메뉴 건너뛰기




Volumn 9, Issue 1, 2012, Pages 54-67

Exogenous Testosterone, Cardiovascular Events, and Cardiovascular Risk Factors in Elderly Men: A Review of Trial Data

Author keywords

Cardiovascular Events; Cardiovascular Risk; Elderly Men; Exogenous Testosterone; Hypogonadal; Testosterone Treatment

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TESTOSTERONE; TESTOSTERONE UNDECANOATE; TISSUE FACTOR PATHWAY INHIBITOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84855360204     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02337.x     Document Type: Article
Times cited : (65)

References (59)
  • 1
    • 4344674127 scopus 로고    scopus 로고
    • Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: The MINOS study
    • Szulc P, Duboeuf F, Marchand F, Delmas PD. Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: The MINOS study. Am J Clin Nutr 2004;80:496-503.
    • (2004) Am J Clin Nutr , vol.80 , pp. 496-503
    • Szulc, P.1    Duboeuf, F.2    Marchand, F.3    Delmas, P.D.4
  • 2
    • 0036904691 scopus 로고    scopus 로고
    • Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
    • Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 2002;57A:M772-7.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57 A
    • Iannuzzi-Sucich, M.1    Prestwood, K.M.2    Kenny, A.M.3
  • 3
    • 26444515048 scopus 로고    scopus 로고
    • The decline of androgen levels in elderly men and its clinical and therapeutic implications
    • Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833-76.
    • (2005) Endocr Rev , vol.26 , pp. 833-876
    • Kaufman, J.M.1    Vermeulen, A.2
  • 5
    • 76149135996 scopus 로고    scopus 로고
    • Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: A randomized, double-blind, placebo-controlled study
    • Srinivas-Shankar U, Roberts SA, Connolly MJ, O'Connell MD, Adams JE, Oldham JA, Wu FC. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: A randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010;95:639-50.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 639-650
    • Srinivas-Shankar, U.1    Roberts, S.A.2    Connolly, M.J.3    O'Connell, M.D.4    Adams, J.E.5    Oldham, J.A.6    Wu, F.C.7
  • 10
    • 33744781458 scopus 로고    scopus 로고
    • Testosterone and atherosclerosis in aging men: Purported association and clinical implications
    • Jones RD, Nettleship JE, Kapoor D, Jones HT, Channer KS. Testosterone and atherosclerosis in aging men: Purported association and clinical implications. Am J Cardiovasc Drugs 2005;5:141-54.
    • (2005) Am J Cardiovasc Drugs , vol.5 , pp. 141-154
    • Jones, R.D.1    Nettleship, J.E.2    Kapoor, D.3    Jones, H.T.4    Channer, K.S.5
  • 11
    • 70349859846 scopus 로고    scopus 로고
    • Gender differences in the cardiovascular effect of sex hormones
    • Vitale C, Mendelsohn ME, Rosano GM. Gender differences in the cardiovascular effect of sex hormones. Nat Rev Cardiol 2009;6:532-42.
    • (2009) Nat Rev Cardiol , vol.6 , pp. 532-542
    • Vitale, C.1    Mendelsohn, M.E.2    Rosano, G.M.3
  • 12
    • 77955272470 scopus 로고    scopus 로고
    • Testosterone deficiency: A risk factor for cardiovascular disease?
    • Jones TH. Testosterone deficiency: A risk factor for cardiovascular disease? Trends Endocrinol Metab 2010;21:496-503.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 496-503
    • Jones, T.H.1
  • 13
    • 70549086629 scopus 로고    scopus 로고
    • The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process
    • Jones TH, Saad F. The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process. Atherosclerosis 2009;207:318-27.
    • (2009) Atherosclerosis , vol.207 , pp. 318-327
    • Jones, T.H.1    Saad, F.2
  • 14
    • 78349305091 scopus 로고    scopus 로고
    • Low serum testosterone and increased mortality in men with coronary heart disease
    • Malkin CJ, Pugh PJ, Morris PD, Asif S, Jones TH, Channer KS. Low serum testosterone and increased mortality in men with coronary heart disease. Heart 2010;96:1821-5.
