Correlations between Terasaki's HLA class i epitopes and HLAMatchmaker-defined eplets on HLA-A, -B and -C antigens

Tissue Antigens

Volumn 74, Issue 2, 2009, Pages 117-133

  Duquesnoy, R J ^a   Marrari, M ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Epitope; Eplet; HLAMatchmaker; Human leukocyte antigen antibody; Human leukocyte antigen A, B, C

Indexed keywords

ALLOANTIBODY; EPITOPE; HLA A ANTIGEN; HLA ANTIBODY; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA C ANTIGEN; MONOCLONAL ANTIBODY;

ALGORITHM; ANTIBODY SPECIFICITY; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ANTIGENICITY; ARTICLE; COMPARATIVE STUDY; EPITOPE MAPPING; HLA MATCHING; HLA SYSTEM; HUMAN; IMMUNOGENICITY; NONHUMAN; PREDICTION; PRIORITY JOURNAL;

ALGORITHMS; ALLELES; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; EPITOPE MAPPING; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-C ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; MODELS, MOLECULAR;

EID: 67650450539     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2009.01271.x     Document Type: Article

References (51)

1. Pei R, Lee JH, Shih NJ, Chen M, Terasaki PI. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 2003 : 75 : 43 9.
2. El-Awar N, Cook DJ, Terasaki P. HLA class I epitopes: A and B loci. In : Terasaki P, Cecka M, eds. Clinical Transplants 2006, 79 94.
3. El-Awar N, Lee JH, Tarsitani C et al. HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Human Immunol 2007 : 68 : 170 80.
4. El-Awar NR, Akaza T, Terasaki PI et al. Human leukocyte antigen class I epitopes: update to 103 total epitopes, including the C locus. Transplantation 2007 : 84 : 532 40.
5. El-Awar N, Terasaki PI, Cai J et al. Epitopes of the HLA-A, B, C, DR, DQ and MICA antigens. Clinical Transplants 2007 : 175 94.
6. Cai J, Terasaki PI, Mao Q et al. Development of nondonor-specific HLA-DR antibodies in allograft recipients is associated with shared epitopes with mismatched donor DR antigens. Amer J Transplantation 2006 : 6 : 2947 54.
7. Deng CT, El-Awar N, Ozawa M et al. Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipients. Transplantation 2008 : 86 : 452 9.
8. Cai J, Terasaki P. Post-transplantation antibody monitoring and HLA antibody epitope identification. Curr Opin Immunol 2008 : 20 : 602 6.
9. Amit A, Mariuzza R, Phillips S, Poljak R. Three-dimensional structure of an antigen-antibody complex at 2.8 Angstrom resolution. Science 1986 : 233 : 747 52.
10. Sheriff S, Silverton EW, Padlan EA et al. Three-dimensional structure of an antibody-antigen complex. Proc Natl Acad Sci U S A 1987 : 84 : 8075 9.
11. Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Human Immunol 2006 : 67 : 847 62.
12. Davies D, Padlan E, Sheriff S. Antibody-antigen complexes. Annu Rev Biochem 1990 : 59 : 439 73.
13. Braden B, Goldman E, Mariuzza R, Poljak R. Anatomy of an antibody molecule: structure, kinetics, thermodynamics and mutational studies of the antilysozyme antibody D. Immunol Rev 1998 : 163 : 45 57. (Pubitemid 28327861)
14. Novotny J. Protein antigenicity: a thermodynamic approach. Mol Immunol 1991 : 28 : 201 8.
15. Van Regenmortel M. Reductionism and the search for structure-function relationships in antibody molecules. J Mol Recognit 2002 : 15 : 240 7.
16. DeLano W. Unraveling hot spots in binding interfaces: progress and challenges. Curr Opin Struct Biol 2002 : 12 : 14 20. (Pubitemid 34142715)
17. Duquesnoy RJ, Marrari M. HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. II. Verification of the algorithm and determination of the relative immunogenicity of amino acid triplet-defined epitopes. Human Immunol 2002 : 63 : 353 63.
18. Lobashevsky AL, Senkbeil RW, Shoaf JL et al. The number of amino acid residues mismatches correlates with flow cytometry crossmatching results in high PRA renal patients. Human Immunol 2002 : 63 : 364 74.
19. Duquesnoy RJ, Howe J, Takemoto S. HLAmatchmaker: a molecularly based algorithm for histocompatibility determination. IV. An alternative strategy to increase the number of compatible donors for highly sensitized patients. Transplantation 2003 : 75 : 889 97.
20. Duquesnoy RJ, Takemoto S, De Lange P, Doxiadis IIN, Schreuder GMT, Claas FHJ. HLAMatchmaker: a molecularly based algorithm for histocompatibility determination III. Effect of matching at the HLA-A, B amino acid triplet level on kidney transplant survival. Transplantation 2003 : 75 : 884 9.
21. Boehringer D, Reinhard T, Duquesnoy R et al. Beneficial effect of matching at the HLA-A and B amino-acid triplet level on rejection free survival in penetrating keratoplasty. Transplantation 2004 : 77 : 417 21.
22. Claas FHJ, Witvliet M, Duquesnoy RJ, Persijn G, Doxiadis IIN. The acceptable mismatch program as a fast tool to transplant highly sensitized patients awaiting a post-mortal kidney: short waiting time and excellent graft outcome. Transplantation 2004 : 78 : 190 3.
23. Dankers MKA, Witvliet MD, Roelen DL et al. The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched HLA antigens. Transplantation 2004 : 128 : 1236 9.
