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Volumn 16, Issue 21, 2010, Pages 2369-2376

ATTEMPTS system: A macromolecular prodrug strategy for cancer drug delivery

Author keywords

ATTEMPTS; Cancer; Cell penetrating peptide; CPP; Prodrug; Protein drug delivery

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; CAMPTOTHECIN; CELL PENETRATING PEPTIDE; DOXORUBICIN; GELONIN; HEPARIN; LIPOSOME; POLYELECTROLYTE; POLYMER; PROTAMINE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 77955599946     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210791920441     Document Type: Review
Times cited : (37)

References (57)
  • 1
    • 52049105453 scopus 로고    scopus 로고
    • Recent trends in targeted anticancer prodrug and conjugate design
    • Singh Y, Palombo M, Sinko PJ. Recent trends in targeted anticancer prodrug and conjugate design. Curr Med Chem 2008; 15: 1802-26.
    • (2008) Curr Med Chem , vol.15 , pp. 1802-1826
    • Singh, Y.1    Palombo, M.2    Sinko, P.J.3
  • 2
    • 69249117394 scopus 로고    scopus 로고
    • Current prodrug design for drug discovery
    • Hsieh PW, Hung CF, Fang JY. Current prodrug design for drug discovery. Curr Pharm Des 2009; 15: 2236-50.
    • (2009) Curr Pharm Des , vol.15 , pp. 2236-2250
    • Hsieh, P.W.1    Hung, C.F.2    Fang, J.Y.3
  • 3
    • 5644276383 scopus 로고    scopus 로고
    • Delivery of bioactive molecules into the cell: The Trojan horse approach
    • Dietz GP, Bahr M. Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol Cell Neurosci 2004; 27: 85-131.
    • (2004) Mol Cell Neurosci , vol.27 , pp. 85-131
    • Dietz, G.P.1    Bahr, M.2
  • 4
    • 0024209811 scopus 로고
    • Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein
    • Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein. Cell 1988; 55: 1179-88.
    • (1988) Cell , vol.55 , pp. 1179-1188
    • Green, M.1    Loewenstein, P.M.2
  • 5
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988; 55: 1189-93.
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 6
    • 25144520907 scopus 로고    scopus 로고
    • On the mechanisms of the internalization of S4(13)-PV cell-penetrating peptide
    • Mano M, Teodosio C, Paiva A, et al. On the mechanisms of the internalization of S4(13)-PV cell-penetrating peptide. Biochem J 2005; 390: 603-12.
    • (2005) Biochem J , vol.390 , pp. 603-612
    • Mano, M.1    Teodosio, C.2    Paiva, A.3
  • 7
    • 33847351351 scopus 로고    scopus 로고
    • Noncovalent protein transduction in plant cells by macropinocytosis
    • Chang M, Chou JC, Chen CP, et al. Noncovalent protein transduction in plant cells by macropinocytosis. New Phytol 2007; 174: 46-56.
    • (2007) New Phytol , vol.174 , pp. 46-56
    • Chang, M.1    Chou, J.C.2    Chen, C.P.3
  • 8
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999; 285: 1569-72.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3
  • 9
    • 0028054797 scopus 로고
    • Tat-mediated delivery of heterologous proteins into cells
    • Fawell S, Seery J, Daikh Y, et al. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 1994; 91: 664-8.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 664-668
    • Fawell, S.1    Seery, J.2    Daikh, Y.3
  • 10
    • 56049093057 scopus 로고    scopus 로고
    • Cell-penetrating and cell-targeting peptides in drug delivery
    • Vives E, Schmidt J, Pelegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim Biophys Acta 2008; 1786(2): 126-38.
    • (2008) Biochim Biophys Acta , vol.1786 , Issue.2 , pp. 126-138
    • Vives, E.1    Schmidt, J.2    Pelegrin, A.3
  • 11
    • 28144440865 scopus 로고    scopus 로고
    • Peptide-enhanced cellular internalization of proteins in neuroscience
    • Dietz GP, Bahr M. Peptide-enhanced cellular internalization of proteins in neuroscience. Brain Res Bull 2005; 68: 103-14.
