Birnbaum, D.4    Coulier, F.5
  • 10
    • 78649995921 scopus 로고    scopus 로고
    • The molecular background of aggressive B cell lymphomas as a basis for targeted therapy
    • D. de Jong, and P.O. Balague The molecular background of aggressive B cell lymphomas as a basis for targeted therapy J. Pathol. 223 2011 274 282
    • (2011) J. Pathol. , vol.223 , pp. 274-282
    • De Jong, D.1    Balague, P.O.2
  • 12
    • 0027932308 scopus 로고
    • Characterization of the increased cytotoxicity of gelonin anti-T cell immunoconjugates compared with ricin A chain immunoconjugates
    • D.M. Fishwild, H.M. Wu, S.F. Carroll, and S.L. Bernhard Characterization of the increased cytotoxicity of gelonin anti-T cell immunoconjugates compared with ricin A chain immunoconjugates Clin. Exp. Immunol. 97 1 1994 10 18 (Pubitemid 24244048)
    • (1994) Clinical and Experimental Immunology , vol.97 , Issue.1 , pp. 10-18
    • Fishwold, D.M.1    Wu, H.-M.2    Carroll, S.F.3    Bernhard, S.L.4
  • 14
    • 79955515280 scopus 로고    scopus 로고
    • Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: Mechanisms and clinical implications
    • J.T. Garrett, and C.L. Arteaga Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: Mechanisms and clinical implications Cancer Biol. Ther. 11 9 2011 793 800
    • (2011) Cancer Biol. Ther. , vol.11 , Issue.9 , pp. 793-800
    • Garrett, J.T.1    Arteaga, C.L.2
  • 16
    • 0025907541 scopus 로고
    • In vitro studies of the effect of MAb NDA 4 linked to toxin on the proliferation of a human EBV-transformed lymphoblastoid B cell line and of gibbon MLA leukemia cell line
    • P. Harris, E. Reed, D.W. King, and N. Suciu-Foca In vitro studies of the effect of MAb NDA 4 linked to toxin on the proliferation of a human EBV-transformed lymphoblastoid B cell line and of gibbon MLA leukemia cell line Cell. Immunol. 134 1 1991 85 95
    • (1991) Cell. Immunol. , vol.134 , Issue.1 , pp. 85-95
    • Harris, P.1    Reed, E.2    King, D.W.3    Suciu-Foca, N.4
  • 17
    • 0024849184 scopus 로고
    • Immunotoxins: A clinical review of their use in the treatment of malignancies
    • A.A. Hertler, and A.E. Frankel Immunotoxins: A clinical review of their use in the treatment of malignancies J. Clin. Oncol. 7 12 1989 1932 1942 (Pubitemid 20014343)
    • (1989) Journal of Clinical Oncology , vol.7 , Issue.12 , pp. 1932-1942
    • Hertler, A.A.1    Frankel, A.E.2
  • 19
    • 77955599946 scopus 로고    scopus 로고
    • ATTEMPTS system: A macromolecular prodrug strategy for cancer drug delivery
    • Y. Huang, Y.S. Park, J. Wang, C. Moon, Y.M. Kwon, and H.S. Chung ATTEMPTS system: A macromolecular prodrug strategy for cancer drug delivery Curr. Pharm. Des. 16 21 2010 2369 2376
    • (2010) Curr. Pharm. Des. , vol.16 , Issue.21 , pp. 2369-2376
    • Huang, Y.1    Park, Y.S.2    Wang, J.3    Moon, C.4    Kwon, Y.M.5    Chung, H.S.6
  • 20
    • 77956337746 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer: Poised to deliver?
