The role of IL-13 in the generation of dendritic cells in vitro

Journal of Immunotherapy

Volumn 22, Issue 6, 1999, Pages 506-513

  Morse, Michael A ^a   Kim Lyerly, H ^a   Li, Yiwen ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cytotoxic T lymphocytes; Dendritic cells; IL 13; IL 4

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD20 ANTIGEN; CD3 ANTIGEN; CD86 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 13; RECOMBINANT INTERLEUKIN 4;

ACTIVE IMMUNIZATION; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; MIXED LYMPHOCYTE REACTION; MONONUCLEAR CELL; PRIORITY JOURNAL;

ANTIGENS; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA; CULTURE MEDIA, SERUM-FREE; DENDRITIC CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE CULTURE TEST, MIXED; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032697971     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/00002371-199911000-00005     Document Type: Article

References (20)

1. Steinman RM. The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 1991;9:271-96.
2. Morse MA, Zhou LJ, Tedder TF, Lyerly HK, Smith C. Generation of dendritic cells in vitro from peripheral blood mononuclear cells with GM-CSF, IL-4, and TNF-a for use in cancer immunotherapy. Ann Surg 1997;226:6-16.
3. Romani N, Grüner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994;180:83-93.
4. Bender A, Sapp M, Schuler G, Steinman RM, Bhardwadj N. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods 1996; 196:121-35.
5. + ThO, Thl, and Th2 T cell clones and EBV-transformed B cells. Int Immunol 1995;7:1405-16.
6. Zurawski SM, Vega F Jr, Huyghe B, Zurawski G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 1993; 12:2663-70.
7. Vita N, Lefort S, Laurent P, Caput D, Ferrara P. Characterization and comparison of the interleukin-13 receptor with the interleukin-4 receptor on several cell types. J Biol Chem 1995;270:3512-7.
8. Kondo M, Takeshita T, Ishii N, et al. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 1993;262:1874-7.
9. Russell SM, Keegan AD, Harada N, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 1993;262:1880-3.
10. McKenzie ANJ, Culpepper JA, de Waal Malefyt R, et al. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sei USA 1993;90 3735-9.
11. Sakamoto O, Hashiyama M, Minty A, Ando M, Suda T. Interleukin-13 selectively suppresses the growth of human macrophage progenitors at the late stage. Blood 1995;85:3487-93.
12. Cosentino G, Soprana E, Thienes CP, Siccardi AG, Viale G, Vercelli D. IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal human monocytes. J Immunol 1995;155:3145-51.
13. de Waal Malefyt R, Figdor CG, Huijbens R, et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol 1993;151:6370-81.
14. Piemonti L, Bernasconi S, Luini W, et al. IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF. Eur Cytokine Netw 1995;6:245-52.
15. Zurawski SM, Vega F, Huyghe B, Zurawski G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 1993; 12:2663-70.
16. Jacobsen SE, Okkenbaug C, Veichy P, et al. Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells. J Exp Med 1994;180:75-82.
17. Minty A, Chalon P, Derocq J-M, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993;362:248-50.
18. Vita N, Lefort S, Laurent P, et al. Characterization and comparison of the interleukin 13 receptor with the interleukin 4 receptor on several cell types. J Biol Chem 1995;270:3512-7.
19. Romani N, Reider D, Heuer M, et al. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 1996; 196:137-51.
20. Mukherji B, Chakraborty NG, Yamasaki S, et al. Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells. Proc Natl Acad Sci USA 1995;92:8078-82.