    • (2005) Brain Res Bull , vol.68 , pp. 103-114
    • Dietz, G.P.1    Bahr, M.2
  • 12
    • 68549110328 scopus 로고    scopus 로고
    • Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics
    • Heitz F, Morris MC, Divita G. Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol 2009; 157(2): 195-206.
    • (2009) Br J Pharmacol , vol.157 , Issue.2 , pp. 195-206
    • Heitz, F.1    Morris, M.C.2    Divita, G.3
  • 13
    • 2342595835 scopus 로고    scopus 로고
    • Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
    • Wadia JS, Stan RV, Dowdy SF. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 2004; 10: 310-5.
    • (2004) Nat Med , vol.10 , pp. 310-315
    • Wadia, J.S.1    Stan, R.V.2    Dowdy, S.F.3
  • 14
    • 11844268027 scopus 로고    scopus 로고
    • Cationic TAT peptide transduction domain enters cells by macropinocytosis
    • Kaplan IM, Wadia JS, Dowdy SF. Cationic TAT peptide transduction domain enters cells by macropinocytosis. J Control Release 2005; 102: 247-53.
    • (2005) J Control Release , vol.102 , pp. 247-253
    • Kaplan, I.M.1    Wadia, J.S.2    Dowdy, S.F.3
  • 15
    • 0025797055 scopus 로고
    • Endocytosis and targeting of exogenous HIV-1 Tat protein
    • Mann DA, Frankel AD. Endocytosis and targeting of exogenous HIV-1 Tat protein. EMBO J 1991; 10: 1733-9.
    • (1991) EMBO J , vol.10 , pp. 1733-1739
    • Mann, D.A.1    Frankel, A.D.2
  • 16
    • 0030966373 scopus 로고    scopus 로고
    • Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size
    • Rusnati M, Coltrini D, Oreste P, et al. Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. J Biol Chem 1997; 272: 11313-20.
    • (1997) J Biol Chem , vol.272 , pp. 11313-11320
    • Rusnati, M.1    Coltrini, D.2    Oreste, P.3
  • 17
    • 0032568934 scopus 로고    scopus 로고
    • The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists
    • Rusnati M, Tulipano G, Urbinati C, et al. The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists. J Biol Chem 1998; 273: 16027-37.
    • (1998) J Biol Chem , vol.273 , pp. 16027-16037
    • Rusnati, M.1    Tulipano, G.2    Urbinati, C.3
  • 18
    • 0035793619 scopus 로고    scopus 로고
    • Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans
    • Tyagi M, Rusnati M, Presta M, et al. Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 2001; 276: 3254-61.
    • (2001) J Biol Chem , vol.276 , pp. 3254-3261
    • Tyagi, M.1    Rusnati, M.2    Presta, M.3
  • 19
    • 0034802647 scopus 로고    scopus 로고
    • Heparin binding by the HIV-1 tat protein transduction domain
    • Hakansson S, Jacobs A, Caffrey M. Heparin binding by the HIV-1 tat protein transduction domain. Protein Sci 2001; 10: 2138-9.
    • (2001) Protein Sci , vol.10 , pp. 2138-2139
    • Hakansson, S.1    Jacobs, A.2    Caffrey, M.3
  • 20
    • 0041664911 scopus 로고    scopus 로고
    • Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states
    • Hakansson S, Caffrey M. Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states. Biochemistry 2003; 42: 8999-9006.
    • (2003) Biochemistry , vol.42 , pp. 8999-9006
    • Hakansson, S.1    Caffrey, M.2
  • 21
    • 0346688716 scopus 로고    scopus 로고
    • Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: Binding mechanism and thermodynamic parameters
    • Ziegler A, Seelig J. Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters. Biophys J 2004; 86: 254-63.