    • B. Hughes Antibody-drug conjugates for cancer: Poised to deliver? Nat. Rev. Drug Discov. 9 9 2010 665 667
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.9 , pp. 665-667
    • Hughes, B.1
  • 21
    • 0036237495 scopus 로고    scopus 로고
    • Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents: A new generation of therapeutics
    • M. Hursey, D.L. Newton, H.J. Hansen, D. Ruby, D.M. Goldenberg, and S.M. Rybak Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents: A new generation of therapeutics Leuk. Lymphoma 43 5 2002 953 959 (Pubitemid 34460876)
    • (2002) Leukemia and Lymphoma , vol.43 , Issue.5 , pp. 953-959
    • Hursey, M.1    Newton, D.L.2    Hansen, H.J.3    Ruby, D.4    Goldenberg, D.M.5    Rybak, S.M.6
  • 22
    • 79952088805 scopus 로고    scopus 로고
    • Trastuzumab-DM1: Building a chemotherapy-free road in the treatment of human epidermal growth factor receptor 2-positive breast cancer
    • S.J. Isakoff, and J. Baselga Trastuzumab-DM1: Building a chemotherapy-free road in the treatment of human epidermal growth factor receptor 2-positive breast cancer J. Clin. Oncol. 29 4 2011 351 354
    • (2011) J. Clin. Oncol. , vol.29 , Issue.4 , pp. 351-354
    • Isakoff, S.J.1    Baselga, J.2
  • 23
    • 78651066552 scopus 로고    scopus 로고
    • Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells
    • B. Kloo, D. Nagel, M. Pfeifer, M. Grau, M. Duwel, and M. Vincendeau Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells Proc. Natl. Acad. Sci. USA 108 1 2011 272 277
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , Issue.1 , pp. 272-277
    • Kloo, B.1    Nagel, D.2    Pfeifer, M.3    Grau, M.4    Duwel, M.5    Vincendeau, M.6
  • 24
    • 34547935736 scopus 로고    scopus 로고
    • Cell killing by antibody-drug conjugates
    • DOI 10.1016/j.canlet.2007.04.010, PII S0304383507001991
    • Y.V. Kovtun, and V.S. Goldmacher Cell killing by antibody-drug conjugates Cancer Lett. 255 2 2007 232 240 (Pubitemid 47268641)
    • (2007) Cancer Letters , vol.255 , Issue.2 , pp. 232-240
    • Kovtun, Y.V.1    Goldmacher, V.S.2
  • 25
    • 0035214047 scopus 로고    scopus 로고
    • Toxin-labeled monoclonal antibodies
    • DOI 10.2174/1389201013378635
    • R.J. Kreitman Toxin-labeled monoclonal antibodies Curr. Pharm. Biotechnol. 2 4 2001 313 325 (Pubitemid 33138540)
    • (2001) Current Pharmaceutical Biotechnology , vol.2 , Issue.4 , pp. 313-325
    • Kreitman, R.J.1
  • 26
    • 70350148193 scopus 로고    scopus 로고
    • Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies
    • R.J. Kreitman Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies Curr. Pharm. Des. 15 23 2009 2652 2664
    • (2009) Curr. Pharm. Des. , vol.15 , Issue.23 , pp. 2652-2664
    • Kreitman, R.J.1
  • 27
    • 77951687835 scopus 로고    scopus 로고
    • Delivery and therapeutic potential of human granzyme B
    • F.C. Kurschus, and D.E. Jenne Delivery and therapeutic potential of human granzyme B Immunol. Rev. 235 1 2010 159 171
    • (2010) Immunol. Rev. , vol.235 , Issue.1 , pp. 159-171
    • Kurschus, F.C.1    Jenne, D.E.2
  • 28
    • 1642389211 scopus 로고    scopus 로고
    • Killing of target cells by redirected granzyme B in the absence of perforin
    • DOI 10.1016/S0014-5793(04)00187-5, PII S0014579304001875
    • F.C. Kurschus, M. Kleinschmidt, E. Fellows, K. Dornmair, R. Rudolph, and H. Lilie Killing of target cells by redirected granzyme B in the absence of perforin FEBS Lett. 562 1-3 2004 87 92 (Pubitemid 38388452)
