Effects of Oral Testosterone Treatment on Myocardial Perfusion and Vascular Function in Men With Low Plasma Testosterone and Coronary Heart Disease

American Journal of Cardiology

Volumn 101, Issue 5, 2008, Pages 618-624

  Webb, Carolyn M ^a,b   Elkington, Andrew G ^b   Kraidly, Mustafa M ^a,b   Keenan, Niall ^b   Pennell, Dudley J ^a,b   Collins, Peter ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ANDROSTANOLONE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; BLOOD CLOTTING FACTOR 7; ESTRADIOL; FIBRINOGEN; FOLLITROPIN; GLUCOSE; GLYCERYL TRINITRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LUTEINIZING HORMONE; PLASMINOGEN ACTIVATOR; SALBUTAMOL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE UNDECANOATE; ANDROGEN; DRUG DERIVATIVE; LIPOPROTEIN; TESTOSTERONE;

ADULT; AGED; ANGINA PECTORIS; ANTHROPOMETRY; AORTA; ARTERIAL STIFFNESS; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; CROSSOVER PROCEDURE; ENDOTHELIUM CELL; EXERCISE; FIRST PASS EFFECT; HEART MUSCLE PERFUSION; HEMOSTASIS; HUMAN; ISCHEMIC HEART DISEASE; MALE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PULSE WAVE; QUALITY OF LIFE; RADIAL ARTERY; RANDOMIZED CONTROLLED TRIAL; TONOMETRY; BLOOD; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CORONARY ARTERY DISEASE; DRUG EFFECT; HEART STROKE VOLUME; HEMATOCRIT; HIP; HISTOLOGY; MANOMETRY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; ORAL DRUG ADMINISTRATION; VASCULAR ENDOTHELIUM;

ADMINISTRATION, ORAL; ADULT; AGED; ANDROGENS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CORONARY CIRCULATION; CORONARY DISEASE; CROSS-OVER STUDIES; ENDOTHELIUM, VASCULAR; HEMATOCRIT; HIP; HUMANS; LIPOPROTEINS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MANOMETRY; MIDDLE AGED; STROKE VOLUME; TESTOSTERONE;

EID: 41949099962     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2007.09.114     Document Type: Article

References (27)

1. Wu F.C., and von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 24 (2003) 183-217
2. Webb C.M., McNeill J.G., Hayward C.S., de Ziegler D., and Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary artery disease. Circulation 100 (1999) 1690-1696
3. English K.M., Steeds R.P., Jones T.H., Diver M.J., and Channer K.S. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 102 (2000) 1906-1911
4. Christian T.F., Rettmann D.W., Aletras A.H., Liao S.L., Taylor J.L., Balaban R.S., and Arai A.E. Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging. Radiology 232 (2004) 677-684
5. Elkington A.G., Ablitt N.A., Yang G.Z., Firmin D.N., and Pennell D.J. Interstudy reproducibility of quantitative perfusion cardiovascular magnetic resonance. J Cardiovasc Magn Reson 7 (2005) 815-822
6. Maceira A.M., Prasad S.K., Khan M., and Pennell D.J. Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 8 (2006) 417-426
7. Jerosch-Herold M., Wilke N., and Stillman A.E. Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution. Med Phys 25 (1988) 73-84
8. Hayward C.S., Kraidly M., Webb C.M., and Collins P. Assessment of endothelial function using peripheral waveform analysis. A clinical application. J Am Coll Cardiol 40 (2002) 521-528
9. Stewart A.L., Hays R.D., and Ware Jr. J.E. The MOS short-form general health survey. Reliability and validity in a patient population. Med Care 26 (1988) 724-735
10. Wahrborg P., and Emanuelsson H. The Cardiac Health Profile: content, reliability and validity of a new disease-specific quality of life questionnaire. Coron Artery Dis 7 (1996) 823-829
11. Daig I., Heinemann L.A., Kim S., Leungwattanakij S., Badia X., Myon E., Moore C., Saad F., Potthoff P., and Thai D.M. The Aging Males' Symptoms (AMS) Scale: review of its methodological characteristics. Health Qual Life Outcomes 1 (2003) 77
12. London G., Guerin A., Pannier B., Marchais S., Benetos A., and Safar M. Increased systolic pressure in chronic uremia. Role of arterial wave reflections. Hypertension 20 (1992) 10-19
13. Panting J.R., Gatehouse P.D., Yang G.Z., Grothues F., Firmin D.N., Collins P., and Pennell D.J. Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. N Engl J Med 346 (2002) 1948-1953
14. Ahimastos A.A., Formosa M., Dart A.M., and Kingwell B.A. Gender differences in large artery stiffness pre- and post puberty. J Clin Endocrinol Metab 88 (2003) 5375-5380
15. Hougaku H., Fleg J.L., Najjar S.S., Lakatta E.G., Harman S.M., Blackman M.R., and Metter E.J. Relationship between androgenic hormones and arterial stiffness based on longitudinal hormone measurements. Am J Physiol 290 (2006) E234-E242
16. Willum-Hansen T., Staessen J.A., Torp-Pedersen C., Rasmussen S., Thijs L., Ibsen H., and Jeppesen J. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 113 (2006) 664-670
17. Mattace-Raso F.U., van der Cammen T.J., Hofman A., van Popele N.M., Bos M.L., Schalekamp M.A., Asmar R., Reneman R.S., Hoeks A.P., Breteler M.M., and Witteman J.C. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113 (2006) 657-663
18. Kang S.M., Jang Y., Kim J.Y., Chung N., Cho S.Y., Chae J.S., and Lee J.H. Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Am J Cardiol 89 (2002) 862-864
19. Orshal J.M., and Khalil R.A. Gender, sex hormones, and vascular tone. Am J Physiol 286 (2004) R233-R249
20. Gonzales R.J., Ghaffari A.A., Duckles S.P., and Krause D.N. Testosterone treatment increases thromboxane function in rat cerebral arteries. Am J Physiol 289 (2005) H578-H585
21. Dobrzycki S., Serwatka W., Nadlewski S., Korecki J., Jackowski R., Paruk J., Ladny J.R., and Hirnle T. An assessment of correlations between endogenous sex hormone levels and the extensiveness of coronary heart disease and the ejection fraction of the left ventricle in males. J Med Invest 50 (2003) 162-169
22. Golden K.L., Marsh J.D., Jiang Y., Brown T., and Moulden J. Gonadectomy of adult male rats reduces contractility of isolated cardiac myocytes. Am J Physiol 285 (2003) E449-E453
23. Scheuer J., Malhotra A., Schaible T.F., and Capasso J. Effects of gonadectomy and hormonal replacement on rat hearts. Circ Res 61 (1987) 12-19
24. Schaible T.F., Malhotra A., Ciambrone G., and Scheuer J. The effects of gonadectomy on left ventricular function and cardiac contractile proteins in male and female rats. Circ Res 54 (1984) 38-49
25. Nieschlag E., Mauss J., Coert A., and Kicovic P. Plasma androgen levels in men after oral administration of testosterone or testosterone undecanoate. Acta Endocrinol 79 (1975) 366-374
26. Hirschhauser C., Hopkinson C.R., Sturm G., and Coert A. Testosterone undecanoate: a new orally active androgen. Acta Endocrinol 80 (1975) 179-187
27. Jaffe M.D. Effect of testosterone cypionate on postexercise ST segment depression. Br Heart J 39 (1977) 1217-1222