    • (2004) Biophys J , vol.86 , pp. 254-263
    • Ziegler, A.1    Seelig, J.2
  • 22
    • 0036159271 scopus 로고    scopus 로고
    • Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat
    • Silhol M, Tyagi M, Giacca M, et al. Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat. Eur J Biochem 2002; 269: 494-501.
    • (2002) Eur J Biochem , vol.269 , pp. 494-501
    • Silhol, M.1    Tyagi, M.2    Giacca, M.3
  • 23
    • 0034613057 scopus 로고    scopus 로고
    • The antennapedia peptide penetratin translocates across lipid bilayers - the first direct observation
    • Thoren PE, Persson D, Karlsson M, et al. The antennapedia peptide penetratin translocates across lipid bilayers - the first direct observation. FEBS Lett 2000; 482: 265-8.
    • (2000) FEBS Lett , vol.482 , pp. 265-268
    • Thoren, P.E.1    Persson, D.2    Karlsson, M.3
  • 24
    • 27744493266 scopus 로고    scopus 로고
    • Modeling the endosomal escape of cell-penetrating peptides: Transmembrane pH gradient driven translocation across phospholipid bilayers
    • Magzoub M, Pramanik A, Graslund A. Modeling the endosomal escape of cell-penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers. Biochemistry 2005; 44: 14890-7.
    • (2005) Biochemistry , vol.44 , pp. 14890-14897
    • Magzoub, M.1    Pramanik, A.2    Graslund, A.3
  • 25
    • 0035858295 scopus 로고    scopus 로고
    • ATTEMPTS: A heparin/protamine-based prodrug approach for delivery of thrombolytic drugs
    • Liang JF, Park YJ, Song H, et al. ATTEMPTS: a heparin/protamine-based prodrug approach for delivery of thrombolytic drugs. J Control Release 2001; 72: 145-56.
    • (2001) J Control Release , vol.72 , pp. 145-156
    • Liang, J.F.1    Park, Y.J.2    Song, H.3
  • 26
    • 0032170936 scopus 로고    scopus 로고
    • Delivery system for targeted thrombolysis without the risk of hemorrhage
    • Byun Y, Yang VC. Delivery system for targeted thrombolysis without the risk of hemorrhage. ASAIO J 1998; 44: M638-41.
    • (1998) ASAIO J , vol.44
    • Byun, Y.1    Yang, V.C.2
  • 27
    • 0037122735 scopus 로고    scopus 로고
    • ATTEMPTS: A heparin/protaminebased delivery system for enzyme drugs
    • Liang JF, Li YT, Song H, et al. ATTEMPTS: a heparin/protaminebased delivery system for enzyme drugs. J Control Release 2002; 78: 67-79.
    • (2002) J Control Release , vol.78 , pp. 67-79
    • Liang, J.F.1    Li, Y.T.2    Song, H.3
  • 28
    • 10044275517 scopus 로고    scopus 로고
    • Application of ATTEMPTS for drug delivery
    • Naik SS, Liang JF, Park YJ, et al. Application of ATTEMPTS for drug delivery. J Control Release 2005; 101: 35-45.
    • (2005) J Control Release , vol.101 , pp. 35-45
    • Naik, S.S.1    Liang, J.F.2    Park, Y.J.3
  • 29
    • 0037428958 scopus 로고    scopus 로고
    • ATTEMPTS: A heparin/protamine-based triggered release system for the delivery of enzyme drugs without associated side-effects
    • Park YJ, Liang JF, Song H, et al. ATTEMPTS: a heparin/protamine-based triggered release system for the delivery of enzyme drugs without associated side-effects. Adv Drug Deliv Rev 2003; 55: 251-65.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 251-265
    • Park, Y.J.1    Liang, J.F.2    Song, H.3
  • 30
    • 28244485412 scopus 로고    scopus 로고
    • Construction and characterization of a t-PA mutant for use in ATTEMPTS: A drug delivery system for achieving targeted thrombolysis
    • Yang VC, Naik SS, Song H, et al. Construction and characterization of a t-PA mutant for use in ATTEMPTS: a drug delivery system for achieving targeted thrombolysis. J Control Release 2005; 110: 164-76.