    • (2004) FEBS Letters , vol.562 , Issue.1-3 , pp. 87-92
    • Kurschus, F.C.1    Kleinschmidt, M.2    Fellows, E.3    Dornmair, K.4    Rudolph, R.5    Lilie, H.6    Jenne, D.E.7
  • 30
    • 77951010885 scopus 로고    scopus 로고
    • Aggressive lymphomas
    • G. Lenz, and L.M. Staudt Aggressive lymphomas N. Engl. J. Med. 362 15 2010 1417 1429
    • (2010) N. Engl. J. Med. , vol.362 , Issue.15 , pp. 1417-1429
    • Lenz, G.1    Staudt, L.M.2
  • 31
    • 70350090137 scopus 로고    scopus 로고
    • Novel strategies to augment genetically delivered. immunotoxin molecular therapy for cancer therapy
    • X. Liu, J. Wu, S. Zhang, C. Li, and Q. Huang Novel strategies to augment genetically delivered. immunotoxin molecular therapy for cancer therapy Cancer Gene Ther. 16 11 2009 861 872
    • (2009) Cancer Gene Ther. , vol.16 , Issue.11 , pp. 861-872
    • Liu, X.1    Wu, J.2    Zhang, S.3    Li, C.4    Huang, Q.5
  • 33
    • 33847415945 scopus 로고    scopus 로고
    • The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA
    • DOI 10.1158/1535-7163.MCT-06-0254
    • M.A. Lyu, L.H. Cheung, W.N. Hittelman, J.W. Marks, R.C. Aguiar, and M.G. Rosenblum The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA Mol. Cancer Ther. 6 2 2007 460 470 (Pubitemid 46332448)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.2 , pp. 460-470
    • Lyu, M.-A.1    Cheung, L.H.2    Hittelman, W.N.3    Marks, J.W.4    Aguiar, R.C.T.5    Rosenblum, M.G.6
  • 34
    • 77951694051 scopus 로고    scopus 로고
    • The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo
    • M.A. Lyu, D. Rai, K.S. Ahn, B. Sung, L.H. Cheung, and J.W. Marks The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo Neoplasia 12 5 2010 366 375
    • (2010) Neoplasia , vol.12 , Issue.5 , pp. 366-375
    • Lyu, M.A.1    Rai, D.2    Ahn, K.S.3    Sung, B.4    Cheung, L.H.5    Marks, J.W.6
  • 35
    • 77956651261 scopus 로고    scopus 로고
    • The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma
    • M.A. Lyu, B. Sung, L.H. Cheung, J.W. Marks, B.B. Aggarwal, and C.T. Ricardo The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma Biochem. Pharmacol. 80 9 2010 1335 1342
    • (2010) Biochem. Pharmacol. , vol.80 , Issue.9 , pp. 1335-1342
    • Lyu, M.A.1    Sung, B.2    Cheung, L.H.3    Marks, J.W.4    Aggarwal, B.B.5    Ricardo, C.T.6
  • 36
    • 77954963893 scopus 로고    scopus 로고
    • Use of trastuzumab in HER2-positive metastatic breast cancer beyond disease progression: A systematic review of published studies
    • A. Mannocci, E. De Feo, C. de Waure, M.L. Specchia, M.R. Gualano, and C. Barone Use of trastuzumab in HER2-positive metastatic breast cancer beyond disease progression: A systematic review of published studies Tumori 96 3 2010 385 391
    • (2010) Tumori , vol.96 , Issue.3 , pp. 385-391
    • Mannocci, A.1    De Feo, E.2    De Waure, C.3    Specchia, M.L.4    Gualano, M.R.5    Barone, C.6
  • 38
    • 0032783692 scopus 로고    scopus 로고
    • Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis
    • DOI 10.1016/S0161-5890(99)00057-7, PII S0161589099000577
    • A.M. McCall, G.P. Adams, A.R. Amoroso, U.B. Nielsen, L. Zhang, and E. Horak Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis Mol. Immunol. 36 7 1999 433 445 (Pubitemid 29336224)
    • (1999) Molecular Immunology , vol.36 , Issue.7 , pp. 433-445
    • McCall, A.M.1    Adams, G.P.2    Amoroso, A.R.3    Nielsen, U.B.4    Zhang, L.5    Horak, E.6    Simmons, H.7    Schier, R.8    Marks, J.D.9    Weiner, L.M.10
  • 39
    • 0028109444 scopus 로고