    • (2010) Heart , vol.96 , pp. 1821-1825
    • Malkin, C.J.1    Pugh, P.J.2    Morris, P.D.3    Asif, S.4    Jones, T.H.5    Channer, K.S.6
  • 17
    • 0036398754 scopus 로고    scopus 로고
    • Cardiovascular effects of androgens
    • Weidemann W, Hanke H. Cardiovascular effects of androgens. Cardiovasc Drug Rev 2002;20:175-98.
    • (2002) Cardiovasc Drug Rev , vol.20 , pp. 175-198
    • Weidemann, W.1    Hanke, H.2
  • 19
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials
    • Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S. Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 2005;60:1451-7.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3    Kenny, A.M.4    Urban, R.J.5    Tenover, J.L.6    Bhasin, S.7
  • 27
    • 64649083354 scopus 로고    scopus 로고
    • The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
    • Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis. BMC Public Health 2009;9:1-20.
    • (2009) BMC Public Health , vol.9 , pp. 1-20
    • Guh, D.P.1    Zhang, W.2    Bansback, N.3    Amarsi, Z.4    Birmingham, C.L.5    Anis, A.H.6
  • 28
    • 77953326025 scopus 로고    scopus 로고
    • Cardiovascular disease and androgens: A review
    • Kaushik M, Sontineni SP, Hunter C. Cardiovascular disease and androgens: A review. Int J Cardiol 2010;142:8-14.
    • (2010) Int J Cardiol , vol.142 , pp. 8-14
    • Kaushik, M.1    Sontineni, S.P.2    Hunter, C.3
  • 29
    • 0034108483 scopus 로고    scopus 로고
    • Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms
    • English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, Channer KS. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J 2000;21:890-4.
    • (2000) Eur Heart J , vol.21 , pp. 890-894
    • English, K.M.1    Mandour, O.2    Steeds, R.P.3    Diver, M.J.4    Jones, T.H.5    Channer, K.S.6
  • 30
    • 68949172537 scopus 로고    scopus 로고
    • Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study
    • Caminiti G, Volterrani M, Iellamo F, Marazzi G, Massaro R, Miceli M, Mammi C, Piepoli M, Fini M, Rosano GM. Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 2009;54:919-27.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 919-927
    • Caminiti, G.1    Volterrani, M.2    Iellamo, F.3    Marazzi, G.4    Massaro, R.5    Miceli, M.6    Mammi, C.7    Piepoli, M.8    Fini, M.9    Rosano, G.M.10
  • 32
    • 32144435225 scopus 로고    scopus 로고
    • Physiologic testosterone therapy has no effect on serum levels of tumour necrosis factor-alpha in men with chronic heart failure
    • Pugh PJ, Jones RD, Malkin CJ, Hall J, Nettleship JE, Kerry KE, Jones TH, Channer KS. Physiologic testosterone therapy has no effect on serum levels of tumour necrosis factor-alpha in men with chronic heart failure. Endocr Res 2005;31:271-83.
    • (2005) Endocr Res , vol.31 , pp. 271-283
    • Pugh, P.J.1    Jones, R.D.2    Malkin, C.J.3    Hall, J.4    Nettleship, J.E.5    Kerry, K.E.6    Jones, T.H.7    Channer, K.S.8
  • 33
    • 28944442442 scopus 로고    scopus 로고
    • Testosterone therapy in men with moderate severity heart failure: A double-blind randomized placebo controlled trial
    • Malkin CJ, Pugh PJ, West JN, van Beek EJ, Jones TH, Channer KS. Testosterone therapy in men with moderate severity heart failure: A double-blind randomized placebo controlled trial. Eur Heart J 2006;27:57-64.
    • (2006) Eur Heart J , vol.27 , pp. 57-64
    • Malkin, C.J.1    Pugh, P.J.2    West, J.N.3    van Beek, E.J.4    Jones, T.H.5    Channer, K.S.6
  • 34
    • 33846045511 scopus 로고    scopus 로고
    • The effect of testosterone on insulin sensitivity in men with heart failure
    • Malkin CJ, Jones TH, Channer KS. The effect of testosterone on insulin sensitivity in men with heart failure. Eur J Heart Fail 2007;9:44-50.