    • (2005) J Control Release , vol.110 , pp. 164-176
    • Yang, V.C.1    Naik, S.S.2    Song, H.3
  • 31
    • 0011967676 scopus 로고    scopus 로고
    • Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (I): Preparation and characterization
    • Chang LC, Lee HF, Yang Z, et al. Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (I): preparation and characterization. AAPS PharmSci 2001; 3: E17.
    • (2001) AAPS PharmSci , vol.3
    • Chang, L.C.1    Lee, H.F.2    Yang, Z.3
  • 32
    • 36148945638 scopus 로고    scopus 로고
    • In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cellpenetrating peptide
    • Moon C, Kwon YM, Lee WK, et al. In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cellpenetrating peptide. J Control Release 2007; 124: 43-50.
    • (2007) J Control Release , vol.124 , pp. 43-50
    • Moon, C.1    Kwon, Y.M.2    Lee, W.K.3
  • 33
    • 24644512176 scopus 로고    scopus 로고
    • Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: In vitro and in vivo study
    • Park YJ, Chang LC, Liang JF, et al. Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular protein delivery: in vitro and in vivo study. FASEB J 2005; 19: 1555-7.
    • (2005) FASEB J , vol.19 , pp. 1555-1557
    • Park, Y.J.1    Chang, L.C.2    Liang, J.F.3
  • 34
    • 2342476860 scopus 로고    scopus 로고
    • Low molecular weight protamine as an efficient and nontoxic gene carrier: In vitro study
    • Park YJ, Liang JF, Ko KS, et al. Low molecular weight protamine as an efficient and nontoxic gene carrier: in vitro study. J Gene Med 2003; 5: 700-11.
    • (2003) J Gene Med , vol.5 , pp. 700-711
    • Park, Y.J.1    Liang, J.F.2    Ko, K.S.3
  • 35
    • 36949025736 scopus 로고    scopus 로고
    • A novel polyrotaxane-based intracellular delivery system for camptothecin: In vitro feasibility evaluation
    • Moon C, Kwon YM, Lee WK, et al. A novel polyrotaxane-based intracellular delivery system for camptothecin: in vitro feasibility evaluation. J Biomed Mater Res A 2008; 84: 238-46.
    • (2008) J Biomed Mater Res A , vol.84 , pp. 238-246
    • Moon, C.1    Kwon, Y.M.2    Lee, W.K.3
  • 36
    • 72149099569 scopus 로고    scopus 로고
    • The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine
    • Choi YS, Lee JY, Suh JS, et al. The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine. Biomaterials 2010; 31: 1429-43.
    • (2010) Biomaterials , vol.31 , pp. 1429-1443
    • Choi, Y.S.1    Lee, J.Y.2    Suh, J.S.3
  • 37
    • 77953811833 scopus 로고    scopus 로고
    • Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1alpha-oligonucleotide
    • Park YS, Huang Y, Park YJ, et al. Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1alpha-oligonucleotide. J Control Release 2010; 144(1): 82-90.
    • (2010) J Control Release , vol.144 , Issue.1 , pp. 82-90
    • Park, Y.S.1    Huang, Y.2    Park, Y.J.3
  • 38
    • 0035783151 scopus 로고    scopus 로고
    • Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (II): In vitro evaluation of efficacy and toxicity
    • Chang LC, Liang JF, Lee HF, et al. Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (II): in vitro evaluation of efficacy and toxicity. AAPS PharmSci 2001; 3: E18.