    • Characterization of murine and humanized anti-CD33, gelonin immunotoxins reactive against myeloid leukemias
    • DOI 10.1007/BF01534423
    • K.J. McGraw, M.G. Rosenblum, L. Cheung, and D.A. Scheinberg Characterization of murine and humanized anti-CD33, gelonin immunotoxins reactive against myeloid leukemias Cancer Immunol. Immunother. 39 6 1994 367 374 (Pubitemid 24372402)
    • (1994) Cancer Immunology Immunotherapy , vol.39 , Issue.6 , pp. 367-374
    • McGraw, K.J.1    Rosenblum, M.G.2    Cheung, L.3    Scheinberg, D.A.4
  • 40
    • 0028002716 scopus 로고
    • Preparation and characterization of interleukin-2-gelonin conjugates made using different cross-linking reagents
    • G.D. McIntyre, C.F. Scott Jr., J. Ritz, W.A. Blattler, and J.M. Lambert Preparation and characterization of interleukin-2-gelonin conjugates made using different cross-linking reagents Bioconjug. Chem. 5 1 1994 88 97 (Pubitemid 2043895)
    • (1994) Bioconjugate Chemistry , vol.5 , Issue.1 , pp. 88-97
    • McIntyre, G.D.1    Scott Jnr, C.F.2    Ritz, J.3    Blattler, W.A.4    Lambert, J.M.5
  • 41
    • 4444351637 scopus 로고    scopus 로고
    • Retinoic acid-induced CD38 antigen as a target for immunotoxin-mediated killing of leukemia cells
    • K. Mehta, L. Ocanas, F. Malavasi, J.W. Marks, and M.G. Rosenblum Retinoic acid-induced CD38. Antigen as a target for immunotoxin-mediated killing of leukemia cells Mol. Cancer Ther. 3 3 2004 345 352 (Pubitemid 39193710)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.3 , pp. 345-352
    • Mehta, K.1    Ocanas, L.2    Malavasi, F.3    Marks, J.W.4    Rosenblum, M.G.5
  • 42
    • 76549090842 scopus 로고    scopus 로고
    • Recent advances in systemic therapy: Advances in systemic therapy for HER2-positive metastatic breast cancer
    • P.K. Morrow, F. Zambrana, and F.J. Esteva Recent advances in systemic therapy: Advances in systemic therapy for HER2-positive metastatic breast cancer Breast Cancer Res. 11 4 2009 207
    • (2009) Breast Cancer Res. , vol.11 , Issue.4 , pp. 207
    • Morrow, P.K.1    Zambrana, F.2    Esteva, F.J.3
  • 43
    • 0025720108 scopus 로고
    • A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2
    • K. Mujoo, R.A. Reisfeld, L. Cheung, and M.G. Rosenblum A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2 Cancer Immunol. Immunother. 34 3 1991 198 204
    • (1991) Cancer Immunol. Immunother. , vol.34 , Issue.3 , pp. 198-204
    • Mujoo, K.1    Reisfeld, R.A.2    Cheung, L.3    Rosenblum, M.G.4
  • 44
    • 73349091289 scopus 로고    scopus 로고
    • HER2 breast cancer therapies: A review
    • C.G. Murphy, and S. Modi HER2 breast cancer therapies: A review Biologics 3 2009 289 301
    • (2009) Biologics , vol.3 , pp. 289-301
    • Murphy, C.G.1    Modi, S.2
  • 45
    • 79952267158 scopus 로고    scopus 로고
    • Overview of 2008 WHO classification of malignant lymphoma
    • S. Nakamura Overview of 2008 WHO Classification of Malignant Lymphoma Rinsho Byori 58 11 2010 1105 1111
    • (2010) Rinsho Byori , vol.58 , Issue.11 , pp. 1105-1111
    • Nakamura, S.1
  • 46
    • 0031012360 scopus 로고    scopus 로고
    • Synthesis and cytotoxic profile of a diphtheria toxin-neurotrophin-4 chimera
    • A. Negro, and S.D. Skaper Synthesis and cytotoxic profile of a diphtheria toxin-neurotrophin-4 chimera J. Neurochem. 68 2 1997 554 563 (Pubitemid 27044714)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.2 , pp. 554-563
    • Negro, A.1    Skaper, S.D.2
  • 47
    • 0035863726 scopus 로고    scopus 로고
    • Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma
    • DOI 10.1182/blood.V97.2.528
    • D.L. Newton, H.J. Hansen, S.M. Mikulski, D.M. Goldenberg, and S.M. Rybak Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodgkin lymphoma Blood 97 2 2001 528 535 (Pubitemid 32060341)
    • (2001) Blood , vol.97 , Issue.2 , pp. 528-535
    • Newton, D.L.1    Hansen, H.J.2    Mikulski, S.M.3    Goldenberg, D.M.4    Rybak, S.M.5
  • 48
    • 33947274774 scopus 로고    scopus 로고
    • The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells
    • DOI 10.1182/blood-2006-08-042424
    • R. Nimmanapalli, M.A. Lyu, M. Du, M.J. Keating, M.G. Rosenblum, and V. Gandhi The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells Blood 109 6 2007 2557 2564 (Pubitemid 46425902)
    • (2007) Blood , vol.109 , Issue.6 , pp. 2557-2564
    • Nimmanapalli, R.1    Lyu, M.-A.2    Du, M.3    Keating, M.J.4    Rosenblum, M.G.5    Gandhi, V.6
  • 49
    • 79951700897 scopus 로고    scopus 로고
    • Prognostication of diffuse large B-cell lymphoma in the rituximab era
    • M.J. Ninan, P.D. Wadhwa, and P. Gupta Prognostication of diffuse large B-cell lymphoma in the rituximab era Leuk. Lymphoma 52 3 2011 360 373
    • (2011) Leuk. Lymphoma , vol.52 , Issue.3 , pp. 360-373
    • Ninan, M.J.1    Wadhwa, P.D.2    Gupta, P.3
  • 50
    • 79955835059 scopus 로고    scopus 로고
    • Pathogenesis of non-Hodgkin's lymphoma
    • H. Nogai, B. Dorken, and G. Lenz Pathogenesis of non-Hodgkin's lymphoma J. Clin. Oncol. 29 14 2011 1803 1811
    • (2011) J. Clin. Oncol. , vol.29 , Issue.14 , pp. 1803-1811
    • Nogai, H.1    Dorken, B.2    Lenz, G.3
  • 51
    • 0027137389 scopus 로고
    • Cloning and expression of a gene encoding gelonin, a ribosome- inactivating protein from Gelonium multiflorum
    • P.A. Nolan, D.A. Garrison, and M. Better Cloning and expression of a gene encoding gelonin, a ribosome-inactivating protein from Gelonium multiflorum Gene 134 2 1993 223 227
    • (1993) Gene , vol.134 , Issue.2 , pp. 223-227
    • Nolan, P.A.1    Garrison, D.A.2    Better, M.3
  • 55
    • 0038290547 scopus 로고    scopus 로고
    • Immunotoxins containing Pseudomonas exotoxin A: A short history
    • I. Pastan Immunotoxins containing Pseudomonas exotoxin A: A short history Cancer Immunol. Immunother. 52 5 2003 338 341 (Pubitemid 36578027)
    • (2003) Cancer Immunology, Immunotherapy , vol.52 , Issue.5 , pp. 338-341
    • Pastan, I.1
  • 56
    • 67449152479 scopus 로고    scopus 로고
    • Toward an effective targeted chemotherapy for multiple myeloma
    • A.G. Polson, and M.X. Sliwkowski Toward an effective targeted chemotherapy for multiple myeloma Clin. Cancer Res. 15 12 2009 3906 3907
    • (2009) Clin. Cancer Res. , vol.15 , Issue.12 , pp. 3906-3907
    • Polson, A.G.1    Sliwkowski, M.X.2
  • 57
    • 65549151884 scopus 로고    scopus 로고
    • Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
    • A.G. Polson, J. Calemine-Fenaux, P. Chan, W. Chang, E. Christensen, and S. Clark Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection Cancer Res. 69 6 2009 2358 2364
    • (2009) Cancer Res. , vol.69 , Issue.6 , pp. 2358-2364
    • Polson, A.G.1    Calemine-Fenaux, J.2    Chan, P.3    Chang, W.4    Christensen, E.5    Clark, S.6
  • 58
    • 11344290087 scopus 로고    scopus 로고
    • From microarray to bedside: Targeting NF-kappaB for therapy of lymphomas
    • A.B. Rabson, and D. Weissmann From microarray to bedside: Targeting NF-kappaB for therapy of lymphomas Clin. Cancer Res. 11 1 2005 2 6
