The antibody response to an HLA mismatch: A model for nonself-self discrimination in relation to HLA epitope immunogenicity

International Journal of Immunogenetics

Volumn 39, Issue 1, 2012, Pages 1-9

  Duquesnoy, R J ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; EPITOPE; HLA ANTIGEN; IMMUNOGLOBULIN RECEPTOR;

ALLELE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; B LYMPHOCYTE ACTIVATION; GENE REARRANGEMENT; HISTOINCOMPATIBILITY; HLA MATCHING; HUMAN; IMMUNOGENICITY; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR MODEL; PRIORITY JOURNAL; REVIEW;

ALLELES; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; B-LYMPHOCYTES; BLOOD TRANSFUSION; EPITOPES; GENE REARRANGEMENT, B-LYMPHOCYTE; HLA ANTIGENS; HUMANS; ISOANTIBODIES; MODELS, IMMUNOLOGICAL;

EID: 84855345368     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/j.1744-313X.2011.01042.x     Document Type: Review

References (65)

1. Babor, M. & Kortemme, T. (2009) Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility. Proteins, 75, 846.
2. Barbetti, A.A., Park, M.S., Terasaki, P.I., Clark, B. & Fan, J.L. (1989) HLA serologic epitopes. Clinical Transplants, 477.
3. Bogan, A.A. & Thorn, K.S. (1998) Anatomy of hot spots in protein interfaces. Journal of Molecular Biology, 280, 1.
4. Burnet, F.M. (1959) The Clonal Selection Theory of Acquired Immunity. Cambridge Univ. Press, Cambridge, UK.
5. Burnet, F. (1969) Self and Not-Self. Melbourne Univ Press and Cambridge Univ Press, Cambridge, UK.
6. Burnet, F. & Fenner, F. (1949) The Production of Antibodies. Macmillan, Melbourne.
7. Chothia, C. & Lesk, A. (1987) Canonical structures for the hypervariable regions of immunoglobulins. Journal of Molecular Biology, 196, 901.
8. Cohen, I. (1992) The cognitive priciple challenges clonal selection. Immunology Today, 13, 441.
9. Cohn, M., Mitchison, N.A., Paul, W., Silverstein, A.M., Talmage, D. & Weigert, M. (2007) Reflections on the clonal-selection theory. Nature Reviews Immunology, 7, 823.
10. Davies, D., Padlan, E. & Sheriff, S. (1990) Antibody-antigen complexes. Annual Review of Biochemistry, 59, 439.
11. Duquesnoy, R.J. (2006) A structurally based approach to determine HLA compatibility at the humoral immune level. Human Immunology, 67, 847.
12. Duquesnoy, R. (2008) Clinical usefulness of HLAMatchmaker in HLA epitope matching for organ transplantation. Current Opinion in Immunology, 20, 594.
13. Duquesnoy, R. & Marrari, M. (2009a) Correlations between Terasaki's HLA class I epitopes and HLAMatchmaker-defined eplets on HLA-A, -B and -C antigens. Tissue Antigens, 74, 117.
14. Duquesnoy, R.J. & Marrari, M. (2009b) HLAMatchmaker-based definition of structural HLA epitopes detected by alloantibodies. Current Opinion in Organ Transplantation, 14, 403.
15. Duquesnoy, R.J., White, L.T., Fierst, J.W., Vanek, M., Banner, B.F., Iwaki, Y. et al. (1990) Multiscreen serum analysis of highly sensitized renal dialysis patients for antibodies toward public and private class I HLA determinants. Implications for computer-predicted acceptable and unacceptable donor mismatches in kidney transplantation. Transplantation, 50, 427.
16. Duquesnoy, R.J., Mulder, A., Askar, M., Fernandez-Vina, M. & Claas, F.H.J. (2005) HLAMatchmaker-based analysis of human monoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes. Human Immunology, 66, 749.
17. El-Awar, N.R., Akaza, T., Terasaki, P.I. & Nguyen, A. (2007) Human leukocyte antigen class I epitopes: update to 103 total epitopes, including the C locus. Transplantation, 84, 532.
18. Fuller, A.A., Rodey, G.E., Parham, P. & Fuller, T.C. (1990a) Epitope map of the HLA-B7 CREG using affinity-purified human alloantibody probes. Human Immunology, 28, 306.
19. Fuller, A.A., Trevithick, J.E., Rodey, G.E., Parham, P. & Fuller, T.C. (1990b) Topographic map of the HLA-A2 CREG epitopes using human alloantibody probes. Human Immunology, 28, 284.