    • (2001) AAPS PharmSci , vol.3
    • Chang, L.C.1    Liang, J.F.2    Lee, H.F.3
  • 39
    • 0035783265 scopus 로고    scopus 로고
    • Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): Preliminary in vivo evaluation of efficacy and toxicity using a canine model
    • Lee LM, Chang LC, Wrobleski S, et al. Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): preliminary in vivo evaluation of efficacy and toxicity using a canine model. AAPS PharmSci 2001; 3: E19.
    • (2001) AAPS PharmSci , vol.3
    • Lee, L.M.1    Chang, L.C.2    Wrobleski, S.3
  • 40
    • 0037237027 scopus 로고    scopus 로고
    • A less toxic heparin antagonist--low molecular weight protamine
    • Liang JF, Zhen L, Chang LC, et al. A less toxic heparin antagonist--low molecular weight protamine. Biochemistry (Mosc) 2003; 68: 116-20.
    • (2003) Biochemistry (Mosc) , vol.68 , pp. 116-120
    • Liang, J.F.1    Zhen, L.2    Chang, L.C.3
  • 41
    • 0035279632 scopus 로고    scopus 로고
    • Reduced reactivity towards antiprotamine antibodies of a low molecular weight protamine analogue
    • Tsui B, Singh VK, Liang JF, et al. Reduced reactivity towards antiprotamine antibodies of a low molecular weight protamine analogue. Thromb Res 2001; 101: 417-20.
    • (2001) Thromb Res , vol.101 , pp. 417-420
    • Tsui, B.1    Singh, V.K.2    Liang, J.F.3
  • 42
    • 50949115801 scopus 로고    scopus 로고
    • PTD-modified ATTEMPTS system for enhanced asparaginase therapy: A proof-of-concept investigation
    • Kwon YM, Li YT, Liang JF, et al. PTD-modified ATTEMPTS system for enhanced asparaginase therapy: a proof-of-concept investigation. J Control Release 2008; 130: 252-8.
    • (2008) J Control Release , vol.130 , pp. 252-258
    • Kwon, Y.M.1    Li, Y.T.2    Liang, J.F.3
  • 43
    • 0035958878 scopus 로고    scopus 로고
    • Conjugation of folate via gelonin carbohydrate residues retains ribosomalinactivating properties of the toxin and permits targeting to folate receptor positive cells
    • Atkinson SF, Bettinger T, Seymour LW, et al. Conjugation of folate via gelonin carbohydrate residues retains ribosomalinactivating properties of the toxin and permits targeting to folate receptor positive cells. J Biol Chem 2001; 276: 27930-5.
    • (2001) J Biol Chem , vol.276 , pp. 27930-27935
    • Atkinson, S.F.1    Bettinger, T.2    Seymour, L.W.3
  • 44
    • 0019212385 scopus 로고
    • Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A
    • Stirpe F, Olsnes S, Pihl A. Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J Biol Chem 1980; 255: 6947-53.
    • (1980) J Biol Chem , vol.255 , pp. 6947-6953
    • Stirpe, F.1    Olsnes, S.2    Pihl, A.3
  • 45
    • 57049170932 scopus 로고    scopus 로고
    • The ATTEMPTS delivery systems for macromolecular drugs
    • Kwon YM, Li Y, Naik S, et al. The ATTEMPTS delivery systems for macromolecular drugs. Expert Opin Drug Deliv 2008; 5: 1255-66.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 1255-1266
    • Kwon, Y.M.1    Li, Y.2    Naik, S.3
  • 46
    • 70349098869 scopus 로고    scopus 로고
    • Preliminary in vivo evaluation of the protein transduction domain-modified ATTEMPTS approach in enhancing asparaginase therapy
    • Li YT, Kwon YM, Spangrude GJ, et al. Preliminary in vivo evaluation of the protein transduction domain-modified ATTEMPTS approach in enhancing asparaginase therapy. J Biomed Mater Res A 2009; 91: 209-20.
    • (2009) J Biomed Mater Res A , vol.91 , pp. 209-220
    • Li, Y.T.1    Kwon, Y.M.2    Spangrude, G.J.3
  • 47
    • 0023788067 scopus 로고
    • Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
    • Dvorak HF, Nagy JA, Dvorak JT, et al. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 1988; 133: 95-109.