    • (2007) Eur J Heart Fail , vol.9 , pp. 44-50
    • Malkin, C.J.1    Jones, T.H.2    Channer, K.S.3
  • 36
    • 77954620668 scopus 로고    scopus 로고
    • Testosterone deficiency and exercise intolerance in heart failure: Treatment implications
    • Iellamo F, Rosano G, Volterrani M. Testosterone deficiency and exercise intolerance in heart failure: Treatment implications. Curr Heart Fail Rep 2010;7:59-65.
    • (2010) Curr Heart Fail Rep , vol.7 , pp. 59-65
    • Iellamo, F.1    Rosano, G.2    Volterrani, M.3
  • 37
    • 41949099962 scopus 로고    scopus 로고
    • Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease
    • Webb CM, Elkington AG, Kraidly MM, Keenan N, Pennell DJ, Collins P. Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease. Am J Cardiol 2008;101:618-24.
    • (2008) Am J Cardiol , vol.101 , pp. 618-624
    • Webb, C.M.1    Elkington, A.G.2    Kraidly, M.M.3    Keenan, N.4    Pennell, D.J.5    Collins, P.6
  • 38
    • 3242717140 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life
    • Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, Channer KS. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart 2004;90:871-6.
    • (2004) Heart , vol.90 , pp. 871-876
    • Malkin, C.J.1    Pugh, P.J.2    Morris, P.D.3    Kerry, K.E.4    Jones, R.D.5    Jones, T.H.6    Channer, K.S.7
  • 39
    • 3242667701 scopus 로고    scopus 로고
    • The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
    • Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab 2004;89:3313-8.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3313-3318
    • Malkin, C.J.1    Pugh, P.J.2    Jones, R.D.3    Kapoor, D.4    Channer, K.S.5    Jones, T.H.6
  • 40
    • 14644391580 scopus 로고    scopus 로고
    • Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina
    • Smith AM, English KM, Malkin CJ, Jones RD, Jones TH, Channer KS. Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina. Eur J Endocrinol 2005;152:285-91.
    • (2005) Eur J Endocrinol , vol.152 , pp. 285-291
    • Smith, A.M.1    English, K.M.2    Malkin, C.J.3    Jones, R.D.4    Jones, T.H.5    Channer, K.S.6
  • 41
    • 70349242235 scopus 로고    scopus 로고
    • Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men
    • Mathur A, Malkin C, Saeed B, Muthusamy R, Jones TH, Channer K. Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men. Eur J Endocrinol 2009;161:443-9.
    • (2009) Eur J Endocrinol , vol.161 , pp. 443-449
    • Mathur, A.1    Malkin, C.2    Saeed, B.3    Muthusamy, R.4    Jones, T.H.5    Channer, K.6
  • 42
    • 77953286935 scopus 로고    scopus 로고
    • Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease
    • Cornoldi A, Caminiti G, Marazzi G, Vitale C, Patrizi R, Volterrani M, Miceli M, Fini M, Spera G, Rosano G. Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease. Int J Cardiol 2010;142:50-5.
    • (2010) Int J Cardiol , vol.142 , pp. 50-55
    • Cornoldi, A.1    Caminiti, G.2    Marazzi, G.3    Vitale, C.4    Patrizi, R.5    Volterrani, M.6    Miceli, M.7    Fini, M.8    Spera, G.9    Rosano, G.10
  • 43
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study. Circulation 2000;102:1906-11.
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 44
    • 0033584717 scopus 로고    scopus 로고
    • Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease
    • Webb CM, McNeill JG, Hayward CS, de Zeigler D, Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 1999;100:1690-6.
    • (1999) Circulation , vol.100 , pp. 1690-1696
    • Webb, C.M.1    McNeill, J.G.2    Hayward, C.S.3    de Zeigler, D.4    Collins, P.5
  • 46
    • 33644981693 scopus 로고    scopus 로고
    • Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis
    • Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis. JAMA 2006;295:1288-99.