20. Gay, D., Saunders, T., Camper, S. & Weigert, M. (1993) Receptor editing: an approach by autoreactive B cells to escape tolerance. Journal of Experimental Medicine, 177, 999.
21. Getzoff, E.D., Tainer, J.A., Lerner, R.A. & Geysen, H.M. (1988) The chemistry and mechanisnm of antibody binding to protein antigens. Advances in Immunology, 43, 1.
22. Harpprecht, J., Olde, K., Westphal, E. & Muller-Ruchholtz, W. (1989) Serological mapping of HLA-epitopes with monoclonal antibodies and its interpretation by sequenced HLA-molecules. Tissue Antigens, 34, 170.
23. Hayakawa, K., Asano, M., Shinton, S., Gui, M., Allman, D., Stewart, C. et al. (1999) Positive selection of natural autoreactive B cells. Science, 285, 113.
24. Heltemes, L. & Manser, T. (2002) Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development. Journal of Immunology, 169, 1283.
25. Hildebrand, W.H., Madrigal, J.A., Belich, M.P., Zemmour, J., Ward, F.E., Williams, R.C. et al. (1992a) Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix. Journal of Immunology, 149, 3563.
26. Hildebrand, W.H., Madrigal, J.A., Little, A.M. & Parham, P. (1992b) HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix. Journal of Immunology, 148, 1155.
27. Hogue, C. (1997) Cn3D: a new generation of three-dimensional molecular structure viewer. Trends in Biochemical Sciences, 22, 314.
28. Hulsmeyer, M., Chames, P., Hillig, R., Stanfield, R., Held, G., Coulie, P. et al. (2005) A major histocompatibility complex-peptide-restricted antibody and T cell receptor molecules recognize their Target by distinct binding modes. Crystal structure of human leukocyte antigen (HLA)-A1 -MAGE-A1 complex with Fab-Hyb3. Journal of Biological Chemistry, 280, 2972.
29. Janeway, C. (1992) The immune system evolved to discriminate infectious nonself from noninfectious self. Immunology Today, 13, 11.
30. Jerne, N.K. (1955) The natural selection theory of antibody formation. Proceedings of the National Academy of Sciences of the United States of America, 41, 849.
31. Jerne, N. (1974) Towards a network theory of the immune system. Annals de l"Institute Pasteur Immunol (Paris), 125, 373.
32. Kabat, E.A. (1978) The structural basis of antibody complementarity. Advances in Protein Chemistry, 32, 1.
33. Kabat, E.A., Wu, T. & Bilofsky, H. (1977) Unusual distribution of amino acids in complementarity-determining (hypervarible) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody-combining sites. Journal of Biological Chemistry, 252, 6609.
34. Kim, S., Davis, M., Sinn, E., Patten, P. & Hood, L. (1981) Antibody diversity: somatic hypermutation of rearranged VH genes. Cell, 27, 573.
35. Kuroda, D., Shirai, H., Kobori, M. & Nakamura, H. (2009) Systematic classification of CDR-L3 in antibodies: implications of the light chain subtypes and the VL-VH interface. Proteins, 75, 139.
36. Laune, D., Molina, K., Ferrieres, G., Mani, J.-C., Cohen, P., Simon, D. et al. (1997) Systematic exploration of the antigen binding activity of synthetic peptides isolated from the variable regions of immunoglobulins. Journal of Biological Chemistry, 272, 30937.
37. Lederberg, J. (1959) Genes and antibodies: do antigens bear instructions for antibody specificity or do they select cell lines that arise by mutation? Science, 129, 1649.
38. Lutz, C.T., Smith, K.D., Greazel, N.S., Mace, B.E., Jensen, D.A., McCutcheon, J.A. et al. (1994) Bw4-reactive and Bw6-reactive antibodies recognize multiple distinct HLA structures that partially overlap in the alpha-1 helix. Journal of Immunology, 153, 4099.
39. MacCallum, R.M., Martin, A.C.R. & Thornton, J.M. (1996) Antibody-antigen interactions: contact analysis and binding site topography. Journal of Molecular Biology, 262, 732.
40. Marrari, M. & Duquesnoy, R. (2009) Correlations between Terasaki's HLA class II epitopes and HLAMatchmaker-defined eplets on HLA-DR, -DQ and -DP antigens. Tissue Antigens, 74, 134.