    • (2005) Clin. Cancer Res. , vol.11 , Issue.1 , pp. 2-6
    • Rabson, A.B.1    Weissmann, D.2
  • 59
    • 38949203047 scopus 로고    scopus 로고
    • Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the α-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies
    • DOI 10.1158/1078-0432.CCR-07-1250
    • M.K. Robinson, C. Shaller, K. Garmestani, P.S. Plascjak, K.M. Hodge, and Q.A. Yuan Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies Clin. Cancer Res. 14 3 2008 875 882 (Pubitemid 351231172)
    • (2008) Clinical Cancer Research , vol.14 , Issue.3 , pp. 875-882
    • Robinson, M.K.1    Shaller, C.2    Garmestani, K.3    Plascjak, P.S.4    Hodge, K.M.5    Yuan, Q.-A.6    Marks, J.D.7    Waldmann, T.A.8    Brechbiel, M.W.9    Adams, G.P.10
  • 60
    • 70350145130 scopus 로고    scopus 로고
    • Development of novel, highly cytotoxic fusion constructs containing granzyme B: Unique mechanisms and functions
    • M.G. Rosenblum, and S. Barth Development of novel, highly cytotoxic fusion constructs containing granzyme B: Unique mechanisms and functions Curr. Pharm. Des. 15 23 2009 2676 2692
    • (2009) Curr. Pharm. Des. , vol.15 , Issue.23 , pp. 2676-2692
    • Rosenblum, M.G.1    Barth, S.2
  • 61
    • 0026127688 scopus 로고
    • A specific and potent immunotoxin composed of antibody ZME-018 and the plant toxin gelonin
    • M.G. Rosenblum, J.L. Murray, L. Cheung, R. Rifkin, S. Salmon, and R. Bartholomew A specific and potent immunotoxin composed of antibody ZME-018 and the plant toxin gelonin Mol. Biother. 3 1 1991 6 13
    • (1991) Mol. Biother. , vol.3 , Issue.1 , pp. 6-13
    • Rosenblum, M.G.1    Murray, J.L.2    Cheung, L.3    Rifkin, R.4    Salmon, S.5    Bartholomew, R.6
  • 63
    • 0029057959 scopus 로고
    • Amino acid sequence analysis, gene construction, cloning, and expression of gelonin, a toxin derived from Gelonium multiflorum
    • M.G. Rosenblum, W.A. Kohr, K.L. Beattie, W.G. Beattie, W. Marks, and P.D. Toman Amino acid sequence analysis, gene construction, cloning, and expression of gelonin, a toxin derived from Gelonium multiflorum J. Interferon Cytokine Res. 15 6 1995 547 555
    • (1995) J. Interferon Cytokine Res. , vol.15 , Issue.6 , pp. 547-555
    • Rosenblum, M.G.1    Kohr, W.A.2    Beattie, K.L.3    Beattie, W.G.4    Marks, W.5    Toman, P.D.6
  • 64
    • 0032904481 scopus 로고    scopus 로고
    • Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: In vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models
    • M.G. Rosenblum, L.K. Shawver, J.W. Marks, J. Brink, L. Cheung, and B. Langton-Webster Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: In vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models Clin. Cancer Res. 5 4 1999 865 874 (Pubitemid 29180839)
    • (1999) Clinical Cancer Research , vol.5 , Issue.4 , pp. 865-874
    • Rosenblum, M.G.1    Shawver, L.K.2    Marks, J.W.3    Brink, J.4    Cheung, L.5    Langton-Webster, B.6
  • 65
    • 20744450629 scopus 로고    scopus 로고
    • Delivery into cells: Lessons learned from plant and bacterial toxins
    • DOI 10.1038/sj.gt.3302525, Vector Traffic
    • K. Sandvig, and B. van Deurs Delivery into cells: Lessons learned from plant and bacterial toxins Gene Ther. 12 11 2005 865 872 (Pubitemid 40852204)
    • (2005) Gene Therapy , vol.12 , Issue.11 , pp. 865-872
    • Sandvig, K.1    Van Deurs, B.2
  • 66
    • 0028168637 scopus 로고
    • Crystallization of a scRIP-gelonin isolated from plant seeds Gelonium multiforum