    • (1988) Am J Pathol , vol.133 , pp. 95-109
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, J.T.3
  • 48
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000; 65: 271-84.
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3
  • 49
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986; 46: 6387-92.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 50
    • 11144229887 scopus 로고    scopus 로고
    • Tumor imaging by means of proteolytic activation of cell-penetrating peptides
    • Jiang T, Olson ES, Nguyen QT, et al. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci USA 2004; 101: 17867-72.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17867-1772
    • Jiang, T.1    Olson, E.S.2    Nguyen, Q.T.3
  • 51
    • 77749335904 scopus 로고    scopus 로고
    • Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides
    • Aguilera TA, Olson ES, Timmers MM, et al. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr Biol (Camb) 2009; 1: 371-81.
    • (2009) Integr Biol (Camb) , vol.1 , pp. 371-381
    • Aguilera, T.A.1    Olson, E.S.2    Timmers, M.M.3
  • 52
    • 77749254873 scopus 로고    scopus 로고
    • Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival
    • Nguyen QT, Olson ES, Aguilera TA, et al. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci USA 2010; 107: 4317-22.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4317-4322
    • Nguyen, Q.T.1    Olson, E.S.2    Aguilera, T.A.3
  • 53
    • 34547657290 scopus 로고    scopus 로고
    • Enhanced transfection of tumor cells in vivo using Smart pH-sensitive TAT-modified pegylated liposomes
    • Kale AA, Torchilin VP. Enhanced transfection of tumor cells in vivo using Smart pH-sensitive TAT-modified pegylated liposomes. J Drug Target 2007; 15: 538-45.
    • (2007) J Drug Target , vol.15 , pp. 538-545
    • Kale, A.A.1    Torchilin, V.P.2
  • 54
    • 36248943575 scopus 로고    scopus 로고
    • Smart drug carriers: PEGylated TATpmodified pH-sensitive liposomes
    • Kale AA, Torchilin VP. Smart drug carriers: PEGylated TATpmodified pH-sensitive liposomes. J Liposome Res 2007; 17: 197-203.
    • (2007) J Liposome Res , vol.17 , pp. 197-203
    • Kale, A.A.1    Torchilin, V.P.2
  • 55
    • 27744443447 scopus 로고    scopus 로고
    • Interactions of primary amphipathic cell penetrating peptides with model membranes: Consequences on the mechanisms of intracellular delivery of therapeutics
    • Deshayes S, Morris MC, Divita G, Heitz F. Interactions of primary amphipathic cell penetrating peptides with model membranes: consequences on the mechanisms of intracellular delivery of therapeutics. Curr Pharm Des 2005; 11(28): 3629-38.
    • (2005) Curr Pharm Des , vol.11 , Issue.28 , pp. 3629-3638
    • Deshayes, S.1    Morris, M.C.2    Divita, G.3    Heitz, F.4
  • 56
    • 59849102702 scopus 로고    scopus 로고
    • Protein transduction revisited: Novel insights into the mechanism underlying intracellular delivery of proteins
    • Edenhofer F. Protein transduction revisited: novel insights into the mechanism underlying intracellular delivery of proteins. Curr Pharm Des 2008; 14(34): 3628-36.
    • (2008) Curr Pharm Des , vol.14 , Issue.34 , pp. 3628-3636
    • Edenhofer, F.1
  • 57
    • 69249117394 scopus 로고    scopus 로고
    • Current prodrug design for drug discovery
    • Hsieh PW, Hung CF, Fang JY. Current prodrug design for drug discovery. Curr Pharm Des 2009; 15(19): 2236-50.
    • (2009) Curr Pharm Des , vol.15 , Issue.19 , pp. 2236-2250
    • Hsieh, P.W.1    Hung, C.F.2    Fang, J.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.