41. Marrari, M., Mostecki, J., Mulder, A., Balazs, I., Claas, F. & Duquesnoy, R. (2010) Human monoclonal antibody reactivity with HLA class I epitopes defined by pairs of mismatched eplets and self eplets. Transplantation, 90, 1468.
42. Matzinger, P. (1994) Tolerance, danger, and the extended family. Annual Review of Immunology, 12, 991.
43. McCutcheon, J.A. & Lutz, C.T. (1992) Mutagenesis around residue 176 on HLA-B*0702 characterizes multiple distinct epitopes for anti-HLA antibodies. Human Immunology, 35, 125.
44. McCutcheon, J.A., Smith, K.D., Valenzuela, A., Aalbers, K. & Lutz, C.T. (1993) HLA-B*0702 antibody epitopes are affected indirectly by distant antigen residues. Human Immunology, 36, 69.
45. Morris, S., Moroldo, M., Giannini, E., Orekhova, T. & Finkelman, F. (2000) In vivo survival of autoreactive B cells: characterization of long-lived B cells. Journal of Immunology, 164, 3035.
46. Mulder, M., Eijsink, C., Kester, M.G.D., Franke, M.E.I., Kardol, M.J., Heemskerk, M.H.M. et al. (2005) Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies. Journal of Immunology, 175, 5950.
47. Nossal, G. & Pike, B. (1980) Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proceedings of the National Academy of Sciences of the United States of America, 77, 1602.
48. Novotny, J. (1991) Protein antigenicity: a thermodynamic approach. Molecular Immunology, 28, 201.
49. Padlan, E.A. (1994) Anatomy of the antibody molecule. Molecular Immunology, 31, 169.
50. Park, M.S., Barbetti, A.A., Geer, L.I., Clark, B.D., Terasaki, P.I., Aoki, J. et al. (1990) HLA epitopes detected by serology. Clinical Transplants, 515.
51. Pelanda, R. & Torre, R. (2006) Receptor editing for better or for worse. Current Opinion in Immunology, 18, 184.
52. Pillai, S., Cariappa, A. & Moran, S. (2004) Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunological Reviews, 197, 206.
53. Poljak, R., Amzel, L., Avey, H., Chen, B., Phizackerley, R. & Saul, F. (1973) Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2, 8-A resolution. Proceedings of the National Academy of Sciences of the United States of America, 70, 3305.
54. Pradeu, T. & Carosella, E. (2006) On the definition of a criterion of immunogenicity. Proceedings of the National Academy of Sciences of the United States of America, 103, 17858.
55. Rodey, G.E., Neylan, J.F., Whelchel, J.D., Revels, K.W. & Bray, R.A. (1994) Epitope specificity of HLA class I alloantibodies. I. Frequency analysis of antibodies to private versus public specificities in potential transplant recipients. Human Immunology, 39, 272.
56. Schroeder Jr, H., Zemlin, M., Khass, M., Nguyen, H. & Schelonka, R. (2010) Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production. Critical Reviews in Immunology, 30, 327.
57. Shirai, H., Kidera, A. & Nakamura, H. (1999) H3-rules: identification of CDR-H3 structures in antibodies. FEBS Letters, 455, 188.
58. Silverstein, A. & Rose, N. (1997) On the mystique of the immunological self. Immunological Reviews, 159, 197.
59. Tauber, A. (1994) The Immune Self: Theory or Metaphor? Cambridge Univ Press, Cambridge, UK.
60. Tiegs, S., Russell, D. & Nemazee, D. (1993) Receptor editing in self-reactive bone marrow B cells. Journal of Experimental Medicine, 177, 1009.
61. Tonegawa, S. (1983) Somatic generation of antibody diversity. Nature, 302, 575.
62. Van Regenmortel, M. (2002) Reductionism and the search for structure-function relationships in antibody molecules. Journal of Molecular Recognition, 15, 240.
63. Wardemann, H., Yurasov, S., Schaefer, A., Young, J., Meffre, E. & Nussenzweig, M. (2003) Predominant autoantibody production by early human B cell precursors. Science, 301, 1374.
64. Wedemayer, G., Patten, P., Wang, L., Schultz, P. & Stevens, R. (1997) Structural insights into the evolution of an antibody combining site. Science, 276, 1665.
65. Wu, T., Johnson, G. & Kabat, E. (1993) Length distribution of CDRH3 in antibodies. Proteins, 16, 1.