    • P. Satyamurthy, M.V. Hosur, S. Misquith, A. Surolia, and K.K. Kannan Crystallization of a scRIP-gelonin isolated from plant seeds Gelonium multiforum Proteins 19 4 1994 340 342
    • (1994) Proteins , vol.19 , Issue.4 , pp. 340-342
    • Satyamurthy, P.1    Hosur, M.V.2    Misquith, S.3    Surolia, A.4    Kannan, K.K.5
  • 67
    • 0029294084 scopus 로고
    • In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library
    • R. Schier, J.D. Marks, E.J. Wolf, G. Apell, C. Wong, and J.E. McCartney In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library Immunotechnology 1 1 1995 73 81
    • (1995) Immunotechnology , vol.1 , Issue.1 , pp. 73-81
    • Schier, R.1    Marks, J.D.2    Wolf, E.J.3    Apell, G.4    Wong, C.5    McCartney, J.E.6
  • 68
    • 0023628956 scopus 로고
    • A new cytotoxin specific for the target cells of corticotropin-releasing factor
    • J. Schwartz, B. Penke, J. Rivier, and W. Vale A new cytotoxin specific for the target cells of corticotropin-releasing factor Endocrinology 121 4 1987 1454 1460 (Pubitemid 17155895)
    • (1987) Endocrinology , vol.121 , Issue.4 , pp. 1454-1460
    • Schwartz, J.1    Penke, B.2    Rivier, J.3    Vale, W.4
  • 69
    • 67649886201 scopus 로고    scopus 로고
    • Potent antibody drug conjugates for cancer therapy
    • P.D. Senter Potent antibody drug conjugates for cancer therapy Curr. Opin. Chem. Biol. 13 3 2009 235 244
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , Issue.3 , pp. 235-244
    • Senter, P.D.1
  • 70
    • 0036354718 scopus 로고    scopus 로고
    • Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin
    • DOI 10.1006/jsre.2001.6305
    • H. Shinohara, S. Morita, M. Kawai, A. Miyamoto, T. Sonoda, and I. Pastan Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin J. Surg. Res. 102 2 2002 169 177 (Pubitemid 34969464)
    • (2002) Journal of Surgical Research , vol.102 , Issue.2 , pp. 169-177
    • Shinohara, H.1    Morita, S.2    Kawai, M.3    Miyamoto, A.4    Sonoda, T.5    Pastan, I.6    Tanigawa, N.7
  • 71
    • 33750191271 scopus 로고    scopus 로고
    • Targeting B-lymphocyte stimulator/B-cell activating factor and a proliferation-inducing ligand in hematologic malignancies
    • L. Shivakumar, and S. Ansell Targeting B-lymphocyte stimulator/B-cell activating factor and a proliferation-inducing ligand in hematologic malignancies Clin. Lymphoma Myeloma 7 2 2006 106 108 (Pubitemid 44596592)
    • (2006) Clinical Lymphoma and Myeloma , vol.7 , Issue.2 , pp. 106-108
    • Shivakumar, L.1    Ansell, S.2
  • 72
    • 54049089018 scopus 로고    scopus 로고
    • Granzyme B-H22 (scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes
    • B. Stahnke, T. Thepen, M. Stocker, R. Rosinke, E. Jost, and R. Fischer Granzyme B-H22 (scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes Mol. Cancer Ther. 7 9 2008 2924 2932
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.9 , pp. 2924-2932
    • Stahnke, B.1    Thepen, T.2    Stocker, M.3    Rosinke, R.4    Jost, E.5    Fischer, R.6
  • 74
    • 0019212385 scopus 로고
    • Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A
    • F. Stirpe, S. Olsnes, and Pihl A. Gelonin A new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A J. Biol. Chem. 255 14 1980 6947 6953 (Pubitemid 11234436)
    • (1980) Journal of Biological Chemistry , vol.255 , Issue.14 , pp. 6947-6953
    • Stirpe, F.1    Olsnes, S.2    Pihl, A.3
  • 75
    • 27144553866 scopus 로고    scopus 로고
    • The NF-κB signalling pathway: A therapeutic target in lymphoid malignancies?