24. Duquesnoy RJ, Witvliet MJ, Doxiadis IIN, de Fijter H, Claas FHJ. HLAMatchmaker-based strategy to identify acceptable HLA class I mismatches for highly sensitized kidney transplant candidates. Transplant International 2004 : 7 : 31 8.
25. Adeyi OE, Girnita A, Awadalla Y et al. Serum analysis after kidney transplant nephrectomy reveals restricted antibody specificity patterns against donor HLA class I antigens. Transpl Immunol 2005 : 14 : 53 62. (Pubitemid 40462290)
26. Claas FHJ, Dankers MK, Oudshoorn M et al. Differential immunogenicity of HLA mismatches in clinical transplantation. Transplant Immunol 2005 : 14 : 187 91.
27. Doxiadis IIN, Duquesnoy RJ, Claas FHJ. Extending options for highly sensitized patients to receive a suitable kidney graft. Curr Opin Immunol 2005 : 17 : 536 40.
28. Nambiar A, Duquesnoy RJ, Adams S et al. HLAMatchmaker-driven analysis of response to HLA matched platelet transfusions in alloimmunized patients. Blood 2006 : 107 : 1680 7.
29. Haririan A, Fagoaga O, Daneshvar H et al. Predictive value of HLA epitope matching using HLAMatchmaker for graft outcomes in a predominantly African-American renal transplant cohort. Clin Transplant 2006 : 20 : 226 33.
30. Valentini RP, Nehlsen-Cannarella SL, Gruber SA et al. Intravenous immunoglubulin, HLA allele typing and HLAMatchmaker facilitate successful transplantation in highly sensitized pediatric renal allograft recipients. Pediatr Transplant 2007 : 11 : 77 81. (Pubitemid 46100959)
31. Duquesnoy RJ. "Match and Treat", an effective strategy for transplanting highly sensitized pediatric transplant candidates? (Invited Editorial). Pediatr Transplant 2007 : 11 : 3 4. (Pubitemid 46100948)
32. Duquesnoy R. Structural epitope matching for HLA alloimmunized thrombocytopenic patients: a new strategy to provide more effective platelet transfusion support? Transfusion 2008 : I48 : 221 7.
33. Duquesnoy R. Clinical usefulness of HLAMatchmaker in HLA epitope matching for organ transplantation. Curr Opinion Immunol 2008 : 20 : 594 601.
34. Kosmoliaptsis V, Bradley J, Sharples L et al. Predicting the immunogenicity of human leukocyte antigen class I alloantigens using structural epitope analysis determined by HLAMatchmaker. Transplantation 2008 : 85 : 1817 25.
35. Duquesnoy R. HLA class II antibodies and transplant outcome (invited analysis and commentary). Transplantation 2008 : 86 : 638 40.
36. Duquesnoy R, Awadalla Y, Lomago J et al. Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes. Transplant Immunol 2008 : 18 : 352 60.
37. Akkoc N, Scornik JC. HLA epitope matching. Contribution of matched residues to epitopes recognized by alloantibodies. Transplantation 1991 : 52 : 903 7.
38. McCutcheon JA, Lutz CT. Mutagenesis around residue 176 on HLA-B*0702 characterizes multiple distinct epitopes for anti-HLA antibodies. Human Immunol 1992 : 35 : 125 31.
39. Smith KD, Lutz CT. Alloreactive T cell recognition of MHC class I molecules. The T cell receptor interacts with limited regions of the MHC class I long alpha helices. J Immunol 1997 : 158 : 2805 12.
40. Duquesnoy RJ, Mulder A, Askar M, Fernandez-Vina M, Claas FHJ. HLAMatchmaker-based analysis of human monoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes. Hum Immunol 2005 : 66 : 749 61.
41. Duquesnoy R. Update on HLAMatchmaker: a molecularly based algorithm for histocompatibility determination at the epitope level. EFI Newsletter 2007 : P 37 42 and ASHI Quarterly 2007 : P 74 82.
42. Hogue C. Cn3D: a new generation of three-dimensional molecular structure viewer. Trends Biochem Sci 1997 : 22 : 314 6.
43. Marsh SG, Bodmer JG. HLA-DR and -DQ epitopes and monoclonal antibody specificity. Immunol Today 1989 : 10 : 305 12.
44. Klohe E, Fu XT, Ballas M, Karr RW. HLA-DR beta chain residues that are predicted to be located in the floor of the peptide-binding groove contribute to antibody-binding epitopes. Human Immunol 1993 : 37 : 51 8.
45. Drover S, Marshall WH, Kwok WW, Nepom GT, Karr RW. Amino acids in the peptide-binding groove influence an antibody-defined, disease-associated HLA-DR epitope. Scand J Immunol 1994 : 39 : 539 50.
46. Fu X-T, Drover S, Marshall WH, Karr RW. HLA-DR residues accessible under the peptide-binding groove contribute to polymorphic antibody epitopes. Hum Immunol 1995 : 43 : 243 50.
47. Smith KD, Mace BE, Valenzuela A et al. Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies. J Immunol 1996 : 157 : 2470 8.
48. Duquesnoy RJ. HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm. Human Immunol 2002 : 63 : 339 52.
49. Duquesnoy RJ, Claas FHJ. Progress Report of 14th International Histocompatibility Workshop Project on the structural basis of HLA Compatibility. Tissue Antigens 2007 : 69 (Suppl. 1 180 4.
50. Smith KD, Kurago ZB, Lutz CT. Conformational changes in MHC class I molecules. Antibody, T-cell receptor, and NK cell recognition in an HLA-B7 model system. Immunologic Research 1997 : 16 : 243 59.
51. Hulsmeyer M, Chames P, Hillig R et al. A Major Histocompatibility Complex-Peptide-restricted antibody and T Cell Receptor molecules recognize their Target by distinct binding modes. Crystal structure of Human Leukocyte Antigen (HLA)-A1 -MAGE-A1 complex with Fab-Hyb3. J Biol Chem 2005 : 280 : 2972 80.