메뉴 건너뛰기




Volumn 91, Issue 1, 2012, Pages 127-136

The glucocorticoid dexamethasone programs human dendritic cells for enhanced phagocytosis of apoptotic neutrophils and inflammatory response

Author keywords

Apoptophagocytic genes; Inflammation; T cell activation; TNF

Indexed keywords

ADENOSINE RECEPTOR; CD14 ANTIGEN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1QA; DEXAMETHASONE; MERTK ENZYME; PHOSPHOTRANSFERASE; PROTEIN ADORA3; UNCLASSIFIED DRUG;

EID: 84855326534     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0511243     Document Type: Article
Times cited : (22)

References (59)
  • 1
    • 77954396042 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: Implications in health and disease
    • Elliott, M. R., Ravichandran, K. S. (2010) Clearance of apoptotic cells: implications in health and disease. J. Cell Biol. 189, 1059-1070.
    • (2010) J. Cell Biol , vol.189 , pp. 1059-1070
    • Elliott, M.R.1    Ravichandran, K.S.2
  • 2
    • 77649152255 scopus 로고    scopus 로고
    • Autoimmunity and the clearance of dead cells
    • Nagata, S., Hanayama, R., Kawane, K. (2010) Autoimmunity and the clearance of dead cells. Cell 140, 619-630.
    • (2010) Cell , vol.140 , pp. 619-630
    • Nagata, S.1    Hanayama, R.2    Kawane, K.3
  • 3
    • 77953440032 scopus 로고    scopus 로고
    • Neutrophil apoptosis: Relevance to the innate immune response and inflammatory disease
    • Fox, S., Leitch, A. E., Duffin, R., Haslett, C., Rossi, A. G. (2010) Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease. J. Innate Immun. 2, 216-227.
    • (2010) J. Innate Immun , vol.2 , pp. 216-227
    • Fox, S.1    Leitch, A.E.2    Duffin, R.3    Haslett, C.4    Rossi, A.G.5
  • 5
    • 77956255766 scopus 로고    scopus 로고
    • Find-me and eat-me signals in apoptotic cell clearance: Progress and conundrums
    • Ravichandran, K. S. (2010) Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums. J. Exp. Med. 207, 1807-1817.
    • (2010) J. Exp. Med , vol.207 , pp. 1807-1817
    • Ravichandran, K.S.1
  • 6
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman, R. M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
    • (1991) Annu. Rev. Immunol , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 7
    • 33845898737 scopus 로고    scopus 로고
    • Steady-state and inflammatory dendriticcell development
    • Shortman, K., Naik, S. H. (2007) Steady-state and inflammatory dendriticcell development. Nat. Rev. Immunol. 7, 19-30.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 19-30
    • Shortman, K.1    Naik, S.H.2
  • 8
    • 34250893815 scopus 로고    scopus 로고
    • Intrinsic and cooperative antigenpresenting functions of dendritic-cell subsets in vivo
    • Villadangos, J. A., Schnorrer, P. (2007) Intrinsic and cooperative antigenpresenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 7, 543-555.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 543-555
    • Villadangos, J.A.1    Schnorrer, P.2
  • 9
    • 0033486007 scopus 로고    scopus 로고
    • T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
    • Kaliński, P., Hilkens, C. M., Wierenga, E. A., Kapsenberg, M. L. (1999) T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20, 561-567.
    • (1999) Immunol. Today , vol.20 , pp. 561-567
    • Kaliński, P.1    Hilkens, C.M.2    Wierenga, E.A.3    Kapsenberg, M.L.4
  • 10
    • 35348948374 scopus 로고    scopus 로고
    • Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
    • van Beelen, A. J., Zelinkova, Z., Taanman-Kueter, E. W., Muller, F. J., Hommes, D. W., Zaat, S. A., Kapsenberg, M. L., de Jong, E. C. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27, 660-669.
    • (2007) Immunity , vol.27 , pp. 660-669
    • van Beelen, A.J.1    Zelinkova, Z.2    Taanman-Kueter, E.W.3    Muller, F.J.4    Hommes, D.W.5    Zaat, S.A.6    Kapsenberg, M.L.7    de Jong, E.C.8
  • 12
    • 58049209834 scopus 로고    scopus 로고
    • Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    • Joffre, O., Nolte, M. A., Sporri, R., Reise Sousa, C. (2009) Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol. Rev. 227, 234-247.
    • (2009) Immunol. Rev , vol.227 , pp. 234-247