    • DOI 10.1517/14728222.9.5.1045
    • A. Stoffel The NF-kappaB signalling pathway: A therapeutic target in lymphoid malignancies? Expert Opin. Ther. Targets 9 5 2005 1045 1061 (Pubitemid 41488839)
    • (2005) Expert Opinion on Therapeutic Targets , vol.9 , Issue.5 , pp. 1045-1061
    • Stoffel, A.1
  • 76
    • 74849092615 scopus 로고    scopus 로고
    • Antibody-drug conjugate targets
    • B.A. Teicher Antibody-drug conjugate targets Curr. Cancer Drug Targets 9 8 2009 982 1004
    • (2009) Curr. Cancer Drug Targets , vol.9 , Issue.8 , pp. 982-1004
    • Teicher, B.A.1
  • 78
    • 0026900417 scopus 로고
    • Immunotoxins to human small-cell lung cancer
    • E.J. Wawrzynczak, and E.J. Derbyshire Immunotoxins to human small-cell lung cancer Cell Biophys. 21 1-3 1992 13 23
    • (1992) Cell Biophys. , vol.21 , Issue.13 , pp. 13-23
    • Wawrzynczak, E.J.1    Derbyshire, E.J.2
  • 79
    • 79961118371 scopus 로고    scopus 로고
    • Pharma interest surges in antibody drug conjugates
    • S. Webb Pharma interest surges in antibody drug conjugates Nat. Biotechnol. 29 4 2011 297 298
    • (2011) Nat. Biotechnol. , vol.29 , Issue.4 , pp. 297-298
    • Webb, S.1
  • 80
    • 80052633325 scopus 로고    scopus 로고
    • Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma
    • X. Wen, M.A. Lyu, R. Zhang, W. Lu, Q. Huang, and D. Liang Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma Mol. Imaging Biol. 13 4 2011 721 729
    • (2011) Mol. Imaging Biol. , vol.13 , Issue.4 , pp. 721-729
    • Wen, X.1    Lyu, M.A.2    Zhang, R.3    Lu, W.4    Huang, Q.5    Liang, D.6
  • 81
    • 60849116672 scopus 로고    scopus 로고
    • Pseudomonas exotoxin A: From virulence factor to anti-cancer agent
    • P. Wolf, and U. Elsasser-Beile Pseudomonas exotoxin A: From virulence factor to anti-cancer agent Int. J. Med. Microbiol. 299 3 2009 161 176
    • (2009) Int. J. Med. Microbiol. , vol.299 , Issue.3 , pp. 161-176
    • Wolf, P.1    Elsasser-Beile, U.2
  • 82
    • 33747862957 scopus 로고    scopus 로고
    • BLyS and B cell homeostasis
    • DOI 10.1016/j.smim.2006.06.001, PII S1044532306000820
    • R.T. Woodland, M.R. Schmidt, and C.B. Thompson BLyS and B cell homeostasis Semin. Immunol. 18 5 2006 318 326 (Pubitemid 44287557)
    • (2006) Seminars in Immunology , vol.18 , Issue.5 , pp. 318-326
    • Woodland, R.T.1    Schmidt, M.R.2    Thompson, C.B.3
  • 83
    • 49749150515 scopus 로고    scopus 로고
    • HER2-targeting recombinant protein with truncated pseudomonas exotoxin A translocation domain efficiently kills breast cancer cells
    • L. Zhang, J. Zhao, T. Wang, C.J. Yu, L.T. Jia, and Y.Y. Duan HER2-targeting recombinant protein with truncated pseudomonas exotoxin A translocation domain efficiently kills breast cancer cells Cancer Biol. Ther. 7 8 2008 1226 1231
    • (2008) Cancer Biol. Ther. , vol.7 , Issue.8 , pp. 1226-1231
    • Zhang, L.1    Zhao, J.2    Wang, T.3    Yu, C.J.4    Jia, L.T.5    Duan, Y.Y.6
  • 84
    • 0036394271 scopus 로고    scopus 로고
    • Immunobiology of tumor necrosis factor receptor superfamily
    • DOI 10.1385/IR:26:1-3:323
    • T. Zhou, J.D. Mountz, and R.P. Kimberly Immunobiology of tumor necrosis factor receptor superfamily Immunol. Res. 26 1-3 2002 323 336 (Pubitemid 35177509)
    • (2002) Immunologic Research , vol.26 , Issue.1-3 , pp. 323-336
    • Zhou, T.1    Mountz, J.D.2    Kimberly, R.P.3
  • 86
    • 70349696649 scopus 로고    scopus 로고
    • Affitoxin - A novel recombinant, HER2-specific, anticancer agent for targeted therapy of HER2-positive tumors
    • R. Zielinski, I. Lyakhov, A. Jacobs, O. Chertov, G. Kramer-Marek, and N. Francella Affitoxin - A novel recombinant, HER2-specific, anticancer agent for targeted therapy of HER2-positive tumors J. Immunother. 32 8 2009 817 825
    • (2009) J. Immunother. , vol.32 , Issue.8 , pp. 817-825
    • Zielinski, R.1    Lyakhov, I.2    Jacobs, A.3    Chertov, O.4    Kramer-Marek, G.5    Francella, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.