Human monoclonal antibody reactivity with human leukocyte antigen class i epitopes defined by pairs of mismatched eplets and self-eplets

Transplantation

Volumn 90, Issue 12, 2010, Pages 1468-1472

  Marrari, Marilyn ^a   Mostecki, Justin ^b   Mulder, Arend ^c   Claas, Frans ^c   Balazs, Ivan ^b   Duquesnoy, Rene J ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b Gen Probe Transplant Diagnostics   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Class I HLA antigen; Epitope structure; Eplet; HLA epitope; HLAMatchmaker; Monoclonal antibody

Indexed keywords

ALLOANTIBODY; EPITOPE; HLA ANTIGEN CLASS 1; HUMAN MONOCLONAL ANTIBODY;

ALGORITHM; ALLELE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; COMPLEMENTARITY DETERMINING REGION; FEMALE; HLA MATCHING; HLA SYSTEM; HUMAN; HUMORAL IMMUNITY; IMMUNOGENICITY; PRIORITY JOURNAL; SURFACE PROPERTY; TRANSPLANTATION;

ALGORITHMS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; AUTOANTIBODIES; EPITOPES; FEMALE; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNITY, HUMORAL; MODELS, MOLECULAR; PREGNANCY; TRANSPLANTATION IMMUNOLOGY;

EID: 78650842080     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182007b74     Document Type: Article

References (23)

1. El-Awar NR, Akaza T, Terasaki PI, et al. Human leukocyte antigen class I epitopes: update to 103 total epitopes, including the C locus. Transplantation 2007; 84: 532.
2. El-Awar N, Terasaki PI, Nguyen A, et al. New HLA class I epitopes defined by murine monoclonal antibodies. Hum Immunol 2010; 71: 456.
3. Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 2006; 67: 847.
4. Duquesnoy R. Clinical usefulness of HLAMatchmaker in HLA epitope matching for organ transplantation. Curr Opin Immunol 2008; 20: 594.
5. Duquesnoy RJ, Marrari M. HLAMatchmaker-based definition of structural human leukocyte antigen epitopes detected by alloantibodies. Curr Opin Organ Transplant 2009; 14: 403.
6. Duquesnoy RJ, Marrari M. Correlations between Terasaki's HLA class I epitopes and HLAMatchmaker-defined eplets on HLA-A, -B and -C antigens. Tissue Antigens 2009; 74: 117.
7. Marrari M, Duquesnoy RJ. Correlations between Terasaki's HLA class II epitopes and HLAMatchmaker-defined eplets on HLA-DR and -DP antigens. Tissue Antigens 2009; 74: 134.
8. Duquesnoy RJ, Mulder A, Askar M, et al. HLAMatchmaker-based analysis ofhumanmonoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes. Hum Immunol 2005; 66: 749.
9. Davies DR, Padlan EA, Sheriff S. Antibody-antigen complexes. Annu Rev Biochem 1990; 59: 439.
10. MacCallum RM, Martin AC, Thornton JM. Antibody-antigen interactions: Contact analysis and binding site topography. J Mol Biol 1996; 262: 732.
11. Padlan EA. Anatomy of the antibody molecule. Mol Immunol 1994; 31: 169.
12. Murphy K, Travers P, Walport M, et al. Janeway's immunobiology [ed. 7]. New York, Garland Science 2008, p 887.
13. Gaudin E, Rosado M, Agenes F, et al. B-cell homeostasis, competition, resources, and positive selection by self-antigens. Immunol Rev 2004; 197: 102.
14. Cancro MP, Kearney JF. B Cell Positive Selection: Road Map to the Primary Repertoire. J Immunol 2004; 173: 15.
15. Gay D, Saunders T, Camper S, et al. Receptor editing: An approach by autoreactive B cells to escape tolerance. J Exp Med 1993; 177: 999.
16. Tiegs SL, Russell DM, Nemazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med 1993; 177: 1009.
17. Retter MW, Nemazee D. Receptor editing occurs frequently during normal B cell development. J Exp Med 1998; 188: 1231.
18. Tze LE, Baness EA, Hippen KL, et al. Ig Light Chain Receptor Editing in Anergic B cells. J Immunol 2000; 165: 6796.
19. Wardemann H, Hammersen J, Nussenzweig MC. Human autoantibody silencing by immunoglobulin light chains. J Exp Med 2004; 200: 191.
20. Mulder A, Kardol M, Blom J, et al. A human monoclonal antibody, produced following in vitro immunization, recognizing an epitope shared by HLA-A2 subtypes and HLA-A28. Tissue Antigens 1993; 42: 27.
21. Mulder A, Kardol M, Blom J, et al. Successful strategy for the large scale development of HLA-specific human monoclonal antibodies. In: 12th International Histocompatibility Workshop. Paris, France, EDR Publishers 1996, pp 354-356.
22. Mulder A, Kardol M, Regan J, et al. Reactivity of twenty-two cytotoxic human monoclonal HLA antibodies towards soluble HLA class I in an enzyme-linked immunosorbent assay (PRA-STAT). Hum Immunol 1997; 56: 106.
23. Hogue CW. Cn3D: a new generation of three-dimensional molecular structure viewer. Trends Biochem Sci 1997; 22: 314.