    • Joffre, O.1    Nolte, M.A.2    Sporri, R.3    Reise Sousa, C.4
  • 13
  • 14
    • 0026446156 scopus 로고
    • GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
    • Caux, C., Dezutter-Dambuyant, C., Schmitt, D., Banchereau, J. (1992) GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360, 258-261.
    • (1992) Nature , vol.360 , pp. 258-261
    • Caux, C.1    Dezutter-Dambuyant, C.2    Schmitt, D.3    Banchereau, J.4
  • 16
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α
    • Sallusto, F., Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109-1118.
    • (1994) J. Exp. Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 19
    • 0032697971 scopus 로고    scopus 로고
    • The role of IL-13 in the generation of dendritic cells in vitro
    • Morse, M. A., Lyerly, H. K., Li, Y. (1999) The role of IL-13 in the generation of dendritic cells in vitro. J. Immunother. 22, 506-513.
    • (1999) J. Immunother , vol.22 , pp. 506-513
    • Morse, M.A.1    Lyerly, H.K.2    Li, Y.3
  • 20
    • 0032999123 scopus 로고    scopus 로고
    • Interleukin-13 is involved in functional maturation of human peripheral blood monocyte-derived dendritic cells
    • Sato, K., Nagayama, H., Tadokoro, K., Juji, T., Takahashi, T. A. (1999) Interleukin-13 is involved in functional maturation of human peripheral blood monocyte-derived dendritic cells. Exp. Hematol. 27, 326-336.
    • (1999) Exp. Hematol , vol.27 , pp. 326-336
    • Sato, K.1    Nagayama, H.2    Tadokoro, K.3    Juji, T.4    Takahashi, T.A.5
  • 21
    • 0027305137 scopus 로고
    • Phagocytosis of antigens by Langerhans cells in vitro
    • Reise Sousa, C., Stahl, P. D., Austyn, J. M. (1993) Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178, 509-519.
    • (1993) J. Exp. Med , vol.178 , pp. 509-519
    • Reise Sousa, C.1    Stahl, P.D.2    Austyn, J.M.3
  • 22
    • 0029148878 scopus 로고
    • Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
    • Sallusto, F., Cella, M., Danieli, C., Lanzavecchia, A. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
    • (1995) J. Exp. Med , vol.182 , pp. 389-400
    • Sallusto, F.1    Cella, M.2    Danieli, C.3    Lanzavecchia, A.4
  • 23
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • Albert, M. L., Pearce, S. F., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., Bhardwaj, N. (1998) Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188, 1359-1368.
    • (1998) J. Exp. Med , vol.188 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3    Sauter, B.4    Roy, P.5    Silverstein, R.L.6    Bhardwaj, N.7
  • 24
    • 2442637158 scopus 로고    scopus 로고
    • Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells
    • Miyasaka, K., Hanayama, R., Tanaka, M., Nagata, S. (2004) Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur. J. Immunol. 34, 1414-1422.
    • (2004) Eur. J. Immunol , vol.34 , pp. 1414-1422
    • Miyasaka, K.1    Hanayama, R.2    Tanaka, M.3    Nagata, S.4
  • 25
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert, M. L., Sauter, B., Bhardwaj, N. (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 26
    • 0041571629 scopus 로고    scopus 로고
    • Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: Relevance to systemic vasculitis
    • Clayton, A. R., Prue, R. L., Harper, L., Drayson, M. T., Savage, C. O. (2003) Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis. Arthritis Rheum. 48, 2362-2374.
    • (2003) Arthritis Rheum , vol.48 , pp. 2362-2374
    • Clayton, A.R.1    Prue, R.L.2    Harper, L.3    Drayson, M.T.4    Savage, C.O.5
  • 27
    • 33745320045 scopus 로고    scopus 로고
    • Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: A new link between leukocytes upstream of T lymphocytes
    • Megiovanni, A. M., Sanchez, F., Robledo-Sarmiento, M., Morel, C., Gluckman, J. C., Boudaly, S. (2006) Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes. J. Leukoc. Biol. 79, 977-988.
    • (2006) J. Leukoc. Biol , vol.79 , pp. 977-988
    • Megiovanni, A.M.1    Sanchez, F.2    Robledo-Sarmiento, M.3    Morel, C.4    Gluckman, J.C.5    Boudaly, S.6
  • 29
    • 78649574843 scopus 로고    scopus 로고
    • PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils
    • Majai, G., Gogolak, P., Ambrus, C., Vereb, G., Hodrea, J., Fésüs, L., Rajnavolgyi, E. (2010) PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils. J. Leukoc. Biol. 88, 981-991.
    • (2010) J. Leukoc. Biol , vol.88 , pp. 981-991
    • Majai, G.1    Gogolak, P.2    Ambrus, C.3    Vereb, G.4    Hodrea, J.5    Fésüs, L.6    Rajnavolgyi, E.7
  • 30
    • 0027471333 scopus 로고
    • Immunosuppressive therapy for autoimmune diseases
    • Hoffman, G. S. (1993) Immunosuppressive therapy for autoimmune diseases. Ann. Allergy 70, 263-274.
    • (1993) Ann. Allergy , vol.70 , pp. 263-274
    • Hoffman, G.S.1
  • 31
    • 0030802018 scopus 로고    scopus 로고
    • Glucocorticoids and immune function: Unknown dimensions and new frontiers
    • Wilckens, T., De Rijk, R. (1997) Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol. Today 18, 418-424.
    • (1997) Immunol. Today , vol.18 , pp. 418-424
    • Wilckens, T.1    de Rijk, R.2
  • 32
    • 33644776504 scopus 로고    scopus 로고
    • Update on glucocorticoid action and resistance
    • Ito, K., Chung, K. F., Adcock, I. M. (2006) Update on glucocorticoid action and resistance. J. Allergy Clin. Immunol. 117, 522-543.
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 522-543
    • Ito, K.1    Chung, K.F.2    Adcock, I.M.3
  • 33
    • 0034049874 scopus 로고    scopus 로고
    • Glucocorticoids in T cell development and function*
    • Ashwell, J. D., Lu, F. W., Vacchio, M. S. (2000) Glucocorticoids in T cell development and function*. Annu. Rev. Immunol. 18, 309-345.
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 309-345
    • Ashwell, J.D.1    Lu, F.W.2    Vacchio, M.S.3
  • 34
    • 0031081426 scopus 로고    scopus 로고
    • Mechanism of gene expression by the glucocorticoid receptor: Role of protein-protein interactions
    • McEwan, I. J., Wright, A. P., Gustafsson, J. A. (1997) Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactions. Bioessays 19, 153-160.
    • (1997) Bioessays , vol.19 , pp. 153-160
    • McEwan, I.J.1    Wright, A.P.2    Gustafsson, J.A.3
  • 35
    • 0029801742 scopus 로고    scopus 로고
    • Regulation of cytokine and cytokine receptor expression by glucocorticoids
    • Almawi, W. Y., Beyhum, H. N., Rahme, A. A., Rieder, M. J. (1996) Regulation of cytokine and cytokine receptor expression by glucocorticoids. J. Leukoc. Biol. 60, 563-572.
    • (1996) J. Leukoc. Biol , vol.60 , pp. 563-572
    • Almawi, W.Y.1    Beyhum, H.N.2    Rahme, A.A.3    Rieder, M.J.4
  • 36
    • 0035879302 scopus 로고    scopus 로고
    • Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac
    • Giles, K. M., Ross, K., Rossi, A. G., Hotchin, N. A., Haslett, C., Dransfield, I. (2001) Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac. J. Immunol. 167, 976-986.
    • (2001) J. Immunol , vol.167 , pp. 976-986
    • Giles, K.M.1    Ross, K.2    Rossi, A.G.3    Hotchin, N.A.4    Haslett, C.5    Dransfield, I.6
  • 38
    • 33748162638 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells: Cytokine modulation comes of age
    • Rutella, S., Danese, S., Leone, G. (2006) Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108, 1435-1440.
    • (2006) Blood , vol.108 , pp. 1435-1440
    • Rutella, S.1    Danese, S.2    Leone, G.3
  • 40
    • 0033430255 scopus 로고    scopus 로고
    • Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells
    • Matasić, R., Dietz, A. B., Vuk-Pavlovic, S. (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J. Leukoc. Biol. 66, 909-914.
    • (1999) J. Leukoc. Biol , vol.66 , pp. 909-914
    • Matasić, R.1    Dietz, A.B.2    Vuk-Pavlovic, S.3
  • 41
  • 43
    • 34250351211 scopus 로고    scopus 로고
    • PPARγ-dependent regulation of human macrophages in phagocytosis of apoptotic cells
    • Majai, G., Sarang, Z., Csomos, K., Zahuczky, G., Fésüs, L. (2007) PPARγ-dependent regulation of human macrophages in phagocytosis of apoptotic cells. Eur. J. Immunol. 37, 1343-1354.
    • (2007) Eur. J. Immunol , vol.37 , pp. 1343-1354
    • Majai, G.1    Sarang, Z.2    Csomos, K.3    Zahuczky, G.4    Fésüs, L.5
  • 45