    • (2006) JAMA , vol.295 , pp. 1288-1299
    • Ding, E.L.1    Song, Y.2    Malik, V.S.3    Liu, S.4
  • 47
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • Kapoor D, Goodwin E, Channer KS, Jones TH. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol 2006;154:899-906.
    • (2006) Eur J Endocrinol , vol.154 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4
  • 48
    • 34249103249 scopus 로고    scopus 로고
    • The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes
    • Kapoor D, Clarke S, Stanworth R, Channer KS, Jones TH. The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. Eur J Endocrinol 2007;156:595-602.
    • (2007) Eur J Endocrinol , vol.156 , pp. 595-602
    • Kapoor, D.1    Clarke, S.2    Stanworth, R.3    Channer, K.S.4    Jones, T.H.5
  • 49
    • 69949178483 scopus 로고    scopus 로고
    • Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone
    • Heufelder AE, Saad F, Bunck MC, Gooren L. Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J Androl 2009;30:726-33.
    • (2009) J Androl , vol.30 , pp. 726-733
    • Heufelder, A.E.1    Saad, F.2    Bunck, M.C.3    Gooren, L.4
  • 50
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blind placebo-controlled Moscow study
    • Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ, Saad F. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blind placebo-controlled Moscow study. Clin Endocrinol (Oxf) 2010;73:602-12.
    • (2010) Clin Endocrinol (Oxf) , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3    Gooren, L.J.4    Giltay, E.J.5    Saad, F.6
  • 51
    • 77957567733 scopus 로고    scopus 로고
    • Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study
    • Aversa A, Bruzziches R, Francomano D, Rosano G, Isidori AM, Lenzi A, Spera G. Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study. J Sex Med 2010;7:3495-503.
    • (2010) J Sex Med , vol.7 , pp. 3495-3503
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3    Rosano, G.4    Isidori, A.M.5    Lenzi, A.6    Spera, G.7
  • 52
    • 3042742257 scopus 로고    scopus 로고
    • Metabolic and inflammation variable clusters and prediction of type 2 diabetes: Factor analysis using directly measured insulin sensitivity
    • Hanley AJ, Festa A, D'Agostino RB Jr, Wagenknecht LE, Savage PJ, Tracy RP, Saad MF, Haffner SM. Metabolic and inflammation variable clusters and prediction of type 2 diabetes: Factor analysis using directly measured insulin sensitivity. Diabetes 2004;53:1773-81.
    • (2004) Diabetes , vol.53 , pp. 1773-1781
    • Hanley, A.J.1    Festa, A.2    D'Agostino Jr, R.B.3    Wagenknecht, L.E.4    Savage, P.J.5    Tracy, R.P.6    Saad, M.F.7    Haffner, S.M.8
  • 53
    • 38149032364 scopus 로고    scopus 로고
    • Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men
    • Allan CA, Strauss BJ, Burger HG, Forbes EA, McLachlan RI. Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. J Clin Endocrinol Metab 2008;93:139-46.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 139-146
    • Allan, C.A.1    Strauss, B.J.2    Burger, H.G.3    Forbes, E.A.4    McLachlan, R.I.5
  • 55
    • 70449585552 scopus 로고    scopus 로고
    • Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels
    • Agledahl I, Brodin E, Svartberg J, Hansen JB. Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels. Thromb Haemost 2009;102:945-50.
    • (2009) Thromb Haemost , vol.102 , pp. 945-950
    • Agledahl, I.1    Brodin, E.2    Svartberg, J.3    Hansen, J.B.4
  • 56
    • 33845968457 scopus 로고    scopus 로고
    • Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men
    • Katznelson L, Robinson MW, Coyle CL, Lee H, Farrell CE. Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Eur J Endocrinol 2006;155:867-75.
    • (2006) Eur J Endocrinol , vol.155 , pp. 867-875
    • Katznelson, L.1    Robinson, M.W.2    Coyle, C.L.3    Lee, H.4    Farrell, C.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.