    • 77950942385 scopus 로고    scopus 로고
    • Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages
    • Hodrea, J., Demeny, M. A., Majai, G., Sarang, Z., Korponay-Szabo, I. R., Fésüs, L. (2010) Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages. Immunol. Lett. 130, 74-81.
    • (2010) Immunol. Lett , vol.130 , pp. 74-81
    • Hodrea, J.1    Demeny, M.A.2    Majai, G.3    Sarang, Z.4    Korponay-Szabo, I.R.5    Fésüs, L.6
  • 46
    • 68149164365 scopus 로고    scopus 로고
    • Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages
    • McColl, A., Bournazos, S., Franz, S., Perretti, M., Morgan, B. P., Haslett, C., Dransfield, I. (2009) Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J. Immunol. 183, 2167-2175.
    • (2009) J. Immunol , vol.183 , pp. 2167-2175
    • McColl, A.1    Bournazos, S.2    Franz, S.3    Perretti, M.4    Morgan, B.P.5    Haslett, C.6    Dransfield, I.7
  • 47
    • 79959588042 scopus 로고    scopus 로고
    • Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of MERTK in enhanced phagocytosis
    • Zahuczky, G., Kristof, E., Majai, G., Fésüs, L. (2011) Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of MERTK in enhanced phagocytosis. PLoS ONE 6, e21349.
    • (2011) PLoS ONE , vol.6
    • Zahuczky, G.1    Kristof, E.2    Majai, G.3    Fésüs, L.4
  • 48
    • 0029842517 scopus 로고    scopus 로고
    • Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype
    • Kim, Y. C., Ji, X. D., Jacobson, K. A. (1996) Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J. Med. Chem. 39, 4142-4148.
    • (1996) J. Med. Chem , vol.39 , pp. 4142-4148
    • Kim, Y.C.1    Ji, X.D.2    Jacobson, K.A.3
  • 49
    • 0036709920 scopus 로고    scopus 로고
    • Cell-specific regulation of apoptosis by glucocorticoids: Implication to their anti-inflammatory action
    • Amsterdam, A., Tajima, K., Sasson, R. (2002) Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inflammatory action. Biochem. Pharmacol. 64, 843-850.
    • (2002) Biochem. Pharmacol , vol.64 , pp. 843-850
    • Amsterdam, A.1    Tajima, K.2    Sasson, R.3
  • 50
    • 60549117005 scopus 로고    scopus 로고
    • Handbook of experimental pharmacology dendritic cells: The use of dexamethasone in the induction of tolerogenic DCs
    • Van Kooten, C., Stax, A. S., Woltman, A. M., Gelderman, K. A. (2009) Handbook of experimental pharmacology dendritic cells: the use of dexamethasone in the induction of tolerogenic DCs. Handb. Exp. Pharmacol. 188, 233-249.
    • (2009) Handb. Exp. Pharmacol , vol.188 , pp. 233-249
    • van Kooten, C.1    Stax, A.S.2    Woltman, A.M.3    Gelderman, K.A.4
  • 51
    • 79952799756 scopus 로고    scopus 로고
    • Cellular processing of the glucocorticoid receptor gene and protein: New mechanisms for generating tissuespecific actions of glucocorticoids
    • Oakley, R. H., Cidlowski, J. A. (2011) Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissuespecific actions of glucocorticoids. J. Biol. Chem. 286, 3177-3184.
    • (2011) J. Biol. Chem , vol.286 , pp. 3177-3184
    • Oakley, R.H.1    Cidlowski, J.A.2
  • 52
    • 0036804796 scopus 로고    scopus 로고
    • Transglutaminase 2: An enigmatic enzyme with diverse functions
    • Fésüs, L., Piacentini, M. (2002) Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem. Sci. 27, 534-539.
    • (2002) Trends Biochem. Sci , vol.27 , pp. 534-539
    • Fésüs, L.1    Piacentini, M.2
  • 56
  • 57
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • Hasko ́, G., Linden, J., Cronstein, B., Pacher, P. (2008) Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 7, 759-770.
    • (2008) Nat. Rev. Drug Discov , vol.7 , pp. 759-770
    • Haskó, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 59
    • 78649545971 scopus 로고    scopus 로고
    • Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells
    • Ding, Y., Gao, Z. G., Jacobson, K. A., Suffredini, A. F. (2010) Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells. J. Pharmacol. Exp. Ther. 335, 693-702.
    • (2010) J. Pharmacol. Exp. Ther , vol.335 , pp. 693-702
    • Ding, Y.1    Gao, Z.G.2    Jacobson, K.A.3    Suffredini, A.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.